CN103656627B - A kind of vitamin C collagen compound effervescent tablet and preparation method thereof - Google Patents
A kind of vitamin C collagen compound effervescent tablet and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of vitamin C collagen compound effervescent tablet and preparation method thereof, it is chosen by weight percentage: vitamin C 0.5 ~ 2%, collagen protein 25 ~ 40%, phycocyanin 5 ~ 15%, lactalbumin 5 ~ 15%, inulin 5 ~ 15%, green tea extract 1 ~ 5%, Semen Vitis viniferae extract 5 ~ 10% are as primary raw material, and adjuvant sodium bicarbonate 5 ~ 10%, tartaric acid 5 ~ 10%, citric acid 2 ~ 5%, polyvidone 2 ~ 5%, stevioside 5 ~ 10% and magnesium stearate 0.5 ~ 2% are prepared into effervescent tablet.Vitamin C collagen compound effervescent tablet component of the present invention is natural, proportioning science, carry taking convenience, safe and reliable, dissolve rapid-action, defying age, looks improving and the skin nourishing successful; Its preparation method rational technology, strong operability, easily accomplishes scale production.
Description
Technical field
The present invention relates to food and the preparation of the nutritive quality changing food, especially a kind of vitamin C collagen compound effervescent tablet and preparation method thereof.
Background technology
Nowadays, our everyone health being on the hazard in various degree, comprises operating pressure, living environment and air pollution, drinking water pollutes, economic pressures etc.Particularly modern " white collar " stratum and some mental works are the crowd of occupation, and relative stress is very large, cause series skin problems such as having a haggard face, skin dimness, mottle and wrinkle increase.
And the good result of collagen protein in crease-resistant Firm by people cognition, it can supply the necessary nutrient of skin, increases the content of skin collagen, skin corium is obtained full, recovers the plump and elasticity of skin, prevents wrinkle from producing; Also effectively can promote skin regeneration, help the skin of defect or depression to recover normal.Meanwhile, the effects such as vitamin C has prevention pigmentation, promotes the synthesis of collagen protein, the immunity of the liver protecting, raising human body, have been commonly used by people for the old and feeble aspect of delaying human body.Both combinations are used for improve skin and beauty treatment prior art report.Such as, disclosed in 15 days June in 2011 disclosed in CN 102091322 A Chinese invention patent application description " compound preparation of a kind of collagen tablet and preparation method thereof ", its composition and content are: collagen protein powder 985g, vitamin C 12g, peach flavor 3g, makes tablet.For another example, disclosed in JIUYUE in 2013 18 days disclosed in CN 103300382 A Chinese invention patent application description " defying age collagen peptide nutrient ", it raw material comprising following weight percentage ratio is made: Stichopus japonicus extract 4%-6%, Vc 4%-6%, Sargassum extract 5%-7%, glucosamine hydrochloride 5%-7%, selenium trace, surplus is the long-acting oligopeptide of collagen protein, and total amount is 100%; The consumption of described selenium is 0.02-0.03g/kg.It makes powder.For another example, " composite collagen protein liquid " its its component that CN1939535A Chinese invention patent application disclosed in 4 days April in 2007 is announced is the mixture of collagen protein and vitamin and purified water, it is characterized in that: described vitamin is vitamin C, the component of described composite collagen protein liquid and component ratio are: in every 100ml composite collagen protein liquid, collagen protein is 10-1000mg, vitamin C is 10-800mg, and all the other are purified water; It makes liquid preparation.And for example, disclosed in 18 days January in 2012 disclosed in CN 102318822 A Chinese invention patent application description " composite collagen capsule and preparation method thereof ", weight consists of: collagen protein 30 ~ 50%, vitamin C 4 ~ 12%, vitamin E 2 ~ 4%, Semen Vitis viniferae extract 10 ~ 20%, surplus is soybean protein.It makes capsule.Vitamin C collagen protein supplement disclosed in above-mentioned open file, one is mostly be tablet, capsule, liquid preparation and granule, and wherein tablet, capsule, the decomposition of granule effective ingredient and rate of release are slow; Liquid preparation carries inconvenience; Two is that nutritional labeling is single, and comprehensive effect is undesirable.
Effervescent tablet is a kind of novel tablet of recent domestic Application and Development.First, when drinking-water put into by effervescent tablet, under the effect of gas-producing disintegrant, at once produce a large amount of bubble (carbon dioxide), make the rapid disintegrate of tablet and thawing, the carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, the aesthetic feeling as soda pop is had when drinking-water is drunk in entrance, effervescent tablet is taken being made into liquid before use, is easy to swallow, bioavailability is high, little to gastrointestinal irritation; Secondly, the effective ingredient of effervescent tablet dissolves in the short period of time, and onset is rapid, and bioavailability is high; 3rd, be convenient to preserve and carry.
Therefore, research and develop a kind of have improve body immunity, looks improving and the skin nourishing effect vitamin C collagen compound effervescent tablet be an important topic.
Summary of the invention
Adopting to overcome vitamin C collagen protein supplement in prior art the deficiency that tablet, capsule, granule effective ingredient decomposition rate are slow, liquid preparation carries inconvenience and single, the comprehensive effect of nutritional labeling is undesirable, the invention provides that a kind of component is natural, proportioning science, safe and reliable, rational vitamin C collagen compound effervescent tablet of taking convenience, successful, manufacturing process and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is: a kind of vitamin C collagen compound effervescent tablet, it is characterized in that: it is made up by weight percentage of following component: vitamin C 0.5 ~ 2%, collagen protein 25 ~ 40%, phycocyanin 5 ~ 15%, lactalbumin 5 ~ 15%, inulin 5 ~ 15%, green tea extract 1 ~ 5%, Semen Vitis viniferae extract 5 ~ 10%, and adjuvant sodium bicarbonate 5 ~ 10%, tartaric acid 5 ~ 10%, citric acid 2 ~ 5%, polyvidone 2 ~ 5%, stevioside 5 ~ 10% and magnesium stearate 0.5 ~ 2%; The percentage by weight sum of each component is 100%.
The preferred technical solution of the present invention is: a kind of vitamin C collagen compound effervescent tablet, it is made up by weight percentage of following component: vitamin C 1%, collagen protein 35%, phycocyanin 8%, lactalbumin 8%, inulin 13%, green tea extract 3%, Semen Vitis viniferae extract 6%, and adjuvant sodium bicarbonate 6%, tartaric acid 6%, citric acid 3%, polyvidone 3%, stevioside 7% and magnesium stearate 1%.
A preparation method for vitamin C collagen compound effervescent tablet, is characterized in that: through following process steps:
(a) raw material be chosen in 300,000 grades of clean areas, according to percentage by weight weigh vitamin C 0.5 ~ 2%, collagen protein 25 ~ 40%, phycocyanin 5 ~ 15%, lactalbumin 5 ~ 15%, inulin 5 ~ 15%, green tea extract 1 ~ 5%, Semen Vitis viniferae extract 5 ~ 10%, sodium bicarbonate 5 ~ 10%, tartaric acid 5 ~ 10%, citric acid 2 ~ 5%, polyvidone 2 ~ 5%, stevioside 5 ~ 10%, magnesium stearate 0.5 ~ 2%;
(b) sieve will choose in step (a) vitamin C, collagen protein, phycocyanin, lactalbumin, inulin, green tea extract, Semen Vitis viniferae extract respectively cross 80 ~ 100 mesh sieves; Sodium bicarbonate, tartaric acid, citric acid, polyvidone, stevioside, magnesium stearate cross 100 ~ 120 mesh sieves respectively, airtightly seal up for safekeeping, for subsequent use;
C the vitamin C sieved in step (b), collagen protein, phycocyanin, lactalbumin, inulin, green tea extract, Semen Vitis viniferae extract, tartaric acid, citric acid, stevioside to add in a batch mixer and are dry mixed to evenly by () mixing successively; The sodium bicarbonate sieved in step (b), polyvidone are added successively in another batch mixer and be dry mixed to evenly;
D () is granulated and is added PVP solution respectively by two batch mixers described in step (c), by the material wet mixing in two batch mixers to evenly, make suitable soft material; Then soft material is added respectively in the granulation machine that 30 eye mesh screens are housed and make wet granular;
E () dries and wet granular obtained for step (d) is put into drying baker respectively, control bake out temperature 50 ~ 60 DEG C, by wet grain drying to water content 4 ~ 6%, obtain dried particles;
(f) granulate, mix dried particles step (e) obtained and carry out granulate respectively by the granulation machine that 24 eye mesh screens are housed; Dried particles after granulate is poured in batch mixer, and then adds the magnesium stearate of sieving in step (b), be mixed to mixing, obtain mixed material;
G the mixed material obtained in step (f) is placed in tablet machine tabletted by () tabletting, obtain effervescent tablet;
(h) choosing pick, pack step (g) is obtained effervescent tablet choosing picks remove sliver, loose pieces, surface defective tablet defective, then carry out bottling, encapsulating, finished product.
The present invention adopts vitamin C, collagen protein, phycocyanin, lactalbumin, inulin, green tea extract and Semen Vitis viniferae extract to be primary raw material, adds adjuvant sodium bicarbonate, tartaric acid, citric acid, polyvidone, stevioside and magnesium stearate and prepares vitamin C collagen compound effervescent tablet.Wherein,
Selected vitamin C, also known as ascorbic acid, is also described as beauty treatment vitamin.Vitamin C can help the infringement reducing radical pair skin, contributes to reducing wrinkle and improving skin texture.Scientific experiments proves, free radical and lipid peroxide are the major incentive of human senility.Sufficient vitamin C can suppress the formation of the harmful substance such as interior free yl, lipid peroxide, reduces dermal melanin calm, makes whitening skin, the aging of delaying human body.Vitamin C is the coenzyme of proline hydroxylase, contributes to proline hydroxylating and forms hydroxyproline.Ascorbic effect is activation proline hydroxylase and lysyl hydroxylase, promotes that proline and lysine are to the conversion of hydroxyproline and hydroxylysine, and then promotes the formation of collagen in histiocyte interstitial;
Selected collagen protein (collagen) is a kind of biological polymer substance, a kind of white, opaque, unbranched fibroid protein, it is the key component of skin, account for the proportion of dermal layer of the skin 80%, it constitutes a fine and closely woven elasticated net in skin, firm pinning moisture, supports skin.It can supplement the nutrition needed for skin layers, and Collage Activitv in skin is strengthened, and to skin care, slow down aging, beauty treatment, wrinkle-chasing, hair care etc. have certain effect;
Selected phycocyanin is isolated a kind of dark blue powder from spirulina, and color and luster is attractive in appearance.Phycocyanin is one of rare chromoprotein of occurring in nature, not only bright-colored, and itself is a kind of nutritious protein, and its aminoacid composition is complete, and essential amino acids content is high.Phycocyanin have anticancer, promote cell substitution, maintenance ovary, to impel in human body the effects such as synthesis elastin;
The essential amino acids A wide selection of colours and designs of selected lactalbumin, abundant amount and ratio is suitable are the high-quality proteins that a kind of nutritive value is higher.Many kinds of substance is had to participate in forming body nonspecific defense barrier in lactalbumin, comprise lactoferrin, lactoperoxidase, immunoglobulin, alpha-lactalbumin and the bacteriolysin with antibacterial action, and the antibacterial peptide of some caseins or whey protein source, have effectively effects such as antibacterium, virus and immunomodulating;
Selected inulin is deposit property polysaccharide in plant, be mainly derived from plant, such as extract in Herba Cichorii, Jerusalem artichoke, agave plant and refine and obtain inulin product, it has blood fat reducing, aid digestion and defecation, Ginkgo Biloba function, dispels the effects such as eczema, skin Caring, fat-reducing, it is a kind of excellent fat substitute, configurable high fibre diet, as bacillus bifidus multiplicaiton factor, in health food;
Selected green tea extract is the active component extracted from green tea blade, mainly comprises tea polyphenols etc.Tea polyphenols obviously can reduce serum total cholesterol, triglyceride, the low-density lipoprotein cholesterol content of hyperlipemia, has the effect recovering and protect vascular endothelial function simultaneously; Lipid peroxidation process capable of blocking, improves the activity of human enzymes, thus plays effect of mutation, anticancer; Tea polyphenols heavy metal has strong adsorption, can form complex with heavy metal and produce precipitation, is conducive to alleviating the toxic action that heavy metal produces human body; Tea polyphenols, by improving human immunoglobulin total amount and making it maintain high level, stimulates the change of antibody activity, thus improves the overall immune ability of people, and can promote self conditioning functions of human body; Tea polyphenols has very strong antibacterial action and Inhibitory activity, can prevent and treat dermatosis, skin allergy effect, go the effects such as skin pigment;
Selected Semen Vitis viniferae extract (OPC) is the effective active nutrition extracted from natural grape seed, is the new and effective Natural antioxidant material that can not synthesize in a kind of human body.It is the antioxidation that current occurring in nature finds, the material that Scavenging ability is the strongest, its antioxidant activity is 50 times of vitamin E, 20 times of vitamin C, it can effectively remove free radical unnecessary in human body, has superpower slow down aging and the effect of enhancing immunity.Procyanidin is the main active in Semen Vitis viniferae extract, can repair injured collagen protein and elastic fiber, have astriction, can tighten up skin, prevent wrinkle of skin from occurring ahead of time, life-time service can make skin smooth, high resilience, has the effect of looks improving and the skin nourishing;
In vitamin C collagen compound effervescent tablet of the present invention, selected vitamin C, collagen protein, lactalbumin are as most basic women's nutrient raw material, promote the synthesis of collagen protein, repair damaged skin cell; Add phycocyanin again as natural pigment and natural high protein supplement, be aided with natural inulin and reduce skin pigmentation, the antioxidation of green tea extract and Semen Vitis viniferae extract and removing human free radical, primary raw material Synergistic of the present invention, plays the effects such as superpower slow down aging, enhancing immunity and looks improving and the skin nourishing altogether.Vitamin C collagen compound effervescent tablet of the present invention has that component is natural, proportioning science, carry taking convenience, safe and reliable, dissolve advantage that is rapid-action, successful.Its preparation method rational technology, workable, easily accomplish scale production.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
A kind of vitamin C collagen compound effervescent tablet, it is made up by weight percentage of following component: vitamin C 1%, collagen protein 35%, phycocyanin 8%, lactalbumin 8%, inulin 13%, green tea extract 3%, Semen Vitis viniferae extract 6%, and adjuvant sodium bicarbonate 6%, tartaric acid 6%, citric acid 3%, polyvidone 3%, stevioside 7% and magnesium stearate 1%.
Embodiment 2
A kind of vitamin C collagen compound effervescent tablet, it is made up by weight percentage of following component: vitamin C 1.5%, collagen protein 40%, phycocyanin 5%, lactalbumin 12%, inulin 5%, green tea extract 5%, Semen Vitis viniferae extract 5%, and adjuvant sodium bicarbonate 5%, tartaric acid 8%, citric acid 2%, polyvidone 5%, stevioside 5% and magnesium stearate 1.5%.
Embodiment 3
A kind of vitamin C collagen compound effervescent tablet, it is made up by weight percentage of following component: Catergen %, collagen protein 30%, phycocyanin 15%, lactalbumin 5%, inulin 6%, green tea extract 2%, Semen Vitis viniferae extract 8%, and adjuvant sodium bicarbonate 10%, tartaric acid 5%, citric acid 3%, polyvidone 2%, stevioside 10% and magnesium stearate 2%.
Embodiment 4
A kind of vitamin C collagen compound effervescent tablet, it is made up by weight percentage of following component: vitamin C 0.5%, collagen protein 25%, phycocyanin 5%, lactalbumin 15%, inulin 15%, green tea extract 1%, Semen Vitis viniferae extract 10%, and adjuvant sodium bicarbonate 6%, tartaric acid 10%, citric acid 2%, polyvidone 2%, stevioside 8% and magnesium stearate 0.5%.
The preparation method of a kind of vitamin C collagen compound effervescent tablet given in the embodiment of the present invention 1 ~ 4, through following process steps:
(a) raw material be chosen in 300,000 grades of clean areas, according to given by embodiment 1 ~ 4 percentage by weight weigh vitamin C, collagen protein, phycocyanin, lactalbumin, inulin, green tea extract, Semen Vitis viniferae extract, sodium bicarbonate, tartaric acid, citric acid, polyvidone, stevioside, magnesium stearate;
(b) sieve will choose in step (a) vitamin C, collagen protein, phycocyanin, lactalbumin, inulin, green tea extract, Semen Vitis viniferae extract respectively cross 80 ~ 100 mesh sieves; Sodium bicarbonate, tartaric acid, citric acid, polyvidone, stevioside, magnesium stearate cross 100 ~ 120 mesh sieves respectively, airtightly seal up for safekeeping, for subsequent use;
C the vitamin C sieved in step (b), collagen protein, phycocyanin, lactalbumin, inulin, green tea extract, Semen Vitis viniferae extract, tartaric acid, citric acid, stevioside to add in batch mixer and are dry mixed 30 minutes to evenly by () mixing successively; The sodium bicarbonate sieved in step (b), polyvidone are added successively in another batch mixer and be dry mixed 30 minutes to even;
D () is granulated and is added PVP solution respectively by two batch mixers described in step (c), by the material wet mixing in two batch mixers 30 minutes to evenly, make suitable soft material; Then soft material is added respectively in the granulation machine that 30 eye mesh screens are housed and make wet granular;
E () dries and wet granular obtained for step (d) is put into drying baker respectively, control bake out temperature 50 ~ 60 DEG C, by wet grain drying to water content 4 ~ 6%, obtain dried particles;
(f) granulate, mix dried particles step (e) obtained and carry out granulate respectively by the granulation machine that 24 eye mesh screens are housed; Dried particles after granulate is poured in batch mixer, and then adds the magnesium stearate of sieving in step (b), mix 30 minutes to mixing, obtain mixed material;
G the mixed material obtained in step (f) is placed in the tablet that tablet machine is pressed into 4g/ sheet by () tabletting, obtain effervescent tablet;
(h) choosing pick, pack step (g) is obtained effervescent tablet choosing picks remove sliver, loose pieces, surface defective tablet defective, then carry out bottling, encapsulating, finished product.
effect of a kind of vitamin C collagen effervescent tablet looks improving and the skin nourishing is further illustrated below by human experiment laboratory report.
, object and method
1.1, tested material: the vitamin C collagen effervescent tablet that the technique provided by the embodiment of the present invention 1 is prepared is as laboratory sample.
1.2, study subject: by the principle of voluntariness select 35-60 year have chloasma experimenter 30 example.
1.2.1, diagnostic criteria: the visible chloasma of Head And Face naked eyes, the place such as multiple cheekbone, nose, lip, week, without sufferings symptom;
1.2.2, the person's of including in standard: all have chloasma volunteer, all can carry out test-meal experiment through being up to the standards;
1.2.3, eliminator's standard: age those who do not meet, gestation or women breast-feeding their children, to this health food allergy sufferers; Be associated with the severe primary diseases such as conscience kidney and hemopoietic system, psychotic; Do not meet inclusive criteria, not by regulation test food, effect or data not umbra sound effect or analysis person cannot be judged.
1.3, form is contrasted: adopt self cross-reference form.
1.4, taking dose and the time: each 2, every day 2 times, continuous 30 days, experimenter cut out about the medicine of face-beautifying and spot-removing or other health foods and cosmetics at experimental session.
1.5, instrument and reagent: F-820 type blood counting instrument, MIDIRON urinates ten analysers (Germany produces), Olympus fully-automatic analyzer (Japan produces), model AU600, Institute of Geography, Academia Sinica's development and design, Mapping Press 1992 publishes " practical standard colour atla " (the 1st edition), and biochemical reagents box is all bought.
, observation index
2.1, both effectiveness observation: before and after experiment, each inspection once.
2.1.1, ordinary circumstance:
Detailed medical history-taking, understands experimenter's diet, observes main clinic symptoms: feeling of fatigue, agitation, sleep etc.;
Before and after test-meal, add up integrated value by symptom weight (serious symptom 3 points, moderate 2 points, mild 1 point), and improve (each symptom improves 2 points significantly, improves 1 point effectively) calculating improvement rate with regard to its cardinal symptom.
2.1.2, Head And Face chloasma detects:
2.1.2.1, size change: long-neck and the width of using the same chloasma in the tested front and back of tape measure, reference area (cm
2);
2.1.2.2, shade change: develop according to Institute of Geography, Academia Sinica, Mapping Press 1992 brown (the folded color that Y+M+Bk is namely yellow+pinkish red+black) colour atla published in " practical standard colour atla " (the 1st edition) is the criterion of chloasma shade: I degree (15,20,5), II degree (30,40,10), III (40,60,15).
2.3, safety is observed:
2.3.1, blood and routine urianlysis: red blood cell count(RBC), hemoglobin, cytometry, urinates ten inspections;
2.3.2, Biochemical Indexes:
Serum albumin ALB, total protein TO, heart kidney liver function (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT, carbamide UREA, inosine CRE, blood glucose GLU, blood fat (T-CHOL TC, triglyceride TG);
2.3.3, auxiliary examination: Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest.
, spot-removal function judge
Effective: chloasma color decline II degree, or area reduce >=30%, do not produce new chloasma;
Effective: chloasma color decline I degree, or area reduces < 30%, and >=10% does not produce new chloasma;
Invalid: area of chloasma reduces < 10%, and color is without significant change.
, experimental result
4.1, general status: observe chloasma experimenter 30 example altogether, be women, minimum 35 years old of age, maximum 58 years old, 42 ± 4.5 years old mean age, average course of disease 4.40 ± 2.19 years.
4.2, chloasma shade change:
| Project | Before test | After test-meal | Difference |
| Colour atla | 2.21±0.32 | 2.06±0.27 | -0.15±0.06 |
4.3, area of chloasma size variation:
| Project | Before test | After test-meal | Difference |
| Area of chloasma (cm 2） | 40.1±5.05 | 37.3±4.02 | -2.8±1.03 |
4.4, efficacy assessments:
| Project | Effective | Effectively | Invalid | Total effective rate (%) |
| Number of cases | 5 | 16 | 9 | 21 |
| Effect rate (%) | 16.7% | 53.3% | 30.0% | 70% |
4.5, cardinal symptom improves situation:
| Cardinal symptom | Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| Feeling of fatigue | 14 | 2 | 6 | 6 | 57.1 |
| Irritated | 19 | 1 | 9 | 9 | 52.6 |
| Sleep | 13 | 2 | 5 | 6 | 53.9 |
4.6, symptom integral change:
| Number of cases | Before test | In test-meal | After test-meal |
| 30 | 3.34±0.62 | 3.12±0.43 | 3.05.±0.35 |
4.7, safety index detects:
| Project | Number of cases | Before test | After test-meal |
| TP(g/L) | 30 | 68.46±2.26 | 67.81±1.02 |
| ALB（g/L） | 30 | 44.21±1.62 | 43.87±1.53 |
| ALB（u/L） | 30 | 14.16±4.22 | 13.29±4.05 |
| AST（u/L） | 30 | 19.91±4.11 | 18.37±3.24 |
| GLU（mmol./L） | 30 | 4.80±0.65 | 4.70±0.71 |
| TC（mmol/L） | 30 | 4.58±0.64 | 4.27±0.57 |
| TG(mmol/L) | 30 | 0.95±0.56 | 1.13±0.68 |
| UREA (mmol/L) | 30 | 5.45±0.67 | 4.85±0.71 |
| CRE(mmol/L) | 30 | 76.26±2.11 | 74.97±1.03 |
| HGB(mmol/L) | 30 | 116.32±5.31 | 117.19±4.08 |
| RBC(×10 12L) | 30 | 4.24±0.61 | 4.31±0.051 |
| WBC(×10 9/L) | 30 | 5.62±0.52 | 5.56±0.46 |
| Urinate ten | 30 | Normally | Normally |
Known through upper table, before and after test-meal, indices is in normal range.
4.8, auxiliary examination Abdominal B type ultrasonography, electrocardiogram, x-ray chest is all in normal range.
conclusion
5.1, curative effect: 30 routine chloasma experimenters take experimental products of the present invention 30 days on request, and area of chloasma on average reduces 2.8 ± 1.03 cm
2, lighter, wherein effective 5 examples, effective 16 examples, total effective rate 70%, illustrates that this product has the effect of beauty treatment (functions of removing chloasma).
The symptom such as feeling of fatigue, agitation, sleep of experimental products of the present invention to chloasma experimenter is improved effect.
5.2, safety: before and after experimental products test-meal of the present invention, the Testing index such as hemoglobin, erythrocyte, leukocyte, total serum protein, albumin, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT, inosine, carbamide, blood glucose, blood fat and routine urinalysis, all in normal range, illustrate that product is to the healthy dance harmful effect of experimenter.
After experimental products test-meal of the present invention, have no irritated and other untoward reaction.
Claims (1)
1. a vitamin C collagen compound effervescent tablet, it is characterized in that: it is made up by weight percentage of following component: vitamin C 1%, collagen protein 35%, phycocyanin 8%, lactalbumin 8%, inulin 13%, green tea extract 3%, Semen Vitis viniferae extract 6%, and adjuvant sodium bicarbonate 6%, tartaric acid 6%, citric acid 3%, polyvidone 3%, stevioside 7% and magnesium stearate 1%.
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| CN104824660B (en) * | 2015-04-08 | 2018-01-19 | 王书敏 | A kind of collagen saussurea involucrata small peptide effervescent tablet and preparation method thereof |
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| CN105815648A (en) * | 2016-03-08 | 2016-08-03 | 河南科技学院 | Phycocyanin effervescent tablet, preparation method and applications thereof |
| CN106215175A (en) * | 2016-07-27 | 2016-12-14 | 中山大学 | Phycocyanin vitamin C compound effervescent tablet and preparation method thereof |
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| EP3967155A4 (en) * | 2019-05-10 | 2023-01-11 | DIC Corporation | Food/beverage for beautiful skin |
| WO2020230347A1 (en) * | 2019-05-10 | 2020-11-19 | Dic株式会社 | Food/beverage for beautiful skin |
| CN117837769A (en) * | 2024-01-24 | 2024-04-09 | 河海大学 | Phycocyanin effervescent tablet and preparation method thereof |
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