CN101594887A - 使用由诸如壳聚糖的亲水聚合物泡沫形成的止血剂微粒的止血成分、组件、系统和方法 - Google Patents

使用由诸如壳聚糖的亲水聚合物泡沫形成的止血剂微粒的止血成分、组件、系统和方法 Download PDF

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Publication number
CN101594887A
CN101594887A CNA2006800308228A CN200680030822A CN101594887A CN 101594887 A CN101594887 A CN 101594887A CN A2006800308228 A CNA2006800308228 A CN A2006800308228A CN 200680030822 A CN200680030822 A CN 200680030822A CN 101594887 A CN101594887 A CN 101594887A
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CN
China
Prior art keywords
chitosan
hemorrhage
medicament
granule
microgranule
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Pending
Application number
CNA2006800308228A
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English (en)
Chinese (zh)
Inventor
西蒙·J·麦卡锡
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Hemcon Inc
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Hemcon Inc
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Publication date
Application filed by Hemcon Inc filed Critical Hemcon Inc
Publication of CN101594887A publication Critical patent/CN101594887A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0094Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/00463Plasters use haemostatic
    • A61F2013/00472Plasters use haemostatic with chemical means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00902Plasters containing means
    • A61F2013/00927Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
    • A61F2013/00931Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors chitin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Composite Materials (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNA2006800308228A 2005-07-13 2006-07-13 使用由诸如壳聚糖的亲水聚合物泡沫形成的止血剂微粒的止血成分、组件、系统和方法 Pending CN101594887A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69873405P 2005-07-13 2005-07-13
US60/698,734 2005-07-13

Publications (1)

Publication Number Publication Date
CN101594887A true CN101594887A (zh) 2009-12-02

Family

ID=37637971

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2006800308228A Pending CN101594887A (zh) 2005-07-13 2006-07-13 使用由诸如壳聚糖的亲水聚合物泡沫形成的止血剂微粒的止血成分、组件、系统和方法
CNA200680033731XA Pending CN101547686A (zh) 2005-07-13 2006-07-13 使用由壳聚糖形成的止血剂颗粒并包含聚-4-羟基丁酸酯聚合物网状材料的止血成分、组件、系统和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA200680033731XA Pending CN101547686A (zh) 2005-07-13 2006-07-13 使用由壳聚糖形成的止血剂颗粒并包含聚-4-羟基丁酸酯聚合物网状材料的止血成分、组件、系统和方法

Country Status (9)

Country Link
US (1) US20070166387A1 (https=)
EP (2) EP1906896A4 (https=)
JP (2) JP2009502749A (https=)
KR (2) KR20080044238A (https=)
CN (2) CN101594887A (https=)
AU (2) AU2006268143A1 (https=)
CA (2) CA2614750A1 (https=)
IL (2) IL188683A0 (https=)
WO (2) WO2007009090A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104874029A (zh) * 2015-03-30 2015-09-02 陕西佰傲再生医学有限公司 一种止血防粘连材料及其制备方法
CN105431176A (zh) * 2013-05-30 2016-03-23 医疗行业产品有限公司 可降解的止血剂组合物
CN114848668A (zh) * 2021-01-20 2022-08-05 香港中文大学 具有促进伤口愈合和快速止血功能的组合物
CN120919383A (zh) * 2025-10-13 2025-11-11 吉林大学 一种用于腹腔镜手术的医用海绵及其制备方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741335B2 (en) 2002-06-14 2014-06-03 Hemcon Medical Technologies, Inc. Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan
EP1401352B1 (en) 2001-06-14 2012-03-21 Kenton W. Gregory Method for producing a chitosan wound dressing
US9204957B2 (en) 2005-03-17 2015-12-08 Hemcon Medical Technologies, Inc. Systems and methods for hemorrhage control and or tissue repair
JP5160102B2 (ja) * 2006-02-14 2013-03-13 甲陽ケミカル株式会社 非晶質の部分脱アセチル化キチン塩のスポンジ状止血材及びその製造方法
WO2007139845A2 (en) 2006-05-23 2007-12-06 Providence Health System-Oregon D/B/A Providence St. Vincent Medical Center Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ
CN101801676B (zh) * 2007-07-18 2012-10-03 巴斯夫欧洲公司 激光敏感涂料制剂
GB2461019B (en) 2008-04-25 2013-06-05 Medtrade Products Ltd Haemostatic material
WO2009134447A1 (en) 2008-05-02 2009-11-05 Providence Health System-Oregon D/B/A Providence St. Vincent Medical Center Wound dressing devices and methods
WO2010042540A1 (en) 2008-10-06 2010-04-15 Providence Health System - Oregon Foam medical devices and methods
CN101862469B (zh) * 2010-05-28 2013-03-13 武汉人福医疗用品有限公司 一种壳聚糖衍生物快速止血颗粒及其制备方法
US9561300B2 (en) 2011-09-26 2017-02-07 Yes, Inc. Hemostatic compositions and dressings for bleeding
US8993831B2 (en) * 2011-11-01 2015-03-31 Arsenal Medical, Inc. Foam and delivery system for treatment of postpartum hemorrhage
GB2514597A (en) * 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition
TR201713929A2 (tr) 2017-09-20 2019-04-22 Montero Gida Sanayi Ve Ticaret Anonim Sirketi Ki̇tosan ve alji̇natin hemostati̇k kompozi̇syonlari
US20210060203A1 (en) * 2017-12-29 2021-03-04 Tricol Biomedical, Inc. Tissue adherent chitosan material that resists dissolution
WO2019133931A1 (en) 2017-12-29 2019-07-04 Tricol Biomedical, Inc. Delivery systems for control of bleeding in transurethral prostatectomy
US12156791B2 (en) 2017-12-29 2024-12-03 Tricol Biomedical, Inc. Chitosan dressing for control of bleeding in transurethral prostatectomy
KR102521769B1 (ko) * 2020-07-20 2023-04-14 주식회사 테라시온바이오메디칼 국소 지혈 파우더 조성물 및 이의 제조방법

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US2923664A (en) * 1957-09-11 1960-02-02 Johnson & Johnson Hemostatic product
US4958011A (en) * 1983-06-27 1990-09-18 Bade Maria L Ester-stabilized chitin
JPS61240963A (ja) * 1985-04-18 1986-10-27 ユニチカ株式会社 創傷被覆保護材
US4952618A (en) * 1988-05-03 1990-08-28 Minnesota Mining And Manufacturing Company Hydrocolloid/adhesive composition
US4948540A (en) * 1988-08-01 1990-08-14 Semex Medical, Inc. Method of preparing collagen dressing sheet material
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5836970A (en) * 1996-08-02 1998-11-17 The Kendall Company Hemostatic wound dressing
JP3368323B2 (ja) * 1997-05-14 2003-01-20 独立行政法人農業生物資源研究所 キチンビーズ、キトサンビーズ、これらビーズの製造方法及びこれらビーズからなる担体並びに微胞子虫胞子の製造法
ES2525553T3 (es) * 1999-03-25 2014-12-26 Metabolix, Inc. Dispositivos y aplicaciones médicas de polímeros polihidroxialcanoato
EP1401352B1 (en) * 2001-06-14 2012-03-21 Kenton W. Gregory Method for producing a chitosan wound dressing
JP4955156B2 (ja) * 2001-06-25 2012-06-20 ユニチカ株式会社 止血材
US6992233B2 (en) * 2002-05-31 2006-01-31 Medafor, Inc. Material delivery system
US20050137512A1 (en) * 2003-12-23 2005-06-23 Campbell Todd D. Wound dressing and method for controlling severe, life-threatening bleeding
EP2860292B1 (en) * 2003-05-08 2020-07-22 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105431176A (zh) * 2013-05-30 2016-03-23 医疗行业产品有限公司 可降解的止血剂组合物
CN114949334A (zh) * 2013-05-30 2022-08-30 医疗行业产品有限公司 可降解的止血剂组合物
CN104874029A (zh) * 2015-03-30 2015-09-02 陕西佰傲再生医学有限公司 一种止血防粘连材料及其制备方法
CN104874029B (zh) * 2015-03-30 2018-04-27 陕西佰傲再生医学有限公司 一种止血防粘连材料及其制备方法
CN114848668A (zh) * 2021-01-20 2022-08-05 香港中文大学 具有促进伤口愈合和快速止血功能的组合物
CN114848668B (zh) * 2021-01-20 2024-03-26 香港中文大学 具有促进伤口愈合和快速止血功能的组合物
CN120919383A (zh) * 2025-10-13 2025-11-11 吉林大学 一种用于腹腔镜手术的医用海绵及其制备方法

Also Published As

Publication number Publication date
CN101547686A (zh) 2009-09-30
IL188682A0 (en) 2008-08-07
AU2006268143A1 (en) 2007-01-18
AU2006268143A8 (en) 2008-03-20
JP2009502749A (ja) 2009-01-29
WO2007009090A2 (en) 2007-01-18
KR20080044238A (ko) 2008-05-20
WO2007009090A3 (en) 2008-11-06
WO2007009050A2 (en) 2007-01-18
IL188683A0 (en) 2008-08-07
CA2614750A1 (en) 2007-01-18
JP2009505685A (ja) 2009-02-12
KR20080030094A (ko) 2008-04-03
EP1906896A2 (en) 2008-04-09
CA2615058A1 (en) 2007-01-18
WO2007009050A3 (en) 2009-06-11
AU2006267047A1 (en) 2007-01-18
EP1906895A2 (en) 2008-04-09
US20070166387A1 (en) 2007-07-19
EP1906896A4 (en) 2009-05-27

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Application publication date: 20091202