CN101434635A - 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法 - Google Patents
一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法 Download PDFInfo
- Publication number
- CN101434635A CN101434635A CNA2007101705372A CN200710170537A CN101434635A CN 101434635 A CN101434635 A CN 101434635A CN A2007101705372 A CNA2007101705372 A CN A2007101705372A CN 200710170537 A CN200710170537 A CN 200710170537A CN 101434635 A CN101434635 A CN 101434635A
- Authority
- CN
- China
- Prior art keywords
- water
- preparation
- triterpenoid
- compound
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Description
化合物A | PH=2 | 蒸馏水 | PH=10 |
峰面积 | 1247385 | 1206926 | 1232216 |
百分比* | 103.4% | 100% | 102.1% |
Claims (10)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101705372A CN101434635B (zh) | 2007-11-16 | 2007-11-16 | 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法 |
EP08855158A EP2213679B1 (en) | 2007-11-16 | 2008-11-05 | Water-soluble triterpenephenol compounds having antitumor activity and the preparation thereof |
JP2010533416A JP5425799B2 (ja) | 2007-11-16 | 2008-11-05 | 抗腫瘍活性を有する水溶性トリテルペンフェノール化合物及びその調製方法 |
PCT/CN2008/072959 WO2009067891A1 (fr) | 2007-11-16 | 2008-11-05 | Composés de triterpènephénol solubles dans l'eau ayant une activité anti-tumorale et leur préparation |
US12/743,101 US8299125B2 (en) | 2007-11-16 | 2008-11-05 | Water-soluble triterpenephenol compounds having antitumor activity and the preparation thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101705372A CN101434635B (zh) | 2007-11-16 | 2007-11-16 | 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101434635A true CN101434635A (zh) | 2009-05-20 |
CN101434635B CN101434635B (zh) | 2012-05-16 |
Family
ID=40678021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007101705372A Active CN101434635B (zh) | 2007-11-16 | 2007-11-16 | 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8299125B2 (zh) |
EP (1) | EP2213679B1 (zh) |
JP (1) | JP5425799B2 (zh) |
CN (1) | CN101434635B (zh) |
WO (1) | WO2009067891A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103642887A (zh) * | 2013-11-21 | 2014-03-19 | 华侨大学 | 一种雷公藤红素衍生物的制备方法及其产品和应用 |
CN104829679A (zh) * | 2014-02-10 | 2015-08-12 | 上海华拓医药科技发展有限公司 | 一类水溶性南蛇藤素衍生物及其用途 |
CN105985401A (zh) * | 2015-02-16 | 2016-10-05 | 上海华拓医药科技发展有限公司 | 一种雷公藤红素衍生物、其制备方法及用途 |
CN107073016A (zh) * | 2014-03-26 | 2017-08-18 | 儿童医学中心公司 | 用于治疗肥胖症的雷公藤红素和衍生物 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102532239A (zh) * | 2010-12-24 | 2012-07-04 | 苏州宝泽堂医药科技有限公司 | 一种从雷公藤中提取去甲泽拉木醛的方法 |
US11123364B2 (en) | 2011-06-21 | 2021-09-21 | Bvw Holding Ag | Medical device comprising boswellic acid |
LT2900230T (lt) | 2012-09-27 | 2019-01-10 | The Children`S Medical Center Corporation | Junginiai, skirti nutukimo gydymui ir jų panaudojimo būdai |
US10808005B2 (en) | 2016-07-04 | 2020-10-20 | Ixmedicine (Xiamen) Biological Technology Company Limited | Ligand for orphan nuclear receptor Nur77 and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2277568B1 (es) * | 2005-12-30 | 2008-04-01 | Consejo Superior De Investigaciones Cientificas | Derivados de triterpenoquinona y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias. |
US20110263693A1 (en) * | 2006-03-31 | 2011-10-27 | Dana-Farber Cancer Institute, Inc. | Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors |
-
2007
- 2007-11-16 CN CN2007101705372A patent/CN101434635B/zh active Active
-
2008
- 2008-11-05 JP JP2010533416A patent/JP5425799B2/ja not_active Expired - Fee Related
- 2008-11-05 EP EP08855158A patent/EP2213679B1/en not_active Not-in-force
- 2008-11-05 WO PCT/CN2008/072959 patent/WO2009067891A1/zh active Application Filing
- 2008-11-05 US US12/743,101 patent/US8299125B2/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103642887A (zh) * | 2013-11-21 | 2014-03-19 | 华侨大学 | 一种雷公藤红素衍生物的制备方法及其产品和应用 |
CN104829679A (zh) * | 2014-02-10 | 2015-08-12 | 上海华拓医药科技发展有限公司 | 一类水溶性南蛇藤素衍生物及其用途 |
CN104829679B (zh) * | 2014-02-10 | 2017-12-22 | 上海华拓医药科技发展有限公司 | 一类水溶性南蛇藤素衍生物及其用途 |
CN107073016A (zh) * | 2014-03-26 | 2017-08-18 | 儿童医学中心公司 | 用于治疗肥胖症的雷公藤红素和衍生物 |
CN105985401A (zh) * | 2015-02-16 | 2016-10-05 | 上海华拓医药科技发展有限公司 | 一种雷公藤红素衍生物、其制备方法及用途 |
CN105985401B (zh) * | 2015-02-16 | 2020-10-09 | 上海华拓医药科技发展有限公司 | 一种雷公藤红素衍生物、其制备方法及用途 |
Also Published As
Publication number | Publication date |
---|---|
JP5425799B2 (ja) | 2014-02-26 |
CN101434635B (zh) | 2012-05-16 |
WO2009067891A1 (fr) | 2009-06-04 |
US8299125B2 (en) | 2012-10-30 |
EP2213679A4 (en) | 2010-12-15 |
JP2011503123A (ja) | 2011-01-27 |
EP2213679B1 (en) | 2012-06-06 |
US20100267983A1 (en) | 2010-10-21 |
EP2213679A1 (en) | 2010-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: SHANGHAI HUATUO MEDICINE SCI-TECH DEVELOPMENT CO., Free format text: FORMER NAME: SHANGHAI HUATUO MEDICAL SCIENCE CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 200333 No. 90, Shulan Road, Shanghai, Yangpu District Patentee after: Shanghai Huatuo Medicine Sci-Tech Development Co., Ltd. Address before: 200333 No. 90, Shulan Road, Shanghai, Yangpu District Patentee before: Shanghai Huatuo Medical Science Co., Ltd. |
|
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090520 Assignee: HARBIN LAIBOTEN PHARMACEUTICAL CO., LTD. Assignor: Shanghai Huatuo Medical Science Co., Ltd. Contract record no.: 2014310000157 Denomination of invention: Water-soluble phenolic triterpenoid with antineoplastic activity and preparation thereof Granted publication date: 20120516 License type: Exclusive License Record date: 20140929 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model |