CN103539769B - 用作激酶抑制剂和hsp90抑制剂的大环化合物 - Google Patents
用作激酶抑制剂和hsp90抑制剂的大环化合物 Download PDFInfo
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- CN103539769B CN103539769B CN201310414870.9A CN201310414870A CN103539769B CN 103539769 B CN103539769 B CN 103539769B CN 201310414870 A CN201310414870 A CN 201310414870A CN 103539769 B CN103539769 B CN 103539769B
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83715406P | 2006-08-11 | 2006-08-11 | |
| US60/837,154 | 2006-08-11 | ||
| US85873106P | 2006-11-13 | 2006-11-13 | |
| US60/858,731 | 2006-11-13 | ||
| CN2007800381410A CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800381410A Division CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103539769A CN103539769A (zh) | 2014-01-29 |
| CN103539769B true CN103539769B (zh) | 2016-03-16 |
Family
ID=39082315
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310414870.9A Active CN103539769B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
| CN2007800381410A Active CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800381410A Active CN101588799B (zh) | 2006-08-11 | 2007-08-10 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8067412B2 (enExample) |
| EP (1) | EP2136799B1 (enExample) |
| JP (1) | JP5465006B2 (enExample) |
| CN (2) | CN103539769B (enExample) |
| CA (1) | CA2696021C (enExample) |
| ES (1) | ES2651019T3 (enExample) |
| WO (1) | WO2008021213A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8212012B2 (en) * | 2004-11-03 | 2012-07-03 | University Of Kansas | Novobiocin analogues having modified sugar moieties |
| US9120774B2 (en) | 2004-11-03 | 2015-09-01 | University Of Kansas | Novobiocin analogues having modified sugar moieties |
| CA2696021C (en) | 2006-08-11 | 2015-09-29 | Nicolas Winssinger | Macrocyclic compounds useful as inhibitors of kinases and hsp90 |
| US7960353B2 (en) * | 2007-05-10 | 2011-06-14 | University Of Kansas | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders |
| RU2478630C2 (ru) | 2007-12-07 | 2013-04-10 | ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД. | Промежуточные соединения и способы получения зеараленоновых макролидных аналогов |
| RU2534527C2 (ru) * | 2008-01-15 | 2014-11-27 | Юниверсите Де Страсбур | Синтез лактонов резорциловой кислоты, используемых в качестве терапевтических агентов |
| US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
| US20100022635A1 (en) * | 2008-07-28 | 2010-01-28 | University Of Kansas | Heat shock protein 90 inhibitor dosing methods |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| WO2011041593A1 (en) * | 2009-09-30 | 2011-04-07 | University Of Kansas | Novobiocin analogues and treatment of polycystic kidney disease |
| CA2808866A1 (en) * | 2010-08-20 | 2012-02-23 | The Hospital For Sick Children | Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing |
| AU2011319685B2 (en) * | 2010-10-22 | 2016-02-04 | Le Centre National De La Recherche Scientifique | Pochoxime conjugates useful for the treatment of HSP90 related pathologies |
| WO2013062923A1 (en) * | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp. | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
| CA2938626A1 (en) | 2013-07-26 | 2015-01-29 | John Rothman | Compositions to improve the therapeutic benefit of bisantrene |
| US10434085B2 (en) | 2015-06-04 | 2019-10-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
| WO2022089449A1 (zh) * | 2020-10-26 | 2022-05-05 | 山东大学 | 一种特异性热休克蛋白90α亚型抑制剂制备及其应用 |
| WO2025226862A1 (en) * | 2024-04-24 | 2025-10-30 | Circle Pharma, Inc. | Cyclin inhibitors |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3196019A (en) | 1964-04-06 | 1965-07-20 | Purdue Research Foundation | Anabolic and estrogenic compound and process of making |
| US3239346A (en) * | 1965-02-15 | 1966-03-08 | Commercial Solvents Corp | Estrogenic compounds and animal growth promoters |
| FR96016E (fr) | 1966-06-29 | 1972-05-19 | Commercial Solvents Corp | Composé utilisable comme supplément alimentaire pour les animaux. |
| US3453367A (en) | 1966-06-29 | 1969-07-01 | Commercial Solvents Corp | Methods for treating inflammation with estrogenic compounds |
| NL131183C (enExample) | 1966-12-13 | |||
| US3758511A (en) | 1967-01-18 | 1973-09-11 | Merck & Co Inc | Preparation of d,1-zearalenones |
| US3551454A (en) | 1967-07-26 | 1970-12-29 | Merck & Co Inc | Preparation of optically active (-)-zearalenone and intermediates therefor |
| US3586701A (en) | 1967-08-24 | 1971-06-22 | Commercial Solvents Corp | Norzearalane and its production |
| US3887583A (en) | 1968-05-15 | 1975-06-03 | Commercial Solvents Corp | Products and process |
| US3591608A (en) * | 1968-11-15 | 1971-07-06 | Ayerst Mckenna & Harrison | Macrocyclic ketolactones |
| US3621036A (en) | 1969-02-27 | 1971-11-16 | Merck & Co Inc | Derivatives of zearalane |
| US3704249A (en) | 1969-05-01 | 1972-11-28 | Merck & Co Inc | Synthesis of the biologically active diastereoisomer of (-) zearalanol |
| US3860616A (en) | 1969-05-01 | 1975-01-14 | Merck & Co Inc | Synthesis of d,1-zearalanol |
| BE757083A (fr) | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | Nouveaux produits a activite antibacterienne |
| BE757082A (fr) | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | Procede de preparation de nouveaux produits a activite antibacterienne |
| US3687982A (en) | 1971-03-09 | 1972-08-29 | Commercial Solvents Corp | Separation of mixed diastereoisomers of zearalanol |
| US3901922A (en) | 1972-04-25 | 1975-08-26 | Commercial Solvents Corp | Synthesis of zearalanone and related compounds and intermediates useful in their synthesis |
| US3903115A (en) | 1972-04-25 | 1975-09-02 | Commercial Solvents Corp | Synthesis of zearalanes II and related compounds and intermediates useful in the syntheses thereof |
| US3901921A (en) | 1972-04-25 | 1975-08-26 | Commercial Solvents Corp | Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof |
| US3836544A (en) | 1972-04-25 | 1974-09-17 | Commercial Solvents Corp | Synthesis of zearalanes ii and related compounds and intermediates useful in the syntheses thereof |
| US3852307A (en) | 1972-04-25 | 1974-12-03 | Commercial Solvents Corp | Synthesis of zearalanone and related compounds |
| US3957825A (en) | 1972-04-25 | 1976-05-18 | Commercial Solvents Corporation | Process for synthesizing zearalanone and related compounds |
| US3810918A (en) | 1972-04-25 | 1974-05-14 | Commercial Solvent Corp | Synthesis of zearalanone |
| US3925423A (en) | 1974-01-22 | 1975-12-09 | Commercial Solvents Corp | Resorcyclic acid lactones and their production |
| US3965275A (en) | 1974-02-11 | 1976-06-22 | Commercial Solvents Corporation | Composition and method |
| US3954805A (en) | 1974-06-06 | 1976-05-04 | Commercial Solvents Corporation | Process for preparing zearalene type compounds |
| US4035504A (en) | 1975-05-12 | 1977-07-12 | Imc Chemical Group, Inc. | Method for treating cholesterolemia by administering resorcylic acid lactone derivatives |
| US4088658A (en) | 1976-11-04 | 1978-05-09 | Imc Chemical Group, Inc. | Synthesis of dideoxyzearalane and related compounds |
| US4042602A (en) | 1976-11-04 | 1977-08-16 | Imc Chemical Group, Inc. | Synthesis of dideoxyzearalane and related compounds |
| US4228079A (en) | 1978-10-30 | 1980-10-14 | W. R. Grace & Co. | Dialkoxy monorden derivatives |
| US4670249A (en) | 1985-04-12 | 1987-06-02 | International Minerals & Chemical Corp. | Growth-promoting compositions |
| EP0248916A1 (en) * | 1986-06-05 | 1987-12-16 | C.R.C. Compagnia di Ricerca Chimica S.p.A. | Method for separation of 3S,7R-3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one from its 3S,7S-diastereomer |
| US4751239A (en) | 1987-06-29 | 1988-06-14 | International Minerals & Chemical Corp. | 6' Carbonate esters of zearalanol and its derivatives |
| US4778821A (en) | 1987-07-15 | 1988-10-18 | International Minerals & Chemical Corp. | Method for controlling helmintic parasites |
| US4849447A (en) | 1987-10-13 | 1989-07-18 | Pitman-Moore, Inc. | Zearalanol derivatives with anabolic activity |
| US4902711A (en) | 1988-01-19 | 1990-02-20 | Pitman-Moore, Inc. | 6' Carbamate esters of zearalanol and its derivatives |
| US5650430A (en) | 1990-06-06 | 1997-07-22 | Sankyo Company, Limited | Radicicol derivatives, their preparation and their anti-tumor activity |
| KR920000763A (ko) | 1990-06-06 | 1992-01-29 | 가와무라 요시부미 | 라디시콜 유도체, 그 제조방법 및 그의 항종양 활성 |
| JPH06279279A (ja) | 1993-03-26 | 1994-10-04 | Tsumura & Co | 血管新生阻害剤 |
| JPH06298764A (ja) | 1993-04-15 | 1994-10-25 | Kyowa Hakko Kogyo Co Ltd | 免疫抑制剤 |
| US5795910A (en) | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| US5731343A (en) | 1995-02-24 | 1998-03-24 | The Scripps Research Institute | Method of use of radicicol for treatment of immunopathological disorders |
| JP3938936B2 (ja) | 1995-04-26 | 2007-06-27 | 協和醗酵工業株式会社 | ラディシコール誘導体 |
| US5710174A (en) | 1995-06-07 | 1998-01-20 | Zymo Genetics, Inc. | Factor XIIIA inhibitor |
| JPH09202781A (ja) | 1996-01-25 | 1997-08-05 | Sankyo Co Ltd | ラディシコール誘導体 |
| WO1998018780A1 (en) | 1996-10-25 | 1998-05-07 | Kyowa Hakko Kogyo Co., Ltd. | Radicicol derivatives |
| JPH10265381A (ja) | 1997-03-24 | 1998-10-06 | Sankyo Co Ltd | 血管再狭窄予防剤 |
| AU3534499A (en) | 1998-04-24 | 1999-11-16 | Kyowa Hakko Kogyo Co. Ltd. | Radicicol derivatives |
| JP2002533389A (ja) * | 1998-12-24 | 2002-10-08 | ノーベーション ファーマシューティカルズ インコーポレーテッド | mRNA安定性に影響する化合物およびそのための使用 |
| JP2000236894A (ja) | 1999-02-19 | 2000-09-05 | Kyowa Hakko Kogyo Co Ltd | ラディシコールの製造方法 |
| WO2002002123A1 (en) | 2000-06-29 | 2002-01-10 | Trustees Of Boston University | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
| ATE526019T1 (de) | 2000-07-28 | 2011-10-15 | Sloan Kettering Inst Cancer | Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen |
| US6734209B2 (en) | 2001-08-03 | 2004-05-11 | Board Of Regents The University Of Texas System | Synthetic salicylihalamides, apicularens and derivatives thereof |
| AU7815201A (en) | 2000-08-04 | 2002-02-18 | Univ Texas | Synthetic salicylihalamides, apicularens and derivatives thereof |
| US6956039B2 (en) | 2000-08-18 | 2005-10-18 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocylic compounds |
| EP1315732B1 (en) | 2000-08-25 | 2006-06-07 | Sloan-Kettering Institute For Cancer Research | Radicicol and monocillin and their analogues and uses thereof |
| JP2005519848A (ja) | 2000-11-02 | 2005-07-07 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Hsp90に結合するための小分子組成物 |
| JP2004292315A (ja) | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | Tak1阻害剤 |
| US20030211469A1 (en) | 2001-07-16 | 2003-11-13 | Lloyd Waxman | Inhibiting hepatitis c virus processing and replication |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| JP2003113183A (ja) * | 2001-10-05 | 2003-04-18 | Kyowa Hakko Kogyo Co Ltd | リウマチ治療剤 |
| EP1450784A4 (en) * | 2001-11-09 | 2005-02-09 | Conforma Therapeutics Corp | HSP90-INHIBITABLE ZEARALANOL COMPOUNDS AND METHOD FOR THEIR PREPARATION AND USE |
| WO2003050295A2 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
| GB0202871D0 (en) | 2002-02-07 | 2002-03-27 | Cancer Res Ventures Ltd | Assays,methods and means |
| WO2003076424A1 (en) | 2002-03-08 | 2003-09-18 | Eisai Co. Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| CN1652743A (zh) * | 2002-04-17 | 2005-08-10 | 大正制药株式会社 | 毛发生长补剂 |
| WO2004024142A1 (ja) * | 2002-08-29 | 2004-03-25 | Kyowa Hakko Kogyo Co., Ltd. | Hsp90ファミリー蛋白質阻害剤 |
| US20060251574A1 (en) | 2002-12-12 | 2006-11-09 | Adeela Kamal | Cytotoxins and diagnostic imaging agents comprising hsp90 ligands |
| US7959915B2 (en) | 2003-03-12 | 2011-06-14 | Tufts University | Inhibitors of extracellular Hsp90 |
| WO2005018674A1 (ja) | 2003-08-22 | 2005-03-03 | Kyowa Hakko Kogyo Co., Ltd. | イムノグロブリン遺伝子の転座を伴う疾患の治療薬 |
| US20080108694A1 (en) * | 2003-12-19 | 2008-05-08 | Samuel J Danishefsky | Novel Macrocycles and Uses Thereof |
| US20050267087A1 (en) | 2004-04-28 | 2005-12-01 | Vassiliki Poulaki | Inflammatory eye disease |
| US20060079494A1 (en) | 2004-09-27 | 2006-04-13 | Santi Daniel V | Specific kinase inhibitors |
| WO2006119456A2 (en) | 2005-05-04 | 2006-11-09 | University Of Vermont And State Agricultural College | Methods and compositions for treating toxoplasma |
| CA2696021C (en) | 2006-08-11 | 2015-09-29 | Nicolas Winssinger | Macrocyclic compounds useful as inhibitors of kinases and hsp90 |
-
2007
- 2007-08-10 CA CA2696021A patent/CA2696021C/en active Active
- 2007-08-10 CN CN201310414870.9A patent/CN103539769B/zh active Active
- 2007-08-10 CN CN2007800381410A patent/CN101588799B/zh active Active
- 2007-08-10 WO PCT/US2007/017754 patent/WO2008021213A1/en not_active Ceased
- 2007-08-10 US US11/891,652 patent/US8067412B2/en active Active
- 2007-08-10 JP JP2009523852A patent/JP5465006B2/ja not_active Expired - Fee Related
- 2007-08-10 ES ES07811232.3T patent/ES2651019T3/es active Active
- 2007-08-10 EP EP07811232.3A patent/EP2136799B1/en active Active
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2011
- 2011-09-23 US US13/242,496 patent/US8450305B2/en active Active
Non-Patent Citations (1)
| Title |
|---|
| Search for Hsp90 Inhibitors with Potential Anticancer Activity:Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert;Thomas J. Turbyville et al.;《J. Nat. Prod.》;20060203;第69卷(第2期);178-184 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2696021C (en) | 2015-09-29 |
| CN101588799A (zh) | 2009-11-25 |
| CA2696021A1 (en) | 2008-02-21 |
| WO2008021213A1 (en) | 2008-02-21 |
| CN103539769A (zh) | 2014-01-29 |
| US8067412B2 (en) | 2011-11-29 |
| US8450305B2 (en) | 2013-05-28 |
| ES2651019T3 (es) | 2018-01-23 |
| US20120077775A1 (en) | 2012-03-29 |
| JP2010501478A (ja) | 2010-01-21 |
| CN101588799B (zh) | 2013-09-11 |
| EP2136799A4 (en) | 2010-10-27 |
| EP2136799B1 (en) | 2017-10-04 |
| US20080146545A1 (en) | 2008-06-19 |
| EP2136799A1 (en) | 2009-12-30 |
| JP5465006B2 (ja) | 2014-04-09 |
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