GB1209849A - Composition for introducing alkoxybenzamides into the systemic circulatory system - Google Patents
Composition for introducing alkoxybenzamides into the systemic circulatory systemInfo
- Publication number
- GB1209849A GB1209849A GB7524/68A GB752468A GB1209849A GB 1209849 A GB1209849 A GB 1209849A GB 7524/68 A GB7524/68 A GB 7524/68A GB 752468 A GB752468 A GB 752468A GB 1209849 A GB1209849 A GB 1209849A
- Authority
- GB
- United Kingdom
- Prior art keywords
- composition
- circulatory system
- alkoxybenzamide
- ortho
- feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 230000009885 systemic effect Effects 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 abstract 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- JPKKQJKQTPNWTR-KQAYXBCTSA-N [(1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2r)-3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate Chemical compound O.OS(O)(=O)=O.C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1.C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 JPKKQJKQTPNWTR-KQAYXBCTSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229960004782 chlordiazepoxide Drugs 0.000 abstract 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 abstract 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 abstract 1
- 229960003291 chlorphenamine Drugs 0.000 abstract 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- 229960001985 dextromethorphan Drugs 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 229960002179 ephedrine Drugs 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 229940039009 isoproterenol Drugs 0.000 abstract 1
- 229960004815 meprobamate Drugs 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000006199 nebulizer Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229960001412 pentobarbital Drugs 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- OCSOHUROTFFTFO-UHFFFAOYSA-N styramate Chemical compound NC(=O)OCC(O)C1=CC=CC=C1 OCSOHUROTFFTFO-UHFFFAOYSA-N 0.000 abstract 1
- 229960001059 styramate Drugs 0.000 abstract 1
- 239000006190 sub-lingual tablet Substances 0.000 abstract 1
- 229940098466 sublingual tablet Drugs 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Abstract
1,209,849. Compositions comprising orthoalkoxybenzamides. COLGATE-PALMOLIVE CO. 15 Feb., 1968 [20 Feb., 1967], No. 7524/ 68. Heading A5B. An analgesic composition in the form of a nebulizer solution or a sublingual tablet comprises an ortho-alkoxybenzamide containing 1-5 carbon atoms in the alkoxy group and a compatible non-toxic carrier which affords rapid and substantially complete absorption of the ortho-alkoxybenzamide by an oral mucous membrane contiguous to the systemic circulatory system when in contact with the same, the carrier being (1) an aqueous mixture of ethanol and propylene glycol, the ethanol content not exceeding 18% by weight of the composition, or (2) a mixture comprising starch and a sweetener and flavour. Other active ingredients such as acetyl salicylic acid, chlorpheniramine, 2-(diphenyl-methoxy)-N,N-dimethylethylamine HCl, isoproterenol, ephedrine, pentobarbital, meprobamate, styramate, chlordiazepoxide HCl, dexamethane sulphate, atropine sulphate and dextromethorphan HBr may also be present.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61705867A | 1967-02-20 | 1967-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1209849A true GB1209849A (en) | 1970-10-21 |
Family
ID=24472090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7524/68A Expired GB1209849A (en) | 1967-02-20 | 1968-02-15 | Composition for introducing alkoxybenzamides into the systemic circulatory system |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3560625A (en) |
| AT (1) | AT277448B (en) |
| BE (1) | BE711048A (en) |
| DE (1) | DE1667872A1 (en) |
| ES (1) | ES349148A1 (en) |
| FR (1) | FR7355M (en) |
| GB (1) | GB1209849A (en) |
| GR (1) | GR36834B (en) |
| IE (1) | IE32432B1 (en) |
| NL (1) | NL6802422A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627915A1 (en) * | 1992-12-04 | 1994-12-14 | Mayor Pharmaceuticals Laboratories,Inc. | Sprayable analgesic composition and method of use |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3171774D1 (en) * | 1980-03-31 | 1985-09-19 | Teijin Ltd | Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom |
| US6730330B2 (en) | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
| HU227452B1 (en) * | 2001-02-14 | 2011-06-28 | Gw Pharma Ltd | Mucoadhesive pharmaceutical formulation |
| GB0103638D0 (en) * | 2001-02-14 | 2001-03-28 | Gw Pharmaceuticals Ltd | Pharmaceutical formulations |
| US10004684B2 (en) | 2001-02-14 | 2018-06-26 | Gw Pharma Limited | Pharmaceutical formulations |
| DK2314284T3 (en) | 2002-08-14 | 2017-05-22 | Gw Pharma Ltd | LIQUID CANNABINOID FORMULAS FOR MUSHROAD ADMINISTRATION |
-
1967
- 1967-02-20 US US617058A patent/US3560625A/en not_active Expired - Lifetime
- 1967-11-18 GR GR670136834A patent/GR36834B/en unknown
-
1968
- 1968-01-11 ES ES349148A patent/ES349148A1/en not_active Expired
- 1968-02-07 DE DE19681667872 patent/DE1667872A1/en active Pending
- 1968-02-15 GB GB7524/68A patent/GB1209849A/en not_active Expired
- 1968-02-19 AT AT152468A patent/AT277448B/en not_active IP Right Cessation
- 1968-02-19 IE IE206/68A patent/IE32432B1/en unknown
- 1968-02-19 FR FR140313A patent/FR7355M/fr not_active Expired
- 1968-02-20 BE BE711048D patent/BE711048A/xx unknown
- 1968-02-20 NL NL6802422A patent/NL6802422A/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627915A1 (en) * | 1992-12-04 | 1994-12-14 | Mayor Pharmaceuticals Laboratories,Inc. | Sprayable analgesic composition and method of use |
| EP0627915A4 (en) * | 1992-12-04 | 1996-02-07 | Mayor Pharma Lab Inc | Sprayable analgesic composition and method of use. |
Also Published As
| Publication number | Publication date |
|---|---|
| IE32432L (en) | 1968-08-20 |
| IE32432B1 (en) | 1973-08-08 |
| ES349148A1 (en) | 1969-09-01 |
| NL6802422A (en) | 1968-08-21 |
| US3560625A (en) | 1971-02-02 |
| FR7355M (en) | 1969-10-20 |
| AT277448B (en) | 1969-12-29 |
| BE711048A (en) | 1968-07-01 |
| GR36834B (en) | 1969-03-15 |
| DE1667872A1 (en) | 1971-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |