JPS5592341A - Preparation of clathrate compound - Google Patents
Preparation of clathrate compoundInfo
- Publication number
- JPS5592341A JPS5592341A JP4379A JP4379A JPS5592341A JP S5592341 A JPS5592341 A JP S5592341A JP 4379 A JP4379 A JP 4379A JP 4379 A JP4379 A JP 4379A JP S5592341 A JPS5592341 A JP S5592341A
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- drugs
- propionic acid
- clathrate compound
- isobutylphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare a fine powdery and odorless clathrate compound non-irritative to the mucous membranes and useful as a drug, by using an improved saturated aqueous solution method comprising inclusion of 2-(4-isobutylphenyl)-propionic acid in β-cyclodextrin.
CONSTITUTION: A solid clathrate product of 2-(4-isobutylphenyl)-propionic acid in β-cyclodextrin is prepared by mixing 2-(4-isobutyl-phenyl)-propionic acid with the equimolar amount of β-cyclodextrin in a dilute aqueous alkaline solution and adding a dilute mineral acid to the mixture to change the pH of the reaction mixture to acidic, preferably near pH2. The clathrate compound is mixed with additives to give drugs for oral administration, e.g. syrup capsules, fine powder, granules, tablets, etc., or drugs for rectum administration, e.g. suppository. The drugs can be used as antiphlogistics, analgesics or antipyretics.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4379A JPS5592341A (en) | 1979-01-05 | 1979-01-05 | Preparation of clathrate compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4379A JPS5592341A (en) | 1979-01-05 | 1979-01-05 | Preparation of clathrate compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5592341A true JPS5592341A (en) | 1980-07-12 |
Family
ID=11463260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4379A Pending JPS5592341A (en) | 1979-01-05 | 1979-01-05 | Preparation of clathrate compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5592341A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57156412A (en) * | 1981-03-24 | 1982-09-27 | Kyoritsu Yakuhin Kogyo Kk | Preparation containing dextromethorphan hydrobromide |
JPS5821620A (en) * | 1981-07-30 | 1983-02-08 | Riken Kagaku Kogyo Kk | Clathrate of garlic constituents |
JPS58203915A (en) * | 1982-05-20 | 1983-11-28 | Riken Kagaku Kogyo Kk | Cardiac of purified oil of garlic |
US4762702A (en) * | 1984-11-05 | 1988-08-09 | Gerhard Gergely | Pharmaceutical preparation containing ibuprofen and a process for its preparation |
JPS641A (en) * | 1987-03-25 | 1989-01-05 | Nippon Ekishiyou Kk | Masking of agent having strong smell |
US4952565A (en) * | 1986-11-13 | 1990-08-28 | Janko Zmitek | Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same |
-
1979
- 1979-01-05 JP JP4379A patent/JPS5592341A/en active Pending
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57156412A (en) * | 1981-03-24 | 1982-09-27 | Kyoritsu Yakuhin Kogyo Kk | Preparation containing dextromethorphan hydrobromide |
JPS5821620A (en) * | 1981-07-30 | 1983-02-08 | Riken Kagaku Kogyo Kk | Clathrate of garlic constituents |
JPH0366289B2 (en) * | 1981-07-30 | 1991-10-16 | Riken Chemical Ind | |
JPS58203915A (en) * | 1982-05-20 | 1983-11-28 | Riken Kagaku Kogyo Kk | Cardiac of purified oil of garlic |
JPH0366288B2 (en) * | 1982-05-20 | 1991-10-16 | Riken Chemical Ind | |
US4762702A (en) * | 1984-11-05 | 1988-08-09 | Gerhard Gergely | Pharmaceutical preparation containing ibuprofen and a process for its preparation |
US4952565A (en) * | 1986-11-13 | 1990-08-28 | Janko Zmitek | Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same |
JPS641A (en) * | 1987-03-25 | 1989-01-05 | Nippon Ekishiyou Kk | Masking of agent having strong smell |
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