CN101365490B - 用于递送治疗剂的疏水核载体组合物及其制备方法和应用 - Google Patents
用于递送治疗剂的疏水核载体组合物及其制备方法和应用 Download PDFInfo
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- CN101365490B CN101365490B CN2006800521271A CN200680052127A CN101365490B CN 101365490 B CN101365490 B CN 101365490B CN 2006800521271 A CN2006800521271 A CN 2006800521271A CN 200680052127 A CN200680052127 A CN 200680052127A CN 101365490 B CN101365490 B CN 101365490B
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- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81362905P | 2005-12-19 | 2005-12-19 | |
| US60/813,629 | 2005-12-19 | ||
| PCT/US2006/062328 WO2007076371A2 (en) | 2005-12-19 | 2006-12-19 | Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101365490A CN101365490A (zh) | 2009-02-11 |
| CN101365490B true CN101365490B (zh) | 2012-11-28 |
Family
ID=38218806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800521271A Active CN101365490B (zh) | 2005-12-19 | 2006-12-19 | 用于递送治疗剂的疏水核载体组合物及其制备方法和应用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20070141145A1 (cg-RX-API-DMAC10.html) |
| EP (2) | EP1971372B1 (cg-RX-API-DMAC10.html) |
| JP (4) | JP2009520040A (cg-RX-API-DMAC10.html) |
| KR (3) | KR101529318B1 (cg-RX-API-DMAC10.html) |
| CN (1) | CN101365490B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2006330610B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2633070C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007076371A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2003219922B2 (en) * | 2002-02-27 | 2009-09-10 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
| US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| CA2673622A1 (en) * | 2006-12-22 | 2008-07-03 | Imuthes Limited | Lipid |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| US20090074828A1 (en) | 2007-04-04 | 2009-03-19 | Massachusetts Institute Of Technology | Poly(amino acid) targeting moieties |
| US20080312134A1 (en) * | 2007-06-11 | 2008-12-18 | Thomas Hirt | Vesicles for active macromolecule delivery |
| CN101795695B (zh) * | 2007-07-19 | 2016-01-06 | 阿列克斯塞尔公司 | 作为抗癌剂的自组装的两亲性聚合物 |
| US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| WO2009042625A1 (en) * | 2007-09-25 | 2009-04-02 | Idexx Laboratories, Inc. | Pharmaceutical compositions for administering oligonucleotides |
| MX2010003642A (es) | 2007-10-12 | 2010-08-09 | Massachusetts Inst Technology | Nanotecnologia de vacuna. |
| US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
| US20110044968A1 (en) * | 2008-03-10 | 2011-02-24 | Pharmal N Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
| WO2009131852A1 (en) * | 2008-04-21 | 2009-10-29 | Merck & Co., Inc. | Pancreatic beta-cell mass biomarker |
| KR101078302B1 (ko) * | 2008-05-29 | 2011-10-31 | (주)프로넥스 | 약물전달체 |
| WO2010028217A1 (en) * | 2008-09-05 | 2010-03-11 | The Board Of Trustees Of The University Of Illinois | Poly(ethylene glycol) methyl ether carbodiimide coupling reagents for the biological and chemical functionalization of water soluble nanoparticles |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| CA2773737C (en) | 2009-09-09 | 2021-11-16 | Pharmain Corporation | Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same |
| US20110135704A1 (en) * | 2009-12-08 | 2011-06-09 | Shipp John I | Infection Control for Surgical and Trauma Patients |
| CN101829338A (zh) * | 2010-04-23 | 2010-09-15 | 武汉理工大学 | 基于巯嘌呤类药物的新型两亲性大分子前药及其制备方法 |
| RU2702908C2 (ru) | 2012-11-01 | 2019-10-14 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы |
| EP3028049B1 (en) * | 2013-07-31 | 2019-03-20 | Pharnext | Diagnostic tools for alzheimer's disease |
| WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| KR101665176B1 (ko) * | 2014-04-24 | 2016-10-13 | 영남대학교 산학협력단 | 성장촉진용 약학조성물 |
| ES2898700T3 (es) * | 2014-10-27 | 2022-03-08 | Hisamitsu Pharmaceutical Co | Dispositivo de microagujas que contiene una hormona estimulante de los folículos recombinante |
| AU2015343207B2 (en) * | 2014-11-03 | 2019-10-31 | Pharmain Corporation | Method of production of graft co-polymer excipient with a superior peptide and protein binding property |
| WO2016210098A1 (en) | 2015-06-24 | 2016-12-29 | Board Of Regents, The University Of Texas System | Dual assembly nanoparticles |
| AU2016308446A1 (en) | 2015-08-14 | 2018-04-12 | Synedgen, Inc. | Polymers and their methods of use |
| BR112019003898A2 (pt) * | 2016-08-30 | 2019-05-21 | Particle Sciences, Inc. | composição, e, uso da composição |
| CN106620677B (zh) * | 2017-02-06 | 2020-05-08 | 北京大学第一医院 | 一种基于高分子载体的尿激酶制剂及其制备方法 |
| CA3056433A1 (en) | 2017-03-22 | 2018-09-27 | Pharmain Corporation | Npra agonists, compositions, and uses thereof |
| JP7196850B2 (ja) * | 2017-09-05 | 2022-12-27 | 味の素株式会社 | ポリリジン誘導体 |
| DK3505157T3 (da) | 2017-12-29 | 2022-02-28 | Celon Pharma Sa | Tørpulver-ketaminsammensætning til pulmonal indgivelse ved behandlingsresistent depression |
| KR20190127277A (ko) * | 2018-05-04 | 2019-11-13 | 주식회사 삼양바이오팜 | mRNA 전달용 고분자 나노입자 조성물 및 그 제조방법 |
| US20210308075A1 (en) * | 2020-04-07 | 2021-10-07 | Joseph Habboushe | Prevention and treatment of virial infections |
| CN111467499A (zh) * | 2020-04-18 | 2020-07-31 | 中山市君泽科技有限公司 | 一种石墨烯负载联合治疗癌症方法 |
| CN116546982A (zh) * | 2020-05-24 | 2023-08-04 | 李兆阳 | 视黄酸组合物及其方法 |
| US20230416328A1 (en) * | 2020-06-12 | 2023-12-28 | Hirofumi Tachibana | C-Type Natriuretic Peptides and Methods Thereof in Treating Acute Lung Injury |
| US12472195B2 (en) | 2020-07-02 | 2025-11-18 | Purdue Research Foundation | Inhalation formulations of antimicrobial compounds |
| CN112358492B (zh) * | 2020-11-13 | 2022-04-15 | 兰州大学 | 碳硼烷基塞来昔布及其制备和在头颈癌硼中子俘获治疗药物中的应用 |
| CN112402625B (zh) * | 2020-11-19 | 2022-12-09 | 健进制药有限公司 | 负载光敏剂的peg化肝素纳米胶束及其制备方法 |
| CN116744974A (zh) * | 2021-01-01 | 2023-09-12 | 普渡研究基金会 | 用于吸入的多黏菌素的共制剂 |
| CN112618481B (zh) * | 2021-02-22 | 2021-11-09 | 山东第一医科大学附属省立医院(山东省立医院) | 一种改性水凝胶、改性水凝胶微球及其制备方法和应用 |
| CN113444250B (zh) * | 2021-06-18 | 2022-10-25 | 绍兴文理学院附属医院 | 一种含有聚谷氨酸基团的聚甘油脂肪酸酯衍生物及其合成方法和其在药物制剂中的应用 |
| US12128063B2 (en) | 2021-10-05 | 2024-10-29 | International Business Machines Corporation | Biocompatible and biodegradable antiviral polymers |
| CN114042148B (zh) * | 2022-01-13 | 2022-04-15 | 浙江湃肽生物有限公司深圳分公司 | 一种盐酸依特卡肽稳定剂 |
| CN117760980B (zh) * | 2023-12-26 | 2026-05-15 | 南京邮电大学 | 一种基于溶致液晶液滴的葡萄糖检测方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671362A (zh) * | 2002-06-28 | 2005-09-21 | 麦克罗米德公司 | 用于药物递送的生物可降解嵌段共聚组合物 |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614492A (en) * | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US5120712A (en) * | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US7138486B2 (en) * | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US6849708B1 (en) * | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US5118666A (en) * | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US5681543A (en) * | 1988-02-29 | 1997-10-28 | Shering Aktiengesellschaft | Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI |
| US5116603A (en) * | 1989-01-31 | 1992-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Oral antifungal preventative, and method of use |
| US5554388A (en) * | 1989-02-25 | 1996-09-10 | Danbiosyst Uk Limited | Systemic drug delivery compositions comprising a polycationi substance |
| US5744166A (en) * | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| WO1993009176A2 (en) * | 1991-10-29 | 1993-05-13 | Clover Consolidated, Limited | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
| US5770563A (en) | 1991-12-06 | 1998-06-23 | The United States Of America As Represented By The Department Of Health And Human Services | Heparin- and sulfatide binding peptides from the type I repeats of human thrombospondin and conjugates thereof |
| US6113946A (en) * | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| AU682308C (en) * | 1992-04-03 | 2006-08-17 | Regents Of The University Of California, The | Self-assembling polynucleotide delivery system |
| JPH08501097A (ja) * | 1992-09-04 | 1996-02-06 | ザ ゼネラル ホスピタル コーポレーション | 臨床診断及び治療用部分を含む生体適合性ポリマー |
| US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US6284727B1 (en) * | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
| US5763585A (en) * | 1993-10-13 | 1998-06-09 | Anergen, Inc. | Method of making MHC-peptide complexes using metal chelate affinity chromatography |
| MX9504664A (es) * | 1994-03-07 | 1997-05-31 | Dow Chemical Co | Conjugados de dendrimeros bioactivos y/o dirigidos. |
| US5466467A (en) | 1994-03-30 | 1995-11-14 | The United States Of America As Represented By The Secretary Of The Navy | Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes |
| GB9409496D0 (en) * | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
| US20010006943A1 (en) | 1994-12-23 | 2001-07-05 | Ejvind Jensen | Protracted GLP-1 compositions |
| US5855610A (en) | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| EP0830381A4 (en) * | 1995-06-09 | 2000-11-22 | William N Drohan | CHITINE HYDROGELS, PRODUCTION METHOD AND USE |
| US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| AU730969B2 (en) | 1995-10-19 | 2001-03-22 | University Of Washington | Discrete-length polyethylene glycols |
| US5683387A (en) * | 1996-01-29 | 1997-11-04 | Garito; Jon C. | Electrosurgical electrode for skin grafting |
| PL189698B1 (pl) | 1996-03-12 | 2005-09-30 | Pg Txl Co | Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania |
| US6254854B1 (en) * | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US6006753A (en) * | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6153211A (en) | 1997-07-18 | 2000-11-28 | Infimed, Inc. | Biodegradable macromers for the controlled release of biologically active substances |
| US6468532B1 (en) | 1998-01-22 | 2002-10-22 | Genentech, Inc. | Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates |
| US6703359B1 (en) * | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| US6998387B1 (en) | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| GB9811059D0 (en) * | 1998-05-23 | 1998-07-22 | Univ Strathclyde | Polyamino acid vesicles |
| US6509323B1 (en) * | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| US7056734B1 (en) | 1998-08-10 | 2006-06-06 | The United States Of America As Represented By The Department Of Health And Human Services, Nih | Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof |
| IL140892A0 (en) * | 1998-08-12 | 2002-02-10 | Yissum Res Dev Co | Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient |
| US6284725B1 (en) * | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| JP2002534363A (ja) * | 1999-01-08 | 2002-10-15 | エミスフェアー・テクノロジーズ・インク | ポリマー性デリバリー剤及びデリバリー剤化合物 |
| US6365173B1 (en) * | 1999-01-14 | 2002-04-02 | Efrat Biopolymers Ltd. | Stereocomplex polymeric carriers for drug delivery |
| CA2328614C (en) * | 1999-02-12 | 2012-06-26 | Biostream, Inc. | Matrices for drug delivery and methods for making and using the same |
| US6569832B1 (en) | 1999-11-12 | 2003-05-27 | Novo Nordisk A/S | Inhibition of beta cell degeneration |
| CN1487836A (zh) * | 2000-03-14 | 2004-04-07 | 埃米林药品公司 | 胰高糖素样肽1(7-36)对胃窦幽门十二指肠能动性的影响 |
| US6998137B2 (en) * | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
| US6589549B2 (en) * | 2000-04-27 | 2003-07-08 | Macromed, Incorporated | Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles |
| AU2001263230B2 (en) * | 2000-05-19 | 2005-03-10 | Amylin Pharmaceuticals, Llc | Treatment of acute coronary syndrome with glp-1 |
| US6338859B1 (en) * | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
| DK1301213T3 (en) | 2000-07-21 | 2017-03-27 | Revance Therapeutics Inc | MULTI-COMPONENT SYSTEMS FOR BIOLOGICAL TRANSPORT |
| US20040092432A1 (en) * | 2000-08-24 | 2004-05-13 | Thomas Jefferson University | Peptide compositions with effects on cerebral health |
| US6521736B2 (en) | 2000-09-15 | 2003-02-18 | University Of Massachusetts | Amphiphilic polymeric materials |
| CA2395165C (en) * | 2000-10-20 | 2012-05-22 | Mario Ehlers | Treatment of hibernating myocardium and diabetic cardiomyopathy with a glp-1 peptide |
| AU2002239384B2 (en) * | 2000-12-13 | 2007-01-11 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| AU2002228608A1 (en) * | 2000-12-13 | 2002-06-24 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| JP4775985B2 (ja) * | 2000-12-27 | 2011-09-21 | 三井化学株式会社 | 重合体及びその製造方法 |
| ES2315350T3 (es) | 2001-01-12 | 2009-04-01 | Waratah Pharmaceuticals Inc. | Composiciones para la introduccion de la neogenesis de islotes, que contienen unos ligandos para el receptor de gastrina/cck y ligandos para el receptor de efg. |
| JP2005506956A (ja) * | 2001-06-01 | 2005-03-10 | イーライ・リリー・アンド・カンパニー | 長時間作用性glp−1製剤 |
| ES2298378T3 (es) | 2001-06-28 | 2008-05-16 | Novo Nordisk A/S | Formulacion estable de glp-1 modificado. |
| US6586524B2 (en) * | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| AU2002322403A1 (en) * | 2001-08-23 | 2003-03-10 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
| HUP0600437A2 (en) | 2001-10-01 | 2006-09-28 | Lilly Co Eli | Glucagon-like peptides (glp-1) and treatment of respiratory distress |
| US7041646B2 (en) | 2001-10-05 | 2006-05-09 | Bayer Pharmaceuticals Corporation | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists |
| IL161446A0 (en) | 2001-11-26 | 2004-09-27 | Daiichi Suntory Pharma Co Ltd | Medicinal compositions for nasal absorption |
| AU2003208945B2 (en) | 2002-02-20 | 2008-05-01 | Emisphere Technologies, Inc | Method for administering GLP-1 molecules |
| US20050260259A1 (en) * | 2004-04-23 | 2005-11-24 | Bolotin Elijah M | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| AU2003219922B2 (en) * | 2002-02-27 | 2009-09-10 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
| US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| MXPA04012497A (es) | 2002-07-04 | 2005-07-14 | Zealand Pharma As | Glp-1 y metodos para tratar la diabetes. |
| US20040086569A1 (en) * | 2002-08-13 | 2004-05-06 | Medtronic, Inc. | Active agent delivery systems, medical devices, and methods |
| CA2497794A1 (en) | 2002-09-06 | 2004-03-18 | Bayer Pharmaceuticals Corporation | Modified glp-1 receptor agonists and their pharmacological methods of use |
| GB0221941D0 (en) | 2002-09-20 | 2002-10-30 | Univ Strathclyde | Polysoaps |
| US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| US20040209803A1 (en) | 2002-12-19 | 2004-10-21 | Alain Baron | Compositions for the treatment and prevention of nephropathy |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| RU2005133427A (ru) | 2003-03-31 | 2006-04-27 | Алза Корпорейшн (Us) | Безводные однофазные носители и препараты с использованием таких носителей |
| US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| KR101308912B1 (ko) | 2003-06-03 | 2013-09-23 | 노보 노르디스크 에이/에스 | 안정화된 약학적 펩티드 조성물 |
| ES2375056T3 (es) | 2003-06-03 | 2012-02-24 | Novo Nordisk A/S | Composiciones pept�?dicas farmacéuticas estabilizadas. |
| US20060247167A1 (en) | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| JP2007514752A (ja) | 2003-12-16 | 2007-06-07 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | Glp−1医薬組成物 |
| WO2005084180A2 (en) | 2003-12-19 | 2005-09-15 | University Of Cincinnati | Polyamides and polyamide complexes for delivery of oligonucleotide decoys |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| US20050143303A1 (en) | 2003-12-26 | 2005-06-30 | Nastech Pharmaceutical Company Inc. | Intranasal administration of glucose-regulating peptides |
| BRPI0508440A (pt) | 2004-03-03 | 2007-07-24 | Revance Therapeutics Inc | composições e métodos para diagnóstico tópico e transporte terapêutico |
| FR2867679B1 (fr) | 2004-03-17 | 2008-08-22 | Oreal | Composition cosmetiques comprenant des polyamines modifiees et utilisations desdites compositions. |
| US7985424B2 (en) | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| EP1737899B1 (en) | 2004-04-20 | 2015-07-08 | Dendritic Nanotechnologies, Inc. | Dendritic polymers with enhanced amplification and interior functionality |
| US20060134166A1 (en) | 2004-05-25 | 2006-06-22 | Luthra Ajay K | Absorbable biocompatible materials |
| WO2006080951A2 (en) * | 2004-07-01 | 2006-08-03 | Yale University | Targeted and high density drug loaded polymeric materials |
| US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
| CN101027318B (zh) | 2004-07-19 | 2016-05-25 | 比奥孔有限公司 | 胰岛素-低聚物共轭物,制剂及其用途 |
| US20060233857A1 (en) * | 2005-04-14 | 2006-10-19 | Amsden Brian G | Degradable elastomeric network |
| US20090202497A1 (en) | 2005-08-23 | 2009-08-13 | The General Hospital Corporation | Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes |
| WO2007030706A1 (en) | 2005-09-08 | 2007-03-15 | New England Medical Center Hospitals, Inc. | Fragments of the glucagon-like peptide-i and uses thereof |
| AU2005337069B2 (en) | 2005-10-05 | 2011-08-11 | Essity Hygiene And Health Aktiebolag | Absorbent article comprising hydrophilic and hydrophobic regions |
| HUE031341T2 (hu) | 2005-10-25 | 2017-07-28 | Starpharma Pty Ltd | Ellenõrzött sztöchiometriájú makromolekuláris vegyületek |
| PL1965823T3 (pl) | 2005-11-04 | 2017-08-31 | Glaxosmithkline Llc | Sposoby podawania środków hipoglikemicznych |
| KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
| WO2007082331A1 (en) | 2006-01-20 | 2007-07-26 | Starpharma Pty Limited | Modified macromolecule |
| US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
-
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Patent Citations (1)
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|---|---|---|---|---|
| CN1671362A (zh) * | 2002-06-28 | 2005-09-21 | 麦克罗米德公司 | 用于药物递送的生物可降解嵌段共聚组合物 |
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| US9737615B2 (en) | 2017-08-22 |
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| EP3449946A3 (en) | 2020-11-04 |
| KR20080092923A (ko) | 2008-10-16 |
| AU2006330610B2 (en) | 2012-08-16 |
| JP2009520040A (ja) | 2009-05-21 |
| KR20150125732A (ko) | 2015-11-09 |
| CA2633070A1 (en) | 2007-07-05 |
| CN101365490A (zh) | 2009-02-11 |
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