CN102846852B - Composite for lowering blood fat and regulating immunity - Google Patents
Composite for lowering blood fat and regulating immunity Download PDFInfo
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- CN102846852B CN102846852B CN201210374246.6A CN201210374246A CN102846852B CN 102846852 B CN102846852 B CN 102846852B CN 201210374246 A CN201210374246 A CN 201210374246A CN 102846852 B CN102846852 B CN 102846852B
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Abstract
The invention relates to a composite for lowering blood fat and regulating immunity, which comprises the following components of pseudo-ginseng and Liupu tea. An experiment proves that the composite disclosed by the invention has a better effect on lowering blood fat and regulating immunity if being compared with the prior art, and the composite also has a synergy.
Description
Technical field
The present invention relates to a kind of compositions, be specifically related to the compositions of a kind of blood fat reducing, adjusting immunity.
Background technology
Though without the name of disease of hyperlipidemia, think that primary disease belongs to " expectorant is turbid " of the traditional Chinese medical science, " blood stasis " category in Chinese medicine.According to theory of Chinese medical science, the cause of disease of hyperlipidemia can be summarized as: dysfunction of the spleen in transportation, neural virtual loss causes the turbid cohesion of expectorant, for morbidity within because of; Have a liking for food delicious food, greasy and surfeit flavour and change raw expectorant turbid be form outside primary disease because of.Hyperlipidemia is levying of deficiency in origin and excess in superficiality, thus treat appropriate to the occasion treating both the principal and the secondary aspects of a disease at the same time, with tonifying speen and tonifying kidney, nourishing YIN and benefiting blood, blood circulation promoting and blood stasis dispelling, it is main that clearing away heat and loosing the bowels eliminates indigestion and phlegm.
Hypoimmunity is that health is easy to infected as initiation anaphylaxis and autoimmune disease etc.Show as have a delicate constitution, malnutrition, listlessness, fatigue and weak, appetite depression, sleep disorder etc., if things go on like this can cause health and intelligent development bad, also easily bring out major disease.Improve immunity and generally take following methods: keep sufficient sleep and optimistic emotion, fitness campaign, vitimin supplement and mineral, take the food that can improve immunity.
LIUPUCHA belongs to warm nature tea, except having the common health-care effect of other teas, has more that the damp eliminating of relieving summer heat, improving eyesight clear away heart-fire, digestive effect.LIUPUCHA, after hanging ageing, just can have been seen many golden yellow " JINHUA " in tea, this is the yellow mycete of useful quality, its can secreting amylase and oxidase, and the starch in can catalysis Folium Camelliae sinensis is converted into monosaccharide, the oxidation of catalysis polyphenol compound, make Folium Camelliae sinensis soup complexion changed reddish brown, eliminate thick blue or green taste.Scientific experimentation and LIUPUCHA fan sip tea and facts have proved, LIUPUCHA is except the several amino acids that contains needed by human, vitamin and trace element, contained lipase is higher than other teas, therefore LIUPUCHA has the effect that stronger decomposition is greasy, reduce human body class fatty compound, cholesterol, triglyceride, long-term drink can stomach invigorating be reposed, body-building and weight-reducing.LIUPUCHA is except the several amino acids that contains needed by human, vitamin and trace element, contained steatolysis alcohol element is higher than other teas, therefore it is greasy that LIUPUCHA has stronger decomposition, reduce human body class fatty compound, cholesterol, the effect that triglyceride and blood uric acid are high, long-term drink can be reposed in stomach invigorating, fitness and weight losing.The major function of LIUPUCHA health care is: 1, refreshment, allaying tiredness; 2, except greasy, aid digestion, relieving alcoholic intoxication; 3, diuresis removing toxic substances, bactericidal antiphlogistic diseases prevention; 4, blood pressure lowering, prevents arteriosclerosis; 5, radioprotective, suppresses cancer; 6, health care is beautiful, lose weight fat, and life lengthening.Applicable crowd is hypertension, hyperlipidemia (blood glues height, cholesterol is high, triglyceride is high), hyperglycemia (diabetes), the high crowds such as gout that cause of uric acid.
Radix Notoginseng has another name called Radix Notoginseng, and the famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is called " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".In the pharmacy works < < of Qing Dynasty A Supplement to the Compendium of Materia Medica > >, record: " ginseng qi-tonifying first; Radix Notoginseng enriches blood first; taste with and merit also etc., therefore claim Panax pseudoginseng, be the most precious person in Chinese medicine.”。Warm in nature, sweet in the mouth, micro-hardship, nontoxic, return liver, stomach warp.There is hemostasis; Loose blood; Analgesic therapy effect, cures mainly: fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen; Blood stasis amenorrhea; Dysmenorrhea; The cloudy stomachache of the stasis of blood in puerperal; Sore, carbuncle and painful swelling.
In prior art, disclose CN200910114025.3 and disclose a kind of herbal tea of being made by flower of Radix Notoginseng, Herba Duchesneae Indicae, Rhizoma Alpiniae Officinarum, Herb Gynostemmae Pentaphylli, Herba Rabdosiae Lophanthoidis, Semen Ziziphi Spinosae, the Cortex Eucommiae, LIUPUCHA and preparation method thereof, its proportioning is: flower of Radix Notoginseng 3-8%, Herba Duchesneae Indicae 8-12%, Rhizoma Alpiniae Officinarum 3-8%, Herb Gynostemmae Pentaphylli 30-50%, Herba Rabdosiae Lophanthoidis 10-20%, Semen Ziziphi Spinosae 3-8%, Cortex Eucommiae 8-12%, special grade liupu tea 5-15%.There is the effects such as clearing away heat,cooling blood and removing toxin, expelling wind and removing dampness, dissipating blood stasis are promoted blood circulation, mind tranquilizing and the heart calming, promoting the circulation of QI to relieve pain; can significantly reduce cholesterol (TCH), triglyceride (TG), low density lipoprotein, LDL (LDL); high density lipoprotein increasing (HDL), protection blood vessel cell; stop lipid to deposit in blood vessel wall; arteriosclerosis; reduce blood viscosity, adjust blood pressure function; microthrombusis hypertension be can also prevent, hypertension, hyperlipidemia, high blood viscosity, the high disease of uric acid etc. are specially adapted to drunk by people.
Do not see other relevant reports that Radix Notoginseng, LIUPUCHA are share.
Summary of the invention
The object of the present invention is to provide the compositions of a kind of blood fat reducing, adjusting immunity.
The compositions of a kind of blood fat reducing provided by the invention, adjusting immunity, it contains following composition: Radix Notoginseng, LIUPUCHA.
Concrete, compositions provided by the invention, the composition that it contains following weight portion: Radix Notoginseng 150-400 part, LIUPUCHA 400-800 part.
Preferably, compositions provided by the invention, the composition that it contains following weight portion: Radix Notoginseng 180-300 part, LIUPUCHA 500-700 part.
Further preferably, compositions provided by the invention, the composition that it contains following weight portion: 240 parts of Radix Notoginseng, 600 parts of LIUPUCHA.
Or further preferred, compositions provided by the invention, the composition that it contains following weight portion: 300 parts of Radix Notoginseng, 600 parts of LIUPUCHA.
Compositions provided by the invention also contains two kinds in following composition: Flos Chrysanthemi, Fructus Crataegi, the Cortex Eucommiae, Radix Polygoni Multiflori Preparata, Rhizoma Alismatis, Folium Ginkgo, Radix Puerariae, Herb Gynostemmae Pentaphylli.
Preferably, described compositions also contains the composition of following weight portion: Flos Chrysanthemi 200-250 part, Folium Ginkgo 250-350 part.
Preferably, described compositions also contains the composition of following weight portion: Herb Gynostemmae Pentaphylli 100-150 part, Radix Polygoni Multiflori Preparata 100-150 part.
Preferably, described compositions also contains the composition of following weight portion: Rhizoma Alismatis 150-250 part, Fructus Crataegi 450-550 part.
Preferably, described compositions also contains the composition of following weight portion: Radix Puerariae 300-500 part, Cortex Eucommiae 150-200 part.
Below the source of described raw material:
Radix Notoginseng, Flos Chrysanthemi, Fructus Crataegi, the Cortex Eucommiae, Radix Polygoni Multiflori Preparata, Rhizoma Alismatis, Folium Ginkgo, Radix Puerariae, Herb Gynostemmae Pentaphylli: all can, by commercially available purchase, meet < < Chinese Pharmacopoeia > >.
LIUPUCHA: can commercially availablely buy, meet LIUPUCHA provincial standard.
Herb Gynostemmae Pentaphylli: can commercially availablely buy conformance with standard < < Guangxi Chinese crude drug standard > >.
The present invention also provides the preparation method of above-mentioned composition, comprises the following steps: LIUPUCHA, and decocting boils, and filters, and filtrate is concentrated; Radix Notoginseng alcohol reflux, merges LIUPUCHA concentrated solution and Radix Notoginseng extracting solution, dry, obtains.
Concrete, described preparation method, comprises the following steps:
1) according to proportioning, take LIUPUCHA, by 8-15 times of water boiling and extraction 2-3 time, each 1-3, filters, and merging filtrate is concentrated, standby;
2) according to proportioning, take Radix Notoginseng, with 3-10 times of alcohol reflux 2-3 time, each 2-3 hour, filters, merging filtrate, and solution is concentrated into without alcohol taste, merges LIUPUCHA concentrated solution and arasaponin concentrated solution, dry, obtains.
The present invention also provides the another kind of preparation method of above-mentioned composition, comprises the following steps: according to proportioning, take LIUPUCHA, Radix Notoginseng, add water extraction 2-3 time of 6-12 times of medical material amount, filter, and merging filtrate, concentrated, dry, obtain.
The present invention also provides the another kind of preparation method of above-mentioned composition, comprises the following steps: according to proportioning, take LIUPUCHA, Radix Notoginseng, use water extraction 2-3 time, the water that at every turn adds 6-12 times of medical material amount, extraction time is 2-3 hour, filters, merging filtrate, concentrated, add ethanol, standing, filter, concentrated, dry, obtain.
The present invention also provides another preparation method of above-mentioned composition, comprises the following steps: Radix Notoginseng, LIUPUCHA, Flos Chrysanthemi, Folium Ginkgo extracting in water, filter, and concentrated, dry, obtain.
The present invention also provides another preparation method of above-mentioned composition, comprises the following steps: Radix Notoginseng, LIUPUCHA, Herb Gynostemmae Pentaphylli, Radix Polygoni Multiflori Preparata add water boil and extract, and filter, concentrated, dry, obtain.
The present invention also provides another preparation method of above-mentioned composition, comprises the following steps:
LIUPUCHA decocts with water extraction, filters, and merging filtrate, concentrated, standby;
Radix Notoginseng, Rhizoma Alismatis, Fructus Crataegi, add alcohol reflux, filter, and merging filtrate, solution is concentrated into without alcohol taste;
Merge LIUPUCHA concentrated solution and Radix Notoginseng, Rhizoma Alismatis, Fructus Crataegi concentrated solution, dry, obtain.
The present invention also provides another preparation method of above-mentioned composition, comprises the following steps:
LIUPUCHA decocts with water extraction, filters, and merging filtrate, concentrated, standby;
Radix Notoginseng, Radix Puerariae, the Cortex Eucommiae add alcohol reflux, filter, and merging filtrate, solution is concentrated into without alcohol taste;
Merge LIUPUCHA concentrated solution and Radix Notoginseng, Radix Puerariae, Cortex Eucommiae concentrated solution, dry, obtain.
In above-mentioned preparation method:
During described alcohol reflux, the concentration of ethanol used is 50-90%; During extracting in water, add ethanol and staticly settle, adding the concentration of alcohol of solution after alcohol is 30-80%.
The present invention also provides the preparation containing above-mentioned composition, and said preparation is comprised of separately compositions or is comprised of compositions and pharmaceutically acceptable carrier or excipient.
Described preparation is granule, oral liquid, powder or tablet.
In compositions provided by the invention, it is Icing Sugar, dextrin, maltodextrin, starch, water soluble starch, lactose etc. that its granule is filled adjuvant.
Tablet diluent adjuvant is: starch, sucrose, dextrin, lactose, microcrystalline Cellulose etc.
Oral liquid sweeting agent adjuvant is sucrose, aspartame; Antiseptic is sodium benzoate, potassium sorbate.
Above-mentioned preparation can adopt conventional preparation process preparation.
The present invention also provides above-mentioned composition in preparation blood fat reducing, the health product that regulate immunity and the application in medicine.
The bright compositions providing of this law has the following advantages:
1, applicant is at research tradition Chinese herbal medicine and consulted on the basis of a large amount of pharmacy data, through test for many years, and can long-term taking from having found, lipid-lowering effect is good, the Chinese crude drug proportioning that has no side effect and completed the present invention.
2, in compositions provided by the invention:
Radix Notoginseng: be Araliaceae Panax notoginseng(Burk.) dry root of F.H.Chen, records in 11 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
LIUPUCHA: in the specific region for suitable processing, adopt LIUPUCHA processes to make, the postfermented tea with qualitative characteristics such as " six forts fragrant " and red, dense, old, alcohol, should meet Guangxi Zhuang Autonomous Region provincial standard DB45/T581-2009 < < LIUPUCHA > > requirement.
Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Record in 292 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010
Fructus Crataegi: be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Record in 29 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
The Cortex Eucommiae: be the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver).Record in 154 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
Radix Polygoni Multiflori Preparata: be the Preparation process product of Radix Polygoni Multiflori (tuber of polygonum multiflorum thunb Polygonum multiflorum Thuna.), record in 165 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
Rhizoma Alismatis: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientale (Sam.) Juzep..Record in 212 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
Folium Ginkgo: be the dried leaves of Ginkgoaceae plant Ginkgo biloba Ginkgo bilobe L..Record in 296 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
Radix Puerariae: Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Record in 312 pages of mat woven of fine bamboo strips of < < Chinese Pharmacopoeia > > version in 2010.
Herb Gynostemmae Pentaphylli: be the dry herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunb.) Makino.Record in second the 186th page of < < Guangxi Chinese crude drug standard > > version in 1992.
When compositions is Radix Notoginseng and LIUPUCHA:
In LIUPUCHA, lipase can reduce human body class fatty compound, Radix Notoginseng dredging vascellum, and by removing the cause of disease, original is former clearly, makes meridians unimpeded, and qi-blood circulating does not stop, and to reduce teinemia card, can improve anoxia endurance again, has synergy.
When compositions is four kinds of compositions of Radix Notoginseng, LIUPUCHA and other any two kinds of Chinese medicines compositions:
Flos Chrysanthemi, Fructus Crataegi, the Cortex Eucommiae, Radix Polygoni Multiflori Preparata, Rhizoma Alismatis, Folium Ginkgo, Radix Puerariae, Herb Gynostemmae Pentaphylli all health care < < Ministry of Public Health about the notice > > of further standard healthy food material management in " being the kind list of food and medicine " or " the article list that can be used for health food ", the raw material that genus can long-term safety be taken.Above raw material has respectively assistant lipid-lowering or improves anoxia endurance effect, after science compatibility, formula demonstration, carry out the test of animal function assessment, prove: on the basis of Radix Notoginseng and LIUPUCHA, add again above Chinese medicine, its blood fat reducing and raising anoxia endurance more remarkable effect.
3, compositions provided by the invention is medicinal tea safely and effectively, has the effect of blood fat reducing, enhancing immunity, and raw materials used is parts of generic medicinal plants, ample supply and prompt delivery, is easy to get; Finished product adopts pure Chinese medicine formula to produce in conjunction with modern vanguard technology, carries and drink all very convenient.
4, experiment shows, compositions provided by the invention is to blood fat reducing, adjusting immunity, and effect is better than prior art, and has synergy.
5, after compositions provided by the invention brews, soup color is red dense, and fragrance is old thick, flavour glycol, and with pine soot and Semen Arecae taste, it is top grade that mouthfeel and visual enjoyment all belong to.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Unless specified otherwise in the present invention, the concentration of ethanol used is volume ratio.
Embodiment 1: the compositions of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 240g, LIUPUCHA 600g.
2, preparation method:
Get Radix Notoginseng, clean processing, take 240g, then with alcohol heating reflux, extract 3 times, add 60% alcoholic solution of 4 times of medical material weight at every turn, extract for the first time 3 hours, extract for the second time 2 hours, extract for the third time 2 hours, filtrate filters with 120 mesh sieves.Merge above-mentioned filtrate, solution is concentrated into without alcohol taste, standby;
Get LIUPUCHA, clean processing, take 600g, use twice of water rinse, with water extraction 3 times, add the water of 10 times of medical material weight at every turn, extract for the first time 2 hours, extract for the second time 1 hour, extract for the third time 1 hour, filtrate filters with 120 mesh sieves, and merging filtrate is concentrated into 3-5 and rises standby;
Merge LIUPUCHA concentrated solution and Radix Notoginseng extract concentrated solution, being concentrated into relative density is 1.20(60 ℃), dry, obtain.
Embodiment 2: compositions and the granule of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 300g, LIUPUCHA 600g.
2, the preparation method of compositions:
Take Radix Notoginseng, LIUPUCHA, use water extraction 2 times, add the water of 12 times of medical material amounts at every turn, extract 3 hours at every turn, filter, merging filtrate, being concentrated into relative density is 1.25(60 ℃), dry, obtain 234 grams of dry powder.
3, the preparation method of granule: above-mentioned gained dry powder is added to 75 grams of maltodextrins, mix, with reference to the method granulation agent of conventional Chinese medicine preparation.
Embodiment 3: compositions and the tablet of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 300g, LIUPUCHA 500g.
2, the preparation method of compositions:
Get Radix Notoginseng, clean processing, take 300g, then with alcohol heating reflux, extract 2 times, 60% alcoholic solution that at every turn adds 10 times of medical material amounts, extracts 3 hours for the first time, extracts for the second time 3 hours, and filtrate filters with 120 mesh sieves, merge above-mentioned filtrate, solution is concentrated into without alcohol taste, standby;
Get LIUPUCHA, clean processing, take 500g, extracting in water 2 times adds the water of 13 times of medical material amounts at every turn, extracts for the first time 3 hours, extracts for the second time 2 hours, and filtrate filters with 120 mesh sieves, and merging filtrate is concentrated into 3-5 liter, standby;
Merge LIUPUCHA concentrated solution and Radix Notoginseng concentrated solution, being concentrated into relative density is 1.20(60 ℃), dry, obtain 200 grams of dry powder;
3, the preparation method of tablet: dry powder is added to 100 grams of starch, make tablet with reference to the method for conventional Chinese medicine preparation.
Embodiment 4: compositions and the oral liquid of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 180g, LIUPUCHA 700g.
2, the preparation method of compositions:
Take LIUPUCHA, Radix Notoginseng, use water extraction 3 times, add the water of 11 times of medical material amounts at every turn, each extraction 2 hours, filter, merging filtrate, being concentrated into relative density is 1.10(60 ℃), it is 70% that 95% ethanol is adjusted to determining alcohol, standing over night, filters, and being concentrated into relative density is 1.15(60 ℃), dry, obtain 202.4 grams of dry powder;
3, the preparation method of oral liquid: above-mentioned gained dry powder is dissolved by 2.6 kg water, add 180 grams of sucrose and 1.5 Keshan potassium sorbates, embedding, sterilizing, makes oral liquid.
Embodiment 5: the compositions of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 150g, LIUPUCHA 400g, Flos Chrysanthemi 200g, Folium Ginkgo 250g.
2, preparation method:
Take LIUPUCHA, Radix Notoginseng, Flos Chrysanthemi, Folium Ginkgo, with water extraction 3 times, add 10 times of medical material amounts at every turn, extract 2 hours at every turn, filter, merging filtrate, being concentrated into relative density is 1.20(70 ℃), dry, obtain.
Embodiment 6: the compositions of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 200g, LIUPUCHA 300g, Herb Gynostemmae Pentaphylli 150g, Radix Polygoni Multiflori Preparata 100g.
2, preparation method:
Take LIUPUCHA, Radix Notoginseng, Herb Gynostemmae Pentaphylli, Radix Polygoni Multiflori Preparata, use water extraction 3 times, add each the extraction 2 hours of water of 12 times of medical material amounts at every turn, filter, merging filtrate, being concentrated into relative density is 1.18(60 ℃), be drying to obtain.
Embodiment 7: the compositions of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 300g, LIUPUCHA 400g, Rhizoma Alismatis 150g, Fructus Crataegi 450g.
2, preparation method:
According to proportioning, take each composition, get Radix Notoginseng, Rhizoma Alismatis, Fructus Crataegi, with alcohol heating reflux, extract 3 times, 60% alcoholic solution that at every turn adds 8 times of medical material weight, extracts 3 hours for the first time, extracts for the second time 3 hours, extract for the third time 2 hours, filtrate filters with 120 mesh sieves.Merge above-mentioned filtrate, solution is concentrated into without alcohol taste, standby;
Get LIUPUCHA, clean processing, take 400g, use twice of water rinse, with water extraction 3 times, add the water of 12 times of medical material weight at every turn, extract for the first time 2 hours, extract for the second time 2 hours, extract for the third time 1 hour, filtrate filters with 120 mesh sieves, and merging filtrate is concentrated into 3-5 and rises standby;
Merge LIUPUCHA concentrated solution and Radix Notoginseng extract concentrated solution, being concentrated into relative density is 1.15(60 ℃), dry, obtain.
Embodiment 8: compositions and the granule thereof of a kind of blood fat reducing, adjusting immunity
1, raw material: Radix Notoginseng 180g, LIUPUCHA 700g, Radix Puerariae 300g, Cortex Eucommiae 150g.
2, the preparation method of compositions:
According to proportioning, take each composition, get Radix Notoginseng, Radix Puerariae, the Cortex Eucommiae, with alcohol heating reflux, extract 3 times, add 75% alcoholic solution of 14 times of medical material weight at every turn, extract 2 hours at every turn, filtrate filters with 120 mesh sieves.Merge above-mentioned filtrate, solution is concentrated into without alcohol taste, standby;
Get LIUPUCHA, clean processing, take 700g, with water rinse twice, use water extraction 3 times, add the water of 12 times of medical material weight at every turn, extract 2 hours at every turn, filtrate filters with 120 mesh sieves, and merging filtrate is concentrated into 3-5 and rises standby;
Merge LIUPUCHA concentrated solution and Radix Notoginseng extract concentrated solution, being concentrated into relative density is 1.20(70 ℃), dry, obtain 295 grams of dry powder.
3, the preparation of granule: above-mentioned dry gained dry powder is added to 17 grams of maltodextrins, mix, with reference to the method granulation agent of conventional Chinese medicine preparation.
Experimental example 1: heavy metal detects:
The compositions of embodiment 1-8 is detected to heavy metal arsenic, lead, hydrargyrum detection, and detection method is according to being respectively:
The mensuration of total Arsenic in Food and inorganic arsenic, according to GB/T5009.11; The mensuration of Pb in food, according to GB/T5009.12; Total mercury and organomercurial mensuration in food, according to GB/T5009.17.
The results are shown in Table 1:
Table 1: testing result
| Standard | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | |
| Total arsenic Asmg/kg | ≤0.3 | 0.211 | 0.103 | 0.166 | 0.085 | 0.185 | 0.127 | 0.136 | 0.164 |
| Plumbous Pbmg/kg | ≤0.5 | 0.395 | 0.118 | 0.201 | 0.096 | 0.167 | 0.152 | 0.181 | 0.149 |
| Total mercury Hgmg/kg | Must not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect |
Table 1 result shows: in compositions provided by the invention, heavy metal testing result all meets national health food standard-required.
In following effect experiment and toxicological test, the sample preparation methods of each group of embodiment 1-8, Radix Notoginseng group and LIUPUCHA group:
Embodiment group, Radix Notoginseng group, LIUPUCHA group pharmaceutical quantities are all by crude drug amount 2.8g/kg.
Sample treatment before Radix Notoginseng and LIUPUCHA test: get Radix Notoginseng and LIUPUCHA by above weight fraction another name, add 85 ℃ of pure water of 10 times of amounts to soak 30 minutes, use filtered through gauze soak; In kind repeat to soak, extract once.Then merge filtrate twice, with Rotary Evaporators, be evaporated to 500mL, obtain sample extracting solution.With pure water preparation, be subject to test solution more before use.
Embodiment group 1-8 sample: calculate the contained crude drug amount of every g with the actual gained sample size of preparing, dosage is in crude drug amount 2.8mg/kg, and conversion experiment should be given sample size.
Experimental example 2: lipid-lowering test
1, laboratory animal: healthy Kunming mouse, body weight 20-25g, male and female half and half, provide (credit number: SCXK osmanthus 2009-0002) by Guangxi Medical University's Experimental Animal Center;
2, Experimental agents: cholesterol, propylthiouracil.
3, experiment grouping:
Get 130 of healthy Kunming mouses, be divided at random 13 groups, be blank group, model group, positive drug group (simvastatin), 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment, Radix Notoginseng group, LIUPUCHA group, every group 10, male and female half and half.
Each is organized and gives gastric infusion morning, gavage solution is prepared with 2% tween solution, gavage capacity 20ml/kgBW, and each group of embodiment 1-8, Radix Notoginseng group, LIUPUCHA group dosage are all by crude drug amount 2.8g/kg, the consumption of simvastatin is 0.04g/kg, and blank, model group gives equivalent 2% tween solution.
4, experimental technique:
The preparation of 4.1 fat milks:
Get 1g propylthiouracil porphyrize in mortar, standby;
Get 20g Adeps Sus domestica and melt in 40 ℃ of heating in water bath, put in mortar, add 10g cholesterol, 1g propylthiouracil, fully stir, dissolve.Slowly add 10% deoxycholic acid sodium water solution 20ml again, and constantly stir, then add 5ml Tween 80, grinding emulsifying is even, and last adding distil water is to 100ml.Pack in hermetic container, cold preservation, obtains fat milk.
Fat milk is melting prior to 37 ℃ of water-baths before use.
4.2 experimental techniques: except blank group, all the other are respectively organized mice and all give gavage fat milk 20ml/kgBW, continuous 2 weeks.
5, detect index
TG, TC level determination in 5.1 serum: after last gavage, water 12h is can't help in fasting, get blood and measure TC, TG level according to test kit explanation.
MDA content and SOD determination of activity in 5.2 livers: mice is put to death after getting blood, wins liver 0.5g, in normal saline, rinses, filter paper blots, with normal saline homogenate, make 10% liver homogenate liquid, centrifuging and taking supernatant, measures MDA content and SOD activity according to test kit explanation.
6, statistical method: adopt SPSS13.0 software to carry out one factor analysis of variance to experimental data, every data all with
represent.
7, result:
7.1 impacts on serum TC, TG level: in Table 2
Table 2: the impact on mice serum TC, TG
Note: with normal group comparison,
#p < 0.01; With model group comparison,
*p < 0.05,
*< 0.01, with the comparison of LIUPUCHA group,
aMP.AMp.Ampp < 0.05; Compare with Radix Notoginseng group,
▲p < 0.05.
Table 2 result shows:
With normal group comparison, in model group mice serum, TC, TG content are significantly higher than normal group (P < 0.05), prompting modeling success;
With model group comparison, each group of embodiment 1-8, positive controls significantly reduce TC (P < 0.01), and positive controls obviously reduces TC (P < 0.05); In Radix Notoginseng group, LIUPUCHA group mice serum, TC content obviously reduces (P < 0.05).
With Radix Notoginseng group, the contrast of LIUPUCHA group, each group of embodiment 1-8 obviously reduces TC (P < 0.05) respectively.
Relatively, the former TC, TG are lower than the latter for each group of embodiment 5-8 each group and embodiment 1-4.
Experimental result shows: compositions provided by the invention has effect for reducing blood fat, and effect is better than Radix Notoginseng and alone LIUPUCHA, has synergy.
7.2 impacts on liver MDA content and SOD activity: in Table 3
Table 3: the impact on Content of MDA and SOD, GSH-PX activity
Note: with normal group comparison,
#p < 0.05; With model group comparison,
*p < 0.05,
*p<0.01, with the comparison of LIUPUCHA group,
aMP.AMp.Ampp<0.05; With the comparison of Radix Notoginseng group tea group,
▲p<0.05.
Table 3 result shows:
With normal group comparison, in model group mouse liver, MDA content obviously raises (P<0.01), active significantly reduce (P<0.01) of SOD;
With model group comparison, in each group of embodiment 1-8, Radix Notoginseng group and LIUPUCHA group mouse liver, MDA has reduction in various degree, and SOD activity has raise in various degree (P<0.05 or P<0.01).
With Radix Notoginseng group, the contrast of LIUPUCHA group, each group of embodiment 1-8 obviously reduces MDA, (P<0.05) respectively; Embodiment 5-8 respectively organizes SOD activity raise in various degree (P<0.05).
With each group of embodiment 1-4 relatively, it is slightly low that embodiment 5-8 respectively organizes in liver MDA, SOD activity is higher than each group of embodiment 1-4.
Result shows: compositions provided by the invention has lipoid peroxidization resistant, and effect is better than Radix Notoginseng or alone LIUPUCHA, has synergy.
8, discuss: hyperlipemia refers to the class disease that cholesterol in the blood plasma that a variety of causes causes and/or TG level raise, the arch-criminal of the cardiovascular disease such as hypertension, diabetes, atherosclerosis and cerebrovascular disease, serious harm people's health.LIUPUCHA is the natural health-care beverage that the Guangxi people often drink, and is applicable to the crowds such as hypertension, hyperlipidemia, hyperglycemia, has the effects such as clearing away heat-damp and promoting diuresis, dissipating blood stasis are promoted blood circulation, regulating QI to relieve pain, the lipoid and reducing blood pressure that disappears, blood sugar-decreasing mind-easing.
This result of study shows, compositions provided by the invention can effectively reduce hyperlipemia in mice serum total cholesterol content, reduces liver MDA, and increased SOD is active.Point out compositions provided by the invention to have certain assistant lipid-lowering and lipoid peroxidization resistant, effect is better than prior art, and has synergy.
Experimental example 3: the impact on immune function of mice
1, laboratory animal: 270 of healthy KM mices, body weight 18-22g, male and female dual-purpose, Guangxi Medical University's Experimental Animal Center provides (credit number: SCXK osmanthus 2009-0002).
2, experimental drug:
Calf serum, is produced by U.S. Hyclone company;
RPMI 1640, by U.S. Gibco company, produced;
Concanavalin A, Con A (ConA), tetramethyl azo azoles salt (MTT), produced by U.S. Sigma company.
Other reagent are domestic analytical pure.
3, experimental technique and grouping
3.1 Turnover of Mouse Peritoneal Macrophages are engulfed chicken red blood cell experiment
3.1.1 get 110 of healthy Kunming mouses, be divided at random 11 groups, be blank group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment, Radix Notoginseng group, LIUPUCHA group, 10 every group, male and female half and half.Except Normal group, each organizes gavage LIUPUCHA 1 time every day, administration volume 20ml/kg, the isopyknic distilled water of Normal group gavage, continuously 30d.
3.1.2 reference literature method (health food check and assessment technique standard) is tested.
The method providing by face is calculated phagocytic rate and phagocytic index:
Peritoneal macrophage is engulfed 110 of chicken red blood cell experiment Kunming mouses, weight 18-20g.After successive administration 30 days, mice is put to death in cervical vertebra dislocation, along ventrimeson, inject the aseptic PBS-H(of 3ml ice pre-cooling containing the PBS of 10U/ml heparin and 10% calf serum), massage gently abdominal part 5min and cut off stomach wall, sucking-off transudate, then rinse abdominal cavity with the pre-cooling PBS-H of same capacity, merge transudate, the washing of RPMI1640 culture fluid suspension cell 106/ml with pre-cooling, obtain macrophage suspension;
By venous blood samples under the chicken wing, add the Alsever liquid of 5 times of amounts, with PBS, hematocrit value is made into 5% concentration and makes chicken erythrocyte suspension, with macrophage suspension 1ml, add 0.04ml chicken erythrocyte suspension, the centrifugal 5min of 1500r/min, abandons supernatant.Smear, lucky Sa dyeing counting, calculates phagocytic rate and phagocytic index.
Phagocytic rate (%)=engulf macrophage number/macrophage number * 100% of chicken red blood cell
Chicken red blood cell sum/macrophage number of phagocytic index=engulfed
3.2 half hemolysis value (HC
50) mensuration
3.2.1 experiment is divided into groups and the same 3.1.1 of administration;
3.2.2 experimental technique:
After gavage 26d, get Sanguis caprae seu ovis, with normal saline washing 3 times, every Mus, through lumbar injection 2%(v/v, is prepared with normal saline) hematocrit RBC0.2ml carries out immunity, after 5d, win eyeball and get blood, place about 1h, solidification blood and tube wall are peeled off, serum is fully separated out, the centrifugal 10min of 2000r/min, collects serum.
With barbital (SA) buffer, by 200 times of serum dilutions, get 1mL and put in vitro, add successively 10% (with the preparation of SA buffer) hematocrit SRBC0.5mL, complement 1mL (pressing 1:10 dilution with SA buffer).
Separately establish the not control tube of increase serum (replacing with SA buffer).Put in 37 ℃ of waters bath with thermostatic control and be incubated after 30min, ice bath cessation reaction.The centrifugal 10min of 2000r/min, gets supernatant 1mL, adds Dou Shi reagent 3mL.(with the preparation of SA buffer) the hematocrit SRBC0.25mL that simultaneously gets 10%, add Dou Shi reagent to 4mL in another test tube, fully mix, place after 10min, in 540nm, sentence control tube and do blankly, measure and respectively manage trap value respectively.The amount of hemolysin is with half hemolysis value (HC
50) represent, be calculated as follows.
Half hemolysis value (HC
50trap value * extension rate during)=sample optical density value/SRBC HD50
3.3 mouse lymphocytes transform
3.3.1 experiment is divided into groups and the same 3.1.1 of administration
3.3.2 experimental technique:
After successive administration 7d, after the 2h of last administration, cervical vertebra dislocation is put to death and is respectively organized mice.Sterile working takes out spleen, prepares splenocyte suspension, insert respectively in the plate that fills RPMI1640 culture fluid, and by cell dilution, be 1 * 10
7/ ml suspension.In the 96 flat culture plates in hole, every group of 10 holes, respectively add 100 μ l cell suspension and 100 μ lConA (final concentration is 5 μ g/m1), put 37 ℃, 5%CO
2in incubator, cultivate 48h.Inhale and abandon supernatant 100 μ l gently.Add MTT solution (concentration is 5mg/ml) 10 μ l (50 μ g/ hole), 1min vibrates on agitator.Place 5%CO
2in incubator, react 2h.Take out reactant, centrifugal (2000r/min, 5min), abandons supernatant, and every hole adds acidify isopropyl alcohol 120 μ l, with the 30s that vibrates on agitator.At enzyme mark photometer 570nm place, read OD value.
4, statistical procedures adopts SPSS 16.0 softwares to carry out one factor analysis of variance to experimental data, every data all with
represent.
5, result
5.1 engulf the impact of chicken red blood cell ability to Turnover of Mouse Peritoneal Macrophages: in Table 4
Table 4: the impact of Turnover of Mouse Peritoneal Macrophages being engulfed to chicken red blood cell ability
Note: with Normal group comparison,
*p < 0.05,
*p < 0.01, with the comparison of LIUPUCHA group,
aMP.AMp.Ampp < 0.05; With the comparison of Radix Notoginseng group tea group,
▲p < 0.05.
Table 4 result shows:
Compare with Normal group, Peritoneal macrophage function, the phagocytic index of each group of embodiment 1-8, Radix Notoginseng group and LIUPUCHA group mice has increase (with Normal group comparison, P < 0.05 or P < 0.01) in various degree;
Compare with Radix Notoginseng group or LIUPUCHA group respectively, embodiment 1-8 respectively organizes the Peritoneal macrophage function (P < 0.05) of mice, and the peritoneal macrophage phagocytic index that embodiment 5-8 respectively organizes mice obviously increases (P < 0.05).
Compare with each group of embodiment 1-4, embodiment 5-8 respectively organizes Peritoneal macrophage function, phagocytic index all higher than the former.
Result shows, composition effect provided by the invention is better than Radix Notoginseng group or LIUPUCHA group, and has synergy.
5.2 impacts on mice serum hemolysin: in Table 5
Table 5: the impact on mice half hemolysis value (HC50)
Note: with Normal group comparison,
*p < 0.05,
*p < 0.01, with the comparison of LIUPUCHA group,
aMP.AMp.Ampp < 0.05; With the comparison of Radix Notoginseng group tea group,
▲p < 0.05.
Table 5 result shows:
Compare with Normal group, each group of embodiment 1-8 and Radix Notoginseng group can increase the half hemolysis value (P < 0.05 or P < 0.01) of mice in various degree;
Compare with Radix Notoginseng group or LIUPUCHA group respectively, the half hemolysis value that embodiment 1-8 respectively organizes mice obviously increases (P < 0.05).
Compare with each group of embodiment 1-4, embodiment 5-8 respectively organizes half hemolysis value higher than the former.
Result shows: compositions provided by the invention has the effect that improves mice serum hemolysin level, and effect is better than alone Radix Notoginseng or LIUPUCHA, has synergy.
5.3 impacts on mouse spleen lymphocyte conversion test: in Table 6
Table 6: the impact on the conversion test of mice mouse spleen lymphocyte
Note: with Normal group comparison,
*p < 0.05,
*p < 0.01, with the comparison of LIUPUCHA group,
aMP.AMp.Ampp < 0.05; With the comparison of Radix Notoginseng group tea group,
▲p < 0.05.
Table 6 result shows:
Compare with Normal group, each group of embodiment 1-8, Radix Notoginseng group and LIUPUCHA group can strengthen lymphopoiesis ability (P < 0.05 or P < 0.01) in various degree;
Compare with Radix Notoginseng group or LIUPUCHA group respectively, embodiment 1-8 respectively organizes lymphopoiesis ability and obviously strengthens (P < 0.05).
Compare with each group of embodiment 1-4, embodiment 5-8 respectively organizes lymphopoiesis ability and is better than the former.
Result shows: compositions provided by the invention has the effect that improves the conversion of mice mouse spleen lymphocyte, and effect is better than alone Radix Notoginseng or LIUPUCHA.
6, discuss:
Select several immunoassay index observings and inquired into the regulating action of the present invention to mouse immune function.The phagocytic activity of macrophage is very strong, is rich in the materials such as lysosome, acid phosphatase and peroxidase in its endochylema, can non-specifically engulf plurality of antigens, in the nonspecific immune reaction of body, has a very important role.The index of phagocytosis Chang Zuowei reflection macrophage function situation.Experimental result shows: compositions provided by the invention can obviously improve phagocytic index and the phagocytic rate of Turnover of Mouse Peritoneal Macrophages, and the non-specific immunity that said composition can enhancing body is described, effect is better than prior art, and has synergy.
Serum hemolysin is the antibody that bone-marrow-derived lymphocyte is secreted after the various antigenic stimulus of acceptance, is the important indicator of weighing humoral immunity of organism level.Experimental result shows that compositions provided by the invention can make the content of normal mouse serum hemolysin obviously increase, and points out it to have the effect that strengthens mouse humoral immune function, and effect is better than prior art, and has synergy.
Experimental example 4: toxicity test
1, the product that tested medicine: embodiment 1 provides (called after Radix Notoginseng LIUPUCHA), character is sepia extractum (every milliliter is equivalent to medical material 1.87g).With distilled water, being made into 1.24g/ml is for experiment.
2, laboratory animal: KM mice, body weight 19-22g, male and female half and half; 80 of clean level Wistar rats, 180-210g, male and female half and half.Production licence SCXK2009-0003, the animal quality quality certification 0009925 are provided by Guangxi Medical University's Experimental Animal Center.
3, experimental technique and result
3.1 acute toxicity test
Pre-test result 0.4ml/10g animal all survives, and does not detect LD50, therefore carry out maximum dosage-feeding test.Get 40 of mices, each 20 of administration group and matched groups, male and female half and half.Administration group was given mouse stomach administration 3 times in one day, each 0.4ml/10g, and interval 4h, matched group to distilled water, is given general activity situation and the survival condition of two weeks interior animals of observation post administration with method.
3.2 long term toxicity test
3.2.1 ordinary circumstance and body weight: experiment, with 80 of Wistar rats, is divided into 4 groups at random, 20 every group, male and female half and half.27 ± 2 ℃ of room temperatures, humidity 50-70%.Male and female are separated group support, 10 rats of every cage.Gastric infusion (20ml/kg), every day 1 time, 90(3 month continuously), drug withdrawal is observed 2 weeks.Between administration and withdrawal time, observe its hair color, growing state, body weight etc.
3.2.2 blood routine: administration 3 months, matched group and Radix Notoginseng LIUPUCHA extract group are respectively got 12 animals, and 2 weeks each groups of drug withdrawal are got 8, male and female half and half, abdominal aortic blood, carries out hematological indices mensuration.
3.2.3 blood parameters
4, result:
Overview in 4.1 acute toxicity testings: after the administration of administration group mice without excitement, uneasiness, play, jump, perpendicular mao, shed tears, sialorrhea, protruding, writhing response phenomenon.Observe all animals survival 14 days.
In 4.2 long term toxicity tests:
Between administration and withdrawal time, the high, medium and low dosage group of LIUPUCHA extract and the activity of blank treated animal, food ration and excretion etc. are showed no abnormal, hair color gloss, and growth of animal is good, and body weight generally increases.With matched group comparing difference not statistically significant.Show, LIUPUCHA extract is ingested with body weight gain without impact on rat.
In process of the test, due to operate miss, cause a small amount of animal dead.Through the proof that becomes celestial, pour into lung by mistake, irrelevant with drug intoxication.
4.3 hematological indices: in Table 7-1,7-2
Table 7-1: rat blood is learned to the impact (administration 3 months) of index
Table 7-2: rat blood is learned to the impact (administration 3 months) of index
Table 7-1,7-2 result show: compare each index no significant difference of Radix Notoginseng LIUPUCHA group with matched group.
Result shows: compositions provided by the invention is learned index without impact to rat blood.
4.3 blood biochemicals: in Table 8-1,8-2,8-3
Table 8-1: on the impact of rat blood biochemistry (administration 3 months)
Table 8-2: on the impact of rat blood biochemistry (administration 3 months)
Table 8-3: on the impact of rat blood biochemistry (administration 3 months)
Table 8-1,8-2,8-3 result show: Radix Notoginseng LIUPUCHA group administration 3 months and drug withdrawal be each each index of dosage group rat after 14 days, with matched group relatively there are no significant difference.
Result shows: compositions provided by the invention on rat blood biochemical indexes without impact.
4.4, organ index: in Table 9
Table 9: on the impact of Rats Organs and Tissues index (administration 3 months)
Table 9 result shows: administration 3 months, matched group and Radix Notoginseng LIUPUCHA group are put to death 12 animals, 2 weeks each groups of drug withdrawal are put to death 8, male and female half and half, core, liver, spleen, lung, kidney, brain, adrenal gland, testis, uterus, ovary weigh, calculate organ coefficient (organ weight * 100/ body weight), the organ index of each dosage group rat of result and matched group are relatively without significant difference (table 4).
Result shows: compositions provided by the invention on rat main organs index without impact.
4.5, pathological examination:
Administration 3 months, matched group and Radix Notoginseng LIUPUCHA extract group are put to death 12 animals, 2 weeks each groups of drug withdrawal are put to death 8, male and female half and half, core, liver, spleen, lung, kidney, brain (brain, cerebellum, brain stem), spinal cord (neck, breast, waist section), hypophysis, thymus, esophagus, stomach, small intestinal, large intestine, adrenal gland, epididymis, testis, ovary, uterus, bladder, bone marrow, the tissues such as mesenteric lymph node, first each internal organs outward appearance of perusal has or not extremely, with 10% formalin, whole organ-tissues are fixed again, carry out histopathologic examination, there is acute nonsuppurative hepatitis in check result Some Animals, interstitial nephritis, administration group and matched group occur, these pathological changes belong to commonly encountered diseases and the frequently-occurring disease of animal, can get rid of and cause because of drug toxicity.
5, discuss:
In compositions provided by the invention:
Acute toxicity test gastric infusion does not detect LD50, and maximum dosage-feeding is 99.2g/Kg, is equivalent to Coming-of-Age Day with 992 times of dosage, has no toxic reaction generation and dead.
Long term toxicity test rat high dose (49.6g medical material/kg/d, quite 496 times of people's consumption 0.1g medical material/kg/d), middle dosage (24.8g medical material/kg/d, quite 248 times of people's consumption) and low dosage (12.4g medical material/kg/d, quite 124 times of people's consumption) every day gastric infusion once, successive administration 3 months.Each treated animal activity of result, food ration and excretion etc. are showed no abnormal, hair color gloss, and growth of animal is good, and body weight generally increases; Blood routine examination, blood parameters, main organs index are without remarkable change; Although histopathologic examination finds some pathological changes, these are commonly encountered diseases and the frequently-occurring disease of animal, and administration group and matched group occur, and can get rid of drug toxicity institute extremely.
Prompting: compositions gastric infusion provided by the invention to rat without obviously cumulative toxicity and retardance toxic action.
In like manner, other embodiment provided by the invention and compatibility are tested, toxicological test result is identical with embodiment 1.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (13)
1. a compositions for blood fat reducing, adjusting immunity, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: Radix Notoginseng 150-400 part, LIUPUCHA 400-800 part.
2. compositions according to claim 1, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: Radix Notoginseng 180-300 part, LIUPUCHA 500-700 part.
3. compositions according to claim 1, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: 240 parts of Radix Notoginseng, 600 parts of LIUPUCHA.
4. compositions according to claim 1, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: 300 parts of Radix Notoginseng, 600 parts of LIUPUCHA.
5. the compositions described in claim 1-4 any one is in preparation blood fat reducing, the health product that regulate immunity and the application in medicine.
6. a compositions for blood fat reducing, adjusting immunity, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: Radix Notoginseng 150-400 part, LIUPUCHA 400-800 part, Flos Chrysanthemi 200-250 part, Folium Ginkgo 250-350 part.
7. compositions claimed in claim 6 is in preparation blood fat reducing, the health product that regulate immunity and the application in medicine.
8. a compositions for blood fat reducing, adjusting immunity, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: Radix Notoginseng 150-400 part, LIUPUCHA 400-800 part, Herb Gynostemmae Pentaphylli 100-150 part, Radix Polygoni Multiflori Preparata 100-150 part.
9. compositions claimed in claim 8 is in preparation blood fat reducing, the health product that regulate immunity and the application in medicine.
10. a compositions for blood fat reducing, adjusting immunity, is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: Radix Notoginseng 150-400 part, LIUPUCHA 400-800 part, Rhizoma Alismatis 150-250 part, Fructus Crataegi 450-550 part.
11. compositionss claimed in claim 10 are in preparation blood fat reducing, the health product that regulate immunity and the application in medicine.
12. 1 kinds of blood fat reducing, regulate the compositions of immunity, it is characterized in that, described compositions is grouped into by the one-tenth of following weight portion: Radix Notoginseng 150-400 part, LIUPUCHA 400-800 part, Radix Puerariae 300-500 part, Cortex Eucommiae 150-200 part.
Compositions described in 13. claim 12 is in preparation blood fat reducing, the health product that regulate immunity and the application in medicine.
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| CN103535469A (en) * | 2013-10-25 | 2014-01-29 | 瑞福祥药业（广西）有限公司 | Health-care liubao tea and preparation method thereof |
| CN104435649A (en) * | 2014-11-13 | 2015-03-25 | 成都华熹科技有限公司 | Spirulina-containing traditional Chinese medicine composition for enhancing immunity |
| CN104782818A (en) * | 2015-05-11 | 2015-07-22 | 广西梧州茂圣茶业有限公司 | Liubao tea containing composition having function of reducing blood fat |
| CN104782847A (en) * | 2015-05-11 | 2015-07-22 | 广西梧州茂圣茶业有限公司 | Liubao tea containing composition having functions of beautifying and resisting aging |
| CN104782848A (en) * | 2015-05-11 | 2015-07-22 | 广西梧州茂圣茶业有限公司 | Liubao (Chinese character) tea-containing composition with hypoglycemic function |
| CN104814186A (en) * | 2015-05-11 | 2015-08-05 | 广西梧州茂圣茶业有限公司 | Liupu-tea-containing composition with beautifying and anti-aging effects |
| CN104825659A (en) * | 2015-05-11 | 2015-08-12 | 广西梧州茂圣茶业有限公司 | Liupao tea containing composition with blood fat reducing function |
| CN105748769A (en) * | 2016-02-23 | 2016-07-13 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for improving organism immunity and preparation method thereof |
| CN106858249A (en) * | 2017-04-19 | 2017-06-20 | 冼步洁 | A kind of health beverages of reduction blood fat and blood viscosity |
| CN113679753A (en) * | 2021-08-12 | 2021-11-23 | 云南植物药业有限公司 | Oral effervescent tablet for regulating blood fat and blood pressure and improving immunity and preparation method thereof |
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Non-Patent Citations (2)
| Title |
|---|
| 中国黑茶对PPARs的作用研究;宋鲁彬等;《茶叶科学》;20081015(第05期);319-320 * |
| 宋鲁彬等.中国黑茶对PPARs的作用研究.《茶叶科学》.2008,(第05期), |
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