JPS57156412A - Preparation containing dextromethorphan hydrobromide - Google Patents

Preparation containing dextromethorphan hydrobromide

Info

Publication number
JPS57156412A
JPS57156412A JP4304581A JP4304581A JPS57156412A JP S57156412 A JPS57156412 A JP S57156412A JP 4304581 A JP4304581 A JP 4304581A JP 4304581 A JP4304581 A JP 4304581A JP S57156412 A JPS57156412 A JP S57156412A
Authority
JP
Japan
Prior art keywords
dextromethorphan hydrobromide
cyclodextrin
clathrate
preparation
preparation containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4304581A
Other languages
Japanese (ja)
Inventor
Hideaki Taira
Masahiko Sasaki
Nobuyuki Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KIYOURITSU YAKUHIN KOGYO KK
KYORITSU YAKUHIN KOGYO KK
NIHON SHIYOKUHIN KAKOU KK
Japan Maize Products Co Ltd
Nihon Shokuhin Kako Co Ltd
Original Assignee
KIYOURITSU YAKUHIN KOGYO KK
KYORITSU YAKUHIN KOGYO KK
NIHON SHIYOKUHIN KAKOU KK
Japan Maize Products Co Ltd
Nihon Shokuhin Kako Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KIYOURITSU YAKUHIN KOGYO KK, KYORITSU YAKUHIN KOGYO KK, NIHON SHIYOKUHIN KAKOU KK, Japan Maize Products Co Ltd, Nihon Shokuhin Kako Co Ltd filed Critical KIYOURITSU YAKUHIN KOGYO KK
Priority to JP4304581A priority Critical patent/JPS57156412A/en
Publication of JPS57156412A publication Critical patent/JPS57156412A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: The titled preparation in which dextromethorphan hydrobromide used as an antitussive or phlegm looser is combined with cyclodextrin to form a clathrate to improve the irritation, bitterness and solubility of the former.
CONSTITUTION: Dextromethorphan hydrobromide and cyclodextrin, preferably β-cyclodextrin are combined, preferably at a molar ratio of 2/1W1/2, much preferably at 1/1 to form a clathrate of cyclodextrin. The resultant clathrate is prepared by a pharmaceutically permissible method into an oral or injection preparation. The resultant preparation of dextromethorphan hydrobromide shows improved solubility, irritation and bitterness blocking.
COPYRIGHT: (C)1982,JPO&Japio
JP4304581A 1981-03-24 1981-03-24 Preparation containing dextromethorphan hydrobromide Pending JPS57156412A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4304581A JPS57156412A (en) 1981-03-24 1981-03-24 Preparation containing dextromethorphan hydrobromide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4304581A JPS57156412A (en) 1981-03-24 1981-03-24 Preparation containing dextromethorphan hydrobromide

Publications (1)

Publication Number Publication Date
JPS57156412A true JPS57156412A (en) 1982-09-27

Family

ID=12652917

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4304581A Pending JPS57156412A (en) 1981-03-24 1981-03-24 Preparation containing dextromethorphan hydrobromide

Country Status (1)

Country Link
JP (1) JPS57156412A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02212429A (en) * 1989-02-14 1990-08-23 Sanraku Inc Hemoferrum-containing composition
CN100391454C (en) * 2003-09-03 2008-06-04 吕宝光 Preparation of hydrobromic acid dextro methaphen and beta cyclodeatrin compounding object
CN103536527A (en) * 2013-09-16 2014-01-29 南通丝乡丝绸有限公司 Dextromethorphan hydrobromide injection and preparation method thereof
CN114569742A (en) * 2022-05-09 2022-06-03 北京剂泰医药科技有限公司 Composition and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS536416A (en) * 1976-07-01 1978-01-20 Emu Esu Shii Yuugen 55fluorouracli inclusion compound
JPS5592341A (en) * 1979-01-05 1980-07-12 Kaken Pharmaceut Co Ltd Preparation of clathrate compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS536416A (en) * 1976-07-01 1978-01-20 Emu Esu Shii Yuugen 55fluorouracli inclusion compound
JPS5592341A (en) * 1979-01-05 1980-07-12 Kaken Pharmaceut Co Ltd Preparation of clathrate compound

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02212429A (en) * 1989-02-14 1990-08-23 Sanraku Inc Hemoferrum-containing composition
CN100391454C (en) * 2003-09-03 2008-06-04 吕宝光 Preparation of hydrobromic acid dextro methaphen and beta cyclodeatrin compounding object
CN103536527A (en) * 2013-09-16 2014-01-29 南通丝乡丝绸有限公司 Dextromethorphan hydrobromide injection and preparation method thereof
CN114569742A (en) * 2022-05-09 2022-06-03 北京剂泰医药科技有限公司 Composition and preparation method and application thereof

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