CA2646670C - Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus - Google Patents
Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus Download PDFInfo
- Publication number
- CA2646670C CA2646670C CA2646670A CA2646670A CA2646670C CA 2646670 C CA2646670 C CA 2646670C CA 2646670 A CA2646670 A CA 2646670A CA 2646670 A CA2646670 A CA 2646670A CA 2646670 C CA2646670 C CA 2646670C
- Authority
- CA
- Canada
- Prior art keywords
- vessel
- vessels
- array
- magnet
- side wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 46
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 26
- 239000002245 particle Substances 0.000 title claims abstract description 13
- 239000002699 waste material Substances 0.000 claims description 51
- 239000000463 material Substances 0.000 claims description 13
- 238000001746 injection moulding Methods 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 description 12
- 239000004793 Polystyrene Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
- B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/10—Magnetic separation acting directly on the substance being separated with cylindrical material carriers
- B03C1/12—Magnetic separation acting directly on the substance being separated with cylindrical material carriers with magnets moving during operation; with movable pole pieces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06075785A EP1839756A1 (en) | 2006-03-31 | 2006-03-31 | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
| EP06075785.3 | 2006-03-31 | ||
| PCT/EP2007/002491 WO2007112862A2 (en) | 2006-03-31 | 2007-03-21 | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2646670A1 CA2646670A1 (en) | 2007-10-11 |
| CA2646670C true CA2646670C (en) | 2011-09-20 |
Family
ID=36910803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2646670A Expired - Fee Related CA2646670C (en) | 2006-03-31 | 2007-03-21 | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8470267B2 (enExample) |
| EP (2) | EP1839756A1 (enExample) |
| JP (1) | JP4861468B2 (enExample) |
| CN (1) | CN101415498B (enExample) |
| CA (1) | CA2646670C (enExample) |
| WO (1) | WO2007112862A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| EP3718635A1 (en) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Processing particle-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| EP1839756A1 (en) | 2006-03-31 | 2007-10-03 | F.Hoffmann-La Roche Ag | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
| US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| EP3222733B1 (en) | 2007-07-13 | 2021-04-07 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US9011771B2 (en) | 2009-05-15 | 2015-04-21 | Gen-Probe Incorporated | Method and apparatus for effecting automated movement of a magnet in an instrument for performing a magnetic separation procedure |
| JP5623888B2 (ja) | 2009-12-10 | 2014-11-12 | エフ.ホフマン−ラ ロシュアーゲーF.Hoffmann−La Roche Aktiengesellschaft | 分析対象物を分離して検出する方法 |
| SE535983C2 (sv) * | 2010-04-20 | 2013-03-19 | Noviscens Ab | Spruta |
| ES2617599T3 (es) | 2011-04-15 | 2017-06-19 | Becton, Dickinson And Company | Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración |
| BR112014007440B1 (pt) | 2011-09-30 | 2020-11-03 | Becton, Dickinson And Company | lâmina de reagentes unificada e métodos para detectar a presença ou ausência de ponta de pipeta dentro de bainha de pipeta e para determinar o comprimento de ponta de pipeta dentro de bainha de pipeta na mesma |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| EP2607904B1 (en) | 2011-12-21 | 2020-01-15 | Roche Diagnostics GmbH | Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system |
| JP2013134069A (ja) * | 2011-12-26 | 2013-07-08 | Hitachi High-Technologies Corp | 自動分析装置 |
| DK2810080T3 (da) | 2012-02-03 | 2024-06-17 | Becton Dickinson Co | Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests |
| WO2014007937A1 (en) * | 2012-06-08 | 2014-01-09 | Massachusetts Institute Of Technology | Magnet configurations for improved separations of materials |
| BR112015022459B1 (pt) | 2013-03-15 | 2021-10-19 | Becton, Dickinson And Company | Sistema de tubo de processamento e de bandeja transportadora |
| US10220392B2 (en) | 2013-03-15 | 2019-03-05 | Becton, Dickinson And Company | Process tube and carrier tray |
| US11865544B2 (en) | 2013-03-15 | 2024-01-09 | Becton, Dickinson And Company | Process tube and carrier tray |
| CN103881894B (zh) * | 2013-11-01 | 2017-05-10 | 艾康生物技术(杭州)有限公司 | 核酸提取仪 |
| US9656267B2 (en) * | 2015-09-17 | 2017-05-23 | Nvigen, Inc. | Magnetic rack |
| JP6771903B2 (ja) * | 2016-02-29 | 2020-10-21 | シスメックス株式会社 | 検体前処理装置、検体前処理カートリッジおよび検体前処理方法 |
| EP3213819B1 (en) | 2016-03-02 | 2021-09-29 | F. Hoffmann-La Roche AG | Device and method for separation |
| EP3478416A4 (en) * | 2016-06-30 | 2019-12-18 | General Automation Lab Technologies, Inc. | HIGH-RESOLUTION SYSTEMS, KITS, DEVICE AND METHOD USING MAGNETIC BALLS FOR MICROBIOLOGICAL APPLICATIONS WITH HIGH THROUGHPUT |
| US9753044B1 (en) | 2016-07-13 | 2017-09-05 | William J. Palin | Apparatus and method for detecting paramagnetic and superparamagnetic biomarkers |
| JP6995090B2 (ja) * | 2019-07-11 | 2022-01-14 | 日本電子株式会社 | 自動分析装置および自動分析装置の制御方法 |
| EP3834939A1 (en) * | 2019-12-12 | 2021-06-16 | TTP plc | Sample preparation system |
| US11327087B2 (en) * | 2020-04-13 | 2022-05-10 | Brevitest Technologies, Llc | Automated driving of an assay with spaced magnets |
| US20230136755A1 (en) * | 2021-11-03 | 2023-05-04 | Fluent Biosciences Inc. | Devices for improving sample preparation and processing |
| WO2025196474A1 (en) * | 2024-03-17 | 2025-09-25 | Askari Mehdi | Magnetic filter system in the electromechanical equipment of the refineries |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10219541C1 (de) | 2002-05-02 | 2003-12-11 | Koenig & Bauer Ag | Vorrichtung zum Erfassen eines Bahnbruckes an einer eine Bahn verarbeitenden Maschine |
| JPS6484151A (en) * | 1987-09-26 | 1989-03-29 | Olympus Optical Co | Dilution plate for liquid analyzing device |
| DE9006918U1 (de) * | 1990-06-20 | 1990-08-23 | Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft, 5223 Nümbrecht | Pipettenspitzenbehälter |
| DE4301084A1 (de) | 1993-01-16 | 1994-07-21 | Claas Saulgau Gmbh | Kreiselheumaschine |
| ATE212723T1 (de) * | 1993-09-17 | 2002-02-15 | Hoffmann La Roche | Analysengerät mit einer vorrichtung zum abtrennen magnetischer mikropartikel |
| DE4423878A1 (de) | 1994-07-07 | 1996-01-11 | Boehringer Mannheim Gmbh | Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln |
| JP3962789B2 (ja) * | 1995-02-21 | 2007-08-22 | ダブリュー. シディキー,イクバール | 磁性粒子を利用した混合/分離装置及びその方法 |
| US20030127396A1 (en) * | 1995-02-21 | 2003-07-10 | Siddiqi Iqbal Waheed | Apparatus and method for processing magnetic particles |
| EP2275821A1 (en) * | 1995-07-31 | 2011-01-19 | Precision System Science Co., Ltd | Container |
| JP3914552B2 (ja) * | 1995-07-31 | 2007-05-16 | プレシジョン・システム・サイエンス株式会社 | 容器 |
| DE69839294T2 (de) * | 1997-09-29 | 2009-04-09 | F. Hoffmann-La Roche Ag | Gerät zur Abscheidung magnetischer Teilchen |
| IL123210A0 (en) * | 1998-02-06 | 1998-09-24 | Gombinsky Moshe | A device and system for the collection of magnetic particles |
| US6065617A (en) * | 1998-06-15 | 2000-05-23 | Bayer Corporation | Sample tube rack |
| DE19963032A1 (de) * | 1999-12-24 | 2001-06-28 | Roche Diagnostics Gmbh | System zur Bearbeitung von Proben in einer Mehrkammeranordnung |
| DE10063984A1 (de) * | 2000-12-19 | 2002-06-20 | Bilatec Ges Zur Entwicklung Bi | Vorrichtungen zur magnetischen Abtrennung von Magnetpartikeln |
| DE10156790A1 (de) * | 2001-11-19 | 2003-06-18 | Chemagen Biopolymer Technologi | Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln |
| WO2003097240A2 (en) * | 2002-05-17 | 2003-11-27 | Gen-Probe Incorporated | Sample carrier having sample tube blocking means and drip shield for use therewith |
| EP1449551B1 (fr) * | 2003-02-24 | 2011-04-06 | Becton Dickinson France | Ensemble d'éléments pour le groupage de corps de seringue |
| US7000785B2 (en) * | 2003-04-03 | 2006-02-21 | Bio-Rad Laboratories, Inc. | Tube rack accommodating a range of tube diameters |
| US8211386B2 (en) * | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
| EP1839756A1 (en) | 2006-03-31 | 2007-10-03 | F.Hoffmann-La Roche Ag | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
-
2006
- 2006-03-31 EP EP06075785A patent/EP1839756A1/en not_active Withdrawn
-
2007
- 2007-03-21 WO PCT/EP2007/002491 patent/WO2007112862A2/en not_active Ceased
- 2007-03-21 CA CA2646670A patent/CA2646670C/en not_active Expired - Fee Related
- 2007-03-21 US US12/294,509 patent/US8470267B2/en not_active Expired - Fee Related
- 2007-03-21 EP EP07711987A patent/EP2001597A2/en not_active Withdrawn
- 2007-03-21 CN CN2007800122011A patent/CN101415498B/zh not_active Expired - Fee Related
- 2007-03-21 JP JP2009501913A patent/JP4861468B2/ja not_active Expired - Fee Related
-
2013
- 2013-05-22 US US13/900,389 patent/US9381519B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9381519B2 (en) | 2016-07-05 |
| US20130256205A1 (en) | 2013-10-03 |
| US20100284864A1 (en) | 2010-11-11 |
| JP2009531676A (ja) | 2009-09-03 |
| CA2646670A1 (en) | 2007-10-11 |
| EP2001597A2 (en) | 2008-12-17 |
| EP1839756A1 (en) | 2007-10-03 |
| WO2007112862A3 (en) | 2007-12-27 |
| WO2007112862A2 (en) | 2007-10-11 |
| US8470267B2 (en) | 2013-06-25 |
| JP4861468B2 (ja) | 2012-01-25 |
| CN101415498A (zh) | 2009-04-22 |
| CN101415498B (zh) | 2012-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150323 |