CN103539769B - 用作激酶抑制剂和hsp90抑制剂的大环化合物 - Google Patents

用作激酶抑制剂和hsp90抑制剂的大环化合物 Download PDF

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CN103539769B
CN103539769B CN201310414870.9A CN201310414870A CN103539769B CN 103539769 B CN103539769 B CN 103539769B CN 201310414870 A CN201310414870 A CN 201310414870A CN 103539769 B CN103539769 B CN 103539769B
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cancer
compound
disease
hydrogen
alkyl
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CN103539769A (zh
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N·温辛格尔
S·巴尔吕埃娜
M·卡尔普拉斯
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NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Universite de Strasbourg
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CN201310414870.9A 2006-08-11 2007-08-10 用作激酶抑制剂和hsp90抑制剂的大环化合物 Active CN103539769B (zh)

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US83715406P 2006-08-11 2006-08-11
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
US8212012B2 (en) * 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
CN103539769B (zh) 2006-08-11 2016-03-16 斯特拉斯堡大学 用作激酶抑制剂和hsp90抑制剂的大环化合物
US7960353B2 (en) * 2007-05-10 2011-06-14 University Of Kansas Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
MX2010005999A (es) 2007-12-07 2010-06-23 Eisai R&D Man Co Ltd Intermediarios en la sintesis de analogos de macrolidos de zearalenona.
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
KR101835253B1 (ko) 2008-01-15 2018-03-06 유니베르시떼 드 스트라스부르 치료제로서 유용한 레조르실산 락톤의 합성
WO2010014617A1 (en) * 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2011041593A1 (en) * 2009-09-30 2011-04-07 University Of Kansas Novobiocin analogues and treatment of polycystic kidney disease
US9120768B2 (en) 2010-08-20 2015-09-01 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
JP2013543840A (ja) * 2010-10-22 2013-12-09 ユニヴェルシテ・ドゥ・ストラスブール Ｈｓｐ９０関連病態の治療のために有用なポコキシム複合物
WO2013062923A1 (en) * 2011-10-28 2013-05-02 Merck Sharp & Dohme Corp. MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
CN105764501A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群治疗效益的组合物
WO2016196256A2 (en) * 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
WO2022089449A1 (zh) * 2020-10-26 2022-05-05 山东大学 一种特异性热休克蛋白90α亚型抑制剂制备及其应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196019A (en) * 1964-04-06 1965-07-20 Purdue Research Foundation Anabolic and estrogenic compound and process of making
US3239346A (en) * 1965-02-15 1966-03-08 Commercial Solvents Corp Estrogenic compounds and animal growth promoters
US3453367A (en) * 1966-06-29 1969-07-01 Commercial Solvents Corp Methods for treating inflammation with estrogenic compounds
FR96016E (fr) * 1966-06-29 1972-05-19 Commercial Solvents Corp Composé utilisable comme supplément alimentaire pour les animaux.
NL131183C (enExample) * 1966-12-13
US3758511A (en) * 1967-01-18 1973-09-11 Merck & Co Inc Preparation of d,1-zearalenones
US3551454A (en) * 1967-07-26 1970-12-29 Merck & Co Inc Preparation of optically active (-)-zearalenone and intermediates therefor
US3586701A (en) * 1967-08-24 1971-06-22 Commercial Solvents Corp Norzearalane and its production
US3887583A (en) * 1968-05-15 1975-06-03 Commercial Solvents Corp Products and process
US3591608A (en) * 1968-11-15 1971-07-06 Ayerst Mckenna & Harrison Macrocyclic ketolactones
US3621036A (en) * 1969-02-27 1971-11-16 Merck & Co Inc Derivatives of zearalane
US3704249A (en) * 1969-05-01 1972-11-28 Merck & Co Inc Synthesis of the biologically active diastereoisomer of (-) zearalanol
US3860616A (en) * 1969-05-01 1975-01-14 Merck & Co Inc Synthesis of d,1-zearalanol
BE757082A (fr) * 1970-02-16 1971-03-16 Commercial Solvents Corp Procede de preparation de nouveaux produits a activite antibacterienne
BE757083A (fr) * 1970-02-16 1971-03-16 Commercial Solvents Corp Nouveaux produits a activite antibacterienne
US3687982A (en) * 1971-03-09 1972-08-29 Commercial Solvents Corp Separation of mixed diastereoisomers of zearalanol
US3810918A (en) * 1972-04-25 1974-05-14 Commercial Solvent Corp Synthesis of zearalanone
US3852307A (en) * 1972-04-25 1974-12-03 Commercial Solvents Corp Synthesis of zearalanone and related compounds
US3836544A (en) * 1972-04-25 1974-09-17 Commercial Solvents Corp Synthesis of zearalanes ii and related compounds and intermediates useful in the syntheses thereof
US3901921A (en) * 1972-04-25 1975-08-26 Commercial Solvents Corp Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof
US3957825A (en) * 1972-04-25 1976-05-18 Commercial Solvents Corporation Process for synthesizing zearalanone and related compounds
US3901922A (en) * 1972-04-25 1975-08-26 Commercial Solvents Corp Synthesis of zearalanone and related compounds and intermediates useful in their synthesis
US3903115A (en) * 1972-04-25 1975-09-02 Commercial Solvents Corp Synthesis of zearalanes II and related compounds and intermediates useful in the syntheses thereof
US3925423A (en) * 1974-01-22 1975-12-09 Commercial Solvents Corp Resorcyclic acid lactones and their production
US3965275A (en) * 1974-02-11 1976-06-22 Commercial Solvents Corporation Composition and method
US3954805A (en) * 1974-06-06 1976-05-04 Commercial Solvents Corporation Process for preparing zearalene type compounds
US4035504A (en) * 1975-05-12 1977-07-12 Imc Chemical Group, Inc. Method for treating cholesterolemia by administering resorcylic acid lactone derivatives
US4042602A (en) * 1976-11-04 1977-08-16 Imc Chemical Group, Inc. Synthesis of dideoxyzearalane and related compounds
US4088658A (en) * 1976-11-04 1978-05-09 Imc Chemical Group, Inc. Synthesis of dideoxyzearalane and related compounds
US4228079A (en) * 1978-10-30 1980-10-14 W. R. Grace & Co. Dialkoxy monorden derivatives
US4670249A (en) * 1985-04-12 1987-06-02 International Minerals & Chemical Corp. Growth-promoting compositions
EP0248916A1 (en) * 1986-06-05 1987-12-16 C.R.C. Compagnia di Ricerca Chimica S.p.A. Method for separation of 3S,7R-3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one from its 3S,7S-diastereomer
US4751239A (en) * 1987-06-29 1988-06-14 International Minerals & Chemical Corp. 6' Carbonate esters of zearalanol and its derivatives
US4778821A (en) * 1987-07-15 1988-10-18 International Minerals & Chemical Corp. Method for controlling helmintic parasites
US4849447A (en) * 1987-10-13 1989-07-18 Pitman-Moore, Inc. Zearalanol derivatives with anabolic activity
US4902711A (en) * 1988-01-19 1990-02-20 Pitman-Moore, Inc. 6' Carbamate esters of zearalanol and its derivatives
US5650430A (en) * 1990-06-06 1997-07-22 Sankyo Company, Limited Radicicol derivatives, their preparation and their anti-tumor activity
KR920000763A (ko) * 1990-06-06 1992-01-29 가와무라 요시부미 라디시콜 유도체, 그 제조방법 및 그의 항종양 활성
JPH06279279A (ja) 1993-03-26 1994-10-04 Tsumura & Co 血管新生阻害剤
JPH06298764A (ja) 1993-04-15 1994-10-25 Kyowa Hakko Kogyo Co Ltd 免疫抑制剤
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
US5731343A (en) * 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
ATE194610T1 (de) * 1995-04-26 2000-07-15 Kyowa Hakko Kogyo Kk Derivate des radicicols
US5710174A (en) * 1995-06-07 1998-01-20 Zymo Genetics, Inc. Factor XIIIA inhibitor
JPH09202781A (ja) 1996-01-25 1997-08-05 Sankyo Co Ltd ラディシコール誘導体
AU727722B2 (en) * 1996-10-25 2000-12-21 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
JPH10265381A (ja) 1997-03-24 1998-10-06 Sankyo Co Ltd 血管再狭窄予防剤
AU3534499A (en) 1998-04-24 1999-11-16 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
WO2000038674A1 (en) * 1998-12-24 2000-07-06 Novation Pharmaceuticals Inc. COMPOUNDS WHICH AFFECT mRNA STABILITY AND USES THEREFOR
JP2000236894A (ja) 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd ラディシコールの製造方法
WO2002002123A1 (en) 2000-06-29 2002-01-10 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
JP2004505044A (ja) * 2000-07-28 2004-02-19 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ 細胞増殖性障害およびウイルス感染の治療方法
CA2417994A1 (en) * 2000-08-04 2002-02-14 Board Of Regents, The University Of Texas System Synthetic salicylihalamides, apicularens and derivatives thereof
US6734209B2 (en) * 2001-08-03 2004-05-11 Board Of Regents The University Of Texas System Synthetic salicylihalamides, apicularens and derivatives thereof
DK1309569T3 (da) 2000-08-18 2011-01-24 Millennium Pharm Inc N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamidderivater som PDGFRs-inhibitorer
DE60120427D1 (de) * 2000-08-25 2006-07-20 Sloan Kettering Inst Cancer Radicicol und monocillin und ihre analogen und ihre anwendungen
JP2005519848A (ja) * 2000-11-02 2005-07-07 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ Ｈｓｐ９０に結合するための小分子組成物
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
US20030211469A1 (en) * 2001-07-16 2003-11-13 Lloyd Waxman Inhibiting hepatitis c virus processing and replication
US6872715B2 (en) * 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
JP2003113183A (ja) * 2001-10-05 2003-04-18 Kyowa Hakko Kogyo Co Ltd リウマチ治療剤
AU2002356922A1 (en) * 2001-11-09 2003-05-26 Conforma Therapeutics Corporation Hsp90-inhibiting zearalanol compounds and methods of producing and using same
US20050074457A1 (en) * 2001-12-12 2005-04-07 Adeela Kamal Assays and implements for determining and modulating hsp90 binding activity
GB0202871D0 (en) * 2002-02-07 2002-03-27 Cancer Res Ventures Ltd Assays,methods and means
KR101210018B1 (ko) * 2002-03-08 2012-12-07 에자이 알앤드디 매니지먼트 가부시키가이샤 약물로서 유용한 거대고리 화합물
WO2003086334A1 (en) * 2002-04-17 2003-10-23 Taisho Pharmaceutical Co., Ltd. Hair growth tonic
AU2003264357A1 (en) * 2002-08-29 2004-04-30 Kyowa Hakko Kogyo Co., Ltd. Hsp90 FAMILY PROTEIN INHIBITORS
US20060251574A1 (en) * 2002-12-12 2006-11-09 Adeela Kamal Cytotoxins and diagnostic imaging agents comprising hsp90 ligands
US7959915B2 (en) * 2003-03-12 2011-06-14 Tufts University Inhibitors of extracellular Hsp90
JPWO2005018674A1 (ja) * 2003-08-22 2006-10-19 協和醗酵工業株式会社 イムノグロブリン遺伝子の転座を伴う疾患の治療薬
WO2005061481A1 (en) * 2003-12-19 2005-07-07 Sloan-Kettering Institute For Cancer Research Novel ma crocycles and uses thereof
US20050267087A1 (en) * 2004-04-28 2005-12-01 Vassiliki Poulaki Inflammatory eye disease
EP1794137A4 (en) * 2004-09-27 2009-12-02 Kosan Biosciences Inc SPECIFIC KINASE INHIBITORS
WO2006119456A2 (en) * 2005-05-04 2006-11-09 University Of Vermont And State Agricultural College Methods and compositions for treating toxoplasma
CN103539769B (zh) 2006-08-11 2016-03-16 斯特拉斯堡大学 用作激酶抑制剂和hsp90抑制剂的大环化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Search for Hsp90 Inhibitors with Potential Anticancer Activity：Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert;Thomas J. Turbyville et al.;《J. Nat. Prod.》;20060203;第69卷(第2期);178-184 *

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