CN100364527C - Composition of vitamin C and arginine and its application - Google Patents
Composition of vitamin C and arginine and its application Download PDFInfo
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- CN100364527C CN100364527C CNB031502806A CN03150280A CN100364527C CN 100364527 C CN100364527 C CN 100364527C CN B031502806 A CNB031502806 A CN B031502806A CN 03150280 A CN03150280 A CN 03150280A CN 100364527 C CN100364527 C CN 100364527C
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Abstract
The present invention relates to a composition of vitamin C and arginine. The mass proportion of vitamin C to arginine of the composition is 10:1 to 10:4, wherein the composition can be a liquid preparation or a solid preparation. The composition can be dissolved in water or other nutrient fluids. As a compound liquid preparation containing water or other nutrient fluids, the composition can be used as nutriment and a health-care product for improving the immunity of human bodies. The present invention particularly has obvious effects on preventing various diseases (such as SARS) caused by viruses, preventing the generation of tissue fibrosis (such as liver cirrhosis, pulmonary fibrosis, myocardium tissue fibrosis, etc.,) caused by various diseases, lightening tissue fibrosis symptoms caused by various diseases, promoting the absorption of tissue fiber, preventing the generation of scar tissue, improving scar constitution, regulating blood pressure, etc.
Description
Technical field
The present invention relates to a kind of compositions, be particularly related to a kind of vitamin C and arginic compositions, described compositions or other dosage forms that contain this compositions can be used as health product or the medicine that improves body immunity, particularly the various diseases (for example SARS) that causes at pre-anti-virus, the generation of the tissue fibering that causes of prevention various diseases (liver cirrhosis for example, pulmonary fibrosis, cardiac muscular tissue's fibrosis etc.), alleviate tissue fibering symptom that various diseases causes and the absorption that promotes tissue fibers, the generation of prevention of scar tissue, improve cicatrix body constitution and adjust blood pressure etc. significant effect is arranged.
Background technology
Arginine is multi-functional aminoacid, and its metabolite is nitric oxide (NO), hepatoprotective, treatment mental retardation is arranged, promote wound healing, prevents involution of thymus, improves the function of body immunity.Following important function is arranged in many physiological and biochemical procedures of human body:
(1) regulates antiotasis, adjust blood pressure and blood flow;
(2) growth of the senior cognitive function of promotion body;
(3) to intestinal motility, its excretory function of adjusting of pancreas is had certain effect;
(4) to regulating the hepatic protein metabolism very important influence is arranged;
(5) participate in the function of engulfing and killing of macrophage to antibacterial;
(6) regulate macrophage and lymphocytic activation and the effect of cooperatively interacting of the two;
(7) prevent the degeneration of thymus, promote the growth of cell in the thymus;
(8) when thymus generation atrophy, can promote the maturation and the differentiation of CD cell in bone marrow and the lymph node;
(9) can stimulate monocyte and fissional reaction in patient's peripheral blood.
Arginine has significant meaning for animal organism, and arginine is the precursor that generates carbamide and ornithine, and arginine and ornithine can promote the synthetic of carbamide in the liver, releasing ammonia intoxication.
Arginine is the important carrier that transports and store nitrogen in the human body, and is very important in muscle metabolism.It helps the drainage of excess nitrogen in the body; It can stimulate the generation of hormones such as insulin, feritin, rapid generation with ground blood glucose and minimizing fat.Arginine can prevent involution of thymus, replenish the weight that arginine can increase thymus, promotes the growth of thymus medium-sized lymphocyte and CD cell, therefore can improve the immunity of human body.
In addition; what be worth that everybody pays close attention to is; As time goes on; produce some new virus through regular meeting; under the situation of not developing these viral vaccines of antagonism as yet (for example SARS vaccine); because virus has the characteristic (variation) of the arrangement of continuous change base, even develop this vaccine from now on, can not respond with too high to the expected value of its effect.So, have only the immunocompetence that improves human body, be only the unique best approach that can defeat new virus.
Self-evident, because arginic above-mentioned functions, by taking arginine or containing arginic other drug or health product are nothing but a kind of good method that improves body immunity, also be simultaneously the favourable approach of the disease (for example SARS) that causes of prevention and treatment new virus.
But, arginine when directly taking, the mouthfeel smell bad, thus can cause that the user vomits, stomach has the peppery sense of burning.
Ascorbic intake, at present generally speaking, every day, use amount was no more than 500 milligrams, only this dosage has good therapeutic effect for the postoperative pain of reduction of patient, especially reduce pneumonectomy operation back bronchus broken ends of fractured bone generation fistula or post-operative complication certain effect is arranged, especially Drug therapy is produced chemical sproof patient, better curative effect is also arranged.
But only use vitamin C as the generation (for example liver cirrhosis, pulmonary fibrosis, cardiac muscular tissue's fibrosis etc.) that improves various diseases (for example SARS) that body immunity and prevention and treatment virus causes, tissue fibering that the prevention various diseases causes, alleviate the generation of the tissue fibering that various diseases causes and the absorption that promotes tissue fibers, prevention of scar tissue, the effect of improving cicatrix body constitution and adjust blood pressure is not special remarkable.
Summary of the invention
In order to address the above problem, the invention discloses a kind of vitamin C and arginic compositions, the mass ratio of wherein said vitamin C and arginine composition is 10: 1～10: 4; Use every day the gross mass of above-mentioned composition to be 3g～150g, wherein the gross mass of Orally administered composition is 3g～30g; During intravenous drip, should be with reference to the body weight of symptom and user, and adjust consumption by urine examination at any time, ascorbic content should be 0.5～1g/ kilogram user body weight in the general compositions.
According to a kind of vitamin C of the present invention and arginic compositions, wherein the ascorbic quality in the total composition of using every day and is a safe dose to be no more than 100g more than 0.5g.
According to a kind of vitamin C of the present invention and arginic compositions, can add liquid flux according to different needs, make it become liquid dosage form.
According to a kind of vitamin C of the present invention and arginic compositions, wherein said compositions can be dissolved in water or other nutrient liquid, uses as a kind of compound recipe liquid dosage form that includes water or other nutrient liquid.
According to a kind of vitamin C of the present invention and arginic compositions, can in said composition, add excipient substance and excipient in order to form stable solid dosage forms according to different needs.
According to a kind of vitamin C of the present invention and arginic compositions, described solid dosage forms is capsule or tablet.
According to a kind of vitamin C of the present invention and arginic compositions, can be used as the health product or the drug use that improve body immunity.
According to a kind of vitamin C of the present invention and arginic compositions, can be used as all kinds of diseases (for example SARS) drug use that treatment virus causes.
According to a kind of vitamin C of the present invention and arginic compositions, can be used as the tissue fibering that causes of prevention various diseases generation (for example liver cirrhosis, pulmonary fibrosis, cardiac muscular tissue's fibrosis etc.), alleviate the tissue fibering that various diseases causes and the absorption that promotes tissue fibers, prevention of scar tissue generation, improve the drug use of cicatrix body constitution and adjust blood pressure.
The specific embodiment
As everyone knows, the elastic fibers quantity of tissue is constant, and for example if lung tissue because pathological changes causes the pulmonary elastic fibers fracture, will cause that interstitial lung changes, and makes pulmonary function low.On the general custom elastic fibers is referred to as elastin laminin, the fracture of elastin laminin can cause acute emphysema, and normal lung tissue is oppressed, and blood circulation produces obstacle, and the deterioration of the state of an illness causes PI thereupon, and more the back is bad.And use vitamin C and arginic compositions, can increase intravital soluble collagen tissue, therefore prevented the fibrosis of tissue on the one hand, made established fibrous tissue be easy to be absorbed on the other hand, thus prevention and the caused pulmonary insufficiency of treatment interstitial pulmonary fibrosis.
Following mask body illustrated embodiments.
Embodiment one
The male, 70 years old, acutely cough, dyspnea, cyanosis, hyperpyrexia symptom appear, during expiration, supraclavicular fossa concave is arranged, respiratory murmur is faint, and breathing time prolongs, and percussion is tympanitic resonance.Chest X-rays finds that the both sides hilus pulumonis has butterfly-shaped shade, and the breast CT inspection is found, interstitial lung fibrous fracture, and alveolar enlarges.Through the blood gas phase analysis, oxygen content reduces.Made tracheal intubation at above-mentioned symptom, this case diagnosis is a viral pneumonia.
Use vitamin C and arginine composition to carry out the intravenous drip treatment, the consumption of compositions is to restrain 26 grams every day 13 according to the body weight of user, vitamin C and arginic mass ratio are 10: 3 in the compositions, after two weeks, the content of oxygen content (more than 85) and carbon dioxide (approaching 40) all is tending towards normal, do not needed oxygen uptake, pulmonary shadow disappears substantially.
Use during the arginine NO in the urine
x(nitrogen oxide) is entirely normal value.
Embodiment two
The women, 65 years old, be diagnosed as liver cirrhosis, with ascites, CT shows: liver volume is dwindled, fissure broadening, the liver recto is the low-density kitchen range in the form of sheets, a small amount of ascites, splenomegaly is diagnosed as: the right lobule sclerosis of liver (ascites).Use vitamin C and arginine composition to carry out oral medication, the consumption of compositions is grams every days 3.6, vitamin C and arginic mass ratio are 10: 1 in the compositions, every order divides to be taken for three times, and behind two first quarter moons of continuous oral, ascites disappears, liver function shows, only have the TOTAL BILE ACID TBA index to be higher than normal value, other indexs are all normal, and CT examination is expressed as fatty liver (slightly).
Embodiment three
The generation (for example liver cirrhosis, pulmonary fibrosis, cardiac muscular tissue's fibrosis etc.) of the various diseases (for example SARS) that causes for pre-anti-virus, the tissue fibering that the prevention various diseases causes, the generation of prevention of scar tissue, improve cicatrix body constitution, for general adult can be that 1 gram/sky and arginine content are the compositions in 0.3 gram/sky with Vitamin C content, is added in 2 liters of fruit juice and drinks.The back had 50% oxidation in about 90 minutes in the fruit juice because vitamin C is dissolved in, and therefore is preferably in to drink in 90 minutes after the dissolving to finish, or compositions equivalent is divided equally some parts, and the gradation dissolving is drunk again.
Embodiment four
Vitamin C and arginine are made compositions by 10: 1 mass ratio, further make capsule, every capsules contains compositions 0.25mg only, and 12 of every days, gradation is oral.This capsule can be used for the improper fluctuation of adjust blood pressure, and especially fixed to unstable blood pressure user can be avoided after taking because of taking the discomfort that medicine produces.
Embodiment five
According to Vitamin C content is 1 gram/sky, and arginine content is the matching criterion in 0.3 gram/sky, behind attached dose of the other drug of adding appropriate amount, sweeting agent, the excipient etc., is pressed into tablet, is easy to preserve and take.
Embodiment six
According to Vitamin C content is 0.5～1 gram/sky. kg body weight, vitamin C and arginine mass ratio are 10: 1.5～10: 3 matching criterion, and it is diluted in weight ratio is in 0.9% the normal saline, uses as intravenous drip liquid.
Although show with reference to the preferred embodiments of the present invention before this and described the present invention, but it will be understood by those skilled in the art that can according to the present invention make on the various forms and details on variation and can not break away from the spirit and scope that appending claims of the present invention limits.
Claims (8)
1. compositions of being made up of vitamin C and arginine, it is characterized in that: wherein vitamin C and arginic mass ratio are 10: 1～10: 4.
2. according to the compositions of claim 1, it is characterized in that: add liquid flux in the described compositions to form liquid dosage form.
3. according to the compositions of claim 1, it is characterized in that: wherein said compositions is dissolved in water or other nutrient liquid, uses as a kind of compound recipe liquid dosage form that includes water or other nutrient liquid.
4. according to the compositions of claim 1, it is characterized in that: in said composition, add excipient substance and excipient in order to form stable solid dosage forms.
5. according to the compositions of claim 4, it is characterized in that: described solid dosage forms is capsule or tablet.
6. be used to prepare the health product that improve body immunity or the application of medicine according to compositions any among the claim 1-5.
7. be used to prepare treatment and the medicine of prevention viral pneumonia or the application of health product according to compositions any among the claim 1-5.
8. be used to prepare treatment and the medicine of prevention liver cirrhosis or the application of health product according to compositions any among the claim 1-5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031502806A CN100364527C (en) | 2003-07-23 | 2003-07-23 | Composition of vitamin C and arginine and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031502806A CN100364527C (en) | 2003-07-23 | 2003-07-23 | Composition of vitamin C and arginine and its application |
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| Publication Number | Publication Date |
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| CN1568973A CN1568973A (en) | 2005-01-26 |
| CN100364527C true CN100364527C (en) | 2008-01-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031502806A Expired - Fee Related CN100364527C (en) | 2003-07-23 | 2003-07-23 | Composition of vitamin C and arginine and its application |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299676C (en) * | 2005-03-15 | 2007-02-14 | 中国人民解放军第三军医大学 | Anti-anoxia medicinal composition |
| CN1292756C (en) * | 2005-08-08 | 2007-01-03 | 李海涛 | Effervescence tablet preparation for replenishing nutritious elements to human being and its preparation method |
| CN102451351A (en) * | 2010-10-26 | 2012-05-16 | 宁波海逸生物科技有限公司 | Recipe for immunity regulation medicine |
| CN104610202B (en) * | 2015-01-30 | 2017-03-08 | 精晶药业股份有限公司 | A kind of arginic preparation method of vitamin C |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179264A (en) * | 1996-10-14 | 1998-04-22 | 朱丕基 | Gamma-milk |
| CN1229851A (en) * | 1999-03-02 | 1999-09-29 | 华东理工大学 | Hybridizing tumour cell non-serum culture medium |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| DE20116346U1 (en) * | 2001-10-05 | 2001-12-20 | Orthomol Pharmazeutische Vertr | Micronutrient combination product, among others with vitamins and carotenoids |
| CN1362514A (en) * | 2002-01-25 | 2002-08-07 | 华东理工大学 | Serumless medium suitable for growth and maintenance of young hamster kidney cell |
| US20030003162A1 (en) * | 2001-06-19 | 2003-01-02 | Matthias Rath | Composition and method for prevention and treatment of health conditions caused by constriction of smooth muscle cells |
| DE10128934A1 (en) * | 2001-06-18 | 2003-02-06 | Bernhard Sibbe | Well tolerated, natural product-based composition for prophylaxis of angina pectoris, containing specific aminoacids, vitamins and/or peptides, preferably L-arginine, L-carnitine, L-lysine and vitamin C |
| US20030064135A1 (en) * | 2001-04-02 | 2003-04-03 | Robert Portman | Sports drink composition for enhancing glucose uptake into the muscle and extending endurance during physical exercise |
-
2003
- 2003-07-23 CN CNB031502806A patent/CN100364527C/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179264A (en) * | 1996-10-14 | 1998-04-22 | 朱丕基 | Gamma-milk |
| US6051236A (en) * | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| CN1229851A (en) * | 1999-03-02 | 1999-09-29 | 华东理工大学 | Hybridizing tumour cell non-serum culture medium |
| US20030064135A1 (en) * | 2001-04-02 | 2003-04-03 | Robert Portman | Sports drink composition for enhancing glucose uptake into the muscle and extending endurance during physical exercise |
| DE10128934A1 (en) * | 2001-06-18 | 2003-02-06 | Bernhard Sibbe | Well tolerated, natural product-based composition for prophylaxis of angina pectoris, containing specific aminoacids, vitamins and/or peptides, preferably L-arginine, L-carnitine, L-lysine and vitamin C |
| US20030003162A1 (en) * | 2001-06-19 | 2003-01-02 | Matthias Rath | Composition and method for prevention and treatment of health conditions caused by constriction of smooth muscle cells |
| DE20116346U1 (en) * | 2001-10-05 | 2001-12-20 | Orthomol Pharmazeutische Vertr | Micronutrient combination product, among others with vitamins and carotenoids |
| CN1362514A (en) * | 2002-01-25 | 2002-08-07 | 华东理工大学 | Serumless medium suitable for growth and maintenance of young hamster kidney cell |
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| Publication number | Publication date |
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| CN1568973A (en) | 2005-01-26 |
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