CN101611006A - 3-(4-(2,4-二氟苄氧基)-3-溴-6-甲基-2-氧代吡啶-1(2h)-基)-n,4-二甲基苯甲酰胺的制备方法 - Google Patents

3-(4-(2,4-二氟苄氧基)-3-溴-6-甲基-2-氧代吡啶-1(2h)-基)-n,4-二甲基苯甲酰胺的制备方法 Download PDF

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Publication number
CN101611006A
CN101611006A CNA2007800513123A CN200780051312A CN101611006A CN 101611006 A CN101611006 A CN 101611006A CN A2007800513123 A CNA2007800513123 A CN A2007800513123A CN 200780051312 A CN200780051312 A CN 200780051312A CN 101611006 A CN101611006 A CN 101611006A
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China
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compound
formula
alkyl
solvent
halogen
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English (en)
Chinese (zh)
Inventor
丹尼尔·杜克谢雷尔
迈克尔·毛
理查德·冯德恩布斯
戈皮钱德·亚拉曼奇利
拉杰帕·韦德亚纳森
布赖恩·切卡尔
乔治·克莱姆
罗纳德·范德罗斯特
兰迪·格林克
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Pfizer Products Inc
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Pfizer Products Inc
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Publication of CN101611006A publication Critical patent/CN101611006A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
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  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
CNA2007800513123A 2006-12-13 2007-12-05 3-(4-(2,4-二氟苄氧基)-3-溴-6-甲基-2-氧代吡啶-1(2h)-基)-n,4-二甲基苯甲酰胺的制备方法 Pending CN101611006A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86974806P 2006-12-13 2006-12-13
US60/869,748 2006-12-13

Publications (1)

Publication Number Publication Date
CN101611006A true CN101611006A (zh) 2009-12-23

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CNA2007800513123A Pending CN101611006A (zh) 2006-12-13 2007-12-05 3-(4-(2,4-二氟苄氧基)-3-溴-6-甲基-2-氧代吡啶-1(2h)-基)-n,4-二甲基苯甲酰胺的制备方法

Country Status (17)

Country Link
US (1) US7906536B2 (https=)
EP (1) EP2102161B1 (https=)
JP (1) JP2008231090A (https=)
KR (1) KR20090090379A (https=)
CN (1) CN101611006A (https=)
AR (1) AR064312A1 (https=)
AT (1) ATE556055T1 (https=)
AU (1) AU2007331199A1 (https=)
BR (1) BRPI0720757A2 (https=)
CA (1) CA2672256C (https=)
IL (1) IL199239A0 (https=)
MX (1) MX2009006266A (https=)
NZ (1) NZ577639A (https=)
RU (1) RU2411236C1 (https=)
TW (1) TW200837057A (https=)
WO (1) WO2008072079A2 (https=)
ZA (1) ZA200903981B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114641471A (zh) * 2019-10-18 2022-06-17 Fmc公司 用于制备5-溴-2-(3-氯-吡啶-2-基)-2h-吡唑-3-甲酸的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5679159B2 (ja) 2010-07-05 2015-03-04 信越化学工業株式会社 希土類金属抽出剤の合成方法、及び希土類金属の溶媒抽出用有機相
WO2014181213A1 (en) 2013-05-10 2014-11-13 Pfizer Inc. Crystalline form of (sa)-(-)-3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1 (2h)-yl)-n,4-dimethylbenzamide
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3286645B2 (ja) * 1993-03-26 2002-05-27 メルシャン株式会社 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
RS52392B (sr) * 2002-02-14 2013-02-28 Pharmacia Corporation Supstituisani piridinoni kao modulatori p38 map kinaze
CL2004002050A1 (es) * 2003-08-13 2005-06-03 Pharmacia Corp Sa Organizada B Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros.
WO2006021885A1 (en) * 2004-08-26 2006-03-02 Pfizer Inc. Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
CA2640665A1 (en) * 2006-02-10 2007-08-16 Pfizer Products Inc. Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114641471A (zh) * 2019-10-18 2022-06-17 Fmc公司 用于制备5-溴-2-(3-氯-吡啶-2-基)-2h-吡唑-3-甲酸的方法

Also Published As

Publication number Publication date
TW200837057A (en) 2008-09-16
BRPI0720757A2 (pt) 2014-01-14
RU2411236C1 (ru) 2011-02-10
WO2008072079A3 (en) 2008-08-07
ATE556055T1 (de) 2012-05-15
WO2008072079A2 (en) 2008-06-19
EP2102161B1 (en) 2012-05-02
ZA200903981B (en) 2010-08-25
US7906536B2 (en) 2011-03-15
IL199239A0 (en) 2010-03-28
MX2009006266A (es) 2009-06-22
AU2007331199A1 (en) 2008-06-19
CA2672256C (en) 2011-08-30
EP2102161A2 (en) 2009-09-23
NZ577639A (en) 2012-01-12
KR20090090379A (ko) 2009-08-25
CA2672256A1 (en) 2008-06-19
JP2008231090A (ja) 2008-10-02
US20080177077A1 (en) 2008-07-24
AR064312A1 (es) 2009-03-25

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