CN109123612A - A kind of composition with strengthen immunity, health food and preparation method thereof - Google Patents
A kind of composition with strengthen immunity, health food and preparation method thereof Download PDFInfo
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- CN109123612A CN109123612A CN201810968255.5A CN201810968255A CN109123612A CN 109123612 A CN109123612 A CN 109123612A CN 201810968255 A CN201810968255 A CN 201810968255A CN 109123612 A CN109123612 A CN 109123612A
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- strengthen immunity
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The present invention relates to a kind of compositions with strengthen immunity, health food and preparation method thereof.The composition includes the raw material of following parts by weight proportion: 1-10 portions of ganoderma lucidums, 0.5-2 parts of ginsengs, 0.5-2 parts of dendrobium candidums and 0.01-0.1 parts of Saussurea involucrata cultures.Each taste raw material pharmacological property matches, synergistic effect, protects body in the present invention, so that the function of each taste raw material is obtained stronger performance, while avoiding discomfort caused by side effect.
Description
Technical field
The present invention relates to technical field of health care food more particularly to a kind of has effects that the combination enhanced human immunity
Object, health food and preparation method thereof.
Background technique
With the quickening of scientific development and modern life rhythm, people's study and work pressure is increasing, in high intensity
Physiology or in the case that psychological pressure, irregular diet and long-term lacking effectively take exercise, easily cause immunity degradation.
Hypoimmunity crowd size showed in the trend that rises year by year, the low universal society of one kind that increasingly becomes of body immunity in recent years
As.Body immunity, that is, body is when by external infringement, such as when bacterium, poisoning intrusion human body, body resistance it is external enter
The ability invaded.Showing themselves in that for hypoimmunity frequently experiences fatigue；It is often unable to pull oneself together at work；It is easy to catch cold；Wound
Refractory conjunction easy infection；Functions of intestines and stomach decline；It is easy by infectious disease attack etc..
When nearly social people's living standard is continuously improved, in terms of diet, the Diet concept of people, which not only rests on, " to be eaten
Obtain ", but will " health eaten ", that is, be particular about the new era of health, more people begin look for better health care.Health care
Dietotherapy, health rise, allow consumer can be in numerous tonic foods according to the health demand of itself, to select phase
The health food answered.
Currently, there is the health food of numerous strengthen immunities in the market, still, majority formula effect is indefinite, matches
5 is unreasonable, and finished product preparation process is complicated.
Summary of the invention
It is indefinite for existing strengthen immunity health food effect, the problems such as compatibility is unreasonable, the purpose of the present invention is
There is provided a kind of clear efficacy, compatibility rationally and taking safe has effects that the composition of strengthen immunity and health food.
To achieve the above object of the invention, present invention employs the following technical solutions:
It is a kind of to have effects that the composition of strengthen immunity, the composition include ganoderma lucidum, ginseng, dendrobium candidum and saussurea involucrata
Culture.
As further improvement of the invention, the composition includes the raw material of following parts by weight: 1-10 portions of ganoderma lucidums,
0.5-2 parts of ginsengs, 0.5-2 parts of dendrobium candidums and 0.01-0.1 parts of Saussurea involucrata cultures.
As further improvement of the invention, the composition includes the raw material of following parts by weight: 5-8 portions of ganoderma lucidums,
0.8-1.5 parts of ginsengs, 0.8-1.5 parts of dendrobium candidums and 0.02-0.08 parts of Saussurea involucrata cultures.
As further improvement of the invention, the composition includes the raw material of following parts by weight: 6 portions of ganoderma lucidums, 1 part of people
Ginseng, 1 part of dendrobium candidum and 0.05 part of Saussurea involucrata culture.
Preferably, the health food is tablet, granule, capsule or oral solution.
Further, the present invention also provides the preparation methods with the composition of strengthen immunity.The preparation
Method at least includes the following steps:
(1) ginseng, ganoderma lucidum and dendrobium candidum are weighed according to the raw material proportioning；
(2) extraction is added water to cook after sufficiently impregnating the ginseng, ganoderma lucidum and dendrobium candidum, wherein decocting time is 1-
2 hours, extraction time was 3-4 times, was then combined with extracting solution, and carry out filtration processing；
(3) thick paste is first concentrated under reduced pressure into said extracted liquid and then is dried under reduced pressure into dry cream again, finally crushed dry cream
Dried cream powder is obtained after sieve；
(4) Saussurea involucrata culture is weighed according to the raw material proportioning；
(5) Saussurea involucrata culture fine powder will be obtained after Saussurea involucrata culture sieving；
(6) above-mentioned dried cream powder and Saussurea involucrata culture fine powder are uniformly mixed to get mixed powder.
Further, the present invention also provides a kind of has effects that the health food of strengthen immunity comprising above-mentioned composition
Preparation method.The customary adjuvant (starch, vegetable oil etc.) of Food Science permission will be added in the composition, according to a conventional method
Clinically acceptable tablet, granule, capsule or oral solution is made.Preferably tablet, wherein the step of tablet is made is such as
Under:
(1) ginseng, ganoderma lucidum and dendrobium candidum are weighed according to the raw material proportioning；
(2) extraction is added water to cook after sufficiently impregnating the ginseng, ganoderma lucidum and dendrobium candidum, extracting solution is filtered；
(3) said extracted liquid is first condensed into thick paste and then re-dry into dry cream, is obtained after finally dry cream pulverizes and sieves
Dried cream powder；
(4) Saussurea involucrata culture and microcrystalline cellulose are weighed respectively according to the raw material proportioning；
(5) equal increments are uniformly mixed to get mixed powder A after the Saussurea involucrata culture and microcrystalline cellulose being sieved respectively；
(6) above-mentioned dried cream powder and mixed powder A are uniformly mixed to get mixed powder B；
(7) PVP K30 is weighed according to the raw material proportioning, liquid is matched into PVP K30 dissolution, it is molten that adhesive is made
Liquid；
(8) by mixed powder B and binder solution mixing granulation, particle C is obtained；
(9) magnesium stearate is weighed according to the raw material proportioning, Magnesium Stearate is uniformly mixed with the particle C,
Obtain total mix particle D；
(10) by total mix particle D according to 0.5g/ piece, plain piece is made in tabletting；
(11) appropriate hydroxypropyl methyl cellulose, titanium dioxide, talcum powder, polyethylene glycol, famille rose and brilliant blue is taken to be made
Film coating pre-mix dose.
(12) plain piece is subjected to film coating processing with film coating pre-mix dose, obtains coating tablet.
Usage and dosage: 0.5g/ piece, 2 times a day, 2 tablets once.
Compared with the existing technology, provided by the present invention to have effects that the health food of strengthen immunity, the medical knowledge according in
By prescription, ganoderma lucidum is reused in side, nourishing liver and spleen, consolidating righting is monarch drug in a prescription；Compatibility ginseng, dendrobium candidum, enriching yin qi-restoratives, strengthening spleen and lung
Kidney, protect liver gallbladder fill out the five internal organs internal weakness deficiency, are altogether ministerial drug to help the power of enriching yin reinforcing；Saussurea involucrata culture is warm-natured to wander away, except cold strong
Sun, it is adjuvant that priming, which enters blood tool,；All medicines share is played altogether, the function that enriching yin lean liver and spleen is radically reformed with Da Peiben.Each taste in the present invention
Raw material pharmacological property matches, synergistic effect, protects body, so that the function of each taste raw material is obtained stronger performance, while avoiding side effect
Caused discomfort.
And for the internal metabolic activity of effect substance in modern medicine angle analysis prescription:
Ganoderma lucidum mainly contains polysaccharide, ganoderic acid, nucleotide, superoxide dismutase, bioflavonoid, amino acid, albumen
The chemical active ingredients such as matter, wherein ganoderma lucidum polysaccharide is a kind of biological immunomodulator, generally believes that its immune function is that ganoderma lucidum is more
Sugar can directly or indirectly activate the immunocytes such as T cell, B cell, macrophage, natural killer cells (NK), promote without pure
The proliferation of the splenocyte of change in vitro enhances the activity of DNA polymerase a and the secretion of promotion interleukins (IL) etc. and comes in fact
Its existing cellular immunity for enhancing body and humoral immune function.Ganoderma lucidum polysaccharide can be such that T lymphocyte increases, and reinforce reticular endothelium
System function.The ganoderma lucidum polysaccharide Aged Mice low to immunity function, also has facilitation to the generation of antibody forming cell.Its
Nucleotide can boost metabolism, and relieve fatigue rapidly, prevent blood embolization, lower the chance that blood clot generates, advantageously stable
Blood pressure is helped to anti-inflammatory.
The main component of ginseng is panaxoside, and China scientific worker isolates 39 kinds of ginseng monomers from ginseng
Saponin.In addition to panaxoside, ginseng also contains panaxan, Radix Ginseng protein, ginseng essential oil, amino acid, inorganic elements, peptide
The substances such as substance, multivitamin, organic acid, alkaloid, fats, flavonoids enzyme, sterol, nucleosides and lignin.Its
Middle panaxoside mainly has an enhancing immunity of organisms, alleviates that physical strength is antifatigue and the effect of toxonoid.Wherein panaxan
It can the phagocytosis of Stimulated Macrophages and the generation of promotion complement and antibody.Panaxan is to specific immunity and non-specificity
Immune, cellular immunity and humoral immunity all have an impact.Oral panaxan can be such that the B cell of sheep red blood cell, immune mouse increases,
Specific antibody and IgG are dramatically increased in serum.
Dendrobium candidum is orchid family Dendrobium herbaceos perennial.Dendrobium candidum also known as Tiepi Fengdou, earrings dendrobium, iron sheet
Orchid, ribbed hedyotis herb etc. rank first of " Chinese nine big mesonas ".Its is sweet in flavor, cold nature, returns stomach, and kidney channel has Yin-nourishing and body fluid promoting maintenance five
It is dirty, build up health, strengthening the muscles and bones, resist rheumatism, strengthen the spleen and stomach, cholagogue, control disease in the liver and gallbladder, prevention and treatment diabetes, inhibit tumour, subtract
Few Radiotherapy chemotherapy side effect, item eyeshield and moisturizing moisturizing are promoted longevity, and the medical value successive dynasties are praised highly by people.It is main
Contain dendrobium polysaccharide, alkaloid, amino acid, microelement and luxuriant and rich with fragrance class compound etc..Dendrobium candidum polysaccharide object rich in
Matter has the function of enhancing immune function.Modern times reason research also shows: dendrobium candidum can improve stress ability, have good
Antifatigue, resisting oxygen lack.
Saussurea involucrata culture not only contain with active constituent similar in natural snow lotus, also there is comparable various medicines therewith
Reason activity, such as strengthening the bones and muscles trophic nerve, dysregulation body fluid, inhibit platelet aggregation, reducing blood lipid, improve blood circulation, wind-dispelling
Win wet, analgesia, anti-inflammatory, antirheumatic, adjust immune, anti-oxidant, anti-radiation, antifatigue etc., eater can be improved from many aspects
Constitution.Pharmacological research shows that saussurea involucrata has apparent promotion and adjustment effect to mouse cell immune function, to radiation injury
The recovery of immunologic hypofunction has preferable facilitation, can influence panimmunity cell and important cell factor.In addition, this
Invention gets rid of the dependence to national key protected wild plants saussurea involucrata using Saussurea involucrata culture, this composition is made to have scale
The feasibility of production.
Compared with the existing technology, the beneficial effects of the present invention are: health food compatibility of the invention is rigorous and science is closed
The effect of reason, had both met the compatibility theory of traditional Chinese medical science prescription " monarch ", makes synergy between each raw material, reaches nourishing and body-building,
Natural active matter is followed in the intracorporal metabolism group correlative study of people again simultaneously, can significantly increase immunity, have
Constitutional effect.Use ganoderma lucidum for main ingredient, ginseng, dendrobium candidum and Saussurea involucrata culture are adjuvant, pass through the above component
Compatibility has synergy, immunity, constitutional effect can be significantly increased, and edible safety is reliable, without any poison
Side effect can take for a long time and be convenient for carrying.Health food preparation method of the invention is simple, is suitble to produce in enormous quantities.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1
It is a kind of to have effects that the health food of strengthen immunity, the health food include the raw material of following parts by weight:
2g ganoderma lucidum, 2g ginseng, 1g dendrobium candidum and 0.02g Saussurea involucrata culture.
The present invention also provides the preparation methods with the health food of strengthen immunity.The preparation method, until
Less the following steps are included:
Ginseng, ganoderma lucidum and dendrobium candidum are weighed according to the raw material proportioning；
Extraction is added water to cook after the ginseng, ganoderma lucidum and dendrobium candidum are sufficiently impregnated, wherein decocting time is 2 small
When, amount of water is 3 times of composition weight, and extraction time is 4 times, is then combined with extracting solution, and carry out filtration processing；
Thick paste is first concentrated under reduced pressure into said extracted liquid and then is dried under reduced pressure into dry cream again, after finally dry cream pulverizes and sieves
Obtain dried cream powder；
Saussurea involucrata culture is weighed according to the raw material proportioning；
Saussurea involucrata culture fine powder will be obtained after Saussurea involucrata culture sieving；
Above-mentioned dried cream powder and Saussurea involucrata culture fine powder are uniformly mixed to get mixed powder B；
Mixed powder B is crossed into 12 meshes, 55~60 DEG C of drying crush, encapsulated, every 0.5g.
Embodiment 2
It is a kind of to have effects that the health food of strengthen immunity, the health food include the raw material of following parts by weight:
5g ganoderma lucidum, 1g ginseng, 1.5g dendrobium candidum and 0.08g Saussurea involucrata culture.
The present invention also provides the preparation methods with the health food of strengthen immunity.The preparation method, until
Less the following steps are included:
Ginseng, ganoderma lucidum and dendrobium candidum are weighed according to the raw material proportioning；
It decocts and extracts after the ginseng, ganoderma lucidum and dendrobium candidum are sufficiently impregnated, wherein decocting time is 1.5 hours,
Amount of water is 3 times of composition weight, and extraction time is 4 times, is then combined with extracting solution, and carry out filtration processing；
Thick paste is first concentrated under reduced pressure into above-mentioned aqueous extract and then is dried under reduced pressure into dry cream again, finally dry cream pulverizes and sieves
After obtain dried cream powder；
Saussurea involucrata culture is weighed according to the raw material proportioning；
Saussurea involucrata culture fine powder will be obtained after Saussurea involucrata culture sieving；
Above-mentioned dried cream powder and Saussurea involucrata culture fine powder are uniformly mixed to get mixed powder B；
Conventional granulates agent auxiliary material is added in mixed powder B, is prepared into granule according to a conventional method.
Embodiment 3
It is a kind of to have effects that the health food of strengthen immunity, the health food include the raw material of following parts by weight:
6g ganoderma lucidum, 1g ginseng, 1g dendrobium candidum, 0.05g Saussurea involucrata culture, 1.23g microcrystalline cellulose, 0.06g PVP K30 and
0.02g parts of magnesium stearates.
The present invention also provides the preparation methods with the health food of strengthen immunity.The preparation method, until
Less the following steps are included:
Ginseng, ganoderma lucidum and dendrobium candidum are weighed according to the raw material proportioning；
It decocts and extracts after the ginseng, ganoderma lucidum and dendrobium candidum are sufficiently impregnated, wherein decocting time is 2 hours, is added
Water is 3 times of composition weight, and extraction time is 3 times, is then combined with extracting solution, and carry out filtration processing；
Thick paste is first concentrated under reduced pressure into above-mentioned aqueous extract and then is dried under reduced pressure into dry cream again, finally dry cream pulverizes and sieves
After obtain dried cream powder；
Saussurea involucrata culture and microcrystalline cellulose are weighed according to the raw material proportioning；
Equal increments mix after the Saussurea involucrata culture and microcrystalline cellulose are sieved respectively, are mixed after mixing
Powder A；
Above-mentioned dried cream powder and mixed powder A are uniformly mixed to get mixed powder B；
PVP K30 is weighed according to the raw material proportioning, liquid is matched into PVP K30 dissolution, binder solution is made；
By mixed powder B and binder solution mixing granulation, particle C is obtained；
Magnesium stearate is weighed according to the raw material proportioning, Magnesium Stearate is uniformly mixed with the particle C, is obtained
Total mix particle D；
By total mix particle D according to 0.5g/ piece, plain piece is made in tabletting；
Take appropriate hydroxypropyl methyl cellulose, titanium dioxide, talcum powder, polyethylene glycol, famille rose and brilliant blue that film is made
It is coated pre-mixing agent.
The plain piece is subjected to film coating processing with film coating pre-mix dose, obtains coating tablet.
Embodiment 4
It is a kind of to have effects that the health food of strengthen immunity, the health food include the raw material of following parts by weight:
8g ganoderma lucidum, 0.8g ginseng, 0.8g dendrobium candidum and 0.05g Saussurea involucrata culture.
The present invention also provides the preparation methods with the health food of strengthen immunity.The preparation method, until
Less the following steps are included:
Ginseng, ganoderma lucidum and dendrobium candidum are weighed according to the raw material proportioning；
It decocts and extracts after the ginseng, ganoderma lucidum and dendrobium candidum are sufficiently impregnated, wherein decocting time is 1 hour, is added
Water is 3 times of composition weight, and extraction time is 3 times, is then combined with extracting solution, and carry out filtration processing；
Thick paste is first concentrated under reduced pressure into above-mentioned aqueous extract and then is dried under reduced pressure into dry cream again, finally dry cream pulverizes and sieves
After obtain dried cream powder；
Saussurea involucrata culture is weighed according to the raw material proportioning；
Saussurea involucrata culture fine powder will be obtained after Saussurea involucrata culture sieving；
Above-mentioned dried cream powder and Saussurea involucrata culture fine powder are uniformly mixed to get mixed powder B；
Traditional oral liquid auxiliary material is added in mixed powder B, is prepared into oral solution according to a conventional method.
Technical solution in order to better illustrate the present invention is done by comparative example and the embodiment of the present invention into one further below
The comparison of step.
Comparative example 1
It is a kind of to have effects that the health food of strengthen immunity, the health food include the raw material of following parts by weight:
6g grifola frondosus, 1g ginseng, 1g dendrobium candidum, 0.05g Saussurea involucrata culture, 1.23g microcrystalline cellulose, 0.06g PVP K30 and
0.02g parts of magnesium stearates.
Comparative example 2
It is a kind of to have effects that the health food of strengthen immunity, the health food include the raw material of following parts by weight:
6g ganoderma lucidum, 1g Radix Codonopsis, 1g dendrobium candidum, 0.05g Saussurea involucrata culture, 1.23g microcrystalline cellulose, 0.06g PVP K30 and
0.02g parts of magnesium stearates.
Tablet is made according to method same as Example 3 respectively in the composition of each comparative example.
Effect example
1. sample: by formula described in embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1 and comparative example 2 and side
Method prepares sample respectively, is made into the solution of same concentrations with water dissolution respectively.
2. experimental animal: SD rat
3. test method: the mouse spleen lymphocyte transformation experiment (mtt assay) of ConA induction: selecting identical gender, health
The similar 180-220gSD rat of situation, is tested.With oral 2 stomach-fillings of the dosage of 0.3g/kg.bw, daily stomach-filling is primary,
It is observed two weeks after continuous gavage at least 30 days.
4. result: experiment mice cervical dislocation is put to death, and is immersed in 75% medicinal alcohol, sterile to take spleen, is placed in and is filled Hank'
In the sterile small mortar of s liquid, spleen is ground rapidly, splenocyte suspension is made, it is sterile by 6 layers of cell permeable with sterile Hank's liquid
Gauze is filtered in test tube, 1000rpm, and 10min is centrifuged 2 times, is abandoned supernatant and is bounced cell, and 2mL is added containing 10% calf serum
RPMI1640 complete culture solution is resuspended, and measures spleens cell number with cell counter, concentration needed for cell number is tuned into experiment.It will adjust
The cell suspension of whole good cell concentration is divided to two holes to be added in 24 well culture plates, and 50 μ lConA are added in every hole 1mL in a wherein hole
Solution (is equivalent to 5 μ g/ml), and (5%C0 is set in incubator as control in another hole2, 37 DEG C) and culture 72 hours.Culture terminates
First 4 hours, every hole gently sucked supernatant 0.7mL, and RPMI 1640 culture medium and 50 μ l that 0.7mL is free of calf serum is added
MTT/RPMI1640 (5mg/ml), continue culture 4 hours, after culture, 1mL acid isopropyl alcohol is added in every hole, makes purple
Crystallization is completely dissolved, and then moves into this liquid in 96 hole elisa Plates, and each hole dispenses 4 holes as Duplicate Samples, in microplate reader
As a result upper colorimetric is indicated with the OD value at wavelength 570nm.The proliferative capacity of lymphocyte with plus the OD value in the hole ConA subtract and be not added
The OD value in the hole ConA indicates.
Test result is as follows:
As it can be seen that the production being made of the 6g ganoderma lucidum of embodiment 3,1g ginseng, 1g dendrobium candidum and 0.05g Saussurea involucrata culture
Product have the stronger ability for improving immunity, and embodiment 2,4 effect of embodiment are only second to embodiment 3, comparative example 1 and comparative example
After 2 replace ganoderma lucidum and ginseng using the similar component of effect, effect is then substantially reduced, it is seen that four kinds of components in the present invention are multiple
With the technical effect after combination with synergy.
Experimental example
Acute toxicity test
1. sample: by formula described in embodiment 3 and the sample of method preparation.
2. experimental animal: SD rat
3. mouse oral acute toxicity test (MTD method): selecting 180-220gSD rat 20, half male and half female is tried
It tests.With oral 2 stomach-fillings of the dosage of 0.3g/kg.bw, observed two weeks after stomach-filling.Record dead animal number and general health situation.
4. result: with the rat of two kinds of genders of dosage stomach-filling of 0.3g/kg.bw, animal dead is had no in two weeks, also without bright
Aobvious poisoning symptom or adverse reaction.Tested material is greater than 0.3g/kg.bw to female, male SD rat acute oral MTD, belongs to nothing
Malicious class.It the results are shown in Table 1:
The Acute oral tox-hty test result of 1 SD rat of table
Strengthen immunity function test
1. sample: by formula described in embodiment 3 and the sample of method preparation.People is quasi- to be used dosage 2g/60kg.BW. days.
2. experimental animal: SPF grades of male mices, weight 18-22g.
3. dosage selects: tested material sets basic, normal, high three dosage groups of 0.3g/kg.BW, 0.7g/kg.BW, 1.0g/kg.Bw
(10 times, 20 times, 30 times that are respectively equivalent to human body recommended intake) separately set blank control group, every group of 40 animals.It is divided into and exempts from
One group of epidemic disease, two groups, three groups, four groups, wherein one group abnormal for antibody-producting cell test, serum hemolysin measurement and delayed
Reaction test；Two groups are used for lymphocyte transformation test and NK cytoactive detection；Three groups gulp down for Turnover of Mouse Peritoneal Macrophages
Bite chicken red blood cell experiment；Four groups are tested for mouse carbonic clearance.Each dosage group gives the sample stomach-filling of corresponding dosage, blank control
Group is with distilled water stomach-filling, and continuous gavage 30 days.
4. experimental method
The mouse lymphocyte transformation experiment (mtt assay) of 4.1 ConA induction: after continuous gavage 30 days, cervical dislocation is put to death
Animal, sterile taking-up spleen, tears up, and after crossing 200 mesh screens, is washed 3 times with Hank's liquid, 3 are made into complete 1640 culture medium ×
106/m1 cell suspension.It is divided to two holes to be added in 24 well culture plates cell suspension, every hole 1m1 a, hole adds 75 μ lConA liquid (phases
When in 7.5ug/ml), 5%CO is set as control in another hole2, after cultivating 68h in 37 DEG C of carbon dioxide incubators, take out culture
Supernatant 0.7ml is gently sucked out in plate, every hole, and 0.7ml is added and is free of the RPMI 1640 culture medium of calf serum, while MTT is added
50 hole μ l/ (5mg/m1) continues to cultivate 4h.After culture, lm1 acid isopropyl alcohol is added in every hole, and piping and druming mixes, and makes purple knot
Crystalline substance is completely dissolved.Lysate is moved into 2m1 cuvette, OD value is measured at 570nm wavelength, as a result as shown in table 2 below.
4.2 delayed allergies (DTH, vola pedis thicken method): at the 25th day of continuous gavage, animal was injected intraperitoneally 2%
SRBC0.2ml is immune, after continuous gavage 4 days, measures left back vola pedis thickness, measures 3 times and be averaged；Then in measuring point skin
Lower injection 20% (v/v) SRBC, every 20 μ l.Left back vola pedis thickness is measured within 24 hours after injection, measures 3 times and is averaged.Meter
The difference for calculating attack front and back vola pedis thickness, the degree of vola pedis thickness is indicated with difference, as a result as shown in table 3 below.
4.3 serum hemolysins measure (Hemagglutination Method): at the 25th day of continuous gavage, 2%SRBC0.2m1 was injected intraperitoneally in animal
It is immune, after continuing stomach-filling 5 days, extracts eyeball and take blood in centrifuge tube, place 1 hour, removing, 2000r/min is centrifuged 10 minutes,
Serum is collected, serum is made into doubling dilution with physiological saline, the serum of different dilutions is placed in blood-coagulation-board by every part of 12 holes of dilution
In, every 100 μ l of hole adds 100 μ l of 0.5%SRBC suspension, mixes, and observation is as a result, record every hole after setting 37 DEG C of 3h of wet box
Doubt collection degree.Calculating antibody product, as a result as shown in table 4 below.
4.4 antibody-producting cell detections (Jerne improves slide method): at the 25th day of continuous gavage, animal was injected intraperitoneally
2%SRBC0.2ml is immune, and after continuing stomach-filling 5 days, cervical dislocation puts to death animal, and sterile taking-up spleen is torn up, and crosses sieve on the 200th
Afterwards, it is washed 3 times with Hank's liquid, it is spare to be made into 5 × 106/m1 cell suspension with complete 1640 culture medium.Containing 0.5ml table
In the small test tube of layer culture medium (45 DEG C -50 DEG C) plus 50 μ l10%SRBC and 20 μ l splenocyte suspensions, rapid mixing are poured into
On the slide of brush agarose thin layer, after agar solidification, slide level is buckled and is placed on horse, is put into carbon dioxide incubator
After cultivating 1.5h, hemolysis plaque number is counted, as a result as shown in table 5 below.
4.5 Turnover of Mouse Peritoneal Macrophages swallow chicken red blood cell experiment (half intracorporal method): after continuous gavage 30 days, animal abdominal cavity
20% chicken erythrocyte suspension 1ml is injected, after 30 minutes, cervical dislocation is put to death, and is fixed on mouse plate, and stomach wall skin is cut off in center
Skin rotates mouse plate 1 minute through Intraperitoneal injection physiological saline 2ml, and abdominal cavity washing lotion 1ml is sucked out, and mean droplet is set on 2 glass slides
37 DEG C of wet box 30 minutes, taking-up was rinsed in physiological saline, is dried, fixing, and 4%GiemsaPBS is dyed 3 minutes, distilled water drift
It washes and dries, microscopy.Phagocytic percentage and phagocytic index are calculated, as a result as shown in table 6 below.
The experiment of 4.6 mouse carbonic clearances: it after continuous gavage 30 days, is diluted by 0.01ml/g.bw from mouse tail vein injection 1:4
Prepared Chinese ink, timing immediately takes 20 μ l of blood from angular vein clump respectively at 2,10min, 0.1%Na containing 2m1 is added2CO3Solution
In test tube, mix, with spectrophotometer at 600m wavelength densitometric value (OD), with Na2CO3Solution makees blank control, will be small
Mouse is put to death, and liver and spleen are taken, and inhales thousand organ surface blood stains with filter paper, weighing calculates phagocytic index, as a result as shown in table 7 below.
4.7NK cytoactive detection (determination of lactate dehydrogenase method): after continuous gavage 30 days, cervical dislocation puts to death animal,
Spleen is taken out, is torn up, after crossing 200 mesh screens, is washed 3 times with Hank's liquid, it is thin to be made into 2 × 107/m1 with complete 1640 culture medium
Born of the same parents' suspension.300 μ l are taken to be placed in 96 well culture plates the cell suspension of every animal, every 100 μ l of hole, every hole adds target cell
(YAC-1 cell, 4 × 105/m1) 100 μ l, while doing target cell Spontaneous release hole (100 μ l+ culture solution of target cell, 100 μ l)
And maximum each 8 hole relief hole (100 μ l+1%NP-40100 μ l of target cell), 37 DEG C of 5%CO21500r/ is taken out in culture 4 hours
Min is centrifuged 5 minutes.Each 100 μ l of hole supernatant is placed in another culture plate, every hole adds 100 μ l matrix liquids, after ten minutes
Add 30 μ l of 1mol/L HC1 to terminate reaction, OD value is measured at 492nm, calculates NK cell activity rate, as a result as shown in table 8 below.
The influence of the mouse lymphocyte conversion test of 2 ConA of table induction
* it indicates compared with the control group, P < 0.05.
From Table 2, it can be seen that after continuous gavage mouse 30 days, three dosage group OD values compared with the control group, 1.0g/
Kg.bw dosage group OD value difference value has significant difference (P < 0.05).
The influence of 3 mouse delayed allergy (DTH) of table
* it indicates compared with the control group, P < 0.05；* indicate compared with the control group, P < 0.01.
From table 3 it is observed that after continuous gavage mouse 30 days, three dosage group vola pedis thickened degrees and control group phase
Than 0.7g/kg.bw, 1.0g/kg.bw dosage group vola pedis thickened degree have significant difference (P < 0.05.P < 0.01).
The influence of 4 mice serum hemolysin of table
As can be seen from Table 4, after continuous gavage mouse 30 days, three dosage group antibody products compared with the control group, nothing
Significant difference (P > 0.05).
The influence of 5 mouse antibodies cellulation of table
* it indicates compared with the control group, P < 0.05；* indicate compared with the control group, P < 0.01.
As can be seen from Table 5, after continuous gavage mouse 30 days, three dosage group plaque numbers compared with the control group, 0.7g/
Kg.bw, 1.0g/kg.bw dosage group plaque number have significant difference (P < 0.05.P < 0.01).
The influence of 6 mouse macrophage of table phagocytosis chicken red blood cell ability
As can be seen from Table 6, after continuous gavage mouse 30 days, three dosage group Turnover of Mouse Peritoneal Macrophages phagocytosis chickens are red
Compared with the control group, there was no significant difference (P > 0.05) for the phagocytic rate and phagocytic index of cell.
The influence of 7 mouse monokaryons of table-macrophage carbonic clearance ability
As can be seen from Table 7, after continuous gavage mouse 30 days, three dosage group phagocytic index compared with the control group, nothing
Significant difference (P > 0.05).
The active influence of 8 NK cells in mice of table
* indicate compared with the control group, P < 0.01.
As can be seen from Table 8, after continuous gavage mouse 30 days, three dosage group NK cell activity compared with the control group,
0.7g/kg.bw, 1.0g/kg.bw dosage group NK cell activity have significant difference (P < 0.01.P < 0.01).
In conclusion in cellular immune function, humoral immune function, monocytes/macrophages function, NK cell activity four
Any two aspect results of aspect are positive, can determine whether that it has the function of strengthen immunity.Conclusion: oral health food combination of the present invention
Object increase immunity function is significant, has many advantages, such as safe ready.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of have effects that the composition of strengthen immunity, it is characterised in that: the composition includes following parts by weight
Raw material: 1-10 portions of ganoderma lucidums, 0.5-2 parts of ginsengs, 0.5-2 parts of dendrobium candidums and 0.01-0.1 parts of Saussurea involucrata cultures.
2. having effects that the composition of strengthen immunity as described in claim 1, it is characterised in that: the composition include with
The raw material of lower parts by weight: 5-8 portions of ganoderma lucidums, 0.8-1.5 parts of ginsengs, 0.8-1.5 parts of dendrobium candidums and 0.02-0.08 parts of saussurea involucrata trainings
Support object.
3. having effects that the composition of strengthen immunity as described in claim 1, it is characterised in that: the composition include with
The raw material of lower parts by weight: 6 portions of ganoderma lucidums, 1 part of ginseng, 1 part of dendrobium candidum and 0.05 part of Saussurea involucrata culture.
4. a kind of preparation method with the composition of strengthen immunity, it is characterised in that: at least include the following steps:
(1) ginseng, ganoderma lucidum and dendrobium candidum are weighed according to raw material proportioning as claimed in any one of claims 1 to 3；
(2) extraction is added water to cook after sufficiently impregnating the ginseng, ganoderma lucidum and dendrobium candidum, extracting solution is filtered；
(3) said extracted liquid is first condensed into thick paste and then re-dry into dry cream, obtains dry cream after finally dry cream pulverizes and sieves
Powder；
(4) Saussurea involucrata culture is weighed according to raw material proportioning as claimed in any one of claims 1 to 3；
(5) Saussurea involucrata culture fine powder will be obtained after Saussurea involucrata culture sieving；
(6) above-mentioned dried cream powder and Saussurea involucrata culture fine powder are uniformly mixed to get mixed powder.
5. having effects that the preparation method of the composition of strengthen immunity as claimed in claim 4, it is characterised in that: the step
Suddenly decocting time is 1-2 hours in (2), and extraction time is 2-3 times.
6. having effects that the preparation method of the composition of strengthen immunity as claimed in claim 4, it is characterised in that: the step
Suddenly extracting solution is condensed into thick paste to be concentrated under reduced pressure in (3), and it is to be dried under reduced pressure that thick paste, which is dried to dry cream,.
7. a kind of have effects that the health food of strengthen immunity, it is characterised in that described in any item including claims 1 to 3
Has effects that the composition of strengthen immunity.
8. having effects that the health food of strengthen immunity as claimed in claim 7, it is characterised in that: its dosage form be tablet,
Granule, capsule or oral solution.
9. a kind of have effects that the tablet of strengthen immunity, it is characterised in that have including claims 1 to 3 is described in any item
The composition of strengthen immunity effect further includes 1-1.5 parts of microcrystalline celluloses, 0.05-0.08 parts of PVP K30s and 0.01-
0.03 part of magnesium stearate.
10. a kind of preparation method with the tablet of strengthen immunity as claimed in claim 9, it is characterised in that at least
The following steps are included:
(1) extraction is added water to cook after sufficiently impregnating the ginseng, ganoderma lucidum and dendrobium candidum, extracting solution is filtered；
(2) said extracted liquid is first condensed into thick paste and then re-dry into dry cream, obtains dry cream after finally dry cream pulverizes and sieves
Powder；
(3) equal increments are uniformly mixed to get mixed powder A after the Saussurea involucrata culture and microcrystalline cellulose being sieved respectively；
(4) above-mentioned dried cream powder and mixed powder A are uniformly mixed to get mixed powder B；
(5) liquid is matched into PVP K30 dissolution, binder solution is made；
(6) by mixed powder B and binder solution mixing granulation, particle C is obtained；
(7) Magnesium Stearate is uniformly mixed with the particle C, obtains total mix particle D；
(8) plain piece is made in total mix particle D tabletting；
(9) plain piece is subjected to film coating processing, obtains coating tablet.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674042A (en) * | 2019-02-02 | 2019-04-26 | 北京振东光明药物研究院有限公司 | A kind of nutriment and preparation method thereof improving immunity |
| CN110664860A (en) * | 2019-10-12 | 2020-01-10 | 神威药业集团有限公司 | Composition for enhancing immunity and preparation method thereof |
| CN111494555A (en) * | 2020-05-14 | 2020-08-07 | 安徽至开医药生物科技有限公司 | A Chinese medicinal composition used as both medicine and food for improving immunity, and its preparation method |
| CN112655959A (en) * | 2019-10-15 | 2021-04-16 | 神威药业集团有限公司 | Composition for enhancing immunity |
| CN114128820A (en) * | 2020-09-04 | 2022-03-04 | 天津星宇航天生物科技有限公司 | Nutritional preparation for improving physical function of astronaut and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1754564A (en) * | 2004-09-30 | 2006-04-05 | 寿伟康 | Green dendrobium stem pharmaceutical compostition and its preparation method |
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2018
- 2018-08-23 CN CN201810968255.5A patent/CN109123612A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1754564A (en) * | 2004-09-30 | 2006-04-05 | 寿伟康 | Green dendrobium stem pharmaceutical compostition and its preparation method |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674042A (en) * | 2019-02-02 | 2019-04-26 | 北京振东光明药物研究院有限公司 | A kind of nutriment and preparation method thereof improving immunity |
| CN109674042B (en) * | 2019-02-02 | 2022-05-27 | 北京振东光明药物研究院有限公司 | Nutrient for improving immunity and preparation method thereof |
| CN110664860A (en) * | 2019-10-12 | 2020-01-10 | 神威药业集团有限公司 | Composition for enhancing immunity and preparation method thereof |
| CN112655959A (en) * | 2019-10-15 | 2021-04-16 | 神威药业集团有限公司 | Composition for enhancing immunity |
| CN111494555A (en) * | 2020-05-14 | 2020-08-07 | 安徽至开医药生物科技有限公司 | A Chinese medicinal composition used as both medicine and food for improving immunity, and its preparation method |
| CN114128820A (en) * | 2020-09-04 | 2022-03-04 | 天津星宇航天生物科技有限公司 | Nutritional preparation for improving physical function of astronaut and preparation method thereof |
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