CN101522687A - 用于癌症治疗的杂二环噻吩化合物 - Google Patents

用于癌症治疗的杂二环噻吩化合物 Download PDF

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Publication number
CN101522687A
CN101522687A CNA2007800026090A CN200780002609A CN101522687A CN 101522687 A CN101522687 A CN 101522687A CN A2007800026090 A CNA2007800026090 A CN A2007800026090A CN 200780002609 A CN200780002609 A CN 200780002609A CN 101522687 A CN101522687 A CN 101522687A
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alkyl
compound
aryl
heteroaryl
optionally substituted
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Chinese (zh)
Inventor
詹姆斯·F·布莱克
史蒂文·博伊德
贾森·德米斯
约翰·J·高丁诺
艾利森·L·马洛
J·索
艾伦·A·托马斯
H·田
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Array Biopharma Inc
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Array Biopharma Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P31/12—Antivirals
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
CNA2007800026090A 2006-01-30 2007-01-30 用于癌症治疗的杂二环噻吩化合物 Pending CN101522687A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76341406P 2006-01-30 2006-01-30
US60/763,414 2006-01-30

Publications (1)

Publication Number Publication Date
CN101522687A true CN101522687A (zh) 2009-09-02

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Country Status (8)

Country Link
US (1) US8003662B2 (https=)
EP (1) EP1989211A2 (https=)
JP (1) JP2009526761A (https=)
CN (1) CN101522687A (https=)
AR (1) AR059246A1 (https=)
CA (1) CA2636242A1 (https=)
TW (1) TW200806675A (https=)
WO (1) WO2008063202A2 (https=)

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CN102498114A (zh) * 2009-09-03 2012-06-13 阿勒根公司 作为酪氨酸激酶调节剂的化合物
CN109206435A (zh) * 2017-06-29 2019-01-15 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
CN111295386A (zh) * 2018-03-08 2020-06-16 伟迈可生物有限公司 噻吩并吡啶衍生物及含有该衍生物的药物组合物
CN112771053A (zh) * 2019-09-06 2021-05-07 伟迈可生物有限公司 基于生物标志物的治疗组合物
CN115177618A (zh) * 2022-07-26 2022-10-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Flt3抑制剂在制备治疗急性髓系白血病药物中的应用
CN115745999A (zh) * 2021-11-19 2023-03-07 浙江奥洋新材料有限公司 一种可提高反应活性的纤维素碱性醚化、酯化反应溶剂叔丁五元二环胍的结构及其合成路线
CN117209474A (zh) * 2022-06-10 2023-12-12 成都百裕制药股份有限公司 吡咯烷衍生物、药物组合物及其在医药上的应用
CN118894838A (zh) * 2024-07-11 2024-11-05 深圳技术大学 一种酰胺衍生物及其制备方法和应用

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Cited By (10)

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CN109206435A (zh) * 2017-06-29 2019-01-15 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
CN109206435B (zh) * 2017-06-29 2020-09-08 中国医药研究开发中心有限公司 噻吩并[3,2-d]嘧啶类化合物及其制备方法和医药用途
CN111295386A (zh) * 2018-03-08 2020-06-16 伟迈可生物有限公司 噻吩并吡啶衍生物及含有该衍生物的药物组合物
CN112771053A (zh) * 2019-09-06 2021-05-07 伟迈可生物有限公司 基于生物标志物的治疗组合物
CN115745999A (zh) * 2021-11-19 2023-03-07 浙江奥洋新材料有限公司 一种可提高反应活性的纤维素碱性醚化、酯化反应溶剂叔丁五元二环胍的结构及其合成路线
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CN115177618A (zh) * 2022-07-26 2022-10-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Flt3抑制剂在制备治疗急性髓系白血病药物中的应用
CN118894838A (zh) * 2024-07-11 2024-11-05 深圳技术大学 一种酰胺衍生物及其制备方法和应用

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AR059246A1 (es) 2008-03-19
US8003662B2 (en) 2011-08-23
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