CN101553470A - 抗菌的喹啉衍生物 - Google Patents

抗菌的喹啉衍生物 Download PDF

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Publication number
CN101553470A
CN101553470A CNA2007800449358A CN200780044935A CN101553470A CN 101553470 A CN101553470 A CN 101553470A CN A2007800449358 A CNA2007800449358 A CN A2007800449358A CN 200780044935 A CN200780044935 A CN 200780044935A CN 101553470 A CN101553470 A CN 101553470A
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CN
China
Prior art keywords
alkyl
compound
fit
amino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800449358A
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English (en)
Chinese (zh)
Inventor
J·E·G·吉尔蒙特
D·F·A·兰科伊斯
I·多兰奇
K·J·L·M·安德烈斯
A·考尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38126091&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101553470(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Priority to CN201510088659.1A priority Critical patent/CN104744361B/zh
Publication of CN101553470A publication Critical patent/CN101553470A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
CNA2007800449358A 2006-12-06 2007-12-04 抗菌的喹啉衍生物 Pending CN101553470A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510088659.1A CN104744361B (zh) 2006-12-06 2007-12-04 抗菌的喹啉衍生物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125499 2006-12-06
EP06125499.1 2006-12-06

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510088659.1A Division CN104744361B (zh) 2006-12-06 2007-12-04 抗菌的喹啉衍生物

Publications (1)

Publication Number Publication Date
CN101553470A true CN101553470A (zh) 2009-10-07

Family

ID=38126091

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2007800449358A Pending CN101553470A (zh) 2006-12-06 2007-12-04 抗菌的喹啉衍生物
CN201510088659.1A Expired - Fee Related CN104744361B (zh) 2006-12-06 2007-12-04 抗菌的喹啉衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510088659.1A Expired - Fee Related CN104744361B (zh) 2006-12-06 2007-12-04 抗菌的喹啉衍生物

Country Status (32)

Country Link
US (1) US8415475B2 (https=)
EP (1) EP2099758B1 (https=)
JP (1) JP5466011B2 (https=)
KR (1) KR101490222B1 (https=)
CN (2) CN101553470A (https=)
AP (1) AP2479A (https=)
AR (1) AR064151A1 (https=)
AU (1) AU2007328887B2 (https=)
BR (1) BRPI0720220B8 (https=)
CA (1) CA2669819C (https=)
CL (1) CL2007003514A1 (https=)
CY (1) CY1117766T1 (https=)
DK (1) DK2099758T3 (https=)
EA (1) EA016733B1 (https=)
ES (1) ES2573689T3 (https=)
HR (1) HRP20160585T1 (https=)
HU (1) HUE028769T2 (https=)
IL (1) IL199083A (https=)
JO (1) JO3271B1 (https=)
ME (1) ME02498B (https=)
MX (1) MX2009005978A (https=)
MY (1) MY181645A (https=)
NO (1) NO341983B1 (https=)
NZ (1) NZ576823A (https=)
PL (1) PL2099758T3 (https=)
PT (1) PT2099758E (https=)
RS (1) RS54794B1 (https=)
SI (1) SI2099758T1 (https=)
TW (1) TWI406659B (https=)
UA (1) UA100972C2 (https=)
WO (1) WO2008068267A1 (https=)
ZA (1) ZA200903950B (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016008381A1 (zh) * 2014-07-14 2016-01-21 辰欣药业股份有限公司 吡啶衍生物及其作为抗分支杆菌的应用
CN105330595A (zh) * 2014-07-14 2016-02-17 南京明德新药研发股份有限公司 吡啶衍生物及其作为抗分支杆菌的应用
CN105601566A (zh) * 2016-02-02 2016-05-25 张敏 一种护理烧伤后感染的药物组合物
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CN109069514A (zh) * 2016-03-07 2018-12-21 结核病药物开发全球联盟公司 抗菌化合物及其用途
CN111757879A (zh) * 2018-01-29 2020-10-09 卡地拉健康护理有限公司 用作抗菌剂的杂环化合物
CN114129526A (zh) * 2015-01-27 2022-03-04 詹森药业有限公司 可分散组合物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104254527B (zh) 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
ES2607879T3 (es) 2012-04-27 2017-04-04 Janssen Pharmaceutica N.V. Derivados de quinolina antibacterianos
ES2619610T3 (es) 2012-10-16 2017-06-26 Janssen Pharmaceutica Nv Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
CA2888485C (en) 2012-10-16 2021-01-26 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror.gamma.t
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
ES2742843T3 (es) 2013-10-15 2020-02-17 Janssen Pharmaceutica Nv Moduladores de quinolinilo de ROR(gamma)t
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
WO2022084947A1 (en) * 2020-10-22 2022-04-28 Lunella Biotech, Inc. Mitochondrial atp inhibitors targeting the gamma subunit prevent metastasis
KR20240161147A (ko) 2022-03-14 2024-11-12 슬랩 파마슈티컬스 엘엘씨 다중 사이클릭 화합물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018326A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
ATE463482T1 (de) * 2002-07-25 2010-04-15 Janssen Pharmaceutica Nv Chinolinderivate und deren verwendung als mycobakterielle inhibitoren
EA011277B1 (ru) * 2004-01-23 2009-02-27 Янссен Фармацевтика Н.В. Производные хинолина и их применение в качестве ингибиторов микобактерий
EA011359B1 (ru) 2004-01-23 2009-02-27 Янссен Фармацевтика Н.В. Замещенные хинолины и их применение в качестве микобактериальных ингибиторов
CA2554049C (en) * 2004-01-29 2012-12-18 Janssen Pharmaceutica N.V. Quinoline derivatives for use as mycobacterial inhibitors
PL1753427T3 (pl) * 2004-05-28 2008-09-30 Janssen Pharmaceutica Nv Zastosowanie podstawionych pochodnych chinoliny do leczenia chorób wywoływanych przez prątki lekooporne
PL1797115T3 (pl) 2004-09-28 2017-12-29 Janssen Pharmaceutica N.V. Domena wiążąca bakteryjnej syntazy ATP
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016008381A1 (zh) * 2014-07-14 2016-01-21 辰欣药业股份有限公司 吡啶衍生物及其作为抗分支杆菌的应用
CN105330595A (zh) * 2014-07-14 2016-02-17 南京明德新药研发股份有限公司 吡啶衍生物及其作为抗分支杆菌的应用
US9878982B2 (en) 2014-07-14 2018-01-30 Cisen Pharmaceutical Co., Ltd. Pyridine derivatives and anti-mycobacterial use thereof
CN114129526A (zh) * 2015-01-27 2022-03-04 詹森药业有限公司 可分散组合物
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
CN105601566A (zh) * 2016-02-02 2016-05-25 张敏 一种护理烧伤后感染的药物组合物
CN109069514A (zh) * 2016-03-07 2018-12-21 结核病药物开发全球联盟公司 抗菌化合物及其用途
CN109069514B (zh) * 2016-03-07 2023-12-29 结核病药物开发全球联盟公司 抗菌化合物及其用途
CN111757879A (zh) * 2018-01-29 2020-10-09 卡地拉健康护理有限公司 用作抗菌剂的杂环化合物

Also Published As

Publication number Publication date
DK2099758T3 (en) 2016-06-13
BRPI0720220B8 (pt) 2021-05-25
WO2008068267A1 (en) 2008-06-12
AR064151A1 (es) 2009-03-18
AU2007328887A1 (en) 2008-06-12
HK1208437A1 (en) 2016-03-04
EA016733B1 (ru) 2012-07-30
CL2007003514A1 (es) 2008-07-11
BRPI0720220B1 (pt) 2020-06-09
EP2099758A1 (en) 2009-09-16
CN104744361B (zh) 2021-06-08
EA200970535A1 (ru) 2009-10-30
JP5466011B2 (ja) 2014-04-09
ZA200903950B (en) 2010-08-25
CY1117766T1 (el) 2017-05-17
NZ576823A (en) 2012-01-12
IL199083A0 (en) 2010-03-28
HRP20160585T1 (hr) 2016-06-17
KR101490222B1 (ko) 2015-02-05
IL199083A (en) 2014-08-31
TW200838528A (en) 2008-10-01
AP2479A (en) 2012-09-27
UA100972C2 (ru) 2013-02-25
US8415475B2 (en) 2013-04-09
MX2009005978A (es) 2009-06-16
PT2099758E (pt) 2016-06-02
NO341983B1 (no) 2018-03-05
MY181645A (en) 2020-12-30
AU2007328887B2 (en) 2013-01-17
JP2010511668A (ja) 2010-04-15
AP2009004874A0 (en) 2009-06-30
RS54794B1 (sr) 2016-10-31
ME02498B (me) 2017-02-20
CA2669819A1 (en) 2008-06-12
KR20090086604A (ko) 2009-08-13
HUE028769T2 (en) 2017-01-30
TWI406659B (zh) 2013-09-01
US20100048566A1 (en) 2010-02-25
SI2099758T1 (sl) 2016-07-29
ES2573689T3 (es) 2016-06-09
NO20092542L (no) 2009-08-25
EP2099758B1 (en) 2016-03-09
BRPI0720220A2 (pt) 2013-12-24
CN104744361A (zh) 2015-07-01
JO3271B1 (ar) 2018-09-16
CA2669819C (en) 2016-08-30
PL2099758T3 (pl) 2016-08-31

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