CN1651088A - Effervescent preparation using alditol as functional ingredient - Google Patents
Effervescent preparation using alditol as functional ingredient Download PDFInfo
- Publication number
- CN1651088A CN1651088A CN 200410021760 CN200410021760A CN1651088A CN 1651088 A CN1651088 A CN 1651088A CN 200410021760 CN200410021760 CN 200410021760 CN 200410021760 A CN200410021760 A CN 200410021760A CN 1651088 A CN1651088 A CN 1651088A
- Authority
- CN
- China
- Prior art keywords
- effervescent
- sugar alcohol
- acid
- agent
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
An effervescent medicine using sugar alcohol as its functional component is disclosed.
Description
Technical field
The present invention relates to sugar alcohol as the application of effective component in the preparation effervescent, also relate to the effervescent of sugar alcohol as effective component.
Background technology
Sugar alcohol belongs to polyhydric alcohol, and at occurring in nature, xylitol extensively is present in various fruit, the vegetable, be a kind of sweeting agent of natural health, but content is very low.The commodity sugar alcohol is to make raw material with agricultural crops such as corn cob, bagasse, makes through deep processing.Also available corresponding monosaccharide of sugar alcohol or disaccharidase reduction generate, as the reducible generation sorbitol of glucose, and the reducible generation maltose alcohol of maltose, the reducible generation mannitol of fructose etc.
Sugar alcohol is not only sweeting agent, also not only has nutritive value, still has wonderful medical functions and health-care effect.
The sugar alcohol heat is low, only can slowly be absorbed in vivo or the part be utilized, can be used as diabetes patient's sweeting agent, supplementary and auxiliary therapeutical agent; Sugar alcohol can promote liver glycogen synthetic, and the liver function of improvement and lipotropic effect are arranged, and treats B-mode chronic persistent hepatitis, and chronic hepatitis B and liver cirrhosis have obvious curative effects, are hepatitis concurrent disease patient's desirable ancillary drugs; Sugar alcohol can not be produced the bacterial fermentation utilization of dental caries in the oral cavity, can suppress the generation of streptococcus growth and acid, so sugar alcohol can prevent anti-caries; Sugar alcohol also has weight losing function.Also have report, sugar alcohol is to otitis media, even sinusitis has the effect of prevention even auxiliary treatment.
Because its good effect, sugar alcohol is widely used in fields such as food, medicine, light industry.
In preparation, sugar alcohol is used on a small quantity as excipient, to improve the physical behavior of dosage form.
(medicine) and the health food that with the sugar alcohol are effective component can have different dosage form, as tablet, electuary, oral liquid etc.At present existing oral liquid, chewing gum etc.Though tablet is taken, preservation and easy to carry, absorb not as liquid agent.Though it is also convenient that oral fluid agent absorbs easily, uses, and preserves and carry existing problems.Electuary can be avoided its defective, is reasonable dosage form.But comparatively speaking, effervescent then has more advantage.The characteristics of effervescent have excellent characteristics: 1) dissolving is fast, and when contacting with water, acid-base reaction produces carbon dioxide, dissolves in very short time; 2) taking convenience, effervescent can produce the effervescent solution that contains active ingredient, and suitable child, old people and the solid preparation crowd that is difficult for swallowing use; 3) bioavailability height, because exist with liquid agent in short-term, medicine active ingredient time in water is very short, unlikely decomposition failure makes drug effect rapid, the bioavailability height; 4) easy to carry, especially than convenient with liquid agent.And effervescent has good perception effect.
The dosage form of sugar alcohol, existing at present oral liquid, chewing gum etc., it is the effervescent of effective component that Shang Weijian has with the sugar alcohol.
Summary of the invention
In view of effervescent as a kind of in collection sense organ, biological utilisation, preservation, use, convenient all good dosage form, again in view of sugar alcohol excellent drug, effect, be that the effective component preparation is a kind of good mode at effervescent with the sugar alcohol.
The inventor notices that patent application is disclosed as 1167436 " low pressure effervescent tablet ", wherein includes maltose alcohol, Sorbitol, mannitol, lactose, xylitol.But these sugar alcohols are not as effective component, but use as the excipient composition.The purpose of this application is to wish to solve the technology difficult problem of low-pressure compacting effervescent tablet, proposes with sugar alcohol as a kind of excipient, to satisfy the needs of low-pressure tabletting.These characteristics have been done to offer some clarification at Instructions Page 2, and original text is " following preparation of the present invention to be explained in more detail.Described preparation solvent is selected from maltose alcohol, Sorbitol, maltose, trehalose, mannitol, lactose and xylitol.These materials have the character of the required excipient of typical effervescent formulation, i.e. highly dissoluble in (1) water, and (2) sense of taste is good, and (3) handle (good flowability and agent of low hygroscopicity) easily, or the like.In addition, these chemical compounds can give tablet above-mentioned fabulous character." " described concrete component can partly or entirely replace being conventionally used as the purification sucrose of excipient ".Also done clearly explanation " be maltose alcohol with a small amount of excipient in the above-mentioned prescribed limit under the low pressure that is meeting the demands, Sorbitol, maltose, trehalose, mannitol, lactose and xylitol prepare " at the description page 5.Another purpose of this application has also illustrated this problem, i.e. this application provides vitamin low pressure effervescent formulation, also promptly prepares the prepared vitamin effervescent formulation of effervescent according to low pressure.
Other has a small amount of patent application, also is that the sugar alcohol with individual species uses as excipient.
The present invention then is to be effective component with the sugar alcohol, and is not only different with above-mentioned patent application purpose, and technical scheme also is different.
First purpose of the present invention provides with sugar alcohol as the application of effective component in the preparation effervescent.
Another object of the present invention provides with the effervescent of sugar alcohol as effective component.
For achieving the above object, the present invention at first provide with sugar alcohol as effective component in the application of preparation in the effervescent.
Application of the present invention, its technical scheme are to include one or more sugar alcohols, gas-producing disintegrant in the described effervescent.
Application of the present invention, described gas-producing disintegrant includes: one or more edible carbonate, one or more edible organic acids.
The preferred sodium bicarbonate of described edible carbonate, sodium carbonate, potassium bicarbonate, potassium carbonate.
Described edible organic acid optimization citric acid, malic acid, tartaric acid, lactic acid, fumaric acid, gluconic acid, adipic acid.
Application of the present invention, the basic ratio of effervescent is sugar alcohol 5%-95%, edible carbonate 3%-45%, edible organic acid 2%-40%.
Application of the present invention, the content of sugar alcohol is preferably 20%-80% in the effervescent.
Application of the present invention is characterized in that also can being used other drug composition, effective component on the basis of sugar alcohol, gas-producing disintegrant, and excipient, adjuvant, sweeting agent, the flavoring agent that can use acceptable routine on the preparation.
Described other drug composition, effective component are meant pharmaceutical compositions, the effective component of non-sugar alcohol, can be the effective components as medicine; It also can be effective component as health product; It can also be function composition as drink with function.Described other drug composition, effective component can be selected for use as required, also can not select for use.
Described figuration composition and adjuvant, be meant adopt conventional as on the preparation of effervescent or the figuration composition and the adjuvant that use on the dosage form, these figuration compositions and adjuvant are known, as lubricant, wetting agent, binding agent, antiseptic etc., concrete as starch, sucrose, lactose, hydroxypropyl cellulose, polyvinylpyrrolidone, Polyethylene Glycol, ethanol etc.These excipient can be selected different kinds for use as required with adjuvant, as feasible on the preparation, also can not select for use.
Described sweeting agent is the sweeting agent of galenic pharmacy and bromatology notion, refers to give the synthetic or native compound of sweet taste, as stevioside, glucide, Aspartane, glycyrrhizin etc.These sweeting agents can be selected for use as required, also can not select for use.
Described flavoring agent also is known, can be acceptable composition on any biology, on the galenic pharmacy.Flavoring agent also can comprise essence (flavouring agent), as flavoring orange essence, flavoring banana essence, Fructus Myricae rubrae essence, Fructus Citri Limoniae essence, flavoring pineapple essence, vanilla, cream flavour, chocolate essence etc.
Application of the present invention, described sugar alcohol can be the sugar alcohol of any kind of, mainly contains xylitol, Sorbitol (sorbitol), mannitol, maltose alcohol, hydroxyl isomaltulose, erythritol, threitol, lactose, Palatinitol benzylidene sorbitol etc.
Application of the present invention, the preferred xylitol of described sugar alcohol, Sorbitol, mannitol, maltose alcohol, hydroxyl isomaltulose, erythritol, threitol, lactose.
Application of the present invention, described effervescent can be the effervescents as medicine.
Application of the present invention, described effervescent can be the effervescents as health product.
Application of the present invention, described effervescent can be the effervescents as drink with function.
Application of the present invention, described effect can be the effects as medicine.
Application of the present invention, described effect can be the effects as health product.
Application of the present invention, described effect can be the effects as drink with function.
Application of the present invention, described effervescent can be effervescent dosage forms feasible on any preparation.
Application of the present invention, described effervescent is a preferred tablet.
Application of the present invention, described effervescent are the preferred particulates agent.
Application of the present invention, described effervescent are preferred electuaries.
Application of the present invention, described effervescent are preferred powder.
Application of the present invention, described effervescent are preferred dry-eating agent.Described dry-eating agent is to soak, and directly takes direct blistered effervescent in mouth.
Application of the present invention, described effervescent are preferred confection forms.
Application of the present invention, described dry-eating agent is a tablet.
Application of the present invention, described dry-eating agent is a granule.
Application of the present invention, described dry-eating agent is a powder.
Application of the present invention, described dry-eating agent is the confection form.
Application of the present invention, described dry-eating agent is a bubble gum.
Application of the present invention, described dry-eating agent is a chewing gum.
For achieving the above object, the invention provides with the effervescent of sugar alcohol as effective component.
Technical scheme of the present invention is with the effervescent of sugar alcohol as effective component, to it is characterized in that including in the described effervescent one or more sugar alcohols, gas-producing disintegrant.
Effervescent of the present invention, described gas-producing disintegrant includes: one or more edible edible carbonate, one or more edible organic acids.
The preferred sodium bicarbonate of described edible carbonate, sodium carbonate, potassium bicarbonate, potassium carbonate.
Described edible organic acid optimization citric acid, malic acid, tartaric acid, lactic acid, fumaric acid, gluconic acid, adipic acid.
Effervescent of the present invention, the basic ratio of effervescent is sugar alcohol 5%-95%, edible carbonate 3%-45%, edible organic acid 2%-40%.
Effervescent of the present invention, the content of sugar alcohol is preferably 20%-80% in the effervescent.
Effervescent of the present invention is characterized in that also can being used other drug composition, effective component on the basis of sugar alcohol, gas-producing disintegrant, and excipient, adjuvant, sweeting agent, the flavoring agent that can use acceptable routine on the preparation.
Described other drug composition, effective component are meant pharmaceutical compositions, the effective component of non-sugar alcohol, can be the effective components as medicine; It also can be effective component as health product; It can also be function composition as drink with function.Described other drug composition, effective component can be selected for use as required, also can not select for use.
Described figuration composition and adjuvant, be meant adopt conventional as on the preparation of effervescent or the figuration composition and the adjuvant that use on the dosage form, these figuration compositions and adjuvant are known, as lubricant, wetting agent, binding agent, antiseptic etc., concrete as starch, sucrose, lactose, hydroxypropyl cellulose, polyvinylpyrrolidone, Polyethylene Glycol, ethanol etc.These excipient can be selected different kinds for use as required with adjuvant, as feasible on the preparation, also can not select for use.
Described sweeting agent is the sweeting agent of galenic pharmacy and bromatology notion, refers to give the synthetic or native compound of sweet taste, as stevioside, glucide, Aspartane, glycyrrhizin etc.These sweeting agents can be selected for use as required, also can not select for use.
Described flavoring agent also is known, can be acceptable composition on any biology, on the galenic pharmacy.Flavoring agent also can comprise essence (flavouring agent), as flavoring orange essence, flavoring banana essence, Fructus Myricae rubrae essence, Fructus Citri Limoniae essence, flavoring pineapple essence, vanilla, cream flavour, chocolate essence etc.
Effervescent of the present invention, described sugar alcohol can be the sugar alcohol of any kind of, mainly contains xylitol, Sorbitol (sorbitol), mannitol, maltose alcohol, hydroxyl isomaltulose, erythritol, threitol, lactose, Palatinitol benzylidene sorbitol etc.
Effervescent of the present invention, the preferred xylitol of described sugar alcohol, Sorbitol, mannitol, maltose alcohol, hydroxyl isomaltulose, erythritol, threitol, lactose.
Effervescent of the present invention, described effervescent can be the effervescents as medicine.
Effervescent of the present invention, described effervescent can be the effervescents as health product.
Effervescent of the present invention, described effervescent can be the effervescents as drink with function.
Effervescent of the present invention, described effect can be the effects as medicine.
Effervescent of the present invention, described effect can be the effects as health product.
Effervescent of the present invention, described effect can be the effects as drink with function.
Effervescent of the present invention, described effervescent can be effervescent dosage forms feasible on any preparation.
Effervescent of the present invention, described effervescent is a preferred tablet.
Effervescent of the present invention, described effervescent are the preferred particulates agent.
Effervescent of the present invention, described effervescent are preferred electuaries.
Effervescent of the present invention, described effervescent are preferred powder.
Effervescent of the present invention, described effervescent are preferred dry-eating agent.Described dry-eating agent is to soak, and directly takes direct blistered effervescent in mouth.
Effervescent of the present invention, described effervescent are preferred confection forms.
Effervescent of the present invention, described dry-eating agent is a tablet.
Effervescent of the present invention, described dry-eating agent is a granule.
Effervescent of the present invention, described dry-eating agent is a powder.
Effervescent of the present invention, described dry-eating agent is the confection form.
Effervescent of the present invention, described dry-eating agent is a bubble gum.
Effervescent of the present invention, described dry-eating agent is a chewing gum.
Of the present invention with the effervescent of sugar alcohol as effective component, its preparation technology is a common process, specifically is divided into two class methods: direct preparation method and branch component preparation method.
1, direct preparation method:
1) whole supplementary materials are sieved, mesh size is 0.5-1.0mm;
2) mixing;
3) drying;
A, directly be packaged into pouch (1 dose every bag amount), be packaged into sack, make powder.
B, add a little binder or wetting agent, not cause acid-base reaction be advisable (binding agent is selected hydroxypropyl cellulose for use, and wetting agent is preferably selected ethanol or Polyethylene Glycol for use);
A) make granule, drying, be packaged into pouch, make granule.
B) compacting makes tablet in flakes.
1, divides the component preparation method
Adopt acid, alkaline constituents to prepare granule or powder respectively, be mixed with the dosage form that becomes to need then.
Be specially:
1) preparation of acid constituents: the sugar alcohol with 1/2, edible organic acid (as citric acid), excipient (can), flavoring agent (can), make soft material with ethanol, granulate drying.
2) preparation of alkaline constituents: the sugar alcohol with 1/2, edible carbonate (as sodium bicarbonate), excipient (can), flavoring agent (can), make soft material with ethanol, granulate;
3) with two component particles mix homogeneously:
A, drying, spray into essence (can), make effervescent granule, can be used as powder or electuary.
B, tabletting make tablet, can be used as the bubble potus, also are available as the dry-eating agent.
The specific embodiment
The invention provides but be not limited to following examples
Embodiment 1
Maltose alcohol 700g, citric acid 120g, sodium bicarbonate 180g mixes maltose alcohol 350g with citric acid; 350g mixes with sodium bicarbonate in addition.
Acid constituents and alkaline constituents are made soft material with ethanol respectively, granulate.
With two component particles mix homogeneously:
A, drying spray into flavoring orange essence, make effervescent granule, can be used as powder or electuary.
B, adding flavoring orange essence, tabletting makes tablet, can be used as the bubble potus, also is available as the dry-eating agent.
Embodiment 2
Xylitol 400g, mannitol 300g, citric acid 60g, malic acid 60g, sodium bicarbonate 180g divides equally bisection with xylitol and mannitol, and 350g xylitol and mannitol (mixing sugar alcohol) mix with citric acid and malic acid; 350g mixes with sodium bicarbonate in addition.
Acid constituents and alkaline constituents are made soft material with ethanol respectively, granulate.
With two component particles mix homogeneously:
A, drying spray into flavoring orange essence, make effervescent granule, can be used as powder or electuary.
B, adding flavoring orange essence, tabletting makes tablet, can be used as the bubble potus, also is available as the dry-eating agent.
Embodiment 3
Sorbitol 300g, mannitol 400g, citric acid 120g, sodium bicarbonate 180g divides equally bisection with Sorbitol and mannitol, and 350g Sorbitol and mannitol (mixing sugar alcohol) mix with citric acid; 350g mixes with sodium bicarbonate in addition.
Acid constituents and alkaline constituents are made soft material with ethanol respectively, granulate.
With two component particles mix homogeneously:
A, drying spray into flavoring orange essence, make effervescent granule, can be used as powder or electuary.
B, adding flavoring orange essence, tabletting makes tablet, can be used as the bubble potus, also is available as the dry-eating agent.
Embodiment 4
Xylitol 400g, mannitol 300g, citric acid 120g, sodium bicarbonate 180g.Whole supplementary materials are sieved, and mesh size is 0.5mm; Mixing; Dry:
A, directly be packaged into pouch (1 dose every bag amount), be packaged into sack, make powder.
B, add a little binder hydroxypropyl cellulose:
A) make granule, drying, be packaged into pouch, make granule.
B) compacting makes tablet in flakes.
Claims (10)
1, sugar alcohol is as the application of effective component in the preparation effervescent.
2, according to the application of claim 1, the content that it is characterized in that sugar alcohol in the effervescent is 5%-95%.
3,, it is characterized in that the content of sugar alcohol is preferably 20%-80% in the effervescent according to the application of claim 1.
4, be the effervescent of effective component with the sugar alcohol, it is characterized in that including in the described effervescent one or more sugar alcohols, gas-producing disintegrant.
5,, it is characterized in that described gas-producing disintegrant includes: one or more edible carbonate, one or more edible organic acids according to the effervescent of claim 4.Described edible carbonate, preferred sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate; Described edible organic acid optimization citric acid, malic acid, tartaric acid, lactic acid, fumaric acid, gluconic acid, adipic acid.
6,, it is characterized in that basic ratio is sugar alcohol 5%-95%, edible carbonate 3%-45%, edible organic acid 2%-40% according to the effervescent of claim 4.
7, according to claim 4 and 6 arbitrary described effervescents, it is characterized in that on the basis of sugar alcohol, gas-producing disintegrant, also can be used other drug composition, effective component, and excipient, adjuvant, sweeting agent, the flavoring agent that can use acceptable routine on the preparation.
8, according to claim 4,6,7 arbitrary described effervescents, it is characterized in that the preferred xylitol of described sugar alcohol, Sorbitol, mannitol, maltose alcohol, hydroxyl isomaltulose, erythritol, threitol, lactose.
9, according to claim 4,6,7 arbitrary described effervescents, it is characterized in that described effervescent can be as medicine effervescent, as the effervescent of health product, as the effervescent of drink with function.Described effect can be as medicine effect, as the effect of health product, as the effect of drink with function.
10,, it is characterized in that described effervescent can be an effervescent dosage form feasible on any preparation, preferred tablet, granule, electuary, powder, dry-eating agent, confection form according to claim 4,6,7 arbitrary described effervescents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021760 CN1651088A (en) | 2004-02-04 | 2004-02-04 | Effervescent preparation using alditol as functional ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021760 CN1651088A (en) | 2004-02-04 | 2004-02-04 | Effervescent preparation using alditol as functional ingredient |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1651088A true CN1651088A (en) | 2005-08-10 |
Family
ID=34868359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410021760 Pending CN1651088A (en) | 2004-02-04 | 2004-02-04 | Effervescent preparation using alditol as functional ingredient |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1651088A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966165A (en) * | 2009-07-14 | 2011-02-09 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for the oral absorption |
| CN103446166A (en) * | 2012-05-29 | 2013-12-18 | 上野制药株式会社 | Liver function-improving agent |
| CN103892399A (en) * | 2014-04-12 | 2014-07-02 | 曲阜圣香远生物科技有限公司 | Stevioside effervescent tablet suitable for diabetes patients |
| CN103919108A (en) * | 2014-04-12 | 2014-07-16 | 曲阜圣香远生物科技有限公司 | Method for preparing stevia sugar effervescent tablets suitable for diabetic patients to eat |
| CN104306971A (en) * | 2014-10-29 | 2015-01-28 | 张树超 | Medicine composition for resisting cervical cancer with matching of photodynamic therapy |
| CN107875393A (en) * | 2016-09-30 | 2018-04-06 | 深圳市傲来大健康产业有限公司 | A kind of lozenge flavouring and preparation method thereof |
| JP2018183067A (en) * | 2017-04-24 | 2018-11-22 | 株式会社松原製餡所 | Expandable additive and bean jam food product |
| JP2020158431A (en) * | 2019-03-26 | 2020-10-01 | 物産フードサイエンス株式会社 | Gas generation inhibitor, method for producing effervescent composition and effervescent composition |
| EP4045008A4 (en) * | 2019-10-17 | 2023-11-15 | ISP Investments LLC | A stable effervescent co-processed excipient composition and a process for preparing the same |
-
2004
- 2004-02-04 CN CN 200410021760 patent/CN1651088A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966165A (en) * | 2009-07-14 | 2011-02-09 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for the oral absorption |
| CN101966165B (en) * | 2009-07-14 | 2012-06-13 | 无锡健而乐医药科技有限公司 | Solid effervescent mixture for the oral absorption |
| CN103446166A (en) * | 2012-05-29 | 2013-12-18 | 上野制药株式会社 | Liver function-improving agent |
| CN103446166B (en) * | 2012-05-29 | 2017-06-13 | 上野制药株式会社 | Hepatic function remedial agent |
| CN103892399B (en) * | 2014-04-12 | 2015-03-18 | 曲阜圣香远生物科技有限公司 | Stevioside effervescent tablet suitable for diabetes patients |
| CN103919108A (en) * | 2014-04-12 | 2014-07-16 | 曲阜圣香远生物科技有限公司 | Method for preparing stevia sugar effervescent tablets suitable for diabetic patients to eat |
| CN103919108B (en) * | 2014-04-12 | 2015-04-01 | 曲阜圣香远生物科技有限公司 | Method for preparing stevia sugar effervescent tablets suitable for diabetic patients to eat |
| CN103892399A (en) * | 2014-04-12 | 2014-07-02 | 曲阜圣香远生物科技有限公司 | Stevioside effervescent tablet suitable for diabetes patients |
| CN104306971A (en) * | 2014-10-29 | 2015-01-28 | 张树超 | Medicine composition for resisting cervical cancer with matching of photodynamic therapy |
| CN107875393A (en) * | 2016-09-30 | 2018-04-06 | 深圳市傲来大健康产业有限公司 | A kind of lozenge flavouring and preparation method thereof |
| CN107875393B (en) * | 2016-09-30 | 2021-05-18 | 深圳市傲来大健康产业有限公司 | Buccal tablet flavoring agent and preparation method thereof |
| JP2018183067A (en) * | 2017-04-24 | 2018-11-22 | 株式会社松原製餡所 | Expandable additive and bean jam food product |
| JP2020158431A (en) * | 2019-03-26 | 2020-10-01 | 物産フードサイエンス株式会社 | Gas generation inhibitor, method for producing effervescent composition and effervescent composition |
| JP7071941B2 (en) | 2019-03-26 | 2022-05-19 | 物産フードサイエンス株式会社 | Gas generation inhibitor, method for producing effervescent composition and effervescent composition |
| EP4045008A4 (en) * | 2019-10-17 | 2023-11-15 | ISP Investments LLC | A stable effervescent co-processed excipient composition and a process for preparing the same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1651088A (en) | Effervescent preparation using alditol as functional ingredient | |
| CN1939358A (en) | Sarcandra glaber dispersant tablets | |
| CN1857264A (en) | Medicine composition with pioglitazone hydrochloride and glimepiride as active components and its preparing method and use | |
| CN1630523A (en) | Compositions internal or relevant improvement | |
| CN1538812A (en) | Body temp-raising agent of amino acidds for eating or drinking and for medical use | |
| CN1083260C (en) | Novel pharmaceutical composition for the preparation of a stable powder containing an active principle comprising an association of acetylsalicylic acid and metoclopramide | |
| CN1292756C (en) | Effervescence tablet preparation for replenishing nutritious elements to human being and its preparation method | |
| CN1943594A (en) | Oral disintegrating tablet of lysine calcium mono hydrogen phosphate | |
| CN1698663A (en) | Ring form effervescence dosage and preparation method thereof | |
| CN1939423A (en) | Rhizoma corydalis analgetic dispersing tablet | |
| CN1939399A (en) | Blood stream-breaking dispersing tablets | |
| CN1939355A (en) | Ginkgo dispersing tablets | |
| CN1939449A (en) | Infantile heat-clearing and antitussive dispersing tablets | |
| CN1939512A (en) | Infantile overfood dispersing tablets | |
| CN1823795A (en) | Medicinal composition for treating diabetes and its preparation method | |
| CN1778293A (en) | Rutin effervesce agent composition | |
| CN1293831C (en) | Effervescent solid beverage of amino acid chelated calcium and its prepn | |
| CN1195509C (en) | Aminoethanesulfonic acid-containing preparations | |
| CN1634096A (en) | Notoginseng total saponin orally disintegrating tablet | |
| CN1296045C (en) | Oral disintegration tablet of dihydroergotoxine and its derivatives and its preparing process | |
| CN1939430A (en) | Yiqing dispersing tablets | |
| CN1650884A (en) | Effervescent agent using medium glycan or/and polysaccharide dief fiber as functional component | |
| CN1235577C (en) | Products using L-arginine as raw materials | |
| CN101066252A (en) | Aminoglucose calcium tablet and its prepn process | |
| CN1682973A (en) | Cepharanthine oral disintegration tablet and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20050810 |