CN101588799B - 用作激酶抑制剂和hsp90抑制剂的大环化合物 - Google Patents

用作激酶抑制剂和hsp90抑制剂的大环化合物 Download PDF

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CN101588799B
CN101588799B CN2007800381410A CN200780038141A CN101588799B CN 101588799 B CN101588799 B CN 101588799B CN 2007800381410 A CN2007800381410 A CN 2007800381410A CN 200780038141 A CN200780038141 A CN 200780038141A CN 101588799 B CN101588799 B CN 101588799B
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compound
hydrogen
hsp90
compounds
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CN101588799A (zh
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N·温辛格尔
S·巴尔吕埃娜
M·卡尔普拉斯
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Universite de Strasbourg
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CN2007800381410A 2006-08-11 2007-08-10 用作激酶抑制剂和hsp90抑制剂的大环化合物 Active CN101588799B (zh)

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US83715406P 2006-08-11 2006-08-11
US60/837,154 2006-08-11
US85873106P 2006-11-13 2006-11-13
US60/858,731 2006-11-13
PCT/US2007/017754 WO2008021213A1 (en) 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90

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US8212012B2 (en) * 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
CN101588799B (zh) 2006-08-11 2013-09-11 斯特拉斯堡大学 用作激酶抑制剂和hsp90抑制剂的大环化合物
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
CA2708143C (en) 2007-12-07 2016-10-11 Francis G. Fang Intermediates in the synthesis of zearalenone macrolide analogs
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
KR20160017105A (ko) * 2008-01-15 2016-02-15 유니베르시떼 드 스트라스부르 치료제로서 유용한 레조르실산 락톤의 합성
WO2010014617A1 (en) * 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011041593A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
CA2808866A1 (en) 2010-08-20 2012-02-23 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
AU2011319685B2 (en) * 2010-10-22 2016-02-04 Le Centre National De La Recherche Scientifique Pochoxime conjugates useful for the treatment of HSP90 related pathologies
EP2771008A4 (en) * 2011-10-28 2015-04-08 Merck Sharp & Dohme MACROCYCLES FOR INCREASING P53 ACTIVITY AND USES THEREOF
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
US10434085B2 (en) 2015-06-04 2019-10-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
WO2022089449A1 (zh) * 2020-10-26 2022-05-05 山东大学 一种特异性热休克蛋白90α亚型抑制剂制备及其应用

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CN103539769B (zh) 2016-03-16
US8450305B2 (en) 2013-05-28
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US20120077775A1 (en) 2012-03-29
CA2696021A1 (en) 2008-02-21
CA2696021C (en) 2015-09-29
EP2136799B1 (en) 2017-10-04
JP5465006B2 (ja) 2014-04-09
US20080146545A1 (en) 2008-06-19
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