JPS5592341A - Preparation of clathrate compound - Google Patents

Preparation of clathrate compound

Info

Publication number
JPS5592341A
JPS5592341A JP4379A JP4379A JPS5592341A JP S5592341 A JPS5592341 A JP S5592341A JP 4379 A JP4379 A JP 4379A JP 4379 A JP4379 A JP 4379A JP S5592341 A JPS5592341 A JP S5592341A
Authority
JP
Japan
Prior art keywords
cyclodextrin
drugs
propionic acid
clathrate compound
isobutylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4379A
Other languages
Japanese (ja)
Inventor
Shinichi Kimura
Suehiro Matsuda
Takao Goto
Katsunori Hazama
Kiyoshi Masuda
Toshiaki Okuda
Tetsunori Matsubara
Chikanori Tomioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kakenyaku Kako KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kakenyaku Kako KK filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP4379A priority Critical patent/JPS5592341A/en
Publication of JPS5592341A publication Critical patent/JPS5592341A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare a fine powdery and odorless clathrate compound non-irritative to the mucous membranes and useful as a drug, by using an improved saturated aqueous solution method comprising inclusion of 2-(4-isobutylphenyl)-propionic acid in β-cyclodextrin.
CONSTITUTION: A solid clathrate product of 2-(4-isobutylphenyl)-propionic acid in β-cyclodextrin is prepared by mixing 2-(4-isobutyl-phenyl)-propionic acid with the equimolar amount of β-cyclodextrin in a dilute aqueous alkaline solution and adding a dilute mineral acid to the mixture to change the pH of the reaction mixture to acidic, preferably near pH2. The clathrate compound is mixed with additives to give drugs for oral administration, e.g. syrup capsules, fine powder, granules, tablets, etc., or drugs for rectum administration, e.g. suppository. The drugs can be used as antiphlogistics, analgesics or antipyretics.
COPYRIGHT: (C)1980,JPO&Japio
JP4379A 1979-01-05 1979-01-05 Preparation of clathrate compound Pending JPS5592341A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4379A JPS5592341A (en) 1979-01-05 1979-01-05 Preparation of clathrate compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4379A JPS5592341A (en) 1979-01-05 1979-01-05 Preparation of clathrate compound

Publications (1)

Publication Number Publication Date
JPS5592341A true JPS5592341A (en) 1980-07-12

Family

ID=11463260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4379A Pending JPS5592341A (en) 1979-01-05 1979-01-05 Preparation of clathrate compound

Country Status (1)

Country Link
JP (1) JPS5592341A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156412A (en) * 1981-03-24 1982-09-27 Kyoritsu Yakuhin Kogyo Kk Preparation containing dextromethorphan hydrobromide
JPS5821620A (en) * 1981-07-30 1983-02-08 Riken Kagaku Kogyo Kk Clathrate of garlic constituents
JPS58203915A (en) * 1982-05-20 1983-11-28 Riken Kagaku Kogyo Kk Cardiac of purified oil of garlic
US4762702A (en) * 1984-11-05 1988-08-09 Gerhard Gergely Pharmaceutical preparation containing ibuprofen and a process for its preparation
JPS641A (en) * 1987-03-25 1989-01-05 Nippon Ekishiyou Kk Masking of agent having strong smell
US4952565A (en) * 1986-11-13 1990-08-28 Janko Zmitek Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156412A (en) * 1981-03-24 1982-09-27 Kyoritsu Yakuhin Kogyo Kk Preparation containing dextromethorphan hydrobromide
JPS5821620A (en) * 1981-07-30 1983-02-08 Riken Kagaku Kogyo Kk Clathrate of garlic constituents
JPH0366289B2 (en) * 1981-07-30 1991-10-16 Riken Chemical Ind
JPS58203915A (en) * 1982-05-20 1983-11-28 Riken Kagaku Kogyo Kk Cardiac of purified oil of garlic
JPH0366288B2 (en) * 1982-05-20 1991-10-16 Riken Chemical Ind
US4762702A (en) * 1984-11-05 1988-08-09 Gerhard Gergely Pharmaceutical preparation containing ibuprofen and a process for its preparation
US4952565A (en) * 1986-11-13 1990-08-28 Janko Zmitek Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same
JPS641A (en) * 1987-03-25 1989-01-05 Nippon Ekishiyou Kk Masking of agent having strong smell

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