CN101258154B - 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 - Google Patents

作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 Download PDF

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Publication number
CN101258154B
CN101258154B CN2006800322776A CN200680032277A CN101258154B CN 101258154 B CN101258154 B CN 101258154B CN 2006800322776 A CN2006800322776 A CN 2006800322776A CN 200680032277 A CN200680032277 A CN 200680032277A CN 101258154 B CN101258154 B CN 101258154B
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CN
China
Prior art keywords
alkyl
azepine
phenyl
heteroaryl
aryl
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Expired - Fee Related
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CN2006800322776A
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English (en)
Chinese (zh)
Other versions
CN101258154A (zh
Inventor
马克·J·班福德
戴维·M·威尔逊
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of CN101258154A publication Critical patent/CN101258154A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2006800322776A 2005-07-06 2006-07-04 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 Expired - Fee Related CN101258154B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0513886.2 2005-07-06
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds
PCT/EP2006/006613 WO2007025596A1 (en) 2005-07-06 2006-07-04 Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists

Publications (2)

Publication Number Publication Date
CN101258154A CN101258154A (zh) 2008-09-03
CN101258154B true CN101258154B (zh) 2011-01-19

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800322776A Expired - Fee Related CN101258154B (zh) 2005-07-06 2006-07-04 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物

Country Status (27)

Country Link
US (1) US7888347B2 (https=)
EP (1) EP1899350B1 (https=)
JP (1) JP5145218B2 (https=)
KR (1) KR20080037651A (https=)
CN (1) CN101258154B (https=)
AT (1) ATE467636T1 (https=)
AU (1) AU2006286897A1 (https=)
BR (1) BRPI0612719A2 (https=)
CA (1) CA2614232A1 (https=)
CR (1) CR9622A (https=)
CY (1) CY1110711T1 (https=)
DE (1) DE602006014273D1 (https=)
DK (1) DK1899350T3 (https=)
EA (1) EA013600B1 (https=)
ES (1) ES2345841T3 (https=)
GB (1) GB0513886D0 (https=)
HR (1) HRP20100401T1 (https=)
IL (1) IL188184A0 (https=)
MA (1) MA29623B1 (https=)
MX (1) MX2008000383A (https=)
NO (1) NO20080563L (https=)
PL (1) PL1899350T3 (https=)
PT (1) PT1899350E (https=)
SI (1) SI1899350T1 (https=)
UA (1) UA93047C2 (https=)
WO (1) WO2007025596A1 (https=)
ZA (1) ZA200710798B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103382174A (zh) 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
KR20100059919A (ko) 2007-09-24 2010-06-04 코멘티스, 인코포레이티드 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
MX2018014034A (es) * 2016-05-25 2019-08-29 Akarna Therapeutics Ltd Compuestos bicíclicos fusionados para el tratamiento de enfermedades.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325267A (zh) * 1998-09-09 2001-12-05 石原产业株式会社 用作除草剂的稠合的苯衍生物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002542245A (ja) * 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 置換イミダゾール、それらの製造および使用
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
ES2283768T3 (es) * 2002-06-06 2007-11-01 Novo Nordisk A/S Hexahidropirrolo(1,2-a)piracinas, octahidropirido(1,2-a)piracinas y decahidropiracino(1,2-a)acepinas sustituidas.
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
JP2005537290A (ja) 2002-07-25 2005-12-08 ファルマシア・イタリア・エス・ピー・エー キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
EP1539704A1 (en) * 2002-08-20 2005-06-15 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP2133340B1 (en) 2002-12-20 2013-01-16 Glaxo Group Limited Novel benzazepine derivatives
SI1668014T1 (sl) * 2003-09-17 2009-06-30 Janssen Pharmaceutica Nv Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
WO2005123723A1 (en) 2004-06-18 2005-12-29 Glaxo Group Limited 3-cycloalkylbenzazepines as histamine h3 antagonists
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
RU2007125648A (ru) 2004-12-07 2009-01-20 Глэксо Груп Лимитед (GB) Инденильные производные и их применение для лечения неврологических расстройств
US20080161289A1 (en) 2005-03-14 2008-07-03 Glaxo Group Limited Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325267A (zh) * 1998-09-09 2001-12-05 石原产业株式会社 用作除草剂的稠合的苯衍生物

Also Published As

Publication number Publication date
ES2345841T3 (es) 2010-10-04
CN101258154A (zh) 2008-09-03
JP2009500366A (ja) 2009-01-08
WO2007025596A1 (en) 2007-03-08
EA200800264A1 (ru) 2008-06-30
SI1899350T1 (sl) 2010-09-30
MX2008000383A (es) 2008-03-07
CY1110711T1 (el) 2015-06-10
JP5145218B2 (ja) 2013-02-13
NO20080563L (no) 2008-02-01
EA013600B1 (ru) 2010-06-30
US7888347B2 (en) 2011-02-15
DE602006014273D1 (de) 2010-06-24
CR9622A (es) 2008-04-10
HRP20100401T1 (hr) 2010-09-30
IL188184A0 (en) 2008-03-20
UA93047C2 (ru) 2011-01-10
ATE467636T1 (de) 2010-05-15
DK1899350T3 (da) 2010-09-06
CA2614232A1 (en) 2007-03-08
GB0513886D0 (en) 2005-08-10
EP1899350A1 (en) 2008-03-19
PL1899350T3 (pl) 2010-10-29
PT1899350E (pt) 2010-07-21
EP1899350B1 (en) 2010-05-12
MA29623B1 (fr) 2008-07-01
AU2006286897A1 (en) 2007-03-08
ZA200710798B (en) 2008-11-26
KR20080037651A (ko) 2008-04-30
US20080176832A1 (en) 2008-07-24
BRPI0612719A2 (pt) 2010-11-30

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Granted publication date: 20110119

Termination date: 20130704