GB0513886D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
GB0513886D0
GB0513886D0 GBGB0513886.2A GB0513886A GB0513886D0 GB 0513886 D0 GB0513886 D0 GB 0513886D0 GB 0513886 A GB0513886 A GB 0513886A GB 0513886 D0 GB0513886 D0 GB 0513886D0
Authority
GB
United Kingdom
Prior art keywords
novel compounds
neurological
antagonists
processes
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0513886.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GBGB0513886.2A priority Critical patent/GB0513886D0/en
Publication of GB0513886D0 publication Critical patent/GB0513886D0/en
Priority to DE602006014273T priority patent/DE602006014273D1/de
Priority to EP06818218A priority patent/EP1899350B1/en
Priority to CA002614232A priority patent/CA2614232A1/en
Priority to JP2008519862A priority patent/JP5145218B2/ja
Priority to UAA200800190A priority patent/UA93047C2/ru
Priority to HR20100401T priority patent/HRP20100401T1/hr
Priority to AT06818218T priority patent/ATE467636T1/de
Priority to BRPI0612719-3A priority patent/BRPI0612719A2/pt
Priority to PT06818218T priority patent/PT1899350E/pt
Priority to MX2008000383A priority patent/MX2008000383A/es
Priority to DK06818218.7T priority patent/DK1899350T3/da
Priority to PL06818218T priority patent/PL1899350T3/pl
Priority to US11/994,689 priority patent/US7888347B2/en
Priority to KR1020087000265A priority patent/KR20080037651A/ko
Priority to ES06818218T priority patent/ES2345841T3/es
Priority to AU2006286897A priority patent/AU2006286897A1/en
Priority to SI200630733T priority patent/SI1899350T1/sl
Priority to PCT/EP2006/006613 priority patent/WO2007025596A1/en
Priority to EA200800264A priority patent/EA013600B1/ru
Priority to CN2006800322776A priority patent/CN101258154B/zh
Priority to ZA200710798A priority patent/ZA200710798B/xx
Priority to IL188184A priority patent/IL188184A0/en
Priority to CR9622A priority patent/CR9622A/es
Priority to MA30562A priority patent/MA29623B1/fr
Priority to NO20080563A priority patent/NO20080563L/no
Priority to CY20101100713T priority patent/CY1110711T1/el
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB0513886.2A 2005-07-06 2005-07-06 Novel compounds Ceased GB0513886D0 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds
CN2006800322776A CN101258154B (zh) 2005-07-06 2006-07-04 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物
PL06818218T PL1899350T3 (pl) 2005-07-06 2006-07-04 Pochodne pirazolo[3,4-d]azepiny jako antagoniści histaminy H3
KR1020087000265A KR20080037651A (ko) 2005-07-06 2006-07-04 히스타민 ｈ３ 길항제로서의 피라졸로 [３,４-ｄ] 아제핀유도체
CA002614232A CA2614232A1 (en) 2005-07-06 2006-07-04 Pyrazolo [3,4-d] azepine derivatives as histamine h3 antagonists
JP2008519862A JP5145218B2 (ja) 2005-07-06 2006-07-04 ヒスタミンｈ３アンタゴニストとしてのピラゾロ［３，４−ｄ］アゼピン誘導体
UAA200800190A UA93047C2 (ru) 2005-07-06 2006-07-04 ПРОИЗВОДНЫЕ ПИРАЗОЛО[3,4-d]АЗЕПИНА КАК АНТАГОНИСТЫ H3-РЕЦЕПТОРОВ ГИСТАМИНА
HR20100401T HRP20100401T1 (hr) 2005-07-06 2006-07-04 DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI
AT06818218T ATE467636T1 (de) 2005-07-06 2006-07-04 Pyrazoloä3 , 4-düazepinderivate als histamin-h3- antagonisten
BRPI0612719-3A BRPI0612719A2 (pt) 2005-07-06 2006-07-04 derivados de pirazol [3,4-d] azepina como antagonistas de histamina h3
PT06818218T PT1899350E (pt) 2005-07-06 2006-07-04 Derivados de pirazolo[3,4-d]azepina como antagonistas de histamina h3
MX2008000383A MX2008000383A (es) 2005-07-06 2006-07-04 Derivados de pirazolo [3,4-d] acepina como antagonistas de histamina h3.
DK06818218.7T DK1899350T3 (da) 2005-07-06 2006-07-04 Pyrazolo [3,4-D]azepinderivater som histamin-H3-antagonister
DE602006014273T DE602006014273D1 (de) 2005-07-06 2006-07-04 Pyrazoloä3 , 4-düazepinderivate als histamin-h3-antagonisten
US11/994,689 US7888347B2 (en) 2005-07-06 2006-07-04 Pyrazolo [3,4-D]azepine derivatives as histamine H3 antagonists
EP06818218A EP1899350B1 (en) 2005-07-06 2006-07-04 Pyrazolo [3 , 4-d]azepine derivatives as histamine h3 antagonists
ES06818218T ES2345841T3 (es) 2005-07-06 2006-07-04 Derivados de pirazolo(3,4-d)azepina como antagonistas de histamina h3.
AU2006286897A AU2006286897A1 (en) 2005-07-06 2006-07-04 Pyrazolo [3 , 4-d] azepine derivatives as histamine H3 antagonists
SI200630733T SI1899350T1 (sl) 2005-07-06 2006-07-04 Derivati pirazolo d azepina kot antagonisti histamina h
PCT/EP2006/006613 WO2007025596A1 (en) 2005-07-06 2006-07-04 Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists
EA200800264A EA013600B1 (ru) 2005-07-06 2006-07-04 Производные пиразоло[3, 4-d]азепина как антагонисты h3-рецепторов гистамина
ZA200710798A ZA200710798B (en) 2005-07-06 2007-12-12 Pyrazolo [3, 4-D] azepine derivatives as histamine H3 antagonists
IL188184A IL188184A0 (en) 2005-07-06 2007-12-17 Pyrazolo [3,4-d] azepine derivatives as histamine h3 antagonists
CR9622A CR9622A (es) 2005-07-06 2007-12-20 Derivados de pirazolo[3,4-d]azepina como antagonistas de histamina h3
MA30562A MA29623B1 (fr) 2005-07-06 2008-01-09 Derives de pyrazolo [3, 4-d] azepine comme antagonistes d'histamine h3
NO20080563A NO20080563L (no) 2005-07-06 2008-01-30 Pyrazol[3,4-d]azepinderivater som histamin H3 antagonister
CY20101100713T CY1110711T1 (el) 2005-07-06 2010-07-29 Παραγωγα πυραζολο [3,4-d]αζεπινης ως ανταγωνιστες ισταμινης η3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds

Publications (1)

Publication Number Publication Date
GB0513886D0 true GB0513886D0 (en) 2005-08-10

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0513886.2A Ceased GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds

Country Status (27)

Country Link
US (1) US7888347B2 (https=)
EP (1) EP1899350B1 (https=)
JP (1) JP5145218B2 (https=)
KR (1) KR20080037651A (https=)
CN (1) CN101258154B (https=)
AT (1) ATE467636T1 (https=)
AU (1) AU2006286897A1 (https=)
BR (1) BRPI0612719A2 (https=)
CA (1) CA2614232A1 (https=)
CR (1) CR9622A (https=)
CY (1) CY1110711T1 (https=)
DE (1) DE602006014273D1 (https=)
DK (1) DK1899350T3 (https=)
EA (1) EA013600B1 (https=)
ES (1) ES2345841T3 (https=)
GB (1) GB0513886D0 (https=)
HR (1) HRP20100401T1 (https=)
IL (1) IL188184A0 (https=)
MA (1) MA29623B1 (https=)
MX (1) MX2008000383A (https=)
NO (1) NO20080563L (https=)
PL (1) PL1899350T3 (https=)
PT (1) PT1899350E (https=)
SI (1) SI1899350T1 (https=)
UA (1) UA93047C2 (https=)
WO (1) WO2007025596A1 (https=)
ZA (1) ZA200710798B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103382174A (zh) 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
KR20100059919A (ko) 2007-09-24 2010-06-04 코멘티스, 인코포레이티드 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
MX2018014034A (es) * 2016-05-25 2019-08-29 Akarna Therapeutics Ltd Compuestos bicíclicos fusionados para el tratamiento de enfermedades.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6018799A (en) * 1998-09-09 2000-03-27 Ishihara Sangyo Kaisha Ltd. Fused-benzene derivatives useful as herbicides
JP2002542245A (ja) * 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 置換イミダゾール、それらの製造および使用
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
ES2283768T3 (es) * 2002-06-06 2007-11-01 Novo Nordisk A/S Hexahidropirrolo(1,2-a)piracinas, octahidropirido(1,2-a)piracinas y decahidropiracino(1,2-a)acepinas sustituidas.
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
JP2005537290A (ja) 2002-07-25 2005-12-08 ファルマシア・イタリア・エス・ピー・エー キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
EP1539704A1 (en) * 2002-08-20 2005-06-15 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
EP2133340B1 (en) 2002-12-20 2013-01-16 Glaxo Group Limited Novel benzazepine derivatives
SI1668014T1 (sl) * 2003-09-17 2009-06-30 Janssen Pharmaceutica Nv Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
WO2005123723A1 (en) 2004-06-18 2005-12-29 Glaxo Group Limited 3-cycloalkylbenzazepines as histamine h3 antagonists
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
RU2007125648A (ru) 2004-12-07 2009-01-20 Глэксо Груп Лимитед (GB) Инденильные производные и их применение для лечения неврологических расстройств
US20080161289A1 (en) 2005-03-14 2008-07-03 Glaxo Group Limited Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor

Also Published As

Publication number Publication date
ES2345841T3 (es) 2010-10-04
CN101258154A (zh) 2008-09-03
JP2009500366A (ja) 2009-01-08
WO2007025596A1 (en) 2007-03-08
EA200800264A1 (ru) 2008-06-30
SI1899350T1 (sl) 2010-09-30
MX2008000383A (es) 2008-03-07
CY1110711T1 (el) 2015-06-10
JP5145218B2 (ja) 2013-02-13
NO20080563L (no) 2008-02-01
EA013600B1 (ru) 2010-06-30
US7888347B2 (en) 2011-02-15
DE602006014273D1 (de) 2010-06-24
CN101258154B (zh) 2011-01-19
CR9622A (es) 2008-04-10
HRP20100401T1 (hr) 2010-09-30
IL188184A0 (en) 2008-03-20
UA93047C2 (ru) 2011-01-10
ATE467636T1 (de) 2010-05-15
DK1899350T3 (da) 2010-09-06
CA2614232A1 (en) 2007-03-08
EP1899350A1 (en) 2008-03-19
PL1899350T3 (pl) 2010-10-29
PT1899350E (pt) 2010-07-21
EP1899350B1 (en) 2010-05-12
MA29623B1 (fr) 2008-07-01
AU2006286897A1 (en) 2007-03-08
ZA200710798B (en) 2008-11-26
KR20080037651A (ko) 2008-04-30
US20080176832A1 (en) 2008-07-24
BRPI0612719A2 (pt) 2010-11-30

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)