CN101454267B - 姜黄素的合成 - Google Patents

姜黄素的合成 Download PDF

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Publication number
CN101454267B
CN101454267B CN2007800198805A CN200780019880A CN101454267B CN 101454267 B CN101454267 B CN 101454267B CN 2007800198805 A CN2007800198805 A CN 2007800198805A CN 200780019880 A CN200780019880 A CN 200780019880A CN 101454267 B CN101454267 B CN 101454267B
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CN
China
Prior art keywords
vanillin
acetylacetone
curcumin
water
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800198805A
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English (en)
Chinese (zh)
Other versions
CN101454267A (zh
Inventor
克利斯托弗·维瑞里
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DSM IP Assets BV
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DSM IP Assets BV
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Publication date
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Publication of CN101454267A publication Critical patent/CN101454267A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2007800198805A 2006-03-29 2007-03-19 姜黄素的合成 Expired - Fee Related CN101454267B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06006519 2006-03-29
EP06006519.0 2006-03-29
PCT/EP2007/002403 WO2007110168A1 (en) 2006-03-29 2007-03-19 Curcumin synthesis

Publications (2)

Publication Number Publication Date
CN101454267A CN101454267A (zh) 2009-06-10
CN101454267B true CN101454267B (zh) 2012-09-26

Family

ID=38093544

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800198805A Expired - Fee Related CN101454267B (zh) 2006-03-29 2007-03-19 姜黄素的合成

Country Status (7)

Country Link
US (1) US7964755B2 (enExample)
EP (1) EP1999097B1 (enExample)
JP (1) JP5341747B2 (enExample)
KR (1) KR20080112340A (enExample)
CN (1) CN101454267B (enExample)
AT (1) ATE538080T1 (enExample)
WO (1) WO2007110168A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2568043A1 (en) 2007-12-27 2013-03-13 Baxter International Inc. Chemically modified factor IX
US8680143B2 (en) 2008-07-07 2014-03-25 Laila Pharmaceuticals Pvt. Ltd. Orally active curcuminoid compounds
ES2837014T3 (es) * 2012-05-08 2021-06-29 Asac Compania De Biotecnologia E Investig Sa Procedimiento para la síntesis de curcumina
CN102701934A (zh) * 2012-05-30 2012-10-03 江南大学 一种以氧化锌负载氧化镁为催化剂催化合成姜黄素的方法
CN102701933A (zh) * 2012-05-30 2012-10-03 江南大学 一种采用氧化铝负载氟化钾固体碱催化合成姜黄素的方法
CN102911022B (zh) * 2012-10-25 2015-12-09 山东鲁诺动物药业有限公司 一种天然姜黄素类物的人工合成方法
CN103910615A (zh) * 2014-04-09 2014-07-09 西安雅森生物技术有限公司 一种合成姜黄素的方法
CN108101761B (zh) * 2017-12-08 2021-08-03 陕西嘉禾生物科技股份有限公司 一种姜黄素的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194841A (en) * 1959-08-31 1965-07-13 Lever Brothers Ltd Process for preparing hepta-1:6-diene-3:5-diones
US5679864A (en) * 1995-11-03 1997-10-21 Gene Print Inc. Process for the synthesis of curcumin-related compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3821197A1 (de) * 1988-06-23 1989-12-28 Basf Ag Verfahren zur herstellung von (alpha),(beta)-ungesaettigten ketonen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194841A (en) * 1959-08-31 1965-07-13 Lever Brothers Ltd Process for preparing hepta-1:6-diene-3:5-diones
US5679864A (en) * 1995-11-03 1997-10-21 Gene Print Inc. Process for the synthesis of curcumin-related compounds

Also Published As

Publication number Publication date
ATE538080T1 (de) 2012-01-15
US7964755B2 (en) 2011-06-21
JP2009531353A (ja) 2009-09-03
EP1999097B1 (en) 2011-12-21
KR20080112340A (ko) 2008-12-24
WO2007110168A1 (en) 2007-10-04
JP5341747B2 (ja) 2013-11-13
CN101454267A (zh) 2009-06-10
EP1999097A1 (en) 2008-12-10
US20100312015A1 (en) 2010-12-09

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120926

Termination date: 20140319