CN101330904B - 含有低熔点活性成分的固体分散体以及含有它的口服给药片剂 - Google Patents

含有低熔点活性成分的固体分散体以及含有它的口服给药片剂 Download PDF

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Publication number
CN101330904B
CN101330904B CN2006800474904A CN200680047490A CN101330904B CN 101330904 B CN101330904 B CN 101330904B CN 2006800474904 A CN2006800474904 A CN 2006800474904A CN 200680047490 A CN200680047490 A CN 200680047490A CN 101330904 B CN101330904 B CN 101330904B
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China
Prior art keywords
tablet
solid dispersion
oral administration
ibuprofen
pharmaceutically acceptable
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Expired - Fee Related
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CN2006800474904A
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English (en)
Chinese (zh)
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CN101330904A (zh
Inventor
禹锺守
金相煜
李鸿基
柳在国
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Han Mei Technology Corp
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Hanmi Pharmaceutical Co Ltd
Hanmi Holdings Co Ltd
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Publication of CN101330904A publication Critical patent/CN101330904A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800474904A 2005-12-16 2006-12-18 含有低熔点活性成分的固体分散体以及含有它的口服给药片剂 Expired - Fee Related CN101330904B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20050124386 2005-12-16
KR1020050124386 2005-12-16
KR10-2005-0124386 2005-12-16
PCT/KR2006/005526 WO2007069874A1 (en) 2005-12-16 2006-12-18 Solid dispersion comprising an active ingredient having a low melting point and tablet for oral administration comprising same

Publications (2)

Publication Number Publication Date
CN101330904A CN101330904A (zh) 2008-12-24
CN101330904B true CN101330904B (zh) 2012-04-18

Family

ID=38163142

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800474904A Expired - Fee Related CN101330904B (zh) 2005-12-16 2006-12-18 含有低熔点活性成分的固体分散体以及含有它的口服给药片剂

Country Status (14)

Country Link
US (1) US20080292702A1 (https=)
EP (1) EP1968542B1 (https=)
JP (1) JP2009519326A (https=)
CN (1) CN101330904B (https=)
AU (1) AU2006325658B2 (https=)
BR (1) BRPI0619868A8 (https=)
CA (1) CA2633266C (https=)
ES (1) ES2429097T3 (https=)
IL (1) IL191804A0 (https=)
NO (1) NO339674B1 (https=)
NZ (1) NZ569813A (https=)
RU (1) RU2403013C2 (https=)
WO (1) WO2007069874A1 (https=)
ZA (1) ZA200806138B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060119971A (ko) 2003-09-11 2006-11-24 제노포트 인코포레이티드 Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방
KR101005391B1 (ko) * 2008-07-22 2010-12-30 한국콜마 주식회사 덱시부프로펜 함유 서방출성 시럽제 및 그의 제조방법
KR101067224B1 (ko) * 2008-07-22 2011-09-22 한국콜마 주식회사 이부프로펜 함유 서방출성 시럽제 및 그의 제조방법
CN101961306B (zh) * 2009-07-24 2011-11-09 北京化工大学 一种低熔点药物固体分散体的制备方法
CN102144982B (zh) * 2011-03-30 2012-12-12 江苏神龙药业有限公司 一种米诺膦酸片及其制备方法
CN102406940B (zh) * 2011-11-01 2013-07-03 温州大学 一种纳米级片状羧甲基淀粉钠在固体分散体中的应用
WO2013154511A1 (en) * 2012-04-13 2013-10-17 Mahmut Bilgic Film tablet formulations comprising dexibuprofen
UY36046A (es) 2014-03-26 2015-10-30 Millennium Pharm Inc Formulaciones farmacéuticas, procesos para la preparación y métodos de uso
JP6647902B2 (ja) * 2015-10-30 2020-02-14 株式会社ファンケル 徐放性顆粒剤
CN106265522A (zh) * 2016-08-30 2017-01-04 铜陵翔宇商贸有限公司 布洛芬‑pvp共沉淀物及其制备方法
JP7109255B2 (ja) * 2017-05-23 2022-07-29 ライオン株式会社 粉砕物の製造方法及び錠剤の製造方法
JP7147262B2 (ja) * 2017-05-23 2022-10-05 大正製薬株式会社 固形製剤
US10792249B2 (en) * 2017-07-24 2020-10-06 Acryspharm Llc High drug loading pharmaceutical compositions
RU2685294C1 (ru) * 2018-05-10 2019-04-17 Общество с ограниченной ответственностью "ДИНОН" (ООО "ДИНОН") Поглотитель, способ его приготовления (варианты) и способ удаления диоксида углерода из газовых смесей
CN112263567B (zh) * 2020-10-19 2022-05-03 南京易亨制药有限公司 一种布洛芬缓释胶囊及制备方法
CN117363320B (zh) * 2023-12-07 2024-02-13 黑龙江省鑫博鑫交通科技有限公司 一种公路用融雪剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806359A (en) * 1987-04-22 1989-02-21 Mcneilab, Inc. Iburprofen sustained release matrix and process
US4867987A (en) * 1986-06-25 1989-09-19 Mepha Ag Pharmaceutical product for the sustained release of ibuprofen
WO2001041733A2 (en) * 1999-12-09 2001-06-14 The Boots Company Plc Compressed tablet composition comprising a nsaid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56120616A (en) * 1980-02-27 1981-09-22 Kaken Pharmaceut Co Ltd Ibuprofen-containing granule, its preparation, and internal medicine comprising it
GB8601204D0 (en) * 1986-01-18 1986-02-19 Boots Co Plc Therapeutic agents
DE19509807A1 (de) * 1995-03-21 1996-09-26 Basf Ag Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen
IE80467B1 (en) * 1995-07-03 1998-07-29 Elan Corp Plc Controlled release formulations for poorly soluble drugs
US6391338B1 (en) * 1995-09-07 2002-05-21 Biovail Technologies Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
DE19536394A1 (de) * 1995-09-29 1997-04-03 Basf Ag Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze
MX9801835A (es) * 1996-07-08 1998-08-30 Mendell Co Inc Edward Matriz de liberacion sostenida para medicamentos insolubles de dosis altas.
US6787157B1 (en) * 1998-03-10 2004-09-07 Abbott Laboratories Multiphase active ingredient-containing formulations
US6183779B1 (en) * 1999-03-22 2001-02-06 Pharmascience Inc. Stabilized pharmaceutical composition of a nonsteroidal anti-inflammatory agent and a prostaglandin
GB0113839D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867987A (en) * 1986-06-25 1989-09-19 Mepha Ag Pharmaceutical product for the sustained release of ibuprofen
US4806359A (en) * 1987-04-22 1989-02-21 Mcneilab, Inc. Iburprofen sustained release matrix and process
WO2001041733A2 (en) * 1999-12-09 2001-06-14 The Boots Company Plc Compressed tablet composition comprising a nsaid

Also Published As

Publication number Publication date
EP1968542A4 (en) 2010-06-02
JP2009519326A (ja) 2009-05-14
CA2633266A1 (en) 2007-06-21
BRPI0619868A2 (pt) 2011-10-25
HK1126671A1 (en) 2009-09-11
IL191804A0 (en) 2008-12-29
ES2429097T3 (es) 2013-11-13
NO20083151L (no) 2008-09-05
NO339674B1 (no) 2017-01-23
AU2006325658A1 (en) 2007-06-21
WO2007069874A1 (en) 2007-06-21
CN101330904A (zh) 2008-12-24
RU2403013C2 (ru) 2010-11-10
ZA200806138B (en) 2009-11-25
EP1968542A1 (en) 2008-09-17
CA2633266C (en) 2011-08-02
EP1968542B1 (en) 2013-08-14
RU2008129041A (ru) 2010-01-27
US20080292702A1 (en) 2008-11-27
NZ569813A (en) 2011-07-29
AU2006325658B2 (en) 2010-04-08
BRPI0619868A8 (pt) 2016-06-07

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