CN101616591B - 包含二膦酸盐化合物的水混悬液的长期持续释放药物组合物 - Google Patents

包含二膦酸盐化合物的水混悬液的长期持续释放药物组合物 Download PDF

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Publication number
CN101616591B
CN101616591B CN200780047021.7A CN200780047021A CN101616591B CN 101616591 B CN101616591 B CN 101616591B CN 200780047021 A CN200780047021 A CN 200780047021A CN 101616591 B CN101616591 B CN 101616591B
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China
Prior art keywords
acid
salts
calcium
salt
bisphosphonate
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CN200780047021.7A
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Chinese (zh)
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CN101616591A (zh
Inventor
J·Y·张
M·Z·罗
D·费
K·谢
J·F·丁
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Amphastar Pharmaceuticals Inc
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Amphastar Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN200780047021.7A 2006-12-21 2007-12-13 包含二膦酸盐化合物的水混悬液的长期持续释放药物组合物 Active CN101616591B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87680006P 2006-12-21 2006-12-21
US60/876,800 2006-12-21
US11/768,181 2007-06-25
US11/768,181 US8974801B2 (en) 2006-12-21 2007-06-25 Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
PCT/US2007/025569 WO2008085281A1 (en) 2006-12-21 2007-12-13 Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate

Publications (2)

Publication Number Publication Date
CN101616591A CN101616591A (zh) 2009-12-30
CN101616591B true CN101616591B (zh) 2014-06-18

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CN200780047021.7A Active CN101616591B (zh) 2006-12-21 2007-12-13 包含二膦酸盐化合物的水混悬液的长期持续释放药物组合物

Country Status (14)

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US (3) US8974801B2 (enExample)
EP (2) EP2548441B1 (enExample)
JP (1) JP5492564B2 (enExample)
CN (1) CN101616591B (enExample)
BR (1) BRPI0720605A2 (enExample)
CA (1) CA2673058C (enExample)
DK (2) DK2120585T3 (enExample)
ES (2) ES2396733T3 (enExample)
MX (1) MX2009006447A (enExample)
PL (2) PL2548441T3 (enExample)
PT (2) PT2120585E (enExample)
RU (1) RU2453316C2 (enExample)
SI (1) SI2120585T1 (enExample)
WO (1) WO2008085281A1 (enExample)

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KR101813728B1 (ko) * 2009-07-31 2017-12-29 그뤼넨탈 게엠베하 결정화 방법 및 생체이용률
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
AU2010330909B2 (en) 2009-12-18 2014-09-11 Howmedica Osteonics Corp. Post irradiation shelf-stable dual paste direct injectable bone cement precursor systems and methods of making same
CN102453050B (zh) * 2010-11-03 2015-01-07 成都云克药业有限责任公司 一种二膦酸化合物及其制备方法
ES2714701T3 (es) 2010-11-10 2019-05-29 Stryker European Holdings I Llc Proceso para la preparación de una espuma ósea polimérica
WO2012071517A2 (en) 2010-11-24 2012-05-31 Thar Pharmaceuticals, Inc. Novel crystalline forms
WO2013175385A1 (en) 2012-05-20 2013-11-28 Bar-Ilan Research And Development Company Ltd. Bisphosphonates vinylic monomers and polymers and uses thereof
US9492268B2 (en) 2012-11-13 2016-11-15 The Secant Group, Llc Tapered tubular implant formed from woven fabric
WO2017208070A1 (en) 2016-05-31 2017-12-07 Grünenthal GmbH Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis
CN108815117A (zh) * 2018-08-23 2018-11-16 宁波蒙曼生物科技有限公司 一种镇痛药物组合物及其制备方法
CN109930209B (zh) * 2019-03-07 2022-02-15 华南理工大学 一种具高结晶度及长径比双膦酸盐晶体及其制备方法
CN112707934A (zh) * 2020-12-30 2021-04-27 华南理工大学 一种阿仑膦酸钙配合物及其制备方法
CN114349786B (zh) * 2021-12-28 2023-07-11 中国科学院上海硅酸盐研究所 阿仑膦酸钙超长纳米线及其制备方法和应用

Citations (3)

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US20050037089A1 (en) * 2003-08-06 2005-02-17 Jobbins Jill Marie Method for promoting bone growth
US20050234021A1 (en) * 2003-09-10 2005-10-20 Petasis Nicos A Amino phosphonate and amino bis-phosphonate derivatives
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption

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US5356887A (en) 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5358941A (en) 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
WO1995008304A1 (en) * 1993-09-21 1995-03-30 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
US5462932A (en) 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
ES2221019T3 (es) 1996-10-31 2004-12-16 Takeda Chemical Industries, Ltd. Preparacion de liberacion mantenida.
EP1028712B1 (en) 1997-09-19 2005-01-12 Shire Laboratories Inc. Solid solution beadlet
SE9703691D0 (sv) 1997-10-10 1997-10-10 Astra Ab Pharmaceutical compositions
WO1999067809A1 (en) 1998-06-24 1999-12-29 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6342249B1 (en) 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
KR100492110B1 (ko) * 2000-05-05 2005-06-02 에프. 호프만-라 로슈 아게 비스포스폰산 또는 그의 염을 포함하는 피하 투여용겔-유사 약학 조성물
US6350471B1 (en) 2000-05-31 2002-02-26 Pharma Pass Llc Tablet comprising a delayed release coating
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JP4161031B2 (ja) 2000-10-31 2008-10-08 独立行政法人産業技術総合研究所 亜鉛含有リン酸カルシウム微粒子含有懸濁液または粒子溶媒混合系及び亜鉛欠乏症治療剤
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US7488496B2 (en) * 2002-03-06 2009-02-10 Christer Rosen Effervescent compositions comprising bisphosphonates and methods related thereto
US8071574B2 (en) * 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20050037089A1 (en) * 2003-08-06 2005-02-17 Jobbins Jill Marie Method for promoting bone growth
US20050234021A1 (en) * 2003-09-10 2005-10-20 Petasis Nicos A Amino phosphonate and amino bis-phosphonate derivatives
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption

Also Published As

Publication number Publication date
EP2120585A4 (en) 2011-11-23
PL2120585T3 (pl) 2013-03-29
PT2120585E (pt) 2013-01-15
US20150157650A1 (en) 2015-06-11
PL2548441T3 (pl) 2015-02-27
EP2548441B1 (en) 2014-08-27
PT2548441E (pt) 2014-11-27
EP2120585A1 (en) 2009-11-25
RU2009128023A (ru) 2011-01-27
EP2120585B1 (en) 2012-10-03
CA2673058A1 (en) 2008-07-17
ES2524690T3 (es) 2014-12-11
BRPI0720605A2 (pt) 2014-04-08
US8974801B2 (en) 2015-03-10
SI2120585T1 (sl) 2013-05-31
RU2453316C2 (ru) 2012-06-20
CN101616591A (zh) 2009-12-30
US20080153784A1 (en) 2008-06-26
DK2548441T3 (en) 2014-12-08
JP5492564B2 (ja) 2014-05-14
MX2009006447A (es) 2009-07-27
US20150157649A1 (en) 2015-06-11
WO2008085281A1 (en) 2008-07-17
DK2120585T3 (da) 2013-01-21
CA2673058C (en) 2015-11-24
EP2548441A1 (en) 2013-01-23
ES2396733T3 (es) 2013-02-25
JP2010513483A (ja) 2010-04-30

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