CN101553461A - 4-取代的苯氧基苯基乙酸衍生物 - Google Patents

4-取代的苯氧基苯基乙酸衍生物 Download PDF

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CN101553461A
CN101553461A CNA200780039235XA CN200780039235A CN101553461A CN 101553461 A CN101553461 A CN 101553461A CN A200780039235X A CNA200780039235X A CN A200780039235XA CN 200780039235 A CN200780039235 A CN 200780039235A CN 101553461 A CN101553461 A CN 101553461A
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compound
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methyl
alkyl
phenyl
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乔治·多尔蒂
亚当·库克
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Array Biopharma Inc
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Array Biopharma Inc
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102812000A (zh) * 2010-01-06 2012-12-05 潘米拉制药公司 Dp2拮抗剂及其用途
CN104016878A (zh) * 2014-06-24 2014-09-03 中国药科大学 芳基乙酸类衍生物、其制备方法及其医药用途

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ575507A (en) * 2006-08-21 2011-10-28 Array Biopharma Inc 4-substituted phenoxyphenylacetic acid derivatives
WO2008116145A2 (en) * 2007-03-22 2008-09-25 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors
US8362056B2 (en) * 2007-11-05 2013-01-29 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid derivatives
WO2009099902A1 (en) 2008-02-01 2009-08-13 Amira Pharmaceuticals, Inc. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
JP2011512359A (ja) * 2008-02-14 2011-04-21 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物
WO2009108720A2 (en) 2008-02-25 2009-09-03 Amira Pharmaceuticals, Inc. Antagonists of prostaglandin d2 receptors
JP2011518130A (ja) 2008-04-02 2011-06-23 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のアミノアルキルフェニルアンタゴニスト
HRP20140988T1 (hr) 2008-06-25 2014-12-05 Array Biopharma, Inc. Derivati 6-supstituirane fenoksikromankarboksilne kiseline
MX2010014172A (es) 2008-07-03 2011-02-22 Amira Pharmaceuticals Inc Antagonistas de receptores de prostaglandina d2.
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
US8383654B2 (en) 2008-11-17 2013-02-26 Panmira Pharmaceuticals, Llc Heterocyclic antagonists of prostaglandin D2 receptors
CN102325767B (zh) * 2008-12-22 2014-05-14 阵列生物制药公司 7-苯氧基色满羧酸衍生物
CN102395586A (zh) 2009-02-17 2012-03-28 奇斯药制品公司 作为p38map激酶抑制剂的三唑并吡啶衍生物
KR20120038544A (ko) 2009-07-31 2012-04-23 판미라 파마슈티칼스, 엘엘씨 Ｄｐ2 수용체 길항제의 안과용 약학 조성물
SG10201404662YA (en) 2009-08-05 2014-10-30 Panmira Pharmaceuticals Llc Dp2 antagonist and uses thereof
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
JP2015500326A (ja) 2011-12-16 2015-01-05 アトピックス テラピューティクス リミテッド 好酸球性食道炎の治療のためのｃｒｔｈ２拮抗薬およびプロトンポンプ阻害薬の組み合わせ
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1266000A (en) * 1998-11-04 2000-05-22 Basf Aktiengesellschaft 2-phenoxyphenylacetic acid derivatives, method and intermediate products for theproduction thereof, their use, and agents containing the same for combating fun gicidal pests
JP2001072653A (ja) * 1999-07-01 2001-03-21 Taisho Pharmaceut Co Ltd アミノ安息香酸誘導体
GB0015205D0 (en) 2000-06-21 2000-08-09 Karobio Ab Bioisosteric thyroid receptor ligands and method
JP2002193800A (ja) * 2000-12-22 2002-07-10 Taisho Pharmaceut Co Ltd Ｖｅｇｆ受容体拮抗剤
TW200408393A (en) * 2002-10-03 2004-06-01 Ono Pharmaceutical Co Antagonist of lysophosphatidine acid receptor
EP1585511B1 (en) * 2002-12-20 2013-01-23 Amgen Inc. Asthma and allergic inflammation modulators
US7557143B2 (en) * 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
KR100927563B1 (ko) * 2004-08-06 2009-11-23 오쓰까 세이야꾸 가부시키가이샤 방향족 화합물
BRPI0712301A2 (pt) 2006-06-09 2012-01-17 Icos Corp composto, composição farmacêutica, método de antagonização de um receptor dp-2, e, uso de um composto
NZ575507A (en) * 2006-08-21 2011-10-28 Array Biopharma Inc 4-substituted phenoxyphenylacetic acid derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102812000A (zh) * 2010-01-06 2012-12-05 潘米拉制药公司 Dp2拮抗剂及其用途
CN104016878A (zh) * 2014-06-24 2014-09-03 中国药科大学 芳基乙酸类衍生物、其制备方法及其医药用途
CN104016878B (zh) * 2014-06-24 2015-06-10 中国药科大学 芳基乙酸类衍生物、其制备方法及其医药用途

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