JPS56120616A - Ibuprofen-containing granule, its preparation, and internal medicine comprising it - Google Patents
Ibuprofen-containing granule, its preparation, and internal medicine comprising itInfo
- Publication number
- JPS56120616A JPS56120616A JP2434480A JP2434480A JPS56120616A JP S56120616 A JPS56120616 A JP S56120616A JP 2434480 A JP2434480 A JP 2434480A JP 2434480 A JP2434480 A JP 2434480A JP S56120616 A JPS56120616 A JP S56120616A
- Authority
- JP
- Japan
- Prior art keywords
- ibuprofen
- solidified
- granule
- containing granule
- under heating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To make a bulk of ibuprofen of antipyretic, anodyne, and anti-inflammatory agent low, and to improve flow properties and disintegration properties, by melting crude powder of ibuprofen under heating, cooling it so that it is solidified, followed by grinding.
CONSTITUTION: Ibuprofen [chemical name: 2-(4'-isobutylphenyl)propionic acid] alone or its mixture with at least one of an excipient and a disingrator is melted under heating, it is cooled, solidified, and ground to give ibuprofen-containing granule having an apparent specific volume 9.3W11.5ml/5g, angle of repose 40W 47°, ibuprofen content not less than 78wt%. The pharmaceutical preparation of ibuprofen is miniaturized by the use of this granule and is drinkable readily.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2434480A JPS56120616A (en) | 1980-02-27 | 1980-02-27 | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2434480A JPS56120616A (en) | 1980-02-27 | 1980-02-27 | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56120616A true JPS56120616A (en) | 1981-09-22 |
JPS6346726B2 JPS6346726B2 (en) | 1988-09-19 |
Family
ID=12135561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2434480A Granted JPS56120616A (en) | 1980-02-27 | 1980-02-27 | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56120616A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0299668A1 (en) * | 1987-07-17 | 1989-01-18 | The Boots Company PLC | Pharmaceutical composition containing ibuprofen |
EP0362728A2 (en) * | 1988-10-01 | 1990-04-11 | Hoechst Aktiengesellschaft | Process for preparing ibuprofen for direct tabletting |
EP0362731A2 (en) * | 1988-10-01 | 1990-04-11 | Hoechst Aktiengesellschaft | Process for the preparation of medicinal particles with modified flow, storage and formulation qualities, and pharmaceutical compositions containing these particles |
US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
AU776308B2 (en) * | 1999-12-09 | 2004-09-02 | Boots Company Plc, The | Therapeutic agents |
JP2009519326A (en) * | 2005-12-16 | 2009-05-14 | ハンミ ファーム. シーオー., エルティーディー. | Molten solid dispersion containing an active ingredient having a low melting point, and tablet for oral administration containing the same |
WO2013143688A1 (en) | 2012-03-26 | 2013-10-03 | Glatt Ag | Taste-masked ibuprofen granules |
CN105816434A (en) * | 2016-04-19 | 2016-08-03 | 山东新华制药股份有限公司 | Ibuprofen granules and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52111533A (en) * | 1976-03-12 | 1977-09-19 | Kanebo Ltd | Preparation of fine powder of ibuprophene |
-
1980
- 1980-02-27 JP JP2434480A patent/JPS56120616A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52111533A (en) * | 1976-03-12 | 1977-09-19 | Kanebo Ltd | Preparation of fine powder of ibuprophene |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0299668A1 (en) * | 1987-07-17 | 1989-01-18 | The Boots Company PLC | Pharmaceutical composition containing ibuprofen |
US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
EP0362728A2 (en) * | 1988-10-01 | 1990-04-11 | Hoechst Aktiengesellschaft | Process for preparing ibuprofen for direct tabletting |
EP0362731A2 (en) * | 1988-10-01 | 1990-04-11 | Hoechst Aktiengesellschaft | Process for the preparation of medicinal particles with modified flow, storage and formulation qualities, and pharmaceutical compositions containing these particles |
AU776308B2 (en) * | 1999-12-09 | 2004-09-02 | Boots Company Plc, The | Therapeutic agents |
EP1235558B1 (en) * | 1999-12-09 | 2006-05-03 | The Boots Company PLC | Compressed tablet composition comprising a nsaid |
BG66007B1 (en) * | 1999-12-09 | 2010-10-29 | The Boots Company Plc | Therapeutic agents |
US8124124B2 (en) | 1999-12-09 | 2012-02-28 | Reckitt Benckiser Healthcare (Uk) Limited | Compressed tablet formulation comprising non-steroidal anti-inflammatory drugs and methods |
JP2009519326A (en) * | 2005-12-16 | 2009-05-14 | ハンミ ファーム. シーオー., エルティーディー. | Molten solid dispersion containing an active ingredient having a low melting point, and tablet for oral administration containing the same |
WO2013143688A1 (en) | 2012-03-26 | 2013-10-03 | Glatt Ag | Taste-masked ibuprofen granules |
CN105816434A (en) * | 2016-04-19 | 2016-08-03 | 山东新华制药股份有限公司 | Ibuprofen granules and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6346726B2 (en) | 1988-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS56120616A (en) | Ibuprofen-containing granule, its preparation, and internal medicine comprising it | |
EP0274870A2 (en) | Micelles containing a non-steroidal antiinflammatory compound | |
JPS56145298A (en) | Aminophenyl derivative and physiologically active preparation containing the same | |
JPS5636411A (en) | Liquid agent for external use | |
GB2187952B (en) | Therapeutic agents | |
Keinänen et al. | Oral antipyretic therapy: evaluation of the N-aryl-anthranilic acid derivatives mefenamic acid, tolfenamic acid and flufenamic acid | |
JPS55122715A (en) | Antidiabetic agent | |
JPS57145807A (en) | Preparation of ibuprofen pharmaceutical | |
JPS5592341A (en) | Preparation of clathrate compound | |
JPS553763A (en) | Preparation of ice cream containing chip | |
JPS57200355A (en) | 2-mercaptopropionic acid and its preparation | |
JPS5363344A (en) | Preparation of 2-(4'-isobutylphenyl) propionic acid | |
JPS57158719A (en) | Rectal administration pharmaceutical | |
JPS532449A (en) | Preparation of 2-substituted propionic acid derivatives | |
JPH0153644B2 (en) | ||
JPS57153077A (en) | Heat accumulating material | |
JPS56122310A (en) | Suppository | |
JPS5515458A (en) | Hypotensive agent | |
JPS559757A (en) | Ice cream | |
JPS5423131A (en) | Pharmaceutical composition containing acetylsalicylic acid and ethenzamide | |
JPS5382679A (en) | Liquid crystal composition | |
JPS57112328A (en) | Hypotensor comprising 2,3-dihydroxypropyl ester of n-(7- chloro-4-quinolyl)anthranillic acid | |
JPS57140714A (en) | Medicine containing n-(3,4-dihydroxybenzylidene)- aminomethylcarboxylic acid, salt or ester thereof | |
JPS5365867A (en) | Preparation of chenodeoxycholic acid crystal | |
JPS57145801A (en) | Controlling agent against soil blight |