CN101501006A - 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物 - Google Patents

作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物 Download PDF

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Publication number
CN101501006A
CN101501006A CNA2007800201367A CN200780020136A CN101501006A CN 101501006 A CN101501006 A CN 101501006A CN A2007800201367 A CNA2007800201367 A CN A2007800201367A CN 200780020136 A CN200780020136 A CN 200780020136A CN 101501006 A CN101501006 A CN 101501006A
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alkyl
methyl
compound
oxo
dihydropyridazin
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Chinese (zh)
Inventor
P·琼斯
O·金策尔
G·佩斯卡托尔
L·劳格尔布菲
C·舒尔茨-费德姆勒希特
F·菲里诺
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Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CNA2007800201367A 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物 Pending CN101501006A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0610680.1A GB0610680D0 (en) 2006-05-31 2006-05-31 Therapeutic compounds
GB0610680.1 2006-05-31

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CN2013103167261A Division CN103420988A (zh) 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物

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CN101501006A true CN101501006A (zh) 2009-08-05

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CNA2007800201367A Pending CN101501006A (zh) 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物
CN2013103167261A Pending CN103420988A (zh) 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物

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US (1) US8188084B2 (https=)
EP (1) EP2029551B1 (https=)
JP (1) JP5351755B2 (https=)
KR (1) KR101529891B1 (https=)
CN (2) CN101501006A (https=)
AU (1) AU2007266836B2 (https=)
BR (1) BRPI0711741B8 (https=)
CA (1) CA2653529C (https=)
ES (1) ES2702781T3 (https=)
GB (1) GB0610680D0 (https=)
IL (1) IL195113A (https=)
MX (1) MX2008015014A (https=)
NO (1) NO343950B1 (https=)
NZ (1) NZ572815A (https=)
WO (1) WO2007138351A2 (https=)
ZA (1) ZA200809238B (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019427A1 (zh) * 2010-08-09 2012-02-16 上海恒瑞医药有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
CN103833756A (zh) * 2012-11-26 2014-06-04 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和用途
CN104918917A (zh) * 2012-12-31 2015-09-16 卡迪拉保健有限公司 作为聚(adp-核糖)聚合酶-1的选择性抑制剂的取代的酞嗪-1(2h)-酮衍生物
CN105073715A (zh) * 2013-03-13 2015-11-18 中外制药株式会社 二氢哒嗪-3,5-二酮衍生物
CN106749261A (zh) * 2015-11-23 2017-05-31 中国科学院上海药物研究所 一类取代三唑并哌嗪类parp抑制剂及其制备方法和用途
CN112424188A (zh) * 2018-04-30 2021-02-26 里邦医疗公司 作为parp7抑制剂的哒嗪酮
WO2022223022A1 (zh) * 2021-04-23 2022-10-27 四川海思科制药有限公司 一种并环杂环衍生物及其在医药上的应用
CN115745971A (zh) * 2021-12-20 2023-03-07 重庆华森制药股份有限公司 Parp7抑制剂及其应用
US12371421B2 (en) 2019-04-29 2025-07-29 Ribon Therapeutics, Inc. Solid forms of a PARP7 inhibitor
US12617782B2 (en) 2023-05-12 2026-05-05 Ribon Therapeutics, Inc. Pyridazinones as PARP7 inhibitors

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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