JP4861468B2 - 磁性粒子を含む液体から該粒子を分離するための装置、およびかかる装置での使用に適した容器のアレイ - Google Patents

磁性粒子を含む液体から該粒子を分離するための装置、およびかかる装置での使用に適した容器のアレイ Download PDF

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Publication number
JP4861468B2
JP4861468B2 JP2009501913A JP2009501913A JP4861468B2 JP 4861468 B2 JP4861468 B2 JP 4861468B2 JP 2009501913 A JP2009501913 A JP 2009501913A JP 2009501913 A JP2009501913 A JP 2009501913A JP 4861468 B2 JP4861468 B2 JP 4861468B2
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JP
Japan
Prior art keywords
container
array
magnet
containers
pipette tip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009501913A
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English (en)
Japanese (ja)
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JP2009531676A5 (enExample
JP2009531676A (ja
Inventor
ホーレンシュタイン,トービアス
シュネベリ,ロルフ
ベルツ,レーナト
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2009531676A publication Critical patent/JP2009531676A/ja
Publication of JP2009531676A5 publication Critical patent/JP2009531676A5/ja
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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/54Supports specially adapted for pipettes and burettes
    • B01L9/543Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/10Magnetic separation acting directly on the substance being separated with cylindrical material carriers
    • B03C1/12Magnetic separation acting directly on the substance being separated with cylindrical material carriers with magnets moving during operation; with movable pole pieces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
JP2009501913A 2006-03-31 2007-03-21 磁性粒子を含む液体から該粒子を分離するための装置、およびかかる装置での使用に適した容器のアレイ Expired - Fee Related JP4861468B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06075785A EP1839756A1 (en) 2006-03-31 2006-03-31 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
EP06075785.3 2006-03-31
PCT/EP2007/002491 WO2007112862A2 (en) 2006-03-31 2007-03-21 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

Publications (3)

Publication Number Publication Date
JP2009531676A JP2009531676A (ja) 2009-09-03
JP2009531676A5 JP2009531676A5 (enExample) 2010-03-25
JP4861468B2 true JP4861468B2 (ja) 2012-01-25

Family

ID=36910803

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009501913A Expired - Fee Related JP4861468B2 (ja) 2006-03-31 2007-03-21 磁性粒子を含む液体から該粒子を分離するための装置、およびかかる装置での使用に適した容器のアレイ

Country Status (6)

Country Link
US (2) US8470267B2 (enExample)
EP (2) EP1839756A1 (enExample)
JP (1) JP4861468B2 (enExample)
CN (1) CN101415498B (enExample)
CA (1) CA2646670C (enExample)
WO (1) WO2007112862A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2007112114A2 (en) 2006-03-24 2007-10-04 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
EP3222733B1 (en) 2007-07-13 2021-04-07 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
CN113145296B (zh) 2009-05-15 2024-03-29 简·探针公司 用于在执行磁性分离工序的仪器中实现磁体的自动移动的方法和设备
JP5623888B2 (ja) 2009-12-10 2014-11-12 エフ.ホフマン−ラ ロシュアーゲーF.Hoffmann−La Roche Aktiengesellschaft 分析対象物を分離して検出する方法
SE535983C2 (sv) * 2010-04-20 2013-03-19 Noviscens Ab Spruta
EP3709025A1 (en) 2011-04-15 2020-09-16 Becton, Dickinson and Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
CN103959070B (zh) 2011-09-30 2017-05-10 贝克顿·迪金森公司 组合试剂条
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
EP2607904B1 (en) * 2011-12-21 2020-01-15 Roche Diagnostics GmbH Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system
JP2013134069A (ja) * 2011-12-26 2013-07-08 Hitachi High-Technologies Corp 自動分析装置
US10822644B2 (en) 2012-02-03 2020-11-03 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US20130327695A1 (en) * 2012-06-08 2013-12-12 Massachusetts Institute Of Technology Magnet Configurations For Improved Separations Of Magnetic And Non-Magnetic Materials
ES2744596T3 (es) 2013-03-15 2020-02-25 Becton Dickinson Co Tubo de procesamiento y bandeja portadora
US10220392B2 (en) 2013-03-15 2019-03-05 Becton, Dickinson And Company Process tube and carrier tray
US11865544B2 (en) 2013-03-15 2024-01-09 Becton, Dickinson And Company Process tube and carrier tray
CN203700334U (zh) * 2013-11-01 2014-07-09 艾康生物技术(杭州)有限公司 核酸提取仪
US9656267B2 (en) * 2015-09-17 2017-05-23 Nvigen, Inc. Magnetic rack
JP6771903B2 (ja) * 2016-02-29 2020-10-21 シスメックス株式会社 検体前処理装置、検体前処理カートリッジおよび検体前処理方法
EP3213819B1 (en) * 2016-03-02 2021-09-29 F. Hoffmann-La Roche AG Device and method for separation
JP2019520825A (ja) * 2016-06-30 2019-07-25 ジェネラル オートメーション ラボ テクノロジーズ インコーポレイテッド 磁性粒子を用いたハイスループット微生物学適用高分解能システム、キット、装置および方法
US9753044B1 (en) 2016-07-13 2017-09-05 William J. Palin Apparatus and method for detecting paramagnetic and superparamagnetic biomarkers
JP6995090B2 (ja) * 2019-07-11 2022-01-14 日本電子株式会社 自動分析装置および自動分析装置の制御方法
EP3834939A1 (en) * 2019-12-12 2021-06-16 TTP plc Sample preparation system
US11327087B2 (en) * 2020-04-13 2022-05-10 Brevitest Technologies, Llc Automated driving of an assay with spaced magnets
CA3237338A1 (en) * 2021-11-03 2023-05-11 Fluent Biosciences Inc. Devices for improving sample preparation and processing
WO2025196474A1 (en) * 2024-03-17 2025-09-25 Askari Mehdi Magnetic filter system in the electromechanical equipment of the refineries

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6484151A (en) * 1987-09-26 1989-03-29 Olympus Optical Co Dilution plate for liquid analyzing device
WO1997005492A1 (en) * 1995-07-31 1997-02-13 Precision System Science Co., Ltd Vessel
JPH11156231A (ja) * 1997-09-29 1999-06-15 F Hoffmann La Roche Ag 液体中の懸濁磁性粒子の分離装置
JP2001221806A (ja) * 1999-12-24 2001-08-17 Roche Diagnostics Gmbh マルチチャンバ構造においてサンプルを処理するためのシステム
JP2004361422A (ja) * 1995-07-31 2004-12-24 Precision System Science Co Ltd 容器

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10219541C1 (de) 2002-05-02 2003-12-11 Koenig & Bauer Ag Vorrichtung zum Erfassen eines Bahnbruckes an einer eine Bahn verarbeitenden Maschine
DE9006918U1 (de) * 1990-06-20 1990-08-23 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft, 5223 Nümbrecht Pipettenspitzenbehälter
DE4301084A1 (de) 1993-01-16 1994-07-21 Claas Saulgau Gmbh Kreiselheumaschine
ATE212723T1 (de) * 1993-09-17 2002-02-15 Hoffmann La Roche Analysengerät mit einer vorrichtung zum abtrennen magnetischer mikropartikel
DE4423878A1 (de) 1994-07-07 1996-01-11 Boehringer Mannheim Gmbh Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
ATE172890T1 (de) * 1995-02-21 1998-11-15 Iqbal W Dr Siddiqi Apparat und verfahren zum mischen und trennen durch verwendung von magnetischen teilchen
US20030127396A1 (en) * 1995-02-21 2003-07-10 Siddiqi Iqbal Waheed Apparatus and method for processing magnetic particles
IL123210A0 (en) * 1998-02-06 1998-09-24 Gombinsky Moshe A device and system for the collection of magnetic particles
US6065617A (en) * 1998-06-15 2000-05-23 Bayer Corporation Sample tube rack
DE10063984A1 (de) * 2000-12-19 2002-06-20 Bilatec Ges Zur Entwicklung Bi Vorrichtungen zur magnetischen Abtrennung von Magnetpartikeln
DE10156790A1 (de) * 2001-11-19 2003-06-18 Chemagen Biopolymer Technologi Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln
WO2003097240A2 (en) * 2002-05-17 2003-11-27 Gen-Probe Incorporated Sample carrier having sample tube blocking means and drip shield for use therewith
ATE504324T1 (de) * 2003-02-24 2011-04-15 Becton Dickinson France Vorrichtung zur gruppierung von spritzen
US7000785B2 (en) * 2003-04-03 2006-02-21 Bio-Rad Laboratories, Inc. Tube rack accommodating a range of tube diameters
US8211386B2 (en) * 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6484151A (en) * 1987-09-26 1989-03-29 Olympus Optical Co Dilution plate for liquid analyzing device
WO1997005492A1 (en) * 1995-07-31 1997-02-13 Precision System Science Co., Ltd Vessel
JP2004361422A (ja) * 1995-07-31 2004-12-24 Precision System Science Co Ltd 容器
JPH11156231A (ja) * 1997-09-29 1999-06-15 F Hoffmann La Roche Ag 液体中の懸濁磁性粒子の分離装置
JP2001221806A (ja) * 1999-12-24 2001-08-17 Roche Diagnostics Gmbh マルチチャンバ構造においてサンプルを処理するためのシステム

Also Published As

Publication number Publication date
CA2646670A1 (en) 2007-10-11
CA2646670C (en) 2011-09-20
JP2009531676A (ja) 2009-09-03
US20130256205A1 (en) 2013-10-03
US8470267B2 (en) 2013-06-25
US9381519B2 (en) 2016-07-05
US20100284864A1 (en) 2010-11-11
EP2001597A2 (en) 2008-12-17
EP1839756A1 (en) 2007-10-03
WO2007112862A3 (en) 2007-12-27
WO2007112862A2 (en) 2007-10-11
CN101415498B (zh) 2012-11-07
CN101415498A (zh) 2009-04-22

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