CN101153012A - 一种决奈达隆关键中间体的新的制备方法 - Google Patents
一种决奈达隆关键中间体的新的制备方法 Download PDFInfo
- Publication number
- CN101153012A CN101153012A CN 200610113471 CN200610113471A CN101153012A CN 101153012 A CN101153012 A CN 101153012A CN 200610113471 CN200610113471 CN 200610113471 CN 200610113471 A CN200610113471 A CN 200610113471A CN 101153012 A CN101153012 A CN 101153012A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- propoxy
- alkyl
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200610113471 CN101153012B (zh) | 2006-09-29 | 2006-09-29 | 一种决奈达隆关键中间体的新的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200610113471 CN101153012B (zh) | 2006-09-29 | 2006-09-29 | 一种决奈达隆关键中间体的新的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101153012A true CN101153012A (zh) | 2008-04-02 |
CN101153012B CN101153012B (zh) | 2010-06-23 |
Family
ID=39254923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200610113471 Expired - Fee Related CN101153012B (zh) | 2006-09-29 | 2006-09-29 | 一种决奈达隆关键中间体的新的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101153012B (zh) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101993383A (zh) * | 2009-08-26 | 2011-03-30 | 成都伊诺达博医药科技有限公司 | 决奈达隆关键中间体4-[3-(二丁氨基)丙氧基]苯甲酸甲酯的新合成方法 |
EP2388256A1 (en) | 2007-10-02 | 2011-11-23 | Cambrex Karlskoga AB | Process for preparing benzofurans |
CN102321058A (zh) * | 2011-07-20 | 2012-01-18 | 北京赛科药业有限责任公司 | 一种合成盐酸决奈达隆的方法 |
CN102382087A (zh) * | 2011-10-20 | 2012-03-21 | 南京工业大学 | 一种盐酸决奈达隆的制备方法 |
CN102471302A (zh) * | 2010-06-09 | 2012-05-23 | 江苏恒瑞医药股份有限公司 | 决奈达隆及其盐的制备方法 |
CN102666522A (zh) * | 2010-01-08 | 2012-09-12 | 赛诺菲 | 决奈达隆的新的制备方法 |
CN102741238A (zh) * | 2009-12-08 | 2012-10-17 | 赛诺菲 | 制备决奈达隆的新方法 |
US8410167B2 (en) | 2008-04-17 | 2013-04-02 | Sanofi | Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality |
US8602215B2 (en) | 2010-06-30 | 2013-12-10 | Sanofi | Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation |
CN103562195A (zh) * | 2011-03-29 | 2014-02-05 | 赛诺菲 | 通过n-丁基化制备决奈达隆的方法 |
CN103562196A (zh) * | 2011-03-29 | 2014-02-05 | 赛诺菲 | 使用胺中间体化合物制备决奈达隆的还原胺化方法 |
CN103562194A (zh) * | 2011-03-24 | 2014-02-05 | 赛诺菲 | 合成酮基-苯并呋喃衍生物的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2817864B1 (fr) * | 2000-12-11 | 2003-02-21 | Sanofi Synthelabo | Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese |
IL146389A0 (en) * | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
-
2006
- 2006-09-29 CN CN 200610113471 patent/CN101153012B/zh not_active Expired - Fee Related
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2388256A1 (en) | 2007-10-02 | 2011-11-23 | Cambrex Karlskoga AB | Process for preparing benzofurans |
US8410167B2 (en) | 2008-04-17 | 2013-04-02 | Sanofi | Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality |
CN101993383A (zh) * | 2009-08-26 | 2011-03-30 | 成都伊诺达博医药科技有限公司 | 决奈达隆关键中间体4-[3-(二丁氨基)丙氧基]苯甲酸甲酯的新合成方法 |
CN102741238A (zh) * | 2009-12-08 | 2012-10-17 | 赛诺菲 | 制备决奈达隆的新方法 |
CN102666522A (zh) * | 2010-01-08 | 2012-09-12 | 赛诺菲 | 决奈达隆的新的制备方法 |
CN102471302B (zh) * | 2010-06-09 | 2014-03-26 | 江苏恒瑞医药股份有限公司 | 决奈达隆及其盐的制备方法 |
CN102471302A (zh) * | 2010-06-09 | 2012-05-23 | 江苏恒瑞医药股份有限公司 | 决奈达隆及其盐的制备方法 |
US8602215B2 (en) | 2010-06-30 | 2013-12-10 | Sanofi | Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation |
CN103562194A (zh) * | 2011-03-24 | 2014-02-05 | 赛诺菲 | 合成酮基-苯并呋喃衍生物的方法 |
CN103562195A (zh) * | 2011-03-29 | 2014-02-05 | 赛诺菲 | 通过n-丁基化制备决奈达隆的方法 |
CN103562196A (zh) * | 2011-03-29 | 2014-02-05 | 赛诺菲 | 使用胺中间体化合物制备决奈达隆的还原胺化方法 |
CN102321058A (zh) * | 2011-07-20 | 2012-01-18 | 北京赛科药业有限责任公司 | 一种合成盐酸决奈达隆的方法 |
CN102321058B (zh) * | 2011-07-20 | 2014-07-02 | 华润赛科药业有限责任公司 | 一种合成盐酸决奈达隆的方法 |
CN102382087A (zh) * | 2011-10-20 | 2012-03-21 | 南京工业大学 | 一种盐酸决奈达隆的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101153012B (zh) | 2010-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101153012B (zh) | 一种决奈达隆关键中间体的新的制备方法 | |
US4207324A (en) | 1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use | |
CN109020881B (zh) | 一种阿帕替尼的制备方法 | |
CA2384099A1 (en) | Compositions and therapeutic methods involving isoflavones and analogues thereof | |
CN103819450B (zh) | 一种苯甲酸阿格列汀的新制备方法 | |
CN112079848A (zh) | 巴洛沙韦关键中间体的合成方法 | |
CN113233975A (zh) | 一种贝派地酸的制备方法 | |
CN109553513A (zh) | 一种美托洛尔中间体的制备方法 | |
CN112592356A (zh) | 氯诺昔康的合成方法 | |
CN112062712A (zh) | 一种2-(5-溴-3-甲基吡啶-2-基)乙酸盐酸盐的制备方法 | |
CN101817773A (zh) | 手性α-非天然氨基酸的制备方法 | |
CN110183357B (zh) | 一种用于制备沙库比曲中间体的制备方法 | |
CN101717359A (zh) | 吲达帕胺的合成方法 | |
CN100537552C (zh) | 一种制备瑞格列奈的方法 | |
CN104844593A (zh) | 一种阿哌沙班药物中间体的合成方法 | |
CN102675267B (zh) | 盐酸决奈达隆及其中间体的制备方法 | |
CN108707111A (zh) | 一种6(5h)-菲啶酮衍生物的绿色合成方法 | |
CN101948455A (zh) | 一种2-正丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃的制备方法 | |
CN100368375C (zh) | 3-烷氧基-4-烷氧羰基苯乙酸酯及3-烷氧基-4-烷氧羰基苯乙酸的合成方法 | |
CN113816914A (zh) | 一种劳拉西泮中间体的制备方法 | |
CN112645896A (zh) | 一种合成4-芳基异恶唑衍生物的方法 | |
CN104292133A (zh) | 一种抗癌药物伏立诺他的合成方法 | |
CN110372603A (zh) | 一种2-氯-5-氟-6-乙基嘧啶的合成方法 | |
CN106946771B (zh) | 一种3-羟基吡啶类化合物的制备方法 | |
CN114349693B (zh) | 一种度鲁特韦关键中间体的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING VENTUREPHARM BIOTECHNOLOGY CORP. Free format text: FORMER OWNER: DEZHONG WANQUAN PHARMACEUTICALS TECH. DEV. CO., LTD., BEIJING Effective date: 20140926 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100097 HAIDIAN, BEIJING TO: 102206 CHANGPING, BEIJING |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140926 Address after: 102206 Beijing City, Changping District Zhongguancun Life Science Park Boda tower Patentee after: Beijing Wanquan Dezhong Medical Biological Technology Co., Ltd. Address before: 100097 Beijing city Haidian District Sijiqing Wanquan Zhuang 3 Building Patentee before: Dezhong Wanquan Pharmaceuticals Tech. Dev. Co., Ltd., Beijing |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100623 Termination date: 20140929 |
|
EXPY | Termination of patent right or utility model |