CN101374829A - Iap的抑制剂 - Google Patents

Iap的抑制剂 Download PDF

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Publication number
CN101374829A
CN101374829A CNA2006800530088A CN200680053008A CN101374829A CN 101374829 A CN101374829 A CN 101374829A CN A2006800530088 A CNA2006800530088 A CN A2006800530088A CN 200680053008 A CN200680053008 A CN 200680053008A CN 101374829 A CN101374829 A CN 101374829A
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CN
China
Prior art keywords
alkyl
compound
amino
optionally substituted
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800530088A
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English (en)
Chinese (zh)
Inventor
迈克尔·F·T·凯勒
刘易斯·J·加扎德
崔晓薇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CN101374829A publication Critical patent/CN101374829A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
CNA2006800530088A 2005-12-19 2006-12-19 Iap的抑制剂 Pending CN101374829A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75180105P 2005-12-19 2005-12-19
US60/751,801 2005-12-19

Publications (1)

Publication Number Publication Date
CN101374829A true CN101374829A (zh) 2009-02-25

Family

ID=38509952

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800530088A Pending CN101374829A (zh) 2005-12-19 2006-12-19 Iap的抑制剂

Country Status (13)

Country Link
US (2) US8247557B2 (enExample)
EP (1) EP1973899A4 (enExample)
JP (1) JP5155184B2 (enExample)
KR (1) KR20080080203A (enExample)
CN (1) CN101374829A (enExample)
AU (1) AU2006340014B2 (enExample)
CA (1) CA2632807A1 (enExample)
IL (1) IL191997A0 (enExample)
NO (1) NO20083207L (enExample)
NZ (1) NZ594746A (enExample)
RU (1) RU2451025C2 (enExample)
WO (1) WO2007106192A2 (enExample)
ZA (1) ZA200805152B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566447A (zh) * 2016-01-20 2016-05-11 广东工业大学 一种凋亡抑制蛋白的类肽拮抗剂及其合成方法与应用
CN105585583A (zh) * 2016-01-20 2016-05-18 广东工业大学 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用
CN106188098A (zh) * 2016-07-06 2016-12-07 广东工业大学 一种杂化抗癌药物及其制备方法与应用
CN113149908A (zh) * 2021-04-08 2021-07-23 深圳市雁程化工有限公司 一种基于铃木反应的联苯吡菌胺的合成方法
CN113402464A (zh) * 2021-03-15 2021-09-17 深圳市谦陌通辰实验有限公司 一种基于铃木反应的氟唑菌酰胺的合成方法

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MX2007007195A (es) 2004-12-20 2007-10-08 Genentech Inc Inhibidores de pirrolidina de iap.
EA012810B1 (ru) 2005-02-25 2009-12-30 Тетралоджик Фармасеутикалс Димерные ингибиторы ингибиторов белков апоптоза (iap)
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
AU2006308453B9 (en) 2005-10-25 2011-12-01 Pharmascience Inc. IAP BIR domain binding compounds
WO2007106192A2 (en) 2005-12-19 2007-09-20 Genentech, Inc. Inhibitors of iap
TWI504597B (zh) 2006-03-16 2015-10-21 Pharmascience Inc 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
MX2009000824A (es) * 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
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AU2007307763A1 (en) * 2006-10-12 2008-04-17 Novartis Ag Pyrrolydine derivatives as IAP inhibitors
EP2097405A2 (en) * 2006-11-21 2009-09-09 Smithkline Beecham Corporation Anti-viral compounds
CN101605786A (zh) * 2006-12-19 2009-12-16 健泰科生物技术公司 细胞凋亡抑制剂的咪唑并吡啶抑制剂
NZ598890A (en) * 2007-04-30 2013-10-25 Genentech Inc Inhibitors of iap
JP2010528587A (ja) * 2007-05-07 2010-08-26 テトラロジック ファーマシューティカルズ コーポレーション アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法
DK2240506T3 (da) * 2008-01-11 2013-04-08 Genentech Inc IAP inhibitorer
EP2303841A1 (en) 2008-07-14 2011-04-06 Gilead Sciences, Inc. Oxindolyl inhibitor compounds
US8835393B2 (en) 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP
JP2012500272A (ja) * 2008-08-16 2012-01-05 ジェネンテック， インコーポレイテッド Ｉａｐのアザインドールインヒビター
ES2463826T3 (es) 2009-06-08 2014-05-29 Gilead Sciences, Inc. Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina
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NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
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WO2015091584A1 (en) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors
CN115368356B (zh) 2013-12-20 2025-05-09 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途
WO2020027225A1 (ja) 2018-07-31 2020-02-06 ファイメクス株式会社 複素環化合物
JP7764027B2 (ja) 2019-07-31 2025-11-05 ファイメクス株式会社 複素環化合物
US20230056604A1 (en) 2020-01-20 2023-02-23 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
KR20240132251A (ko) 2021-10-22 2024-09-03 유니버시티 오브 휴스턴 시스템 상피 조직의 만성 염증성 손상, 화생, 이형성증 및 암을 치료하기 위한 방법 및 조성물

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566447A (zh) * 2016-01-20 2016-05-11 广东工业大学 一种凋亡抑制蛋白的类肽拮抗剂及其合成方法与应用
CN105585583A (zh) * 2016-01-20 2016-05-18 广东工业大学 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用
CN105585583B (zh) * 2016-01-20 2018-04-13 广东工业大学 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用
CN105566447B (zh) * 2016-01-20 2019-09-20 广东工业大学 一种凋亡抑制蛋白的类肽拮抗剂及其合成方法与应用
CN106188098A (zh) * 2016-07-06 2016-12-07 广东工业大学 一种杂化抗癌药物及其制备方法与应用
CN106188098B (zh) * 2016-07-06 2017-11-03 广东工业大学 一种杂化抗癌药物及其制备方法与应用
CN113402464A (zh) * 2021-03-15 2021-09-17 深圳市谦陌通辰实验有限公司 一种基于铃木反应的氟唑菌酰胺的合成方法
CN113149908A (zh) * 2021-04-08 2021-07-23 深圳市雁程化工有限公司 一种基于铃木反应的联苯吡菌胺的合成方法

Also Published As

Publication number Publication date
KR20080080203A (ko) 2008-09-02
AU2006340014B2 (en) 2012-12-20
EP1973899A4 (en) 2010-10-20
NZ594746A (en) 2013-03-28
JP2009520041A (ja) 2009-05-21
US20090221630A1 (en) 2009-09-03
ZA200805152B (en) 2009-12-30
WO2007106192A3 (en) 2008-04-24
JP5155184B2 (ja) 2013-02-27
CA2632807A1 (en) 2007-09-20
RU2008129683A (ru) 2010-01-27
WO2007106192A2 (en) 2007-09-20
IL191997A0 (en) 2008-12-29
US20120270886A1 (en) 2012-10-25
AU2006340014A1 (en) 2007-09-20
RU2451025C2 (ru) 2012-05-20
NO20083207L (no) 2008-09-17
EP1973899A2 (en) 2008-10-01
US8247557B2 (en) 2012-08-21

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Application publication date: 20090225