CN101130067B - Preparation for replenishing collagen and method of preparing the same - Google Patents
Preparation for replenishing collagen and method of preparing the same Download PDFInfo
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- CN101130067B CN101130067B CN2007101193177A CN200710119317A CN101130067B CN 101130067 B CN101130067 B CN 101130067B CN 2007101193177 A CN2007101193177 A CN 2007101193177A CN 200710119317 A CN200710119317 A CN 200710119317A CN 101130067 B CN101130067 B CN 101130067B
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Abstract
The invention provides a collagen vitamin C effervescent tablet having qualified hardness and quick disintegration and process for preparation, wherein the active constituents includes collagen and vitamin C whose content is 1-50wt%, preferably 5-20wt% and most preferably 8-15%, the auxiliary material comprises effervescent agent, diluent, penetration enhancer and lubricating agent, wherein the penetration enhancer can be selected from sodium chloride with a content of 1-20wt%, preferably 2:-15%, most preferably 5-10%.
Description
Technical field
The present invention relates to a kind of health care medicine and preparation method thereof, particularly a kind of collagen protein and ascorbic effervescent tablet and preparation method thereof of containing with replenishing collagen effect.
Background technology
The skin corium of skin contains abundant collagen protein, collagen protein is by the fibrous transparent colloid substance of triple helix, it is the main structural protein in the connective tissue, they are arranged in order, connect alternately with elastin laminin and to form netted structure, just as the reinforcing bar framework of building supports the plentiful of skin.The retractility of collagen protein is being kept skin elasticity and automatic restorable performance.Collagen protein also adsorbs large quantity of moisture, prevents water evaporates, keeps skin water profit gloss.Collagen protein accounts for the 70-80% of skin dry weight, is the important structure composition of skin, is again indispensable nutrient and protective agent.Hydroxyproline in the collagen protein is the key substance that skin connective tissue forms; Fibrous collagen protein forms network structure, and the tension force and the elastic support of skin are provided.Collagen protein in the skin corium still is epidermal area and skin accessory organ's nutrition supply station, keeps the supply of skin homeostasis and skin histology moisture, nutrition.Therefore, the growth of skin, reparation and nutrition all be unable to do without collagen protein.Collagen protein has important effect aspect delay skin aging.The collagen protein of human body is in constantly in synthetic and the degraded, and the speed of its renewal reduces with age, and the generation of collagen protein reduces in the skin, and the degraded and absorbed of distortion collagen protein also slows down, and makes skin connective tissue aged deterioration gradually.Replenish fresh collagen protein and can promote skin metabolism, activate the synthetic of collagen protein and upgrade the decline of delaying skin structure and function.If can in time replenish skin collagen, keep the thickness of dermal layer of the skin on the one hand, the deep layer damage of shielding of ultraviolet; Promote the degraded of the synthetic and Denatured protein of collagen protein to remove on the one hand, skin repair after the acceleration Exposure to Sunlight then can effectively prevent skin ageing phenomenon, reduces wrinkle and mottle and produces, and keeps skin smooth elasticity, tender pale.Collagen protein effect aspect crease-resistant Firm is obvious, and it supplies with the necessary nutrient of skin, increases skin collagen content, and it is full that skin corium is obtained, and recovers the plump and elasticity of skin, prevents that wrinkle from producing.Collagen protein also has unique repair function, can effectively promote skin regeneration, helps the skin of damaged or depression to recover normal.For example by nourishing skin corium, the cicatrix that the serious acne of deep layer reparation causes; Promote pathological tissues to upgrade, remove sick damage such as scytitis, skin sore, the skin of getting well.
Vitamin C is one of composition that forms collagen protein, helps tooth, skeleton, and the health of skin and blood vessel, accelerating wound healing increases the resistance to disease, helps the absorption of human body to ferrum and calcium, is one of essential antioxidant of health.Associating replenishing collagen and vitamin C, both the collagen protein of disappearance in the added body rapidly also can make the proteic synthetic increase of self collagen in the body, played collaborative effect.Therefore, associating replenishing collagen and vitamin C, has the skin of preventing wrinkle, make skin keep effect smooth, springy, and can nourish the tissue of concluding of skin, hair, fingernail and whole body, effectively eliminate the skin speckle, remove black speck, senile plaque, aging resistance, anti-wrinkle, looks improving and the skin nourishing; Can promote skin regeneration, recover elasticity, improve hair quality, make hair pitch-black beautiful, nourish hair, prevent that the hair bifurcated is rotten, prevent poliosis, alopecia; Can the powerful metabolic effect that promotes skin, hair, fingernail cell.
Effervescent tablet is to be a kind of novel form that disintegrating agent is made with the effervescent material, drop in the water and can produce a large amount of bubbles, and dissolving within a short period of time, have characteristics such as onset is rapid, bioavailability is high, easy to carry, with the characteristics of solid preparation and liquid preparation.And the oral administration effervescing sheet is specially adapted to the patient of child, old people and the solid preparation of can not swallowing.The disintegrate of effervescent tablet in water can not be leaned on manual the stirring and mechanical agitation, dependence be that sour agent is stirred with the carbon dioxide air source that the alkaline agent reaction discharges, the prescription composition is unreasonable, can influence the disintegration rate of whole effervescent tablet in water.When disintegration rate is slack-off, can influence the patience of consumer, its commercial value sharply descends.
Chinese patent CN1939535A discloses and has a kind ofly contained collagen protein and ascorbic composite collagen protein liquid, but said preparation is a liquid form.CN173979 discloses a kind of compound prescription of replenishing collagen, wherein only discloses to contain collagen protein, ascorbic capsule, powder and tablet, but does not disclose effervescent tablet.Because of collagen protein content in preparation many, its compressibility is relatively poor again, as very big difficulty arranged when preparing effervescent tablet, be difficult to when hardness is qualified, satisfy the requirement of rapid disintegrate, therefore, do not have the ascorbic effervescent tablet of collagen protein on the market, document does not also disclose the correlational study of collagen protein vitamin C effervescent tablet.
Summary of the invention
The purpose of this invention is to provide that a kind of hardness is qualified, the disintegrate ascorbic effervescent tablet of collagen protein rapidly, specifically, be a kind of be the effervescent tablet that active component is prepared from collagen protein and vitamin C, adjuvant contains effervescent, diluent, permeation-promoter and lubricant, wherein, permeation-promoter is selected from sodium chloride, and active component collagen protein and the vitamin C content in preparation is 1 to 50% by weight percentage, preferred 5-20%, most preferably 8-15%.The content of permeation-promoter in preparation is 1 to 20% by weight percentage, preferred 2-15%, most preferably 5-10%.
In effervescent tablet of the present invention, effervescent is made up of acid source and carbon dioxide source, wherein, acid source can be selected from one or more in citric acid, tartaric acid, fumaric acid, malic acid, anhydrous citric acid, the sodium dihydrogen citrate salt, optimization citric acid, anhydrous citric acid or its mixture.Carbon dioxide source can be selected from one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium carbonate, the calcium bicarbonate, preferred sodium bicarbonate.Diluent can be selected from one or more in lactose, mannitol, the sorbitol, preferred lactose.Lubricant can be one or more in Polyethylene Glycol, silicon dioxide, Pulvis Talci, the magnesium stearate, preferred Polyethylene Glycol, most preferably polyethylene glycol 6000.Wherein, the content of effervescent in preparation is 30 to 60% by weight percentage, preferred 40-50%.
Can also randomly add sweeting agent or aromatic in the effervescent tablet of the present invention, wherein, sweeting agent can be selected from glucide or its sodium salt, stevioside, aspartame, cyclamate, glycyrrhizin, preferably saccharin sodium, stevioside, aspartame.Aromatic in the effervescent tablet can be selected from various natural and artificial essence and fragrant flavoring agent, concrete as vanillin, cinnamic aldehyde, fragrant lance alcohol, eucalyptol, petitgrain oil, fennel oil, menthol, Oleum menthae, Fructus Citri Limoniae essence, cherry essence, strawberry essence, flavoring pineapple essence, Fructus Myricae rubrae essence, grape essence, chocolate essence, coffee aroma, flavoring peach essence, preferably vanillin, fennel oil, menthol, Fructus Citri Limoniae essence, grape essence, chocolate essence.Effervescent tablet can not add coloring agent in addition, also can add coloring agent, concrete coloring agent that adds such as carotene, sunset yellow, beet red, lemon yellow, chlorophyll, carmine, amaranth, erythrosine.
Effervescent tablet of the present invention has qualified hardness, in water disintegrate rapid, good mouthfeel has good use compliance., the disintegration time of effervescent tablet of the present invention in water was less than 2 minutes, and preferably less than 1 minute, hardness is preferably greater than 30N greater than 20N, more preferably greater than 40N.
Another object of the present invention has provided the preparation method of the ascorbic effervescent tablet of a kind of collagen protein, specifically, be a kind of be the preparation method of the effervescent tablet of active component with collagen protein and vitamin C, the adjuvant of this effervescent tablet contains effervescent, diluent, permeation-promoter and lubricant, wherein, permeation-promoter is selected from sodium chloride, and active component collagen protein and the vitamin C content in preparation is 1 to 50% by weight percentage, preferred 5-20%, most preferably 8-15%.
The preparation method of the collagen protein vitamin C fizzy tablet of this method may further comprise the steps: after collagen protein powder, effervescent, mixing diluents, granulation, dry, granulate, granule adds vitamin C, permeation-promoter and lubricant (as needs, also can randomly add sweeting agent, aromatic and/or coloring agent), mix the back tabletting.
Used wetting agent and/or the binding agent of granulation can be dehydrated alcohol, HPMC alcoholic solution, PVP alcoholic solution or other suitable wetting agent and/or binding agent among the present invention, preferred dehydrated alcohol.
The effervescent of pressing in the prepared collagen protein vitamin C effervescent tablet of the inventive method is made up of acid source and carbon dioxide source, wherein, acid source can be selected from one or more in citric acid, tartaric acid, fumaric acid, malic acid, anhydrous citric acid, the sodium dihydrogen citrate salt, optimization citric acid, anhydrous citric acid or its mixture.Carbon dioxide source can be selected from one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium carbonate, the calcium bicarbonate, preferred sodium bicarbonate.Diluent can be selected from one or more in lactose, mannitol, the sorbitol, preferred lactose.Lubricant can be one or more in Polyethylene Glycol, silicon dioxide, Pulvis Talci, the magnesium stearate, preferred Polyethylene Glycol, most preferably polyethylene glycol 6000.Wherein, the content of effervescent in preparation is 30 to 60% by weight percentage, preferred 40-50%.
By can also randomly adding sweeting agent or aromatic in the prepared collagen protein vitamin C effervescent tablet of the inventive method, wherein, sweeting agent can be selected from glucide or its sodium salt, stevioside, aspartame, cyclamate, glycyrrhizin, preferably saccharin sodium, stevioside, aspartame.Aromatic in the effervescent tablet can be selected from various natural and artificial essence and fragrant flavoring agent, concrete as vanillin, cinnamic aldehyde, fragrant lance alcohol, eucalyptol, petitgrain oil, fennel oil, menthol, Oleum menthae, Fructus Citri Limoniae essence, cherry essence, strawberry essence, flavoring pineapple essence, Fructus Myricae rubrae essence, grape essence, chocolate essence, coffee aroma, flavoring peach essence, preferably vanillin, fennel oil, menthol, Fructus Citri Limoniae essence, grape essence, chocolate essence.Effervescent tablet can not add coloring agent in addition, also can add coloring agent, concrete coloring agent that adds such as carotene, sunset yellow, beet red, lemon yellow, chlorophyll, carmine, amaranth, erythrosine.
Various improvement of the present invention and variation it will be apparent to those skilled in the art that, and without prejudice to the spirit and scope of the present invention.Below concrete preferred implementation the present invention has been described, should not be limited to following specific embodiments but should understand claimed the present invention.For the person of ordinary skill in the field, be that the various improvement of significantly implementing mode of the present invention are all covered by the present invention.
The specific embodiment
Embodiment 1
Collagen protein powder 15g
Vitamin C 200mg
Citric acid 20g
Sodium bicarbonate 17g
Lactose 31.2g
Flavoring orange essence 3g
Aspartame 0.8g
Sodium chloride 8g
Polyethylene glycol 6000 5g
Amount to 100g
After collagen protein powder, citric acid, sodium bicarbonate, lactose mix, make granule (16 order) with dehydrated alcohol, 44 ℃ of dryings, 16 order granulate, granule adds vitamin C, essence, aspartame, sodium chloride, polyethylene glycol 6000, after the mixing, tabletting.(3.5g/ sheet)
Embodiment 2
Collagen protein powder 10g
Vitamin C 200mg
Citric acid 20g
Sodium bicarbonate 20g
Lactose 36.2g
Fructus Citri Limoniae essence 3g
Aspartame 0.8g
Sodium chloride 5g
Polyethylene glycol 6000 5g
Amount to 100g
After collagen protein powder, citric acid, sodium bicarbonate, lactose mix, make granule (16 order) with dehydrated alcohol, 44 ℃ of dryings, 16 order granulate, granule adds vitamin C, essence, aspartame, sodium chloride, polyethylene glycol 6000, after the mixing, tabletting.(3.5g/ sheet)
Embodiment 3
Collagen protein powder 10g
Vitamin C 200mg
Tartaric acid 20g
Sodium bicarbonate 20g
Lactose 36.2g
Strawberry essence 3g
Saccharin sodium 0.8g
Sodium chloride 5g
Polyethylene glycol 6000 5g
Amount to 100g
After collagen protein powder, citric acid, sodium bicarbonate, lactose mix, make granule (16 order) with dehydrated alcohol, 44 ℃ of dryings, 16 order granulate, granule adds vitamin C, essence, aspartame, sodium chloride, polyethylene glycol 6000, after the mixing, tabletting.(3.5g/ sheet)
The comparative example 1
Collagen protein powder 10g
Vitamin C 200mg
Citric acid 20g
Sodium bicarbonate 20g
Lactose 45.2g
Strawberry essence 3g
Saccharin sodium 0.8g
Magnesium stearate 1g
Amount to 100g
After collagen protein powder, citric acid, sodium bicarbonate, lactose mix, make granule (16 order) with dehydrated alcohol, 44 ℃ of dryings, 16 order granulate, granule adds vitamin C, essence, aspartame, sodium chloride, polyethylene glycol 6000, after the mixing, tabletting.(3.5g/ sheet)
Embodiment 4 disintegrations and hardness measurement
The collagen protein vitamin C effervescent tablet of above embodiment preparation is put into 200ml water (20 degrees centigrade) observe, write down its complete disintegrate and molten diffusing time.Adopt hardness analyzer to measure the hardness of the effervescent tablet of above embodiment preparation.
Claims (15)
1. the ascorbic effervescent tablet of collagen protein contains collagen protein, vitamin C, effervescent, diluent, permeation-promoter and lubricant, and wherein, permeation-promoter is selected from sodium chloride, and diluent is selected from lactose.
2. according to the effervescent tablet of claim 1, wherein the content of permeation-promoter in preparation is 1 to 20% by weight percentage.
3. according to the effervescent tablet of claim 1, wherein the content of permeation-promoter in preparation is 2-15%.
4. according to the effervescent tablet of claim 1, wherein the content of permeation-promoter in preparation is 5-10%.
5. according to the effervescent tablet of claim 1, wherein collagen protein and the vitamin C content in preparation is 1 to 50% by weight percentage.
6. according to the effervescent tablet of claim 5, wherein collagen protein and the vitamin C content in preparation is 5-20% by weight percentage.
7. according to the effervescent tablet of claim 5, wherein collagen protein and the vitamin C content in preparation is 8-15% by weight percentage.
8. according to the effervescent tablet of claim 1, wherein effervescent is made up of acid source and carbon dioxide source.
9. effervescent tablet according to Claim 8, acid source is selected from one or more in citric acid, tartaric acid, fumaric acid, malic acid, anhydrous citric acid, the sodium dihydrogen citrate salt, and carbon dioxide source is selected from one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium carbonate, the calcium bicarbonate.
10. according to the effervescent tablet of above arbitrary claim, lubricant wherein is selected from one or more in Polyethylene Glycol, silicon dioxide, Pulvis Talci, the magnesium stearate.
11. according to the effervescent tablet of claim 10, lubricant wherein is selected from polyethylene glycol 6000.
12. according to the effervescent tablet of claim 1, its one-tenth by following weight is grouped into:
Collagen protein powder 15g
Vitamin C 200mg
Citric acid 20g
Sodium bicarbonate 17g
Lactose 31.2g
Flavoring orange essence 3g
Aspartame 0.8g
Sodium chloride 8g
Polyethylene glycol 6000 5g.
13. according to the effervescent tablet of claim 1, its one-tenth by following weight is grouped into:
Collagen protein powder 10g
Vitamin C 200mg
Citric acid 20g
Sodium bicarbonate 20g
Lactose 36.2g
Fructus Citri Limoniae essence 3g
Aspartame 0.8g
Sodium chloride 5g
Polyethylene glycol 6000 5g.
14. according to the effervescent tablet of claim 1, its one-tenth by following weight is grouped into:
Collagen protein powder 10g
Vitamin C 200mg
Tartaric acid 20g
Sodium bicarbonate 20g
Lactose 36.2g
Strawberry essence 3g
Saccharin sodium 0.8g
Sodium chloride 5g
Polyethylene glycol 6000 5g.
15. the preparation method of the effervescent tablet of above arbitrary claim comprises after collagen protein powder, effervescent, the mixing diluents, granulation, dry, granulate add all the other compositions, mix the step of back tabletting.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101193177A CN101130067B (en) | 2007-07-20 | 2007-07-20 | Preparation for replenishing collagen and method of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101193177A CN101130067B (en) | 2007-07-20 | 2007-07-20 | Preparation for replenishing collagen and method of preparing the same |
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| CN101130067A CN101130067A (en) | 2008-02-27 |
| CN101130067B true CN101130067B (en) | 2010-06-09 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824328A (en) * | 2012-09-11 | 2012-12-19 | 山东益宝生物制品有限公司 | Collagen effervescent tablet |
| CN103385347A (en) * | 2013-08-08 | 2013-11-13 | 吴长海 | Collagen composite peptide powder |
| CN104621431A (en) * | 2013-11-12 | 2015-05-20 | 江苏艾兰得营养品有限公司 | Beauty dispersible tablet compound preparation for helping woman delay senescence and preparation method thereof |
| CN103656627B (en) * | 2013-11-21 | 2015-09-02 | 威海百合生物技术股份有限公司 | A kind of vitamin C collagen compound effervescent tablet and preparation method thereof |
| CN107028976B8 (en) * | 2016-02-03 | 2022-01-14 | 中国人民解放军总医院 | Potassium supplementing potassium citrate effervescent tablet and its prepn |
| CN107126554B (en) * | 2017-04-27 | 2018-03-20 | 北京市永康年健康科技有限责任公司 | A kind of collagen product and its preparation method and application |
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| CN1730002A (en) * | 2005-08-08 | 2006-02-08 | 李海涛 | Effervescence tablet preparation for replenishing nutritious elements to human being and its preparation method |
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- 2007-07-20 CN CN2007101193177A patent/CN101130067B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1730002A (en) * | 2005-08-08 | 2006-02-08 | 李海涛 | Effervescence tablet preparation for replenishing nutritious elements to human being and its preparation method |
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Owner name: GUANGZHOU LIANCUN PHARMACEUTICAL TECHNOLOGY CO., L Free format text: FORMER OWNER: BEIJING SHIJI BOKANG PHARMACEUTICAL SCI. + TECH. CO., LTD. Effective date: 20140221 |
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Effective date of registration: 20140221 Address after: Baiyun District of Guangzhou City, Guangdong province 510000 Zhongluotan farmland Road No. 170 Patentee after: Guangzhou Union Medical Science and Technology Co Ltd Address before: 100070 Beijing City, Fengtai District science and Technology Park of Fengtai Haiying Road No. 9, building 3 203 Jintang Patentee before: Beijing Shiji Bokang Pharmaceutical Sci. & Tech. Co., Ltd. |
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Address after: 510080 No. 49 Hongqi Road, Zhongluotan Town, Baiyun District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU LIANCUN MEDICINE TECHNOLOGY CO., LTD. Address before: 170 Liangtian Middle Road, Zhongluotan Town, Baiyun District, Guangzhou Patentee before: Guangzhou Union Medical Science and Technology Co Ltd |