CN1014787B - 苯氧基乙酸衍生物的制备方法 - Google Patents

苯氧基乙酸衍生物的制备方法

Info

Publication number
CN1014787B
CN1014787B CN87106895A CN87106895A CN1014787B CN 1014787 B CN1014787 B CN 1014787B CN 87106895 A CN87106895 A CN 87106895A CN 87106895 A CN87106895 A CN 87106895A CN 1014787 B CN1014787 B CN 1014787B
Authority
CN
China
Prior art keywords
compound
pyrazolyl
preparation
formula
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87106895A
Other languages
English (en)
Chinese (zh)
Other versions
CN87106895A (zh
Inventor
高村则夫
小田邦幸
古田土真一
山口勳
矢野浩二
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of CN87106895A publication Critical patent/CN87106895A/zh
Publication of CN1014787B publication Critical patent/CN1014787B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN87106895A 1986-10-13 1987-10-10 苯氧基乙酸衍生物的制备方法 Expired CN1014787B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP242802/86 1986-10-13
JP24802/86 1986-10-13
JP24280286 1986-10-13

Publications (2)

Publication Number Publication Date
CN87106895A CN87106895A (zh) 1988-04-20
CN1014787B true CN1014787B (zh) 1991-11-20

Family

ID=17094503

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87106895A Expired CN1014787B (zh) 1986-10-13 1987-10-10 苯氧基乙酸衍生物的制备方法

Country Status (17)

Country Link
US (1) US4853404A (https=)
EP (1) EP0268800B1 (https=)
JP (1) JPS63225359A (https=)
KR (1) KR920002296B1 (https=)
CN (1) CN1014787B (https=)
AT (1) ATE72429T1 (https=)
AU (1) AU595385B2 (https=)
CA (1) CA1311483C (https=)
DE (1) DE3776627D1 (https=)
DK (1) DK166879B1 (https=)
ES (1) ES2032284T3 (https=)
FI (1) FI91402C (https=)
GR (1) GR3003727T3 (https=)
HK (1) HK47193A (https=)
HU (1) HU202501B (https=)
IE (1) IE60044B1 (https=)
IL (1) IL84106A (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613720B1 (fr) * 1987-04-10 1990-01-19 Esteve Labor Dr Derives d'aryl-heteroaryl carbinols avec activite analgesique
JPH01316317A (ja) * 1988-03-10 1989-12-21 Tanabe Seiyaku Co Ltd 降圧剤
US4956379A (en) * 1990-02-13 1990-09-11 Bristol-Myers Squibb Company Pyrazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
EP0442448A3 (en) 1990-02-13 1992-08-12 Bristol-Myers Squibb Company Heterocyclic carboxylic acids and esters
US20040067531A1 (en) * 1997-08-20 2004-04-08 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
SI1255752T1 (sl) * 2000-02-15 2007-12-31 Pharmacia & Upjohn Co Llc S pirolom substituirani zaviralci 2-indolinon protein kinaza
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2003031438A1 (en) 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342851A (en) * 1964-10-30 1967-09-19 Merck & Co Inc Esters of [(2-methyleneacyl)phenoxy]-carboxylic acids and a method for their preparation
GB1415295A (en) * 1971-10-14 1975-11-26 Orchimed Sa Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof
CH543472A (fr) * 1969-01-31 1973-10-31 Orchimed Sa Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques
US4107179A (en) * 1977-08-22 1978-08-15 Smithkline Corporation Method for preparing ticrynafen
GB2024209B (en) * 1978-05-31 1982-09-08 Sori Soc Rech Ind Phenoxalkylcarboxylic acids
US4323691A (en) * 1979-10-09 1982-04-06 Abbott Laboratories Hydroxyaminomethyl derivatives of benzoyl di-substituted α-phenoxyalkanoyl esters

Also Published As

Publication number Publication date
GR3003727T3 (https=) 1993-03-16
EP0268800A1 (en) 1988-06-01
US4853404A (en) 1989-08-01
DK166879B1 (da) 1993-07-26
KR880005089A (ko) 1988-06-28
KR920002296B1 (ko) 1992-03-21
AU595385B2 (en) 1990-03-29
JPH0544944B2 (https=) 1993-07-07
CA1311483C (en) 1992-12-15
ES2032284T3 (es) 1993-02-01
FI91402B (fi) 1994-03-15
CN87106895A (zh) 1988-04-20
HK47193A (en) 1993-05-21
FI874473A0 (fi) 1987-10-12
AU7956387A (en) 1988-04-14
JPS63225359A (ja) 1988-09-20
DK532987D0 (da) 1987-10-12
DK532987A (da) 1988-04-14
FI91402C (fi) 1994-06-27
DE3776627D1 (de) 1992-03-19
EP0268800B1 (en) 1992-02-05
IE60044B1 (en) 1994-05-18
IE872668L (en) 1988-04-13
ATE72429T1 (de) 1992-02-15
HU202501B (en) 1991-03-28
IL84106A0 (en) 1988-03-31
IL84106A (en) 1991-07-18
FI874473L (fi) 1988-04-14
HUT50788A (en) 1990-03-28

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C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee