CN101605786A - 细胞凋亡抑制剂的咪唑并吡啶抑制剂 - Google Patents

细胞凋亡抑制剂的咪唑并吡啶抑制剂 Download PDF

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Publication number
CN101605786A
CN101605786A CNA2007800473412A CN200780047341A CN101605786A CN 101605786 A CN101605786 A CN 101605786A CN A2007800473412 A CNA2007800473412 A CN A2007800473412A CN 200780047341 A CN200780047341 A CN 200780047341A CN 101605786 A CN101605786 A CN 101605786A
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CN
China
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group
alkyl
compound
optionally substituted
carbocyclic
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CNA2007800473412A
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English (en)
Chinese (zh)
Inventor
迈克尔·F·T·凯勒
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Genentech Inc
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Genentech Inc
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Publication of CN101605786A publication Critical patent/CN101605786A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNA2007800473412A 2006-12-19 2007-12-14 细胞凋亡抑制剂的咪唑并吡啶抑制剂 Pending CN101605786A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87082106P 2006-12-19 2006-12-19
US60/870,821 2006-12-19

Publications (1)

Publication Number Publication Date
CN101605786A true CN101605786A (zh) 2009-12-16

Family

ID=39361343

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800473412A Pending CN101605786A (zh) 2006-12-19 2007-12-14 细胞凋亡抑制剂的咪唑并吡啶抑制剂

Country Status (12)

Country Link
US (2) US8063218B2 (https=)
EP (1) EP2125809A1 (https=)
JP (1) JP2010513561A (https=)
KR (1) KR20090094461A (https=)
CN (1) CN101605786A (https=)
AU (1) AU2007337104A1 (https=)
BR (1) BRPI0719481A2 (https=)
CA (1) CA2671607A1 (https=)
IL (1) IL198927A0 (https=)
NZ (1) NZ577150A (https=)
RU (1) RU2466131C2 (https=)
WO (1) WO2008079735A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103237801A (zh) * 2010-08-31 2013-08-07 韩美科学株式会社 对细胞有凋亡诱导活性的喹啉或喹唑啉衍生物
WO2019091492A1 (zh) * 2017-11-13 2019-05-16 南京明德新药研发股份有限公司 用作iap抑制剂的smac模拟物及其用途
WO2020177765A1 (zh) * 2019-03-07 2020-09-10 正大天晴药业集团股份有限公司 Iap抑制剂与免疫检查点抑制剂的组合
WO2020228642A1 (zh) * 2019-05-10 2020-11-19 正大天晴药业集团股份有限公司 一种用作iap抑制剂的smac模拟物的结晶及其制备方法

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ES2475207T3 (es) 2004-07-15 2014-07-10 Tetralogic Pharmaceuticals Corporation Compuestos de unión a IAP
DK1836201T4 (da) * 2004-12-20 2013-11-11 Genentech Inc Pyrrolidininhibitorer af IAP.
MX2007010371A (es) * 2005-02-25 2008-01-11 Tetralogic Pharmaceuticals Inhibidores dimericos iap.
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
WO2007048224A1 (en) 2005-10-25 2007-05-03 Aegera Therapeutics Inc. Iap bir domain binding compounds
TWI504597B (zh) 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
MX2009000824A (es) * 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
WO2008014240A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
US20100143499A1 (en) * 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008014229A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
WO2008134679A1 (en) * 2007-04-30 2008-11-06 Genentech, Inc. Inhibitors of iap
JP2010528587A (ja) * 2007-05-07 2010-08-26 テトラロジック ファーマシューティカルズ コーポレーション アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法
AU2009203971A1 (en) * 2008-01-11 2009-07-16 Genentech, Inc. Inhibitors of IAP
JP2011529962A (ja) * 2008-08-02 2011-12-15 ジェネンテック， インコーポレイテッド Ｉａｐのインヒビター
US20110218211A1 (en) * 2008-08-16 2011-09-08 Genentech, Inc. Azaindole inhibitors of iap
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
US20110034469A1 (en) 2009-08-04 2011-02-10 Takeda Pharmaceutical Company Limited Heterocyclic Compound
MX2012006877A (es) 2009-12-18 2012-08-31 Idenix Pharmaceuticals Inc Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado.
US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
KR20140011773A (ko) * 2012-07-19 2014-01-29 한미약품 주식회사 이중 저해 활성을 갖는 헤테로고리 유도체
WO2020027225A1 (ja) 2018-07-31 2020-02-06 ファイメクス株式会社 複素環化合物
JP7764027B2 (ja) 2019-07-31 2025-11-05 ファイメクス株式会社 複素環化合物

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103237801A (zh) * 2010-08-31 2013-08-07 韩美科学株式会社 对细胞有凋亡诱导活性的喹啉或喹唑啉衍生物
CN103237801B (zh) * 2010-08-31 2015-11-25 韩美科学株式会社 对细胞有凋亡诱导活性的喹啉或喹唑啉衍生物
WO2019091492A1 (zh) * 2017-11-13 2019-05-16 南京明德新药研发股份有限公司 用作iap抑制剂的smac模拟物及其用途
CN111247161A (zh) * 2017-11-13 2020-06-05 正大天晴药业集团股份有限公司 用作iap抑制剂的smac模拟物及其用途
US11358950B2 (en) 2017-11-13 2022-06-14 Chia Tai Tiangqing Pharmaceutical Group Co., Ltd. SMAC mimetics used as IAP inhibitors and use thereof
WO2020177765A1 (zh) * 2019-03-07 2020-09-10 正大天晴药业集团股份有限公司 Iap抑制剂与免疫检查点抑制剂的组合
CN113677339A (zh) * 2019-03-07 2021-11-19 正大天晴药业集团股份有限公司 Iap抑制剂与免疫检查点抑制剂的组合
CN113677339B (zh) * 2019-03-07 2023-08-01 正大天晴药业集团股份有限公司 Iap抑制剂与免疫检查点抑制剂的组合
WO2020228642A1 (zh) * 2019-05-10 2020-11-19 正大天晴药业集团股份有限公司 一种用作iap抑制剂的smac模拟物的结晶及其制备方法
CN113748119A (zh) * 2019-05-10 2021-12-03 正大天晴药业集团股份有限公司 一种用作iap抑制剂的smac模拟物的结晶及其制备方法
CN113748119B (zh) * 2019-05-10 2024-04-02 正大天晴药业集团股份有限公司 一种用作iap抑制剂的smac模拟物的结晶及其制备方法

Also Published As

Publication number Publication date
RU2009127800A (ru) 2011-01-27
JP2010513561A (ja) 2010-04-30
BRPI0719481A2 (pt) 2014-02-11
EP2125809A1 (en) 2009-12-02
KR20090094461A (ko) 2009-09-07
AU2007337104A1 (en) 2008-07-03
NZ577150A (en) 2012-04-27
US20100130539A1 (en) 2010-05-27
WO2008079735A1 (en) 2008-07-03
US8063218B2 (en) 2011-11-22
IL198927A0 (en) 2010-02-17
CA2671607A1 (en) 2008-07-03
US20120015974A1 (en) 2012-01-19
RU2466131C2 (ru) 2012-11-10

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Application publication date: 20091216