CN101415498B - 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列 - Google Patents

从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列 Download PDF

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Publication number
CN101415498B
CN101415498B CN2007800122011A CN200780012201A CN101415498B CN 101415498 B CN101415498 B CN 101415498B CN 2007800122011 A CN2007800122011 A CN 2007800122011A CN 200780012201 A CN200780012201 A CN 200780012201A CN 101415498 B CN101415498 B CN 101415498B
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China
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container
magnet
containers
array
liquid
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Expired - Fee Related
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CN2007800122011A
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English (en)
Chinese (zh)
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CN101415498A (zh
Inventor
T·霍伦斯坦
R·施尼贝利
R·贝尔茨
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/10—Magnetic separation acting directly on the substance being separated with cylindrical material carriers
    • B03C1/12—Magnetic separation acting directly on the substance being separated with cylindrical material carriers with magnets moving during operation; with movable pole pieces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
CN2007800122011A 2006-03-31 2007-03-21 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列 Expired - Fee Related CN101415498B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06075785.3 2006-03-31
EP06075785A EP1839756A1 (en) 2006-03-31 2006-03-31 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
PCT/EP2007/002491 WO2007112862A2 (en) 2006-03-31 2007-03-21 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

Publications (2)

Publication Number Publication Date
CN101415498A CN101415498A (zh) 2009-04-22
CN101415498B true CN101415498B (zh) 2012-11-07

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CN2007800122011A Expired - Fee Related CN101415498B (zh) 2006-03-31 2007-03-21 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列

Country Status (6)

Country Link
US (2) US8470267B2 (enExample)
EP (2) EP1839756A1 (enExample)
JP (1) JP4861468B2 (enExample)
CN (1) CN101415498B (enExample)
CA (1) CA2646670C (enExample)
WO (1) WO2007112862A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
EP2407243B1 (en) 2003-07-31 2020-04-22 Handylab, Inc. Multilayered microfluidic device
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US9040288B2 (en) 2006-03-24 2015-05-26 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using the same
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
EP2091647A2 (en) 2006-11-14 2009-08-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US9011771B2 (en) * 2009-05-15 2015-04-21 Gen-Probe Incorporated Method and apparatus for effecting automated movement of a magnet in an instrument for performing a magnetic separation procedure
JP5623888B2 (ja) 2009-12-10 2014-11-12 エフ．ホフマン−ラ ロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 分析対象物を分離して検出する方法
SE535983C2 (sv) * 2010-04-20 2013-03-19 Noviscens Ab Spruta
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
AU2012315595B2 (en) 2011-09-30 2015-10-22 Becton, Dickinson And Company Unitized reagent strip
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
EP2607904B1 (en) * 2011-12-21 2020-01-15 Roche Diagnostics GmbH Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system
JP2013134069A (ja) * 2011-12-26 2013-07-08 Hitachi High-Technologies Corp 自動分析装置
JP6262152B2 (ja) 2012-02-03 2018-01-17 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 分子診断試験の分布及び試験間のコンパチビリティ判断のための外部ファイル
WO2014007937A1 (en) * 2012-06-08 2014-01-09 Massachusetts Institute Of Technology Magnet configurations for improved separations of materials
US11865544B2 (en) 2013-03-15 2024-01-09 Becton, Dickinson And Company Process tube and carrier tray
ES2744596T3 (es) 2013-03-15 2020-02-25 Becton Dickinson Co Tubo de procesamiento y bandeja portadora
US10220392B2 (en) 2013-03-15 2019-03-05 Becton, Dickinson And Company Process tube and carrier tray
CN103881897B (zh) * 2013-11-01 2017-05-10 艾康生物技术(杭州)有限公司 一种核酸提取仪
US9656267B2 (en) * 2015-09-17 2017-05-23 Nvigen, Inc. Magnetic rack
JP6771903B2 (ja) * 2016-02-29 2020-10-21 シスメックス株式会社 検体前処理装置、検体前処理カートリッジおよび検体前処理方法
EP3213819B1 (en) * 2016-03-02 2021-09-29 F. Hoffmann-La Roche AG Device and method for separation
WO2018005391A1 (en) * 2016-06-30 2018-01-04 General Automation Lab Technologies, Inc. High resolution systems, kits, apparatus, and methods using magnetic beads for high throughput microbiology applications
US9753044B1 (en) 2016-07-13 2017-09-05 William J. Palin Apparatus and method for detecting paramagnetic and superparamagnetic biomarkers
JP6995090B2 (ja) * 2019-07-11 2022-01-14 日本電子株式会社 自動分析装置および自動分析装置の制御方法
EP3834939A1 (en) * 2019-12-12 2021-06-16 TTP plc Sample preparation system
US11327087B2 (en) * 2020-04-13 2022-05-10 Brevitest Technologies, Llc Automated driving of an assay with spaced magnets
WO2023081263A1 (en) * 2021-11-03 2023-05-11 Fluent Biosciences Inc. Devices for improving sample preparation and processing
WO2025196474A1 (en) * 2024-03-17 2025-09-25 Askari Mehdi Magnetic filter system in the electromechanical equipment of the refineries

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1295669A (zh) * 1998-02-06 2001-05-16 生物磁性有限公司 转移材料的装置和系统
DE10063984A1 (de) * 2000-12-19 2002-06-20 Bilatec Ges Zur Entwicklung Bi Vorrichtungen zur magnetischen Abtrennung von Magnetpartikeln
US6579453B1 (en) * 1997-09-29 2003-06-17 Roche Diagnostics Corporation Apparatus for separating magnetic particles
EP1441225A1 (en) * 2003-01-27 2004-07-28 Iqbal W. Dr. Siddiqi Apparatus and method for processing magnetic particles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10219541C1 (de) 2002-05-02 2003-12-11 Koenig & Bauer Ag Vorrichtung zum Erfassen eines Bahnbruckes an einer eine Bahn verarbeitenden Maschine
JPS6484151A (en) * 1987-09-26 1989-03-29 Olympus Optical Co Dilution plate for liquid analyzing device
DE9006918U1 (de) * 1990-06-20 1990-08-23 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft, 5223 Nümbrecht Pipettenspitzenbehälter
DE4301084A1 (de) 1993-01-16 1994-07-21 Claas Saulgau Gmbh Kreiselheumaschine
EP0644425B1 (de) * 1993-09-17 2002-01-30 F. Hoffmann-La Roche Ag Analysengerät mit einer Vorrichtung zum Abtrennen magnetischer Mikropartikel
DE4423878A1 (de) 1994-07-07 1996-01-11 Boehringer Mannheim Gmbh Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
DE69600924T2 (de) * 1995-02-21 1999-06-10 Iqbal W. Dr. Brea Calif. Siddiqi Apparat und verfahren zum mischen und trennen durch verwendung von magnetischen teilchen
CA2226776C (en) * 1995-07-31 2007-11-27 Hideji Tajima Multi-vessel container for testing fluids
JP3914552B2 (ja) * 1995-07-31 2007-05-16 プレシジョン・システム・サイエンス株式会社 容器
US6065617A (en) * 1998-06-15 2000-05-23 Bayer Corporation Sample tube rack
DE19963032A1 (de) * 1999-12-24 2001-06-28 Roche Diagnostics Gmbh System zur Bearbeitung von Proben in einer Mehrkammeranordnung
DE10156790A1 (de) * 2001-11-19 2003-06-18 Chemagen Biopolymer Technologi Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln
ATE337097T1 (de) * 2002-05-17 2006-09-15 Gen Probe Inc Probenträger mit feststelleinrichtung und zugehörige tropfschirmvorrichtung
ES2362355T3 (es) * 2003-02-24 2011-07-04 Becton Dickinson France Conjunto de elementos para la agrupación de cuerpos de jeringa.
US7000785B2 (en) * 2003-04-03 2006-02-21 Bio-Rad Laboratories, Inc. Tube rack accommodating a range of tube diameters
US8211386B2 (en) * 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6579453B1 (en) * 1997-09-29 2003-06-17 Roche Diagnostics Corporation Apparatus for separating magnetic particles
CN1295669A (zh) * 1998-02-06 2001-05-16 生物磁性有限公司 转移材料的装置和系统
DE10063984A1 (de) * 2000-12-19 2002-06-20 Bilatec Ges Zur Entwicklung Bi Vorrichtungen zur magnetischen Abtrennung von Magnetpartikeln
EP1441225A1 (en) * 2003-01-27 2004-07-28 Iqbal W. Dr. Siddiqi Apparatus and method for processing magnetic particles

Also Published As

Publication number Publication date
US20130256205A1 (en) 2013-10-03
CN101415498A (zh) 2009-04-22
US9381519B2 (en) 2016-07-05
WO2007112862A3 (en) 2007-12-27
CA2646670A1 (en) 2007-10-11
US20100284864A1 (en) 2010-11-11
US8470267B2 (en) 2013-06-25
EP2001597A2 (en) 2008-12-17
JP4861468B2 (ja) 2012-01-25
EP1839756A1 (en) 2007-10-03
WO2007112862A2 (en) 2007-10-11
CA2646670C (en) 2011-09-20
JP2009531676A (ja) 2009-09-03

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