JP5341747B2 - クルクミンの合成 - Google Patents

クルクミンの合成 Download PDF

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Publication number
JP5341747B2
JP5341747B2 JP2009501908A JP2009501908A JP5341747B2 JP 5341747 B2 JP5341747 B2 JP 5341747B2 JP 2009501908 A JP2009501908 A JP 2009501908A JP 2009501908 A JP2009501908 A JP 2009501908A JP 5341747 B2 JP5341747 B2 JP 5341747B2
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JP
Japan
Prior art keywords
curcumin
vanillin
water
acetylacetone
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009501908A
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English (en)
Japanese (ja)
Other versions
JP2009531353A5 (enExample
JP2009531353A (ja
Inventor
クリストフ ヴェールリ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
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Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of JP2009531353A publication Critical patent/JP2009531353A/ja
Publication of JP2009531353A5 publication Critical patent/JP2009531353A5/ja
Application granted granted Critical
Publication of JP5341747B2 publication Critical patent/JP5341747B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2009501908A 2006-03-29 2007-03-19 クルクミンの合成 Expired - Fee Related JP5341747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06006519.0 2006-03-29
EP06006519 2006-03-29
PCT/EP2007/002403 WO2007110168A1 (en) 2006-03-29 2007-03-19 Curcumin synthesis

Publications (3)

Publication Number Publication Date
JP2009531353A JP2009531353A (ja) 2009-09-03
JP2009531353A5 JP2009531353A5 (enExample) 2013-01-10
JP5341747B2 true JP5341747B2 (ja) 2013-11-13

Family

ID=38093544

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009501908A Expired - Fee Related JP5341747B2 (ja) 2006-03-29 2007-03-19 クルクミンの合成

Country Status (7)

Country Link
US (1) US7964755B2 (enExample)
EP (1) EP1999097B1 (enExample)
JP (1) JP5341747B2 (enExample)
KR (1) KR20080112340A (enExample)
CN (1) CN101454267B (enExample)
AT (1) ATE538080T1 (enExample)
WO (1) WO2007110168A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101952422A (zh) 2007-12-27 2011-01-19 巴克斯特国际公司 化学修饰的因子ix
US8680143B2 (en) 2008-07-07 2014-03-25 Laila Pharmaceuticals Pvt. Ltd. Orally active curcuminoid compounds
EP2857379B1 (en) * 2012-05-08 2020-09-02 Asac Compañía De Biotecnología E Investigación SA Method for the synthesis of curcumin
CN102701934A (zh) * 2012-05-30 2012-10-03 江南大学 一种以氧化锌负载氧化镁为催化剂催化合成姜黄素的方法
CN102701933A (zh) * 2012-05-30 2012-10-03 江南大学 一种采用氧化铝负载氟化钾固体碱催化合成姜黄素的方法
CN102911022B (zh) * 2012-10-25 2015-12-09 山东鲁诺动物药业有限公司 一种天然姜黄素类物的人工合成方法
CN103910615A (zh) * 2014-04-09 2014-07-09 西安雅森生物技术有限公司 一种合成姜黄素的方法
CN108101761B (zh) * 2017-12-08 2021-08-03 陕西嘉禾生物科技股份有限公司 一种姜黄素的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL255427A (enExample) * 1959-08-31
DE3821197A1 (de) * 1988-06-23 1989-12-28 Basf Ag Verfahren zur herstellung von (alpha),(beta)-ungesaettigten ketonen
US5679864A (en) 1995-11-03 1997-10-21 Gene Print Inc. Process for the synthesis of curcumin-related compounds

Also Published As

Publication number Publication date
CN101454267B (zh) 2012-09-26
WO2007110168A1 (en) 2007-10-04
KR20080112340A (ko) 2008-12-24
ATE538080T1 (de) 2012-01-15
CN101454267A (zh) 2009-06-10
EP1999097A1 (en) 2008-12-10
EP1999097B1 (en) 2011-12-21
US7964755B2 (en) 2011-06-21
US20100312015A1 (en) 2010-12-09
JP2009531353A (ja) 2009-09-03

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