CN101223170A - Tpl2激酶的4,6-二氨基-[1,7]萘啶-3-甲腈抑制剂以及其制备和使用方法 - Google Patents
Tpl2激酶的4,6-二氨基-[1,7]萘啶-3-甲腈抑制剂以及其制备和使用方法 Download PDFInfo
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- CN101223170A CN101223170A CNA2006800261965A CN200680026196A CN101223170A CN 101223170 A CN101223170 A CN 101223170A CN A2006800261965 A CNA2006800261965 A CN A2006800261965A CN 200680026196 A CN200680026196 A CN 200680026196A CN 101223170 A CN101223170 A CN 101223170A
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- amino
- alkyl
- naphthyridines
- compound
- formonitrile hcn
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68204405P | 2005-05-18 | 2005-05-18 | |
| US60/682,044 | 2005-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101223170A true CN101223170A (zh) | 2008-07-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800261965A Pending CN101223170A (zh) | 2005-05-18 | 2006-05-17 | Tpl2激酶的4,6-二氨基-[1,7]萘啶-3-甲腈抑制剂以及其制备和使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7432279B2 (en:Method) |
| EP (1) | EP1881981A1 (en:Method) |
| JP (1) | JP2008540667A (en:Method) |
| CN (1) | CN101223170A (en:Method) |
| AU (1) | AU2006247315A1 (en:Method) |
| BR (1) | BRPI0611521A2 (en:Method) |
| CA (1) | CA2608362A1 (en:Method) |
| MX (1) | MX2007014258A (en:Method) |
| WO (1) | WO2006124944A1 (en:Method) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102408426A (zh) * | 2011-09-14 | 2012-04-11 | 湖南有色凯铂生物药业有限公司 | 取代的芳香脲类化合物及其作为抗癌药物的应用 |
| CN107922390A (zh) * | 2015-07-06 | 2018-04-17 | 吉利德科学公司 | Cot调节剂及其使用方法 |
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| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| CN103261167B (zh) * | 2010-12-17 | 2016-05-04 | 霍夫曼-拉罗奇有限公司 | 取代的6，6-稠合含氮杂环化合物及其用途 |
| MX336378B (es) | 2011-08-12 | 2016-01-15 | Senomyx Inc | Modificador del sabor dulce. |
| GB201118675D0 (en) * | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
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| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
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| IN2015DN03795A (en:Method) | 2012-10-24 | 2015-10-02 | Inserm Inst Nat De La Santé Et De La Rech Médicale | |
| WO2014204261A1 (ko) * | 2013-06-21 | 2014-12-24 | 사회복지법인 삼성생명공익재단 | Tpl2의 발현억제제 또는 활성억제제를 유효성분으로 포함하는 신세포암의 예방 또는 치료용 약학적 조성물 |
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| US6355636B1 (en) * | 1999-04-21 | 2002-03-12 | American Cyanamid Company | Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases |
| US6548496B2 (en) | 1999-04-21 | 2003-04-15 | American Cyanamid Company | Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases |
| CZ20013660A3 (cs) * | 1999-04-21 | 2002-01-16 | American Cyanamid Company | Substituované 3-kyano-(1,7),(1,5) a (1,8)-naftyridinové inhibitory tyrosinových kináz |
| US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
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- 2006-05-17 BR BRPI0611521-7A patent/BRPI0611521A2/pt not_active Application Discontinuation
- 2006-05-17 EP EP06759971A patent/EP1881981A1/en not_active Withdrawn
- 2006-05-17 CN CNA2006800261965A patent/CN101223170A/zh active Pending
- 2006-05-17 AU AU2006247315A patent/AU2006247315A1/en not_active Abandoned
- 2006-05-17 MX MX2007014258A patent/MX2007014258A/es active IP Right Grant
- 2006-05-17 CA CA002608362A patent/CA2608362A1/en not_active Abandoned
- 2006-05-17 JP JP2008512451A patent/JP2008540667A/ja not_active Withdrawn
- 2006-05-18 US US11/436,328 patent/US7432279B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102408426A (zh) * | 2011-09-14 | 2012-04-11 | 湖南有色凯铂生物药业有限公司 | 取代的芳香脲类化合物及其作为抗癌药物的应用 |
| CN107922390A (zh) * | 2015-07-06 | 2018-04-17 | 吉利德科学公司 | Cot调节剂及其使用方法 |
| CN107922390B (zh) * | 2015-07-06 | 2019-05-10 | 吉利德科学公司 | Cot调节剂及其使用方法 |
Also Published As
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| WO2006124944A1 (en) | 2006-11-23 |
| JP2008540667A (ja) | 2008-11-20 |
| US20060276498A1 (en) | 2006-12-07 |
| AU2006247315A1 (en) | 2006-11-23 |
| US7432279B2 (en) | 2008-10-07 |
| BRPI0611521A2 (pt) | 2010-09-14 |
| EP1881981A1 (en) | 2008-01-30 |
| CA2608362A1 (en) | 2006-11-23 |
| MX2007014258A (es) | 2008-01-22 |
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