CN105582327A - Atenolol-containing medicine composition for treating high blood pressure and preparation method thereof - Google Patents
Atenolol-containing medicine composition for treating high blood pressure and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine, and particularly relates to an atenolol-containing medicine composition for treating high blood pressure and a preparation method thereof. The atenolol-containing medicine composition for treating high blood pressure is prepared from, by weight, 30-70 parts of atenolol, 2000-4000 parts of Hainan ervatamia roots, 2000-4000 parts of cycas revoluta Thunb., 2000-4000 parts of cunninghamia lanceolata(Lamb.)Hook. and 2000-4000 parts of herba lagotis. As Chinese herbs and atenolol are combined, common adverse reactions caused by atenolol can be avoided, and the treatment effect on high blood pressure can be improved.
Description
Technical field
The invention belongs to medical technical field, be specifically related to the hypertensive drug regimen of a kind for the treatment of that contains atenololThing and preparation method thereof.
Background technology
Hypertension is Important cause of disease and the hazards of cardiovascular and cerebrovascular disease, and the whole world has the people of 20%-30% to suffer from high bloodPress. Hypertension can affect the 26S Proteasome Structure and Function of the heart, brain, kidney, can significantly increase the onset risk of palsy, heart failure, ESRD.The investigation of 95%, 2002 year that essential hypertension accounts for hypertension incidence be presented at more than 18 years old prevalence of China up to18.8%, number of patients reaches 1.6 hundred million. Therefore hypertensive prevention and treatment, becomes great that China and the whole world pays close attention to the mostPublic health problem.
Current hypertensive methods for the treatment of is except changing habits and customs, and topmost effective interference method is exactly that medicine is controlledMalignant boil, conventional antihypertensive drugs is divided into 5 classes at present, clinically alone the and drug combination two class schemes of main employing. But step-downMedicine still has a lot of ask bad reaction, resistance phenomenon and patients that for example Long-term taking medicine causes in clinical applicationBad compliance. There are some researches show that the patient who accepts medicine treatment only has 53% successfully to control blood pressure, make controlling of blood pressure≤140/90mmHg。
Atenolol is the hypertensive beta-blocker of clinical conventional treatment, can combine use with other antihypertensive drugs.But the side effect of long-term taking atenolol is also very large to the injury of human body. What allow the male sex has a headache most is possible cause impotence.This bad reaction has limited atenolol in clinical use.
Summary of the invention
In order to solve the large restriction of atenolol side effect end user group's technical problem, the invention provides a kind of Ah Ti Lip riverYou and the composition of Chinese medicine, by with the compatibility of Chinese medicine, alleviate the bad reaction of atenolol, thereby realize attenuation synergisticObject.
The present invention realizes by following technical scheme:
The hypertensive pharmaceutical composition for the treatment of that contains atenolol, is made up of the bulk drug of following weight proportion: Ah replacingLuo Er 30-70 part, Hainan Ervatamia Root 2000-4000 part, sago cycas 2000-4000 part, China fir tower 2000-4000 part, Lagotis glauca 2000-4000Part.
The above-mentioned hypertensive pharmaceutical composition of the treatment that contains atenolol, its weight portion proportion optimization is: Ah Ti Lip riverThat 80-120, Hainan Ervatamia Root 2500-3500 part, sago cycas 2500-3500 part, China fir tower 2500-3500 part, Lagotis glauca 2500-3500 part.
The above-mentioned hypertensive pharmaceutical composition of the treatment that contains atenolol, its weight portion proportioning the best is: Ah Ti Lip river50 parts of thats, 3000 parts of Hainan Ervatamia Roots, 3000 parts of sago cycas, 3000 parts, China fir tower, 3000 parts of Lagotis glaucas.
In above composition of the present invention, the weight of each taste Chinese medicine is calculated with crude drug, if in grams, as makesPreparation, because varying in size of preparation can be made into 100-1000 agent. Described 100-1000 agent refers to the dosage form of UD,As tablet 100-1000 sheet, capsule 100-1000 grain, granule l00-1000g, oral liquid l00-l000ml, paste l00-L000g, pill 100-1000 ball etc.
More than composition is by weight as proportioning, can increase or reduce according to corresponding proportion, as on a large scale in the time producingProduction can be taking kg as unit, or taking t(ton) be unit; Preparation also can be taking g as unit on a small scale. Weight can increase orReduce, but the constant rate of raw medicinal herbs weight proportion between each composition.
Through science, screening obtains the ratio of above weight proportion, for especial patient, as severe or light disease, obesityOr the patient of slight of stature, can be corresponding the proportioning of amount of adjustment composition, increase or reduce being no more than 100%, drug effect is substantially constant.
Pharmaceutical composition of the present invention, can add separately or as required some medicines of injection volume acceptable auxiliaryMaterial, can adopt galenic pharmacy routine techniques to prepare this pharmaceutical preparation, as pharmaceutically active substance and the acceptable auxiliary material of medicine are mixedClose. In the time making pharmaceutical preparation, can make any pharmaceutically useful peroral dosage form, these formulations are selected from: granule, tablet, capsuleAgent, oral liquid, suck agent, pill, powder, preferably granule.
The preparation method of the above-mentioned hypertensive pharmaceutical composition for the treatment of that contains atenolol, comprises following steps:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add 6 ~ 8 times of water gagings of injection volume for the 1st time, decoct 1 ~ 2Hour, add for the second time 4 ~ 6 times of water gagings of injection volume, decoct 0.5 ~ 1.5 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 55 ~ 65 DEG C ,-0.04 ~-0.08Mpa condition to relative density and is 1.08 ~ 1.12 clearCream, adds ethanol to being 75% containing alcohol amount, places 12 hours, filters, and it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, spraysMist is dried to obtain dry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material separately or mix with the acceptable auxiliary material of medicine, makes according to galenic pharmacy conventional method.
In the preparation method of the above-mentioned hypertensive pharmaceutical composition for the treatment of that contains atenolol, in the step a of portion of institute the 1stThe inferior 7 times of water gagings of injection volume that add, decoct 1.5 hours, add for the second time 5 times of water gagings of injection volume, decoct 1 hour; Described stepIn rapid b, thickening temperature be 60 DEG C, concentrated pressure is-0.06Mpa.
Preferably, state the preparation method of the hypertensive pharmaceutical composition for the treatment of that contains atenolol, detailed step is as follows:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add 7 times of water gagings of injection volume for the 1st time, decoct 1.5 littleTime, add for the second time 5 times of water gagings of injection volume, decoct 1 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 60 DEG C ,-0.06Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried drylyDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material separately or mix with the acceptable auxiliary material of medicine, makes according to galenic pharmacy conventional method.
The acceptable auxiliary material of described medicine is selected from: starch, dolomol, sweet mellow wine, sorbierite, sorbic acid or sylvite,Sodium pyrosulfite, sodium hydrogensulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitaminC, tie up main plain E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or itsThe aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride, sodium lactate, xylitol, dextran, sweet ammoniaAcid, lactose, mannitol, silicon derivative, cellulose and derivative thereof, alginates, gelatin, polyvinylpyrrolidone, glycerine, thirdGlycol, ethanol, polysorbate60～80, department class～80, beeswax, lanolin, atoleine, hexadecanol, gallate ester, three ethanolAmine, basic amino acid, urea, allantoin, calcium carbonate, calcium bicarbonate, surfactant, polyethylene glycol, cyclodextrin, β～ring are stuck with pasteEssence, phospholipid material, kaolin, talcum powder, calcium stearate etc.
The present invention treats hypertensive pharmaceutical composition and is applicable to treat essential hypertension, can be separately or with other step-downsMedicine use in conjunction.
The present invention treats hypertensive pharmaceutical composition usage and dosage:
Oral: to start cumulative dosage from low dose. Conventionally initial dose be one time 1 bag, 2 times on the one; Take with meal.
The present invention treats hypertensive pharmaceutical composition forbids in II-III degree heart block 1. 2 cardiogenic shocksPerson. 3 sick sinus syndromes and severe sinus bradycardia.
In pharmaceutical composition of the present invention,
Hainan Ervatamia Root is the bark of legume Hainan Ervatamia Root Delonixregia (Bojea) Rofin.. Taste is sweet; Light; Cold in nature. ReturnLiver Channel. Function is calming the liver. Main liver pattern of fever hypertension, dizzy, vexed not peaceful.
Sago cycas is called newborn chicken rattan, doggie chicken, is Thelypteridaceae plant sago cycas Stegnogrammacyrtomioides(C.Chr) Ching[Dryopterisstegnogramma (Bl.) C.Chr.var.cyrtomioidesC.Chr.] rootStem. Taste is sweet; Bitter; Cold in nature. Return Liver Channel. Function is calming the liver. Main dizzy; Vexed insomnia; Night sweat.
Shan Ta another name grassleaf sweetflag leaf, mountain calamus, water sword grass, white flag, medicine calamus are aroid China fir tower AcorusThe dry rhizome of tatarinowiiSchott. Taste is pungent, bitter, warm in nature. The thoughts of returning home, stomach warp. Function dampness elimination appetizing, the open-minded phlegm of having one's ideas straightened out, wakes upGod's intelligence development. Not hungry for gastral cavity ruffian, mouthful diarrhea of keeping silent, coma epilepsy, forgetful deafness.
Lagotis glauca is the short spoke Chinese celery of samphire OenantheBenghalensisBenth.EtHook.F.'sHerb. Taste is pungent; Micro-sweet; Cool in nature. Function clearing heat for promoting eruption; Flat liver is calmed the nerves. The Djumah rash initial stage; On liver-yang, laugh at; Insomnia and dreamful sleep.
Beneficial effect of the present invention is: the present invention combines Chinese medicine and atenolol, to avoid atenololCommon allergic reaction, and improve hypertensive result for the treatment of. Clinical test results shows: oral the present invention is containing atenololThe patient of composition, preliminary judgement is better than simple application atenolol person reducing blood pressure aspect horizontal. In addition, of the present inventionImproving aspect the bad reaction of atenolol medicine impotence than simple application atenolol containing atenolol pharmaceutical compositionPerson's effect is (P < 0.05) significantly. Illustrate that the atenolol pharmaceutical composition that contains of the present invention truly has curative effect aspect reducing blood pressure,And have advantages of that side effect is little.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understandsThe present invention, but therefore do not limit the present invention.
Embodiment 1
One is treated hypertensive pharmaceutical composition, is made up of the bulk drug of following weight portion proportioning:
Atenolol 50g, Hainan Ervatamia Root 3000g, sago cycas 3000g, China fir tower 3000g, Lagotis glauca 3000g.
The preparation method of the hypertensive pharmaceutical composition of this treatment:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add injection volume 7 water gagings the 1st time, decoct 1.5 littleTime, add for the second time 5 times of water gagings of injection volume, decoct 1 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 60 DEG C ,-0.06Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried drylyDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material adds injection volume xylitol, sweet mellow wine and β～cyclodextrin, the appropriate granulation agent of adhesive.
Prepare altogether 1000 bags, every bag heavy 5g.
Embodiment 2
One is treated hypertensive pharmaceutical composition, is made up of the bulk drug of following weight portion proportioning:
Atenolol 40g, Hainan Ervatamia Root 3500g, sago cycas 2500g, China fir tower 3500g, Lagotis glauca 2500g.
The preparation method of the hypertensive pharmaceutical composition of this treatment:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add injection volume 8 water gagings the 1st time, decoct 2 hours,Add for the second time 6 times of water gagings of injection volume, decoct 1.5 hours, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 55 DEG C ,-0.08Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried drylyDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material adds injection volume xylitol, sweet mellow wine and β～cyclodextrin,, the appropriate granulation agent of adhesive.
Prepare altogether 1000 bags, every bag heavy 5g.
Embodiment 3
One is treated hypertensive pharmaceutical composition, is made up of the bulk drug of following weight portion proportioning:
Atenolol 60g, Hainan Ervatamia Root 2500g, sago cycas 3500g, China fir tower 2500g, Lagotis glauca 3500g.
The preparation method of the hypertensive pharmaceutical composition of this treatment:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add injection volume 6 water gagings the 1st time, decoct 1 hour,Add for the second time 4 times of water gagings of injection volume, decoct 0.5 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 65 DEG C ,-0.04Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried drylyDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material adds injection volume xylitol, sweet mellow wine and β～cyclodextrin, the appropriate granulation agent of adhesive.
Prepare altogether 1000 bags, every bag heavy 5g.
Embodiment 4
One is treated hypertensive pharmaceutical composition, is made up of the bulk drug of following weight portion proportioning:
Atenolol 70g, Hainan Ervatamia Root 4000g, sago cycas 4000g, China fir tower 4000g, Lagotis glauca 4000g.
The preparation method of the hypertensive pharmaceutical composition of this treatment:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add injection volume 7 water gagings the 1st time, decoct 1.5 littleTime, add for the second time 5 times of water gagings of injection volume, decoct 1 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 60 DEG C ,-0.06Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried drylyDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material adds injection volume xylitol, sweet mellow wine and β～cyclodextrin, the appropriate granulation agent of adhesive.
Prepare altogether 1000 bags, every bag heavy 5g.
Embodiment 5
One is treated hypertensive pharmaceutical composition, is made up of the bulk drug of following weight portion proportioning:
Atenolol 30g, Hainan Ervatamia Root 2000g, sago cycas 2000g, China fir tower 2000g, Lagotis glauca 2000g.
The preparation method of the hypertensive pharmaceutical composition of this treatment:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add injection volume 7 water gagings the 1st time, decoct 1.5 littleTime, add for the second time 5 times of water gagings of injection volume, decoct 1 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 60 DEG C ,-0.06Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried drylyDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material adds injection volume xylitol, sweet mellow wine and β～cyclodextrin, the appropriate granulation agent of adhesive.
Prepare altogether 1000 bags, every bag heavy 5g.
The pharmaceutical composition that contains atenolol prepared by embodiment 1 has carried out clinical testing, and result is as follows:
1. data and method
1.1 research object
100 routine essential hypertension male patients have been selected in this research, all meet WHO diagnostic criteria in 1999, andMeet following condition: 1. make a definite diagnosis for the first time or make a definite diagnosis and be no more than that do not treat half a year and systolic pressure >=140mmHg, diastolic pressure >=90mmHg; 2. without serious acute and chronic complication. Qualified 100 routine patients are divided into observation group and control group at random, everyOrganize 50 examples. Two groups of patients aspect sex, age, body mass index, the course of disease, blood pressure level etc. very physical data comparing difference without systemMeter meaning (P > 0.05), there is comparativity.
1.2 methods for the treatment of
1. control group: apply atenolol treatment on the basis of patient being carried out to the education of hypertension health knowledge, atenololEach 50mg, every day 2 times. 2. observation group: use in conjunction contains on the basis of patient being carried out to the education of hypertension health knowledgeThere is the pharmaceutical composition of atenolol, each 1 bag, every day 2 times. Two groups all taking 1 month as one treatment stage.
1.3 observation index
1. safety indexes: as routine blood test, stool routine examination, liver function, kidney function test, electrocardiogram etc.; 2. health giving quality index: controlBlood pressure level before and after treating, blood pressure normalization rate (systolic pressure≤120mmHg, diastolic pressure≤90mmHg). 3. impotence bad reaction occursSituation.
1.4 statistical method
Adopt SPSS17.0 to carry out the statistical analysis of data. Measurement data adopts t inspection (with mean ± standard deviation tableShow); Grouped data adopts χ2Inspection, using P≤0.05 as there being statistical significance, using P≤0.01 as there being highly statisticsLearn meaning.
2. result
2.1 clinical efficacy results
Treat the systolic pressure of first two groups and the horizontal comparing difference not statistically significant of diastolic pressure (P > 0.05); After treatment two groupsSystolic pressure and diastolic pressure level all obviously reduce before treatment, and difference has statistical significance (P < 0.05); The patient of observation group existsSystolic pressure and diastolic pressure improve degree aspect and are obviously better than control group, and difference has statistical significance (P < 0.05); Observation group controlsBlood pressure normalization rate 96.0%(48/50 after treating) apparently higher than the 78.0%(39/50 of control group), difference have statistical significance (P <0.05); In table 1.
Table 1 liang group patient clinical curative effect comparison
| Group | Number of cases | Time | Systolic pressure (mmHg) | Diastolic pressure (mmHg) |
| Observation group | 50 | Before treatment | 167.81±13.57 | 115.68±12.21 |
| After treatment | 104.25±9.54*# | 70.66±4.47*# | ||
| Control group | 50 | Before treatment | 167.79±13.49 | 115.64±12.24 |
| After treatment | 121.72±11.36* | 98.64±5.98* |
Note: * represents and front relatively P < 0.05 for the treatment of; # represent with treatment of control group after P < 0.05 relatively
2.2 security observed results
In this test, all experimenter carries out respectively safety indexes detection before and after treatment, and result is not found obviously extremely to changeBecome, illustrate that the pharmaceutical composition that contains atenolol of the present invention uses safety.
A situation arises in 2.3 nervous system bad reactions
In this research, the impotence incidence of observation group is 0%(0/50) be starkly lower than the 10%(5/50 of control group), difference has systemMeter is learned meaning (P < 0.05).
3. conclusion
The present invention combines Chinese medicine and atenolol, to avoid the common impotence bad reaction of atenolol, and improvesTo hypertensive result for the treatment of. Clinical test results shows: oral the present invention is containing the patient of atenolol composition, preliminary judgementAspect control blood pressure level, be better than simple application atenolol person. In addition, of the present invention containing atenolol pharmaceutical compositionImproving aspect the bad reaction of atenolol medicine impotence than significantly (P < 0.05) of simple application atenolol person effect. SayBright of the present invention safe and effective aspect reducing blood pressure containing atenolol pharmaceutical composition, and have advantages of that side effect is little.
Claims (7)
1. the hypertensive pharmaceutical composition for the treatment of that contains atenolol, is made up of the bulk drug of following weight portion proportioning:Atenolol 30-70 part, Hainan Ervatamia Root 2000-4000 part, sago cycas 2000-4000 part, China fir tower 2000-4000 part, Lagotis glauca 2000-4000 parts.
2. the hypertensive pharmaceutical composition of the treatment that contains atenolol as claimed in claim 1, is characterized in that, by asThe bulk drug composition of lower weight portion proportioning: atenolol 40-60 part, Hainan Ervatamia Root 2500-3500 part, sago cycas 2500-3500 part, China firTower 2500-3500 part, Lagotis glauca 2500-3500 part.
3. the hypertensive pharmaceutical composition of the treatment that contains atenolol as claimed in claim 2, is characterized in that, by asThe bulk drug composition of lower weight portion proportioning: 50 parts of atenolols, 3000 parts of Hainan Ervatamia Roots, 3000 parts of sago cycas, 3000 parts, China fir tower, the rabbit ear3000 parts of grass.
4. the hypertensive pharmaceutical composition of the treatment that contains atenolol as described in claim 1 or 2 or 3, is characterized in that,Its dosage form is granule.
5. the preparation method of the hypertensive pharmaceutical composition for the treatment of that contains atenolol described in claim 1 or 2 or 3, bagContain following steps:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add 6 ~ 8 times of water gagings of injection volume for the 1st time, decoct 1 ~ 2Hour, add for the second time 4 ~ 6 times of water gagings of injection volume, decoct 0.5 ~ 1.5 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 55 ~ 65 DEG C ,-0.04 ~-0.08Mpa condition to relative density and is 1.08 ~ 1.12 clearCream, adds ethanol to being 75% containing alcohol amount, places 12 hours, filters, and it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, spraysMist is dry, obtains dry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material separately or mix with the acceptable auxiliary material of medicine, makes according to galenic pharmacy conventional method.
6. the preparation method of the hypertensive pharmaceutical composition for the treatment of that contains atenolol as claimed in claim 5, its featureBe,
In the step a of portion of institute, add 7 times of water gagings of injection volume for the 1st time, decoct 1.5 hours, add for the second time 5 times of amounts of injection volumeWater, decocts 1 hour; In described step b, thickening temperature be 60 DEG C, concentrated pressure is-0.06Mpa.
7. the preparation method of the hypertensive pharmaceutical composition for the treatment of that contains atenolol as claimed in claim 5, in detail stepRapid as follows:
A. by Hainan Ervatamia Root, sago cycas, Shan Ta, Lagotis glauca boiling 2 times, add 7 times of water gagings of injection volume for the 1st time, decoct 1.5 littleTime, add for the second time 5 times of water gagings of injection volume, decoct 1 hour, merge decoction liquor, for subsequent use;
B. decoction liquor is condensed under 60 DEG C ,-0.06Mpa condition to relative density and is 1.08 ~ 1.12 clear cream, add ethanol extremelyBe 75% containing alcohol amount, place 12 hours, filter, it is 1.15 ~ 1.20 clear cream that filtrate is concentrated into relative density, and spraying is dried, and obtains dryDry medicinal powder;
C. atenolol and dry medicinal powder are mixed, granulate, obtain the active material of pharmaceutical composition of the present invention;
D. this active material separately or mix with the acceptable auxiliary material of medicine, makes according to galenic pharmacy conventional method.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610175841.5A CN105582327A (en) | 2016-03-27 | 2016-03-27 | Atenolol-containing medicine composition for treating high blood pressure and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610175841.5A CN105582327A (en) | 2016-03-27 | 2016-03-27 | Atenolol-containing medicine composition for treating high blood pressure and preparation method thereof |
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| CN105582327A true CN105582327A (en) | 2016-05-18 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066391A (en) * | 2007-06-29 | 2007-11-07 | 王忠玉 | Medicine composition for treating hypertension |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066391A (en) * | 2007-06-29 | 2007-11-07 | 王忠玉 | Medicine composition for treating hypertension |
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Application publication date: 20160518 |