CN101522687A - 用于癌症治疗的杂二环噻吩化合物 - Google Patents

用于癌症治疗的杂二环噻吩化合物 Download PDF

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Publication number
CN101522687A
CN101522687A CNA2007800026090A CN200780002609A CN101522687A CN 101522687 A CN101522687 A CN 101522687A CN A2007800026090 A CNA2007800026090 A CN A2007800026090A CN 200780002609 A CN200780002609 A CN 200780002609A CN 101522687 A CN101522687 A CN 101522687A
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alkyl
compound
aryl
heteroaryl
optionally substituted
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Chinese (zh)
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詹姆斯·F·布莱克
史蒂文·博伊德
贾森·德米斯
约翰·J·高丁诺
艾利森·L·马洛
J·索
艾伦·A·托马斯
H·田
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Array Biopharma Inc
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Array Biopharma Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
CNA2007800026090A 2006-01-30 2007-01-30 用于癌症治疗的杂二环噻吩化合物 Pending CN101522687A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76341406P 2006-01-30 2006-01-30
US60/763,414 2006-01-30

Publications (1)

Publication Number Publication Date
CN101522687A true CN101522687A (zh) 2009-09-02

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US (1) US8003662B2 (https=)
EP (1) EP1989211A2 (https=)
JP (1) JP2009526761A (https=)
CN (1) CN101522687A (https=)
AR (1) AR059246A1 (https=)
CA (1) CA2636242A1 (https=)
TW (1) TW200806675A (https=)
WO (1) WO2008063202A2 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
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CN102498114A (zh) * 2009-09-03 2012-06-13 阿勒根公司 作为酪氨酸激酶调节剂的化合物
CN109206435A (zh) * 2017-06-29 2019-01-15 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
CN111295386A (zh) * 2018-03-08 2020-06-16 伟迈可生物有限公司 噻吩并吡啶衍生物及含有该衍生物的药物组合物
CN112771053A (zh) * 2019-09-06 2021-05-07 伟迈可生物有限公司 基于生物标志物的治疗组合物
CN115177618A (zh) * 2022-07-26 2022-10-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Flt3抑制剂在制备治疗急性髓系白血病药物中的应用
CN115745999A (zh) * 2021-11-19 2023-03-07 浙江奥洋新材料有限公司 一种可提高反应活性的纤维素碱性醚化、酯化反应溶剂叔丁五元二环胍的结构及其合成路线
CN117209474A (zh) * 2022-06-10 2023-12-12 成都百裕制药股份有限公司 吡咯烷衍生物、药物组合物及其在医药上的应用
CN118894838A (zh) * 2024-07-11 2024-11-05 深圳技术大学 一种酰胺衍生物及其制备方法和应用

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102498114A (zh) * 2009-09-03 2012-06-13 阿勒根公司 作为酪氨酸激酶调节剂的化合物
CN109206435A (zh) * 2017-06-29 2019-01-15 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
CN109206435B (zh) * 2017-06-29 2020-09-08 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
CN111295386A (zh) * 2018-03-08 2020-06-16 伟迈可生物有限公司 噻吩并吡啶衍生物及含有该衍生物的药物组合物
CN112771053A (zh) * 2019-09-06 2021-05-07 伟迈可生物有限公司 基于生物标志物的治疗组合物
CN115745999A (zh) * 2021-11-19 2023-03-07 浙江奥洋新材料有限公司 一种可提高反应活性的纤维素碱性醚化、酯化反应溶剂叔丁五元二环胍的结构及其合成路线
CN117209474A (zh) * 2022-06-10 2023-12-12 成都百裕制药股份有限公司 吡咯烷衍生物、药物组合物及其在医药上的应用
CN117209474B (zh) * 2022-06-10 2026-03-10 康百达（四川）生物医药科技有限公司 吡咯烷衍生物、药物组合物及其在医药上的应用
CN115177618A (zh) * 2022-07-26 2022-10-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Flt3抑制剂在制备治疗急性髓系白血病药物中的应用
CN118894838A (zh) * 2024-07-11 2024-11-05 深圳技术大学 一种酰胺衍生物及其制备方法和应用

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US20070197537A1 (en) 2007-08-23
US8003662B2 (en) 2011-08-23
CA2636242A1 (en) 2008-05-29
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WO2008063202A2 (en) 2008-05-29
TW200806675A (en) 2008-02-01

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