CN1730002A - Effervescence tablet preparation for replenishing nutritious elements to human being and its preparation method - Google Patents
Effervescence tablet preparation for replenishing nutritious elements to human being and its preparation method Download PDFInfo
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- CN1730002A CN1730002A CN 200510041366 CN200510041366A CN1730002A CN 1730002 A CN1730002 A CN 1730002A CN 200510041366 CN200510041366 CN 200510041366 CN 200510041366 A CN200510041366 A CN 200510041366A CN 1730002 A CN1730002 A CN 1730002A
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Abstract
Disclosed is an effervescent tablet preparation for replenishing nutritious elements to human being and its preparation method, which comprises vitamin C, arginine, calcium lactate, citric acid, sodium hydrogen carbonate, egg white sweets, guar gum, 10% ethanol solution, PEG6000, sodium chloride, lemon yellow and fruit. Its preparing process is also disclosed in the invention.
Description
One, technical field
The present invention relates to health food, specifically relating to a kind of is the Weijinggai effervescent tablet preparation and preparation method thereof of a kind of additional human nutrition element for preparing of raw material with the nutrient.
Two, background technology
Calcium is the important element of supporting life, and as eating salt, the people will constantly replenish the calcium in each stage in life.The serious harm of child's calcium deficiency: will influence growth promoter, and can cause children rachitis " X " and " O " type lower limb etc. when serious.The serious harm of teenager calcium deficiency: concentrated, the easy allergy of growing pain, energy, easy catching a cold, monophagia agitation, easily tired, calcium deficiency can make eyeball follow the string, and causes pseudomyopia.The harm of anemia of pregnant woman and women breast-feeding their children's calcium deficiency: all will replenish the calcium women throughout one's life, body development at an early age need be replenished the calcium, and anemia of pregnant woman, puerpera, women breast-feeding their children's calcium deficiency will directly influence two generations's health.The serious harm of old people's calcium deficiency: calcium deficiency can make the old people quicken aging, influences happiness in old age, and severe patient can make the old man spend old age on one's sick bed.Prove that now hypertension, arteriosclerosis, diabetes, heart rate disorder all have direct relation with calcium deficiency.Elderly woman is replenished the calcium immediately because the fracture that osteoporosis causes is howed 2～3 times than old man, and is very urgent!
The L-arginine is white crystals or crystalline powder, and is little smelly, and band highly basic flavor is soluble in water, is insoluble to pure and mild ether.Pharmaceutically be used for the treatment of hepatopathy and hepatic coma, also be used for biochemical research, also can be used as nutritional supplement.
Human body is under serious stress state or wound, infection and some wasting diseases situation, the requirement of vivo acid increases greatly, the synthetic aminoacid of some instincts self also can lack at this moment, studies the variation of these external at random boundary conditions and aminoacid that requirement increases is called the conditionality essential amino acids.At present, maximum have taurine, arginine and a glutamine, and this three seed amino acid plays an important role to each tract of body, also just more comes into one's own in Clinical Application.
Arginic physiological function: arginine is not an essential amino acid, but it truly has the important physical function at human body.When human body is in starvation, protein and takes the photograph body internal protein catabolism such as the people is excessive, wound, puberal growth stage and increase, carbamide generates and output also increases thereupon, because arginine is the intermediate material of ornithine cycle, thereby arginic requirement increases greatly.Human body is under wound (operation, accidental wound, burn) etc. stress situation, and arginine has been obtained better curative effect as special nutrient drug.
Arginine has the effect of regulating immunologic function.In immune system, arginine can improve lymphocyte, cytophagous vigor, and can indirect activation macrophage, neutrophil cell, but the active cell immune system has the good preventing effect to eliminating the stress state to the destruction of thymus.Concurrent infection, the septicemia that occurs for the immunologic hypofunction that causes because of reasons such as operation, severe trauma, burns replenished an amount of arginine clinically, can improve human body immune function effectively.It is pointed out that arginine to immune adjusting instant effect, general three days can take effect.
Arginine has certain inhibitory action to tumor.
Arginine has certain inhibitory action to be because it can suppress some carcinogen to tumor, as acetamide, 7, and 12-dimethylbenzanthracene, N-methyl-N-nitrosourea etc.Dimethylbenzanthracene can cause breast tumor, and additional arginine can weaken the carcinogenecity of dimethylbenzanthracene.Arginic antitumor action may be to work by promoting body that the identification of tumor and antineoplastic are reacted, also may be relevant to the stimulation of thymus with arginine.Bulbus Allii has in very strong antitumor action and the Bulbus Allii that arginine content is very high certain relation.
Arginine is a kind of important aminoacid in the body, promotes that carbamide generates and the reduction blood ammonia in the body.The clinical hepatic coma that is used for is avoided sodium patient and the unusual person of viral hepatitis glutamate pyruvate transaminase.
Ascorbic effect:
1, synthetic Collagen (collagen protein)---to form the important substrate of cartilage, sclerotin, enamel and blood vessel epithelium.
2, promote proline to change the reaction of hydrogen proline into, and the hydrogen proline is one of formation collagen important component, so vitamin C can promote the generation of collagen.
3, keep the normal of connective tissue---because collagen is the intercellular substance that constitutes connective tissue.
4, participation vivo oxidation reduction reaction---vitamin C can be participated in the oxidation reaction of Tyrosine and some material.
5, make the adrenal steroid hormone.
6, promote wound healing and increase to being injured the esthesis that infects equal pressure.
7, at infected, adstante febre, the loss of this vitamin also increases thereupon, so it is played an important role to the reaction that stimulates.
8, Detoxication.
9, improve myocardial function, lower capillary fragility, increase Abwehrkraft des Koepers.
10, the antagonism free radical helps anti-cancer, and cholesterol reducing prevents vitamin C deficiency.
Vitamin C is the jinx of numerous chemical toxicants in the life, and the nitrites material that contains in for example a lot of curing foods, the smoked product can cause sudden change, the distortion of cell in vivo, has stronger carcinogenesis.Yet, when nitrite runs into the vitamin C that doubles from height, just can not be in human body with the synthetic inferior ammonium nitrate of amination harmful to human.
For the child of long-term monophagia, the pregnant and lying-in women that the individual need amount increases, vitimin supplement C is particularly important.In the daily life, the high-risk group of these hypovitaminosis Cs should note replenishing the vitamin C in the life.
Three, summary of the invention
1. goal of the invention
The object of the present invention is to provide a kind of Weijinggai effervescent tablet preparation that can replenish the human nutrition element that adopts nutrients such as arginine, Vc, organic calcium and adjuvant thereof to combine;
Another object of the present invention provides the preparation method of this effervescent tablet preparation.
2, technical scheme
(1) raw material of Weijinggai effervescent tablet preparation is formed and weight proportion
A kind of Weijinggai effervescent tablet preparation of additional human nutrition element is characterized in that it is to be made by following materials of weight proportions: every consumption vitamin C 0.05～0.55g, arginine 0.05～0.80g, calcium lactate 0.10～1.25g, citric acid 0.60～2.50g, sodium bicarbonate 0.80～2.50g, melon glue 0.02～0.20g, PVP10% alcoholic solution 0.50～2.50ml, PEG60000.06～0.20g, protein sugar 0.01～0.20g, solid sodium chloride 0.01～0.20g, lemon yellow pigment 0.05～0.55g, solubility fruit flavoured powder 0.01～0.08g.
Because arginine has many important physical functions to human body,, can add an amount of essence for increasing mouthfeel so in above-mentioned raw materials, can also increase arginine 0.05g～0.80g.
Above-mentioned solubility fruit flavoured powder comprises hami melon powder, spinach sieve powder, Fructus Mali pumilae powder, Fructus Musae powder, honey peach powder etc., to satisfy the needs of people to different taste.
(2) a kind of preparation method of effervescent tablet preparation of additional human nutrition element, its preparation process is:
1. take by weighing arginine 0.05～0.80g, calcium lactate 0.10～1.25g, sodium bicarbonate 0.80～2.50g, protein sugar 0.01～0.20g, melon glue 0.02～0.20g, PEG6000 0.03～0.10g cross 100 mesh sieves respectively, mixing and lemon yellow pigment 0.05～0.30g;
2. essence is made soft material with ethanol solution 0.50～2.50ml mixing of 10%PVP, the wet grain of the 12 mesh sieve systems of crossing, and in 30～60 ℃ of drying for standby;
3. get vitamin C 0.05～0.55g in addition, citric acid 0.60～2.50g, PEG6000 0.03～0.10 cross 100 mesh sieves, mixing and lemon yellow pigment 0.05～0.30g respectively;
4. above-mentioned dry granular is mixed, granulate, baking adds solubility fruit flavoured powder 0.01～0.08g and water miscible solid sodium chloride 0.01～0.25g and crosses 100 mesh sieves for a moment, and mixing, tabletting make the effervescent tablet preparation.
Our the Weijinggai effervescent tablet preparation of development is to be combined by nutrients such as arginine, Vc and organic calcium, and their physiological function is as follows:
Arginine is the indispensable important nutritional labeling of human body, has extremely important physiological function.
1. Nobel's physiology and medical science prize winner finds, the necessary composition in the arginine enzymes metabolism approach that to be NO react with citrulline is the precursor of NO, and NO has antiplatelet aggregation, resisting vascular smooth muscle hyperplasia and antiatherogenic effect.Arginine can reduce serum total cholesterol, LDL and triglyceride, rising HDL (good albumen), and can improve hemorheology, can prevent smoking endothelial cell injury function and atherosclerotic formation.
2. functions of expelling toxin: eat arginine more, can increase the activity of arginase in the liver (arginase), help to change the ammonia in the blood into carbamide and excrete out, therefore, arginine produces effect to the hepatic insufficiency person.
3. immunoloregulation function: arginine can prevent the degeneration of thymus, increases the weight of thymus, promotes the growth of thymus medium-sized lymphocyte.When in the body during atrophy of thymus gland, arginine can promote the maturation and the differentiation of CD cell in skeleton and the lymph node,
Make body keep enough immunocompetences.
The arginine safety non-toxic, concerning the child, arginine also is must aminoacid.
Vitamin C is ascorbic acid again, can prevent and treat vitamin C deficiency, keep the growth and the normal configuration of connective tissue, promote the growth of tooth, bone, increase vascular toughness, and Wheat Protein, be a kind of important free radical scavenger, it can provide electronics to become half hydroascorbic acid and hydroascorbic acid, can remove O
2 -, free radical such as OH, R and ROO.And free radical is the key factor of body aging and numerous disease.
Chinese are for a long time based on vegetable diet, and many in addition people are limited in one's ability to calcium absorption, and the calcium deficiency phenomenon is quite general, and calcium deficiency will cause rickets, osteomalacia, osteoporosis, low blood calcium, renal calculus, old man easily to fracture, bone in children, odontodysplasia.If serum calcium reduces unusually, also can cause tetany, even have various mental disorders.
The actual intake of the many countries in Asia (containing China) calcium is well below arm's length standard, and therefore, every day is particularly important by the nutrition of calcium fortified functional food reasonable supplement calcium.
3, beneficial effect
Drink the Weijinggai effervescent tablet, have safety, effectively, three-in-one function keeps healthy.
(1) safety: long-term drink, safe ready must not change original living habit.
Arginine, Vc, organic calcium all meet China that Chinese Soclety of Nutrition recommends per capita in intake critical field every day.Vc and organic calcium are with the clothes absorption of can mutually promoting.
(2) effectiveness: reduce the cardiovascular and cerebrovascular disease risk, alleviate liver illness such as fatty liver, effectively get rid of vivotoxin.Vc has oxidation resistance, helps to remove excessive free radical in the human body, and free radical causes wearing out just, cancer, diabetes, cardiovascular killer, increases the absorption of organic calcium, keeps bone, tooth is grown and hardness.
(3) the Weijinggai effervescent tablet has plurality of health care functions, and it never contains sucrose, monosaccharide, can not cause obesity, and the diabetes patient can easily drink; The good to eat fruity of the sweet acid indispensable beverage of working especially, travel, lie fallow; Drink when consideration is had a dinner, no matter hot and cold water all can.
(4) dissolving is fast, and when contacting with water, acid-base reaction produces carbon dioxide, dissolves in very short time; The bioavailability height exists with liquid agent in short-term, and trophism composition time in water is very short, unlikely decomposition failure;
(5) taking convenience, the effervescent solution of generation, suitable child, old people and the solid preparation crowd that is difficult for swallowing use.
Four, the specific embodiment
The raw material of embodiment 1 Weijinggai effervescent tablet preparation is formed and weight proportion
A kind of Weijinggai effervescent tablet preparation of additional human nutrition element is characterized in that it is to be made by following materials of weight proportions: every consumption vitamin C 0.40g, arginine 0.60g, calcium lactate 1.00g, citric acid 2.00g, sodium bicarbonate 2.00g, melon glue 0.10g, PVP10% alcoholic solution 2.00ml, PEG6000 0.10g, protein sugar 0.10g, solid sodium chloride 0.10g, lemon yellow pigment 0.40g, solubility fruit flavoured powder 0.06g.
The preparation method of the effervescent tablet preparation of 2 one kinds of additional human nutrition elements of embodiment, its preparation process is:
1. take by weighing arginine 0.20g, calcium lactate 0.80g, sodium bicarbonate 1.20g, protein sugar 0.20g, melon glue 0.15g, PEG6000 0.07g cross 100 mesh sieves, mixing and lemon yellow pigment 0.2g respectively;
2. essence is made soft material with the ethanol solution 0.80ml mixing of 10%PVP, the wet grain of the 12 mesh sieve systems of crossing, and in 45 ℃ of drying for standby;
3. get vitamin C 0.09g in addition, citric acid 1.80g, PEG6000 0.08g cross 100 mesh sieves, mixing and lemon yellow pigment 0.15g respectively;
4. above-mentioned dry granular is mixed, granulate, baking adds solubility hami melon powder 0.05g and water miscible solid sodium chloride 0.10g and crosses 100 mesh sieves for a moment, and mixing, tabletting make the effervescent tablet preparation.
The preparation method of the effervescent tablet preparation of 3 one kinds of additional human nutrition elements of embodiment, its preparation process is:
1. take by weighing arginine 0.08g, calcium lactate 0.70g, sodium bicarbonate 1.50g, protein sugar 0.15g, melon glue 0.08g, PEG6000 0.50g cross 100 mesh sieves, mixing and lemon yellow pigment 0.2g respectively;
2. essence is made soft material with the ethanol solution 1.20ml mixing of 10%PVP, the wet grain of the 12 mesh sieve systems of crossing, and in 50 ℃ of drying for standby,
3. get vitamin C 0.20g in addition, citric acid 1.80g, PEG6000 0.08g cross 100 mesh sieves, mixing and lemon yellow pigment 0.15g respectively;
4. above-mentioned dry granular is mixed, granulate, baking adds solubility fruit Fructus Ananadis comosi powder 0.05g and water miscible solid sodium chloride 0.08g and crosses 100 mesh sieves for a moment, and mixing, tabletting make the effervescent tablet preparation.
The preparation method of the effervescent tablet preparation of 4 one kinds of additional human nutrition elements of embodiment, its preparation process is:
1. take by weighing arginine 0.40g, calcium lactate 1.00g, sodium bicarbonate 2.10g, protein sugar 0.10g, melon glue 0.10g, PEG6000 0.08g cross 100 mesh sieves, mixing and lemon yellow pigment 0.2g respectively;
2. essence is made soft material with the ethanol solution 1.50ml mixing of 10%PVP, the wet grain of the 12 mesh sieve systems of crossing, and in 48 ℃ of drying for standby;
3. get vitamin C 0.40g in addition, citric acid 1.85g, PEG6000 0.09g, arginine 0.3g cross 100 mesh sieves, mixing and lemon yellow pigment 0.25g respectively;
4. above-mentioned dry granular is mixed, granulate, baking adds solubility Fructus Mali pumilae powder 0.05g and water miscible solid sodium chloride 0.08g and crosses 100 mesh sieves for a moment, and mixing, tabletting make the effervescent tablet preparation.
The preparation method of the effervescent tablet preparation of 5 one kinds of additional human nutrition elements of embodiment, its preparation process is:
1. take by weighing arginine 0.60g, calcium lactate 0.90g, sodium bicarbonate 2.10g, protein sugar 0.15g, melon glue 0.15g, PEG6000 0.08g cross 100 mesh sieves, mixing and lemon yellow pigment 0.35g respectively;
2. essence is made soft material with the ethanol solution 1.25ml mixing of 10%PVP, the wet grain of the 12 mesh sieve systems of crossing, and in 35 ℃ of drying for standby;
3. get vitamin C 0.40g in addition, citric acid 1.80g, PEG6000 0.10, and arginine 0.3g crosses 100 mesh sieves, mixing and lemon yellow pigment 0.15g respectively;
4. above-mentioned dry granular is mixed, granulate, baking adds solubility Fructus Musae powder 0.05g and water miscible solid sodium chloride 0.10g and crosses 100 mesh sieves for a moment, and mixing, tabletting make the effervescent tablet preparation.
The preparation method of the effervescent formulation of 6 one kinds of additional human nutrition elements of embodiment, its preparation process is:
1. take by weighing arginine 0.40g, calcium lactate 1.00g, sodium bicarbonate 1.80g, protein sugar 0.10g, melon glue 0.10g, PEG6000 0.08g cross 100 mesh sieves, mixing and lemon yellow pigment 0.3g respectively;
2. essence is made soft material with the ethanol solution 1.50ml mixing of 10%PVP.The wet grain of the 12 mesh sieve systems of crossing, and in 40 ℃ of drying for standby;
3. get vitamin C 0.50g in addition, citric acid 1.80g, PEG6000 0.08g cross 100 mesh sieves, mixing and lemon yellow pigment 0.1g respectively;
4. above-mentioned dry granular is mixed, granulate, baking adds solubility honey peach powder 0.06g and water miscible solid sodium chloride 0.08g and crosses 100 mesh sieves for a moment, and mixing, tabletting make the effervescent tablet preparation.
Claims (4)
1, a kind of Weijinggai effervescent tablet preparation of additional human nutrition element is characterized in that it is to be made by following materials of weight proportions: every consumption vitamin C 0.05～0.55g, arginine 0.05～0.80g, calcium lactate 0.10～1.25g, citric acid 0.60～2.50g, sodium bicarbonate 0.80～2.50g, melon glue 0.02～0.20g, PVP10% alcoholic solution 0.50～2.50ml, PEG60000.06～0.20g, protein sugar 0.01～0.20g, solid sodium chloride 0.01～0.20g, lemon yellow pigment 0.05～0.55g, solubility fruit flavoured powder 0.01～0.08g.
2, effervescent tablet preparation according to claim 1, but it is characterized in that also altar adds arginine 0.05～0.80g and an amount of essence.
3, effervescent tablet preparation according to claim 1 is characterized in that described solubility fruit flavoured powder comprises hami melon powder, spinach sieve powder, Fructus Mali pumilae powder, Fructus Musae powder, honey peach powder.
4, a kind of method for preparing claim 1 Weijinggai effervescent tablet preparation, its preparation process is:
(1) take by weighing arginine 0.05～0.80g, calcium lactate 0.10～1.25g, sodium bicarbonate 0.80～2.50g, protein sugar 0.01～0.20g, melon glue 0.02～0.20g, PEG60000.03～0.10g cross 100 mesh sieves, mixing and lemon yellow pigment 0.3g respectively;
(2) essence is made soft material with ethanol solution 0.50～2.50ml mixing of 10%PVP, the wet grain of the 12 mesh sieve systems of crossing, and in 30～60 ℃ of drying for standby;
(3) get vitamin C 0.05～0.55g in addition, citric acid 0.60～2.50g, PEG60000.03～0.10g cross 100 mesh sieves, mixing and lemon yellow pigment 0.2g respectively;
(4) above-mentioned dry granular is mixed, granulate dries by the fire a moment, and the fruit flavoured powder 0.01～0.08g and the water miscible solid sodium chloride 0.01～0.25g that add solubility cross 100 mesh sieves, and mixing, tabletting make the effervescent tablet preparation.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130067B (en) * | 2007-07-20 | 2010-06-09 | 北京世纪博康医药科技有限公司 | Preparation for replenishing collagen and method of preparing the same |
| CN102600473A (en) * | 2012-04-06 | 2012-07-25 | 安徽山河药用辅料股份有限公司 | Preparation method of premix adjuvant for effervescent tablet |
| CN103689747A (en) * | 2013-12-18 | 2014-04-02 | 江苏江山制药有限公司 | Effervescent tablet capable of fast supplementing energy, and preparation method of effervescent tablet |
| CN105475800A (en) * | 2015-11-24 | 2016-04-13 | 广西壮族自治区农业科学院农产品加工研究所 | Mango effervescent tablet and preparation method thereof |
| CN104434937B (en) * | 2014-12-18 | 2017-04-12 | 郑州拓洋生物工程有限公司 | D-ribose-vitamin C effervescent tablets and preparation method thereof |
| WO2024063715A1 (en) * | 2022-09-20 | 2024-03-28 | Melikoglu Ahmet | Effervescent tablet comprising l-arginine used for healing wounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE173614T1 (en) * | 1993-09-09 | 1998-12-15 | Gerhard Gergely | EFFORTABLE GRANULES AND METHOD FOR THE PRODUCTION THEREOF |
| CN1293831C (en) * | 2003-05-08 | 2007-01-10 | 华振珊 | Effervescent solid beverage of amino acid chelated calcium and its prepn |
| CN100364527C (en) * | 2003-07-23 | 2008-01-30 | 华晨 | Composition of vitamin C and arginine and its application |
-
2005
- 2005-08-08 CN CNB2005100413664A patent/CN1292756C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130067B (en) * | 2007-07-20 | 2010-06-09 | 北京世纪博康医药科技有限公司 | Preparation for replenishing collagen and method of preparing the same |
| CN102600473A (en) * | 2012-04-06 | 2012-07-25 | 安徽山河药用辅料股份有限公司 | Preparation method of premix adjuvant for effervescent tablet |
| CN103689747A (en) * | 2013-12-18 | 2014-04-02 | 江苏江山制药有限公司 | Effervescent tablet capable of fast supplementing energy, and preparation method of effervescent tablet |
| CN104434937B (en) * | 2014-12-18 | 2017-04-12 | 郑州拓洋生物工程有限公司 | D-ribose-vitamin C effervescent tablets and preparation method thereof |
| CN105475800A (en) * | 2015-11-24 | 2016-04-13 | 广西壮族自治区农业科学院农产品加工研究所 | Mango effervescent tablet and preparation method thereof |
| WO2024063715A1 (en) * | 2022-09-20 | 2024-03-28 | Melikoglu Ahmet | Effervescent tablet comprising l-arginine used for healing wounds |
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| CN1292756C (en) | 2007-01-03 |
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