CN108042699A - A kind of pharmaceutical composition for treating insomnia, preparation and preparation method thereof - Google Patents
A kind of pharmaceutical composition for treating insomnia, preparation and preparation method thereof Download PDFInfo
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Abstract
A kind of pharmaceutical composition for treating insomnia, preparation and preparation method thereof, are related to technical field of pharmaceuticals.A kind of pharmaceutical composition for treating insomnia, pharmaceutical composition count in parts by weight including：15~30 parts of 15~25 parts of jujube, 5~15 parts of ginseng, 10~15 parts of spina date seed, 9~30 parts of oyster, 3~9 parts of donkey-hide gelatin, 2~10 parts of Radix Glycyrrhizae, 6~12 parts of the fruit of Chinese wolfberry, 6~12 parts of lily, 6~15 parts of lotus seeds, 10~15 parts of Poria cocos, 6~9 parts of longan, 9~15 parts of mulberries and Chinese yam.The pharmaceutical composition for difficulty falling asleep caused by insomnia, sleep sensory disturbance, poor sleeping quality, sleep it is shallow it is easy have a dream, easily wake up with a start, the symptoms such as Sleep architecture imbalance are with therapeutic effect well.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and more particularly to a kind of pharmaceutical composition for treating insomnia, preparation and its system
Preparation Method.
Background technology
Insomnia refers to difficulty falling asleep, poor sleeping quality, sleep is simple and easy has a dream, easily wakes up with a start etc. a series of symptoms.Insomnia is dirty
The performance of internal organs negative and positive of qi and blood imbalance, usually since mental element and physical factors cause.With modern society's life rhythm not
Disconnected to accelerate, the incidence of insomnia is higher and higher, and insomnia has become the serious factor for restricting modern life.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition for treating insomnia, and the pharmaceutical composition is for insomnia
With preferable therapeutic effect.
The second object of the present invention is to provide a kind of pharmaceutical preparation for treating insomnia.
The third object of the present invention is to provide a kind of preparation method for the pharmaceutical preparation for treating insomnia, preparation method letter
Single easy to operate, obtained pharmaceutical preparation quality is high, good drug efficacy.
The present invention is solved its technical problem and is realized using following technical scheme.
The present invention proposes a kind of pharmaceutical composition for treating insomnia, pharmaceutical composition count in parts by weight including：
15~25 parts of jujube, 5~15 parts of ginseng, 10~15 parts of spina date seed, 9~30 parts of oyster, 3~9 parts of donkey-hide gelatin, Radix Glycyrrhizae 2
~10 parts, 6~12 parts of the fruit of Chinese wolfberry, 6~12 parts of lily, 6~15 parts of lotus seeds, 10~15 parts of Poria cocos, 6~9 parts of longan, mulberries 9~
15 parts and 15~30 parts of Chinese yam.
The present invention proposes a kind of pharmaceutical preparation for treating insomnia, the pharmaceutical composition system mainly being had a sleepless night by above-mentioned treatment
Into.
The present invention also proposes a kind of pharmaceutical preparation of above-mentioned treatment insomnia, including：
It counts in parts by weight, by oyster and water according to solid-liquid ratio 1：5~8 mixing decoct 10~20min after with jujube, people
After ginseng, spina date seed, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam mixing decoct 15~25min, filtering
The first filtrate and filter residue are obtained, filter residue is mixed decoction with water obtains the second filtrate, and the first filtrate and the second filtrate, donkey-hide gelatin are mixed
Heating is closed until obtaining liquid after donkey-hide gelatin fusing, liquid is concentrated to give medicinal extract.
The advantageous effect of the embodiment of the present invention is：The pharmaceutical composition for the treatment of insomnia disclosed by the invention, by jujube, people
Ginseng, spina date seed, oyster, donkey-hide gelatin, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam are by suitable proportioning
Composition, which drafts according to theory of traditional Chinese medical science, and pharmaceutical composition compatibility is reasonable, and effect is complementary, can generate and is preferably
System acts on, each component, which shares, to be had effects that invigorate the spleen and benefit qi, nourishing heart tonifying liver, checking exuberance of yang tonifying yin, kidney tonifying moistening lung, sharp heart spleen, tranquilizing the mind will,
Fill blood, adjust the work(of internal organs, and for difficulty falling asleep caused by insomnia, sleep sensory disturbance, poor sleeping quality, sleep is shallow easily does
Dream is easily waken up with a start, and the symptoms such as Sleep architecture imbalance have therapeutic effect well.
Specific embodiment
It, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
A kind of pharmaceutical composition for treating insomnia to the embodiment of the present invention, preparation and preparation method thereof carry out specific below
Explanation.
A kind of pharmaceutical composition for treating insomnia, pharmaceutical composition count in parts by weight including：
15~25 parts of jujube, 5~15 parts of ginseng, 10~15 parts of spina date seed, 9~30 parts of oyster, 3~9 parts of donkey-hide gelatin, Radix Glycyrrhizae 2
~10 parts, 6~12 parts of the fruit of Chinese wolfberry, 6~12 parts of lily, 6~15 parts of lotus seeds, 10~15 parts of Poria cocos, 6~9 parts of longan, mulberries 9~
15 parts and 15~30 parts of Chinese yam.
In some embodiments, count in parts by weight, jujube is 16~22 parts, ginseng is 6~12 parts, spina date seed 11
~14 parts, oyster be 10~25 parts, donkey-hide gelatin is 4~8 parts, Radix Glycyrrhizae is 3~9 parts, the fruit of Chinese wolfberry is 7~10 parts, lily is 7~10
Part, lotus seeds are 7~12 parts, Poria cocos is 11~14 parts, longan is 7~9 parts, mulberries are 10~14 parts, and Chinese yam is 18~25 parts.
In some embodiments, count in parts by weight, jujube is 18~20 parts, ginseng is 8~10 parts, spina date seed 12
~13 parts, oyster be 12~20 parts, donkey-hide gelatin is 5~6 parts, Radix Glycyrrhizae is 5~8 parts, the fruit of Chinese wolfberry is 8~9 parts, lily is 8~9 parts,
Lotus seeds are 8~10 parts, Poria cocos is 12~13 parts, longan is 7~8 parts, mulberries are 11~12 parts, Chinese yam is 20~22 parts.
Jujube, it is warm-natured, it is sweet in flavor.Converge to the spleen channel, stomach, the heart channel of Hang-Shaoyin.It adjusts battalion to defend with tonifying spleen and stomach, nourishing generate fluid, antidote poison
The effect of.It can be used for treatment stomach void deficiency of food, the weak loose stool of spleen, qi-blood-body fluid deficiency, disharmony between ying and wei, palpitation and severe palpitation, hysteria of womam.
Ginseng, sweet in flavor, slight bitter are warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.It, which has, reinforces vital energy, veins takes off admittedly, tonifying spleen benefit
The effect of lung promotes the production of body fluid, tranquilizing the mind.
Spina date seed, it is sweet in flavor, sour, it is mild-natured.Return liver, courage, the heart channel of Hang-Shaoyin.It promotes the production of body fluid with nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating
Effect.Available for treating restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirst.
Oyster, taste is salty, cold nature.Return liver, courage, kidney channel.It is with transquilization with heavy material, the effect of checking exuberance of yang tonifying yin, softening and resolving hard mass.
Available for treating insomnia of palpitating with fear, dizziness ear toot, scrofula subcutaneous nodule, lump in the abdomen lump in the abdomen lump in the abdomen.Calcined oyster shell restrains astringent method, relieving haperacidity analgesic.For certainly
Sweat night sweat, emission and spermatorrhea, under uterine bleeding band, acid regurgitation of having a stomachache.
Donkey-hide gelatin, it is sweet in flavor, it is mild-natured.Return lung, liver and kidney channel.The effect of it has enriching yin of enriching blood, and moisturizes, hemostasis.Available for treating
Blood deficiency chlorosis, dizziness palpitaition, impotence weakness, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough, overstrain cough spitting of blood, haematemesis hematuria are had blood in stool
Uterine bleeding, vaginal bleeding during pregnancy.
Radix Glycyrrhizae, it is sweet in flavor, it is mild-natured.The thoughts of returning home, lung, spleen, stomach.It, which has, invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, emergency
The effect of analgesic, coordinating the drug actions of a prescription.It is weakness of the spleen and the stomach available for treating, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction
Anxious pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
The fruit of Chinese wolfberry, it is sweet in flavor, it is mild-natured.Return liver and kidney channel.It is with nourishing liver and kidney, the effect of benefiting shrewd head.It is empty available for treatment
Labor essence is lost, soreness of waist and knee joint, dizziness and tinnitus, impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision.
Lily, it is sweet in flavor, it is cold in nature.Distributed in heart and lung channels.It is with Yin nourishing and lung moistening, the effect of clearing away the heart fire and tranquillizing.It coughs cough available for treatment
Blood, dysphoria palpitates with fear, insomnia and dreamful sleep are absent-minded.
Lotus seeds, it is sweet in flavor, puckery, it is mild-natured.Returns spleen, kidney, the heart channel of Hang-Shaoyin.It is with tonifying spleen and stopping diarrhea, stop-band, the puckery essence of kidney-nourishing, mental-tranquilization
The effect of.Available for splenasthenic diarrhea is treated, under, pass out semen, palpitation and insomnia.
Poria cocos, it is sweet in flavor, light, it is mild-natured.The thoughts of returning home, lung, spleen, kidney channel.It is with clearing damp and promoting diuresis, the effect of invigorating the spleen, calming heart.It can use
In treatment oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Longan, it is sweet in flavor, it is warm-natured.The thoughts of returning home, the spleen channel.The effect of it fills blood with heart-spleen boosting, tranquilizing the mind will.Available for treating
Consumptive disease is thin and weak, and palpitaition appoints the illnesss such as sad, insomnia forgetfulness, insufficiency of the spleen diarrhoea, postpartum edema, lassitude, spontaneous sweating.
Mulberries, it is sweet in flavor, it is sour, cold in nature.Liver and kidney channel.Its with nourishing yin and supplementing blood, liver-kidney tonifying, promote the production of body fluid to quench thirst, UFA eyesight
Effect.It has a dizzy spell available for what treatment kidney deficiency and liver and deficiency of blood essence lost；Soreness of waist tinnitus；Poliosis；Insomnia and dreamful sleep；Tianjin wound
Yearningly；It quenches one's thirst；Dry constipation of intestines.
Chinese yam, it is sweet in flavor, it is mild-natured.Returns spleen, lung, kidney channel.The effect of it is with tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying puckery essence.It can
For treating spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, and under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) tonifying spleen is good for
Stomach.For spleen eating less, diarrhea loose stool, leukorrhea.
The pharmaceutical composition for the treatment of insomnia disclosed by the invention, by jujube, ginseng, spina date seed, oyster, donkey-hide gelatin, Radix Glycyrrhizae, Chinese holly
Matrimony vine, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam are formed by suitable proportioning, and the pharmaceutical composition is according to middle medical knowledge
By drafting, pharmaceutical composition compatibility is reasonable, and effect is complementary, can generate preferably systemic effect, and each component is shared with tonifying spleen benefit
The effect of gas, nourishing heart tonifying liver, checking exuberance of yang tonifying yin, kidney tonifying moistening lung, sharp heart spleen, tranquilizing the mind will, the work(for the internal organs that fill blood, adjust, for insomnia
Caused difficulty falling asleep, sleep sensory disturbance, poor sleeping quality, sleep it is shallow it is easy have a dream, easily wake up with a start, Sleep architecture lack of proper care etc. diseases
Shape has therapeutic effect well.
A kind of pharmaceutical preparation for treating insomnia, the pharmaceutical composition mainly being had a sleepless night by above-mentioned treatment are made.
In some embodiments, the pharmaceutical composition and pharmacy which is had a sleepless night by above-mentioned treatment are subjected to
Auxiliary material composition.
Further, which includes tablet or pill.It should be noted that the pharmaceutical preparation of present embodiment is not
It is limited to tablet or pill or other dosage forms of the prior art, such as oral liquid, capsule.
A kind of pharmaceutical preparation of above-mentioned treatment insomnia, including：
It counts in parts by weight, by oyster and water according to solid-liquid ratio 1：5~8 mixing decoct 10~20min after with jujube, people
After ginseng, spina date seed, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam mixing decoct 15~25min, filtering
The first filtrate and filter residue are obtained, filter residue is mixed decoction with water obtains the second filtrate, and the first filtrate and the second filtrate, donkey-hide gelatin are mixed
Heating is closed until obtaining liquid after donkey-hide gelatin fusing, liquid is concentrated to give medicinal extract.It should be noted that the material in solid-liquid ratio
Refer to the amount of pharmaceutical composition each component summation, liquid refers to the amount of water.
Further, relative density of the medicinal extract at a temperature of 60 DEG C is 1.1~1.3g/cm3。
Further, medicinal extract is mixed with pharmaceutically acceptable auxiliary material, dried, tabletting can obtain pill or tablet.Wherein, medicine
The acceptable auxiliary material of agent can be xylitol or glucose.It should be noted that pharmaceutically acceptable auxiliary material is not limited to
For xylitol or glucose.
The preparation method of this pharmaceutical preparation, it is simple and practicable, it is workable, drug effect can largely be avoided to be broken
It is bad, the content of active principle in pharmaceutical preparation is remained, so as to ensure drug effect.
Present embodiment also provides a kind of preparation method for the pharmaceutical preparation for treating insomnia, including：
Count in parts by weight, by oyster, jujube, ginseng, spina date seed, donkey-hide gelatin, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos,
Longan, mulberries and Chinese yam are mixed to get mixture, are sent out after mixture is mixed with water and probiotics at a temperature of 80-100 DEG C
After ferment, pharmaceutical solutions are obtained after filtering.
The preparation method of the pharmaceutical preparation, the active ingredient of pharmaceutical composition are converted by probiotics, become by macromolecular
Small molecule, can human body preferably absorb, drug effect is more preferable, and curative effect is faster.In fermentation process, drug reduces medicine by conversion
The detrimental toxicities of object improve the bitter taste of Chinese medicine.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of pharmaceutical preparation for treating insomnia, by the pharmaceutical composition and xylitol system for the treatment of insomnia
Into.The pharmaceutical composition includes：Jujube 22g, ginseng 6g, spina date seed 12g, oyster 15g, donkey-hide gelatin 5g, Radix Glycyrrhizae 9g, fruit of Chinese wolfberry 8g,
Lily 9g, lotus seeds 8g, Poria cocos 10g, longan 9g, mulberries 10g and Chinese yam 30g.
The preparation method of the pharmaceutical preparation, including：By oyster and water according to solid-liquid ratio 1：5 mixing decoct 15min after with it is red
After jujube, ginseng, spina date seed, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam mixing decoct 20min, filtering
The first filtrate and filter residue are obtained, filter residue is mixed decoction with water obtains the second filtrate, and the first filtrate and the second filtrate, donkey-hide gelatin are mixed
Heating is closed until obtaining liquid after donkey-hide gelatin fusing, it is 1.1g/cm that liquid is concentrated to give to the relative density at a temperature of 60 DEG C3
Medicinal extract.By medicinal extract and xylitol according to weight ratio 5:After 1 mixing, dry, tabletting.
Embodiment 2
The present embodiment provides a kind of pharmaceutical preparation for treating insomnia, by the pharmaceutical composition and xylitol system for the treatment of insomnia
Into.The pharmaceutical composition includes：Jujube 16g, ginseng 8g, spina date seed 15g, oyster 25g, donkey-hide gelatin 4g, Radix Glycyrrhizae 10g, fruit of Chinese wolfberry 6g,
Lily 10g, lotus seeds 12g, Poria cocos 14g, longan 6g, mulberries 11g and Chinese yam 20g.
The preparation method of the pharmaceutical preparation, including：By oyster and water according to solid-liquid ratio 1：5~8 mixing decoct 10min after with
After jujube, ginseng, spina date seed, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam mixing decoct 20min, mistake
Filter obtains the first filtrate and filter residue, and filter residue is mixed decoction with water obtains the second filtrate, by the first filtrate and the second filtrate, donkey-hide gelatin
For Hybrid Heating until obtaining liquid after donkey-hide gelatin fusing, it is 1.2g/ that liquid is concentrated to give to the relative density at a temperature of 60 DEG C
cm3Medicinal extract.By medicinal extract and xylitol according to weight ratio 5:After 1 mixing, dry, tabletting.
Embodiment 3
The present embodiment provides a kind of pharmaceutical preparation for treating insomnia, by the pharmaceutical composition and xylitol system for the treatment of insomnia
Into.The pharmaceutical composition includes：Jujube 20g, ginseng 15g, spina date seed 11g, oyster 9g, donkey-hide gelatin 9g, Radix Glycyrrhizae 5g, fruit of Chinese wolfberry 12g,
Lily 11g, lotus seeds 6g, Poria cocos 12g, longan 7g, mulberries 14g and Chinese yam 15g.
The preparation method of the pharmaceutical preparation, including：By oyster and water according to solid-liquid ratio 1：7 mixing decoct 20min after with it is red
After jujube, ginseng, spina date seed, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam mixing decoct 25min, filtering
The first filtrate and filter residue are obtained, filter residue is mixed decoction with water obtains the second filtrate, and the first filtrate and the second filtrate, donkey-hide gelatin are mixed
Heating is closed until obtaining liquid after donkey-hide gelatin fusing, it is 1.3g/cm that liquid is concentrated to give to the relative density at a temperature of 60 DEG C3
Medicinal extract.By medicinal extract and xylitol according to weight ratio 6:After 1 mixing, dry, tabletting.
Embodiment 4
The present embodiment provides a kind of pharmaceutical preparation for treating insomnia, by the pharmaceutical composition and glucose system for the treatment of insomnia
Into.The pharmaceutical composition includes：Jujube 25g, ginseng 13g, spina date seed 13g, oyster 13g, donkey-hide gelatin 12g, Radix Glycyrrhizae 6g, the fruit of Chinese wolfberry
2g, lily 11g, lotus seeds 7g, Poria cocos 10g, longan 11g, mulberries 9g and Chinese yam 25g.
The preparation method of the pharmaceutical preparation, including：By oyster and water according to solid-liquid ratio 1：7 mixing decoct 10min after with it is red
After jujube, ginseng, spina date seed, Radix Glycyrrhizae, the fruit of Chinese wolfberry, lily, lotus seeds, Poria cocos, longan, mulberries and Chinese yam mixing decoct 15min, filtering
The first filtrate and filter residue are obtained, filter residue is mixed decoction with water obtains the second filtrate, and the first filtrate and the second filtrate, donkey-hide gelatin are mixed
Heating is closed until obtaining liquid after donkey-hide gelatin fusing, it is 1.2g/cm that liquid is concentrated to give to the relative density at a temperature of 60 DEG C3
Medicinal extract.By medicinal extract and glucose according to weight ratio 7:After 1 mixing, dry, tabletting.
Embodiment 5
The present embodiment provides a kind of pharmaceutical preparations for treating insomnia, are made of the pharmaceutical composition fermentation for the treatment of insomnia.
The pharmaceutical composition includes：Jujube 18g, ginseng 5g, spina date seed 15g, oyster 20g, donkey-hide gelatin 7g, Radix Glycyrrhizae 7g, fruit of Chinese wolfberry 7g, lily
6g, lotus seeds 15g, Poria cocos 13g, longan 8g, mulberries 12g and Chinese yam 28g.
The preparation method of the pharmaceutical preparation, including：By oyster, jujube, ginseng, spina date seed, donkey-hide gelatin, Radix Glycyrrhizae, the fruit of Chinese wolfberry, hundred
Conjunction, lotus seeds, Poria cocos, longan, mulberries and Chinese yam are mixed to get mixture, at 100 DEG C after mixture is mixed with water and probiotics
At a temperature of ferment after, pharmaceutical solutions are obtained after filtering.Wherein, mixture and the weight ratio of water and probiotics are 14:5:5.
Embodiment 6
The present embodiment provides a kind of pharmaceutical preparations for treating insomnia, are made of the pharmaceutical composition fermentation for the treatment of insomnia.
The pharmaceutical composition includes：Jujube 15g, ginseng 10g, spina date seed 14g, oyster 30g, donkey-hide gelatin 3g, Radix Glycyrrhizae 8g, fruit of Chinese wolfberry 8g, hundred
Close 12g, lotus seeds 7g, Poria cocos 15g, longan 8g, mulberries 15g and Chinese yam 18g.
The preparation method of the pharmaceutical preparation, including：By oyster, jujube, ginseng, spina date seed, donkey-hide gelatin, Radix Glycyrrhizae, the fruit of Chinese wolfberry, hundred
Conjunction, lotus seeds, Poria cocos, longan, mulberries and Chinese yam are mixed to get mixture, at 80 DEG C after mixture is mixed with water and probiotics
At a temperature of ferment after, pharmaceutical solutions are obtained after filtering.Wherein, mixture and the weight ratio of water and probiotics are 3:1:1.
Embodiment 7
The present embodiment provides a kind of pharmaceutical preparations for treating insomnia, are made of the pharmaceutical composition fermentation for the treatment of insomnia.
The pharmaceutical composition includes：Jujube 21g, ginseng 12g, spina date seed 10g, oyster 10g, donkey-hide gelatin 8g, Radix Glycyrrhizae 3g, fruit of Chinese wolfberry 10g, hundred
Close 9g, lotus seeds 9g, Poria cocos 15g, longan 6g, mulberries 13g and Chinese yam 22g.
The preparation method of the pharmaceutical preparation, including：By oyster, jujube, ginseng, spina date seed, donkey-hide gelatin, Radix Glycyrrhizae, the fruit of Chinese wolfberry, hundred
Conjunction, lotus seeds, Poria cocos, longan, mulberries and Chinese yam are mixed to get mixture, at 90 DEG C after mixture is mixed with water and probiotics
At a temperature of ferment after, pharmaceutical solutions are obtained after filtering.Wherein, mixture and the weight ratio of water and probiotics are 10:3:3.
Test example
1. case selection：
This group of case is the insomniac that the course of disease is 1~4 year.Age is 20~70 years old, 45 years old average.It is randomly divided into 8
Group, every group each 30, wherein experimental group is the 1st~7 group, and the 8th group is control group.The data such as age, the state of an illness of this 8 groups of patients without
Significant difference is comparable.
2. therapeutic scheme：
The patient of 1-4 groups (experimental group) takes orally the pharmaceutical preparation of Examples 1 to 4 offer, daily medication three times, each taking
The dose of medicine is 100mg.The patient of 5-7 groups (experimental group) takes orally the pharmaceutical preparation of the offer of embodiment 5~7, takes medicine three daily
Secondary, the dose taken medicine every time is 150mL.8th group of (control group) patient takes orally blank placebo.Continuous treatment 3 months, treatment phase
Between without using other drugs.Its treatment results refer to table 1.
3. clinical evaluation standard：
Recovery from illness：Under conditions of drug is not depended on, the clinical manifestation do not had a sleepless night；
Significantly：Under conditions of drug administration preparation, the insomnia situation of patient is substantially reduced；
It improves：Under conditions of drug administration preparation, the insomnia situation of patient has a degree of mitigation；
It is invalid：Patient does not have the change for finding the state of an illness under conditions of drug administration preparation.
1 clinical test results of table
As can be known from the results of Table 1, pharmaceutical composition provided by the invention has therapeutic effect well to insomnia.Main table
Now：After medication, not use any other drug in the case of, can eliminate, the difficulty falling asleep that relieving insomnia has,
Poor sleeping quality, sleep are shallow easy to have a dream, easily wakes up with a start etc. symptoms.And the pharmaceutical preparation that Examples 1 to 7 provides is right in 3 months
The treated effect of patient is high, wherein recovery from illness and significant patient account for more than the 90% of sum.Illustrate the pharmaceutical composition of the present invention
Object and good to the therapeutic effect of insomnia using pharmaceutical preparation made of the pharmaceutical composition, has rapid-action, eutherapeutic advantage.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of pharmaceutical composition for treating insomnia, which is characterized in that described pharmaceutical composition count in parts by weight including：
15~25 parts of jujube, 5~15 parts of ginseng, 10~15 parts of spina date seed, 9~30 parts of oyster, 3~9 parts of donkey-hide gelatin, Radix Glycyrrhizae 2~10
Part, 6~12 parts of the fruit of Chinese wolfberry, 6~12 parts of lily, 6~15 parts of lotus seeds, 10~15 parts of Poria cocos, 6~9 parts of longan, 9~15 parts of mulberries
And 15~30 parts of Chinese yam.
2. the pharmaceutical composition for the treatment of insomnia according to claim 1, which is characterized in that it counts in parts by weight, it is described red
Jujube is 16~22 parts, the ginseng is 6~12 parts, the spina date seed is 11~14 parts, the oyster is 10~25 parts, Ah
Glue is 4~8 parts, the Radix Glycyrrhizae is 3~9 parts, the fruit of Chinese wolfberry is 7~10 parts, the lily is 7~10 parts, the lotus seeds are 7
~12 parts, the Poria cocos be 11~14 parts, the longan is 7~9 parts, the mulberries are 10~14 parts, the Chinese yam for 18~
25 parts.
3. the pharmaceutical composition for the treatment of insomnia according to claim 1, which is characterized in that it counts in parts by weight, it is described red
Jujube is 18~20 parts, the ginseng is 8~10 parts, the spina date seed is 12~13 parts, the oyster is 12~20 parts, Ah
Glue is 5~6 parts, the Radix Glycyrrhizae is 5~8 parts, the fruit of Chinese wolfberry is 8~9 parts, the lily is 8~9 parts, the lotus seeds be 8~
10 parts, the Poria cocos be 12~13 parts, the longan is 7~8 parts, the mulberries are 11~12 parts, the Chinese yam is 20~22
Part.
4. a kind of pharmaceutical preparation for treating insomnia, which is characterized in that it is mainly treated by claim 1-3 any one of them and lost
The pharmaceutical composition of dormancy is made.
5. the pharmaceutical preparation for the treatment of insomnia according to claim 4, it is characterised in that the pharmaceutical preparation is by the drug
Composition and pharmaceutically acceptable auxiliary material composition.
6. it is according to claim 4 treatment insomnia pharmaceutical preparation, which is characterized in that the pharmaceutical preparation include pill or
Tablet.
7. a kind of preparation method of the pharmaceutical preparation for the treatment of insomnia as claimed in claim 4, which is characterized in that including：
It counts in parts by weight, by the oyster and water according to solid-liquid ratio 1：5~8 mixing decoct 10~20min after with the jujube,
The ginseng, the spina date seed, the Radix Glycyrrhizae, the fruit of Chinese wolfberry, the lily, the lotus seeds, the Poria cocos, the longan,
After the mulberries and Chinese yam mixing decoct 15~25min, the first filtrate and filter residue is obtained by filtration, the filter residue is mixed with water
It closes to decoct and obtains the second filtrate, by first filtrate and second filtrate, the donkey-hide gelatin Hybrid Heating until the donkey-hide gelatin
Liquid is obtained after fusing, the liquid is concentrated to give medicinal extract.
8. the preparation method of the pharmaceutical preparation for the treatment of insomnia according to claim 7, which is characterized in that further including will be described
Medicinal extract is mixed with pharmaceutically acceptable auxiliary material, dried, tabletting.
9. the preparation method of the pharmaceutical preparation for the treatment of insomnia according to claim 8, which is characterized in that the pharmacy can
The auxiliary material of receiving includes glucose sugar and xylitol.
10. a kind of preparation method of the pharmaceutical preparation for the treatment of insomnia as claimed in claim 4, which is characterized in that including：
It counts in parts by weight, by the oyster, the jujube, the ginseng, the spina date seed, the donkey-hide gelatin, the Radix Glycyrrhizae, institute
It states the fruit of Chinese wolfberry, the lily, the lotus seeds, the Poria cocos, the longan, the mulberries and the Chinese yam and is mixed to get mixing
Object after fermenting after the mixture is mixed with water and probiotics at a temperature of 80-100 DEG C, obtains pharmaceutical solutions after filtering.
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| CN114271491A (en) * | 2021-12-15 | 2022-04-05 | 重庆市中药研究院 | Medicinal and edible composition for improving insomnia as well as preparation method and application thereof |
| CN114452350A (en) * | 2022-02-22 | 2022-05-10 | 郑淑之 | Jujube kernel wine capable of relieving insomnia |
| CN115349537A (en) * | 2022-08-19 | 2022-11-18 | 四川省中西医结合医院 | Nerve-soothing and fatigue-resisting health-preserving biscuit and preparation method thereof |
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