JPS57156412A - Preparation containing dextromethorphan hydrobromide - Google Patents
Preparation containing dextromethorphan hydrobromideInfo
- Publication number
- JPS57156412A JPS57156412A JP4304581A JP4304581A JPS57156412A JP S57156412 A JPS57156412 A JP S57156412A JP 4304581 A JP4304581 A JP 4304581A JP 4304581 A JP4304581 A JP 4304581A JP S57156412 A JPS57156412 A JP S57156412A
- Authority
- JP
- Japan
- Prior art keywords
- dextromethorphan hydrobromide
- cyclodextrin
- clathrate
- preparation
- preparation containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: The titled preparation in which dextromethorphan hydrobromide used as an antitussive or phlegm looser is combined with cyclodextrin to form a clathrate to improve the irritation, bitterness and solubility of the former.
CONSTITUTION: Dextromethorphan hydrobromide and cyclodextrin, preferably β-cyclodextrin are combined, preferably at a molar ratio of 2/1W1/2, much preferably at 1/1 to form a clathrate of cyclodextrin. The resultant clathrate is prepared by a pharmaceutically permissible method into an oral or injection preparation. The resultant preparation of dextromethorphan hydrobromide shows improved solubility, irritation and bitterness blocking.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4304581A JPS57156412A (en) | 1981-03-24 | 1981-03-24 | Preparation containing dextromethorphan hydrobromide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4304581A JPS57156412A (en) | 1981-03-24 | 1981-03-24 | Preparation containing dextromethorphan hydrobromide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57156412A true JPS57156412A (en) | 1982-09-27 |
Family
ID=12652917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4304581A Pending JPS57156412A (en) | 1981-03-24 | 1981-03-24 | Preparation containing dextromethorphan hydrobromide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57156412A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02212429A (en) * | 1989-02-14 | 1990-08-23 | Sanraku Inc | Hemoferrum-containing composition |
CN100391454C (en) * | 2003-09-03 | 2008-06-04 | 吕宝光 | Preparation of hydrobromic acid dextro methaphen and beta cyclodeatrin compounding object |
CN103536527A (en) * | 2013-09-16 | 2014-01-29 | 南通丝乡丝绸有限公司 | Dextromethorphan hydrobromide injection and preparation method thereof |
CN114569742A (en) * | 2022-05-09 | 2022-06-03 | 北京剂泰医药科技有限公司 | Composition and preparation method and application thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS536416A (en) * | 1976-07-01 | 1978-01-20 | Emu Esu Shii Yuugen | 55fluorouracli inclusion compound |
JPS5592341A (en) * | 1979-01-05 | 1980-07-12 | Kaken Pharmaceut Co Ltd | Preparation of clathrate compound |
-
1981
- 1981-03-24 JP JP4304581A patent/JPS57156412A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS536416A (en) * | 1976-07-01 | 1978-01-20 | Emu Esu Shii Yuugen | 55fluorouracli inclusion compound |
JPS5592341A (en) * | 1979-01-05 | 1980-07-12 | Kaken Pharmaceut Co Ltd | Preparation of clathrate compound |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02212429A (en) * | 1989-02-14 | 1990-08-23 | Sanraku Inc | Hemoferrum-containing composition |
CN100391454C (en) * | 2003-09-03 | 2008-06-04 | 吕宝光 | Preparation of hydrobromic acid dextro methaphen and beta cyclodeatrin compounding object |
CN103536527A (en) * | 2013-09-16 | 2014-01-29 | 南通丝乡丝绸有限公司 | Dextromethorphan hydrobromide injection and preparation method thereof |
CN114569742A (en) * | 2022-05-09 | 2022-06-03 | 北京剂泰医药科技有限公司 | Composition and preparation method and application thereof |
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