JP5465006B2 - キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物 - Google Patents

キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物 Download PDF

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JP5465006B2
JP5465006B2 JP2009523852A JP2009523852A JP5465006B2 JP 5465006 B2 JP5465006 B2 JP 5465006B2 JP 2009523852 A JP2009523852 A JP 2009523852A JP 2009523852 A JP2009523852 A JP 2009523852A JP 5465006 B2 JP5465006 B2 JP 5465006B2
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cancer
compound
hydrogen
disease
alkyl
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JP2010501478A5 (enExample
JP2010501478A (ja
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ウインサンジエ，ニコラ
バルルエンガ，ソフイア
カープラス，マーテイン
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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JP2009523852A 2006-08-11 2007-08-10 キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物 Expired - Fee Related JP5465006B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83715406P 2006-08-11 2006-08-11
US60/837,154 2006-08-11
US85873106P 2006-11-13 2006-11-13
US60/858,731 2006-11-13
PCT/US2007/017754 WO2008021213A1 (en) 2006-08-11 2007-08-10 Macrocyclic compounds useful as inhibitors of kinases and hsp90

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JP2010501478A JP2010501478A (ja) 2010-01-21
JP2010501478A5 JP2010501478A5 (enExample) 2011-06-30
JP5465006B2 true JP5465006B2 (ja) 2014-04-09

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JP2009523852A Expired - Fee Related JP5465006B2 (ja) 2006-08-11 2007-08-10 キナーゼおよびｈｓｐ９０の阻害剤として有用な大環状化合物

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US (2) US8067412B2 (enExample)
EP (1) EP2136799B1 (enExample)
JP (1) JP5465006B2 (enExample)
CN (2) CN101588799B (enExample)
CA (1) CA2696021C (enExample)
ES (1) ES2651019T3 (enExample)
WO (1) WO2008021213A1 (enExample)

Cited By (1)

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JP2015110624A (ja) * 2008-01-15 2015-06-18 ユニベルシテ・ドウ・ストラスブール 治療薬として有用なレゾルシン酸ラクトンの合成

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US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
CN101588799B (zh) 2006-08-11 2013-09-11 斯特拉斯堡大学 用作激酶抑制剂和hsp90抑制剂的大环化合物
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
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WO2010014617A1 (en) * 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011041593A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
CA2808866A1 (en) 2010-08-20 2012-02-23 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
AU2011319685B2 (en) * 2010-10-22 2016-02-04 Le Centre National De La Recherche Scientifique Pochoxime conjugates useful for the treatment of HSP90 related pathologies
EP2771008A4 (en) * 2011-10-28 2015-04-08 Merck Sharp & Dohme MACROCYCLES FOR INCREASING P53 ACTIVITY AND USES THEREOF
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
US10434085B2 (en) 2015-06-04 2019-10-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
WO2022089449A1 (zh) * 2020-10-26 2022-05-05 山东大学 一种特异性热休克蛋白90α亚型抑制剂制备及其应用

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US8450305B2 (en) 2013-05-28
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US20120077775A1 (en) 2012-03-29
CN101588799B (zh) 2013-09-11
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CA2696021C (en) 2015-09-29
EP2136799B1 (en) 2017-10-04
US20080146545A1 (en) 2008-06-19
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