CN101217947B - 包含壳聚糖和环糊精的纳米颗粒 - Google Patents

包含壳聚糖和环糊精的纳米颗粒 Download PDF

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Publication number
CN101217947B
CN101217947B CN2006800208889A CN200680020888A CN101217947B CN 101217947 B CN101217947 B CN 101217947B CN 2006800208889 A CN2006800208889 A CN 2006800208889A CN 200680020888 A CN200680020888 A CN 200680020888A CN 101217947 B CN101217947 B CN 101217947B
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China
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cyclodextrin
chitosan
nanoparticles
molecules
biologically active
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Expired - Fee Related
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CN2006800208889A
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Chinese (zh)
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CN101217947A (zh
Inventor
M<sup>a</sup>何赛·阿隆索费尔南德斯
马罗什·加西亚富恩特斯
弗兰切斯卡·马埃斯特雷利
保拉·穆拉
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Universidade de Santiago de Compostela
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Universidade de Santiago de Compostela
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
CN2006800208889A 2005-06-02 2006-06-01 包含壳聚糖和环糊精的纳米颗粒 Expired - Fee Related CN101217947B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200501331 2005-06-02
ES200501331A ES2277743B2 (es) 2005-06-02 2005-06-02 Nanoparticulas que comprenden quitosano y ciclodextrina.
PCT/ES2006/000322 WO2006128937A2 (es) 2005-06-02 2006-06-01 Nanoparticulas que comprenden quitosano y ciclodextrina

Publications (2)

Publication Number Publication Date
CN101217947A CN101217947A (zh) 2008-07-09
CN101217947B true CN101217947B (zh) 2012-04-25

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CN2006800208889A Expired - Fee Related CN101217947B (zh) 2005-06-02 2006-06-01 包含壳聚糖和环糊精的纳米颗粒

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Country Link
US (1) US20080220030A1 (enExample)
EP (1) EP1891943A2 (enExample)
JP (1) JP5191884B2 (enExample)
KR (1) KR20080019014A (enExample)
CN (1) CN101217947B (enExample)
AU (1) AU2006254128A1 (enExample)
BR (1) BRPI0613234A2 (enExample)
CA (1) CA2610403A1 (enExample)
ES (1) ES2277743B2 (enExample)
IL (1) IL187696A0 (enExample)
WO (1) WO2006128937A2 (enExample)

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US8372877B2 (en) * 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
CN102008450B (zh) * 2010-12-10 2013-01-30 杭州艾瑞莎生物医药科技有限公司 一种药物-环糊精纳米颗粒及其制备方法
CN102416000B (zh) * 2011-12-13 2013-04-10 张维芬 一种用于肺吸入的壳聚糖季铵盐大孔微球及其制备方法
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CN102908315B (zh) * 2012-11-02 2014-06-04 上海现代药物制剂工程研究中心有限公司 小分子干扰核糖核酸的壳聚糖纳米粒传递系统及制备方法
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CN106822914A (zh) * 2017-01-10 2017-06-13 安徽师范大学 一种羧甲基‑β‑环糊精接枝壳聚糖离子交联纳米粒、制备方法及其应用
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CN110522921A (zh) * 2018-05-24 2019-12-03 广东省医疗器械研究所 一种具有胰岛素捕获功能的胰岛素输运体系的合成方法
CN108849995B (zh) * 2018-06-12 2020-06-30 甘肃省科学院生物研究所 黄帚橐吾提取物纳米杀虫剂及其制备方法
CN109012629B (zh) * 2018-08-16 2021-07-30 南京大学 一种制备磁性羧甲基β-环糊精聚合物的方法及其应用
KR102034982B1 (ko) * 2019-03-08 2019-10-21 주식회사 제론바이오 Pdrn이 캡슐화된 키토산 나노 입자가 포함된 점안제 및 이의 제조 방법
CN109908367A (zh) * 2019-04-30 2019-06-21 南开大学 磺胺酸-β-环糊精介导的超分子纳米粒子在胰岛素的控制释放方面的应用
CN110384684B (zh) * 2019-08-26 2021-04-06 安徽农业大学 一种单羧基壳聚糖/紫草素复合纳米颗粒及其制备方法
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JP7319931B2 (ja) * 2020-01-22 2023-08-02 オリエンタル酵母工業株式会社 キトサン部分分解物の安定化方法、キトサン部分分解物の保存方法および食品用保存剤
KR102172667B1 (ko) * 2020-02-05 2020-11-02 이채현 덱스트린 글루코노 락톤 술폰 유도체의 제조 방법 및 약제학적 조성물 이를 이용한 동물, 인간, 어류 등의 바이러스 질환 예방 및 치료제
CN111437381B (zh) * 2020-02-13 2023-12-12 汕头大学 一种水凝胶微粒及其制备方法
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CN114904493B (zh) * 2022-03-31 2024-09-06 中科院广州化学有限公司 一种离子交联β-环糊精聚合物及其制备方法与应用
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Publication number Publication date
CN101217947A (zh) 2008-07-09
IL187696A0 (en) 2008-08-07
ES2277743B2 (es) 2008-12-16
JP2008542342A (ja) 2008-11-27
BRPI0613234A2 (pt) 2010-12-28
KR20080019014A (ko) 2008-02-29
AU2006254128A1 (en) 2006-12-07
CA2610403A1 (en) 2006-12-07
WO2006128937A3 (es) 2007-02-15
US20080220030A1 (en) 2008-09-11
EP1891943A2 (en) 2008-02-27
JP5191884B2 (ja) 2013-05-08
WO2006128937A2 (es) 2006-12-07
ES2277743A1 (es) 2007-07-16

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