CN104435649A - Spirulina-containing traditional Chinese medicine composition for enhancing immunity - Google Patents
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- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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Abstract
The invention discloses a spirulina-containing traditional Chinese medicine composition for enhancing the immunity. The spirulina-containing traditional Chinese medicine composition comprises the following components: lily, polygonum multiflorum, spirulina, porphyra, sea cucumbers, sea buckthorns, gynostemma pentaphyllum and ginkgo leaves. If the traditional Chinese medicine composition disclosed by the invention is taken for a long term, the organism immunity can be remarkably improved, the body health can be protected, exogenous evil invasion can be avoided, the probability that patients taking the spirulina-containing traditional Chinese medicine composition are infected by diseases can be reduced, the life quality can be improved, and the work efficiency can be increased.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition of the raising immunity containing spirulina.
Background technology
Modern metropolitan cities population density is large, traffic congestion, agglomeration of industries, and air pollution is serious, and the monitoring result of pm2.5 sends warning red repeatedly, the serious old people that have impact on and the immunity of youngsters and children.When season alternation, old people and child are more easily subject to pathogenic wind-cold invasion, infect respiratory tract disease.Meanwhile, city white collar is because rhythm of life is fast, and operating pressure is large, the work of long-time over loading, and lack motion, immunity also reduces greatly, make city white collar also very easily infect wind and cold, or QI and blood is not smooth.
The traditional Chinese medical science thinks that the generation of disease is mainly because exopathogen invasion, and healthy energy is weak, points out in "Nei Jing": " healthy energy deposit in, heresy can not be done " really shows the relation resulting from the advance and retreat of the gas of good and evil of disease.Record in " The Yellow Emperor's Canon of Internal Medicine ": " be therefore sage is therefore sage does not know preventive treatment of disease ", show the attention that the traditional Chinese medical science is nursed one's health for health preserving.Healthy energy in conditioned body, then immunity is powerful, is not easy to catch, and more can improve duty, improves individual mind state, promotes that in body, healthy energy is assembled, and realizes good circulation.
The medicine of the raising immunity that Western medicine provides mostly is single target spot and strengthens promotive factor, and there is many side effect, and Chinese medicine is with the feature of its Mutiple Targets, be particularly good at physiological regulation, can well realize improving health, reduces the infection of urbanite's disease.
Summary of the invention
The object of the invention is to overcome the defect that prior art Chinese medicine and western medicine exists side effect, provide a kind of improve body immunity Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
Improve a pharmaceutical composition for immunity, comprise following composition: Bulbus Lilii, Radix Polygoni Multiflori, spirulina, Thallus Porphyrae, Stichopus japonicus, Fructus Hippophae, Herb Gynostemmae Pentaphylli and Folium Ginkgo.Preferred above-mentioned compositions, weight is: Bulbus Lilii 10-50 part, Radix Polygoni Multiflori 1-20 part, spirulina 1-10 part, Thallus Porphyrae 1-10 part, Stichopus japonicus 1-12 part, Fructus Hippophae 1-12 part, Herb Gynostemmae Pentaphylli 1-12 part, Folium Ginkgo 1-12 part.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, the Chinese medicine composition of the raising immunity of preparation.Although prescription is simple, but the collaborative facilitation comprehensively achieved between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieve the effect that single medicinal herbs do not have, improve the ability of body immunity significantly, and there is no toxic and side effects, be applicable to environmental pollution, season alternation, the hypoimmunity crowd that long-time overwork etc. causes.
Further, preferably improve the pharmaceutical composition of immunity, comprise the composition of following weight portion: Bulbus Lilii 20-30 part, Radix Polygoni Multiflori 5-12 part, spirulina 2-8 part, Thallus Porphyrae 3-9 part, Stichopus japonicus 3-9 part, Fructus Hippophae 3-9 part, Herb Gynostemmae Pentaphylli 3-9 part, Folium Ginkgo 3-9 part.
Further, preferably improve the pharmaceutical composition of immunity, comprise the composition of following weight portion: Bulbus Lilii 25 parts, Radix Polygoni Multiflori 8 parts, spirulina 5 parts, Thallus Porphyrae 6 parts, Stichopus japonicus 6 parts, Fructus Hippophae 6 parts, Herb Gynostemmae Pentaphylli 6 parts, Folium Ginkgo 6 parts.
Compared with prior art, beneficial effect of the present invention: Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, the Chinese medicine composition of the raising immunity of preparation.Although prescription is simple, but the collaborative facilitation comprehensively achieved between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieve the effect that single medicinal herbs do not have, improve the ability of body immunity significantly, and there is no toxic and side effects, be applicable to environmental pollution, season alternation, the hypoimmunity crowd that long-time overwork etc. causes.Long-term taking Chinese medicine composition of the present invention, can significantly improve the immunity of body, protects healthy, prevents exopathogen from invading, and reduce the probability that user catches, quality of making the life better, increases work efficiency.
Detailed description of the invention
In the present invention, Bulbus Lilii, sweet in the mouth, cold in nature, GUIXIN lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN cough caused by dryness, chronic cough hemoptysis, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Radix Polygoni Multiflori, bitter in the mouth, sweet, puckery, slightly warm in nature.Return liver, the heart, kidney channel.Removing toxic substances, eliminating carbuncle, preventing the attack (or recurrence) of malaria, loosening bowel to relieve constipation.For carbuncle sore, scrofula, rubella pruritus, chronic malaria body is empty, dryness of the intestine constipation.The class rudimentary plant of Spirullina in Cyanophyta, Cyanophyceae, hormocystangium order, Oscillariaceae, Spirullina, mainly comprises spirulina maxim, spirulina plalensis.There is potent functions of expelling toxin, to the repair of human organ.Cold in nature, sweet-salty, has resolving phlegm and softening hard masses, clearing away lung-heat, diuresis, and the kidney invigorating is nourished heart, the effect reduced blood pressure.Thallus Porphyrae, belongs to marine products red algae.Sweet in the mouth, warm in nature, can pathogenic fire reducing nourishing kidney, nourshing Yin and drynsessmoistening prescription.Fructus Hippophae, sour-puckery flavor, warm in nature.Return spleen, stomach, lung, heart channel.Strengthening the spleen to promote digestion, eliminating phlegm and stopping cough, promoting blood circulation to remove blood stasis.For insufficiency of the spleen lack of appetite, abdominal pain due to retention of food, cough with copious phlegm, obstruction of qi in the chest and cardialgia, blood stasis amenorrhea, falls and flutters congestive edema.Herb Gynostemmae Pentaphylli, sweet-bitter flavor, cold nature, returns spleen lung meridian.Replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, changes turbid blood fat reducing.For deficiency of spleen-QI and stomach-QI, asthenia lack of appetite, deficiency of the lung cough caused by dryness, has sore throat, hyperlipemia.Folium Ginkgo, sweet in the mouth, hardship, puckery, property is put down.GUIXIN, lung meridian.Blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes turbid blood fat reducing.For obstruction of collaterals by blood stasis, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cough and asthma due to lung deficiency, hyperlipemia.According to traditional Chinese medical science pharmacology, ingredients is grouped together, achieve the collaborative facilitation between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieves the effect that single medicinal herbs do not have, improves the ability of body immunity significantly, and there is no toxic and side effects, effectively can improve body immunity, reduce disease and infect, improve the quality of living and work efficiency.
Pharmaceutical composition of the present invention can adopt but be not limited to following methods:
Preparation method one: get Bulbus Lilii, Radix Polygoni Multiflori, spirulina, Thallus Porphyrae, Stichopus japonicus, Fructus Hippophae, Herb Gynostemmae Pentaphylli and Folium Ginkgo in proportion, pulverized 40-80 mesh sieve respectively, mix homogeneously, after adding the acceptable auxiliary element of pharmacy as required, make the oral type pharmaceutical preparatioies such as tablet, capsule, granule or micropill.
Preparation method two: by Bulbus Lilii, Radix Polygoni Multiflori, Thallus Porphyrae, Stichopus japonicus, Fructus Hippophae, Herb Gynostemmae Pentaphylli and Folium Ginkgo ethanol, water or its mixture reflux, extract, 1-4 time, extracting solution is concentrated into dry, obtains extract.Get spirulina, dry, cryogrinding, crosses 40-80 mesh sieve, obtains spirulina powder.By spirulina powder and said extracted thing mix homogeneously, add the acceptable auxiliary element of pharmacy, make the oral type pharmaceutical preparatioies such as tablet, capsule, drop pill or micropill.
Preparation method three:
Prepare the method for Chinese medicine composition of the present invention, comprise the following steps:
(1) get Bulbus Lilii, add 6-10 times of 10%-30% alcohol reflux 1-4 time, each 1-3 hour, merge extractive liquid, evaporation and concentration, to dry, obtains Bulbus Lilii extract.
(2) get Radix Polygoni Multiflori, section/pulverize (crossing No. four sieves after preferably pulverizing), adds people 10%-40% alcohol reflux 2-5 time, each 0.5-2 hour, merge extractive liquid, after reclaiming ethanol, is concentrated into dry, obtains Radix Polygoni Multiflori extract.
(3) get spirulina, dry, cryogrinding, crosses 40-80 mesh sieve, obtains spirulina powder.
(4) get Thallus Porphyrae, dry, cryogrinding, crosses 40-80 mesh sieve, obtains Thallus Porphyrae powder.
(5) get Stichopus japonicus, add 1-4 times of water, after rubbing corase grind, with colloid mill grinding 10-60 minute, be concentrated into dry, obtain Stichopus japonicus fine powder.
(6) get Fructus Hippophae, through pulverizing obtained powder, this powder being extracted in CO2 supercritical extracting equipment and obtains oily liquids and be Oleum Hippophae.
(7) get Herb Gynostemmae Pentaphylli, decoct with water 2-4 time, each 2-3 hour, collecting decoction, filter, be concentrated into dry, obtain Herb Gynostemmae Pentaphylli extract.
(8) get Folium Ginkgo, add 6-10 times of soak by water 1-3 time, each 1-2 hour, collecting decoction, be concentrated into dry, obtain Folium Ginkgo extract.
(9) by above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into the dosage form such as tablet, capsule.
Wherein most preferably preparation method three, preparation method three is according to different medicines characteristic separately, select suitable extracting method farthest to be extracted by the effective ingredient in medicinal raw material, avoid the impact of the impurity of toxic side effect, so most preferably preparation method three.
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.In the embodiment of the present invention, mixed solution reagent used does not do and illustrates, is percent by volume mixing.Such as 20% ethanol refers to the ethanol water of 20:80 volume ratio.The amount ratio of Raw of the present invention and extracting solution is w/v (kg/L), and such as 8kg medical material 30% alcohol reflux of 4 times of volumes, by the 30:70 ethanol water adding 32L in 8kg medical material.
Embodiment 1
Get Bulbus Lilii 10kg, Radix Polygoni Multiflori 1kg, spirulina 1kg, Thallus Porphyrae 1kg, Stichopus japonicus 2kg, Fructus Hippophae 2kg, Herb Gynostemmae Pentaphylli 1kg, Folium Ginkgo 1kg pulverized 40 mesh sieves, mix homogeneously respectively, add appropriate filler, adhesive and disintegrating agent, make tablet.
Comparative example 1
Get Bulbus Lilii 25kg, Radix Polygoni Multiflori 8kg, Stichopus japonicus 6kg, Fructus Hippophae 6kg, Herb Gynostemmae Pentaphylli 6kg, Folium Ginkgo 6kg pulverized 40 mesh sieves, mix homogeneously respectively, dry, add appropriate filler, adhesive and disintegrating agent, make tablet.
Comparative example 2
Get Bulbus Lilii 25kg, Radix Polygoni Multiflori 8kg, spirulina 5kg Fructus Hippophae 6kg, Herb Gynostemmae Pentaphylli 6kg, Folium Ginkgo 6kg 30% alcohol reflux 4 times, each 1 hour, merge extractive liquid, was concentrated into dry, obtains extract, adds appropriate auxiliary agent, tabletted.
Embodiment 2
Get raw material dosage: Bulbus Lilii 30kg, Radix Polygoni Multiflori 5kg, spirulina 8kg, Thallus Porphyrae 3kg, Stichopus japonicus 3kg, Fructus Hippophae 9kg, Herb Gynostemmae Pentaphylli 9kg, Folium Ginkgo 9kg.Obtain mixed powder by the method for embodiment 1, make capsule casing material with gelatin, make capsule.
Embodiment 3
By Bulbus Lilii 50kg, Radix Polygoni Multiflori 20kg, spirulina 10kg, Thallus Porphyrae 10kg, Stichopus japonicus 12kg, Fructus Hippophae 12kg, Herb Gynostemmae Pentaphylli 12kg, Folium Ginkgo 12kg 30% alcohol reflux 4 times of 4 times of volumes, each 1 hour, merge extractive liquid, was concentrated into dry, obtains extract.By said extracted thing, add appropriate auxiliary agent, tabletted.
Embodiment 4
By Bulbus Lilii 20kg, Radix Polygoni Multiflori 12kg, Fructus Hippophae 9kg, Herb Gynostemmae Pentaphylli 3kg, Folium Ginkgo 3kg water boiling and extraction 4 times, each 1.5 hours, collecting decoction, was concentrated into dry, obtains extract.Get spirulina 2kg, Thallus Porphyrae 9kg, Stichopus japonicus 9kg, after grinding pulping respectively, drying under reduced pressure obtains powder, and after aforementioned extract mix homogeneously, dry, add appropriate auxiliary agent, tabletted.
Embodiment 5
Get Bulbus Lilii 30kg, add 6 times of 30% alcohol reflux 4 times, each 1 hour, merge extractive liquid, evaporation and concentration, to dry, obtains Bulbus Lilii extract.Get Radix Polygoni Multiflori 5kg, section, adds people 40% alcohol reflux 3 times, each 2 hours, merge extractive liquid, after reclaiming ethanol, is concentrated into dry, obtains Radix Polygoni Multiflori extract.Get spirulina 8kg, dry, cryogrinding, crosses 40 mesh sieves, obtains spirulina powder.Get Thallus Porphyrae 3kg, dry, cryogrinding, crosses 40 mesh sieves, obtains Thallus Porphyrae powder.Get Stichopus japonicus 3kg, add 2 times of water, after rubbing corase grind, grind 30 minutes with colloid mill, be concentrated into dry, obtain Stichopus japonicus fine powder.Get Fructus Hippophae 9kg, through pulverizing obtained powder, this powder being extracted in CO2 supercritical extracting equipment and obtains oily liquids and be Oleum Hippophae.Get Herb Gynostemmae Pentaphylli 9kg, decoct with water 4 times, each 3 hours, collecting decoction, filter, be concentrated into dry, obtain Herb Gynostemmae Pentaphylli extract.Get Folium Ginkgo 9kg, add 6 times of soak by water 1 time, each 2 hours, collecting decoction, is concentrated into dry, obtains Folium Ginkgo extract.By above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into capsule.
Embodiment 6
Get Bulbus Lilii 25kg, add 10 times of 10% alcohol reflux 3 times, each 2 hours, merge extractive liquid, evaporation and concentration, to dry, obtains Bulbus Lilii extract.Get Radix Polygoni Multiflori 8kg, cross No. four sieves after pulverizing, add people 10% alcohol reflux 3 times, each 0.5 hour, merge extractive liquid, after reclaiming ethanol, be concentrated into dry, obtain Radix Polygoni Multiflori extract.Get spirulina 5kg, dry, cryogrinding, crosses 40 mesh sieves, obtains spirulina powder.Get Thallus Porphyrae 6kg, dry, cryogrinding, crosses 60 mesh sieves, obtains spirulina powder.Get Stichopus japonicus 6kg, add 1 times of water, after rubbing corase grind, grind 40 minutes with colloid mill, be concentrated into dry, obtain Stichopus japonicus fine powder.Get Fructus Hippophae 6kg, through pulverizing obtained powder, this powder being extracted in CO2 supercritical extracting equipment and obtains oily liquids and be Oleum Hippophae.Get Herb Gynostemmae Pentaphylli 6kg, decoct with water 4 times, each 2 hours, collecting decoction, filter, be concentrated into dry, obtain Herb Gynostemmae Pentaphylli extract.Get Folium Ginkgo 6kg, add 6 times of soak by water 3 times, each 2 hours, collecting decoction, is concentrated into dry, obtains Folium Ginkgo extract.By above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into capsule.
The influence research of Phagocytosis By The Peritoneal Macrophages In Mice
One, test material and reagent:
Product: with embodiment 1,5,6, medicine prepared by comparative example 1-2.
Test animal: experimental animal is kunming mice, male and female half and half, body weight 18 ~ 22 grams.
Two, on the impact of functions of murine peritoneal macrophages/activity
Treating excess syndrome is tested and is divided into 6 groups at random with kunming mice, blank group diet every day, experimental group 5 groups, give test medicine, daily 2 times, after 10 days, after last administration 30 minutes (blank group after feeding 30 minutes), each group of mouse peritoneal only injects 6% chicken erythrocyte suspension 1.5ml/, extract mouse peritoneal liquid, in basis of microscopic observation, to record in 5 minutes macrophage phagocytic chicken red blood cell number in the visual field, and with the formula: phagocytic percentage=by Erythrocytes × 100% in the RBC number/visual field of engulfing; Phagocytic index=by the macrophage number in the Erythrocytes/visual field of engulfing.Calculate phagocytic percentage, experimental result sees the following form.
The impact of functions of murine peritoneal macrophages
Note: compare with comparative example
▲p < 0.05,
★p < 0.05.
Can find out that the mice of experimental group is after using medicine of the present invention continuously from upper table data, the sum of macrophage is strengthened by a small margin, the activity of macrophage is significantly promoted simultaneously, and visible pharmaceutical composition of the present invention has the good effect of building up resistance.
Model case
1. Lee, man, 37 years old, lethargy, fatigue and weak, appetite reduced, sleep disorder.Take Chinese medicine preparation prepared by embodiment 5, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of of taking medicine, symptom alleviates, and continues to take condition after 1 course for the treatment of, notes regulating not recurrence after health.
2. Wang, man, 64 years old, emotion was irritated, anxiety.Take Chinese medicine preparation prepared by embodiment 1, every day 3 times, continuous 5 days is a course for the treatment of, symptom recovery from illness after 2 courses for the treatment of of taking medicine, and does not have recurrence after noting regulating health.
3. Xu certain, female, 49 years old, flu recurrent exerbation, dreaminess, night sweat.Take Chinese medicine preparation prepared by embodiment 6, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of, symptom alleviates, and continues to take condition after 5 courses for the treatment of, notes regulating not recurrence after health.
4. thank certain, female, 44 years old, work is often felt tired spiritless, and slightly does something and has just felt tired.Take Chinese medicine preparation prepared by embodiment 6, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of, symptom alleviates, and continues to take condition after 2 courses for the treatment of, notes regulating not recurrence after health.
Claims (4)
1. improve a pharmaceutical composition for immunity, comprise following composition: Bulbus Lilii, Radix Polygoni Multiflori, spirulina, Thallus Porphyrae, Stichopus japonicus, Fructus Hippophae, Herb Gynostemmae Pentaphylli and Folium Ginkgo.
2. the pharmaceutical composition of raising immunity according to claim 1, it is characterized in that, comprise the composition of following weight portion: Bulbus Lilii 10-50 part, Radix Polygoni Multiflori 1-20 part, spirulina 1-10 part, Thallus Porphyrae 1-10 part, Stichopus japonicus 1-12 part, Fructus Hippophae 1-12 part, Herb Gynostemmae Pentaphylli 1-12 part, Folium Ginkgo 1-12 part.
3. the pharmaceutical composition of raising immunity according to claim 2, it is characterized in that, comprise the composition of following weight portion: Bulbus Lilii 20-30 part, Radix Polygoni Multiflori 5-12 part, spirulina 2-8 part, Thallus Porphyrae 3-9 part, Stichopus japonicus 3-9 part, Fructus Hippophae 3-9 part, Herb Gynostemmae Pentaphylli 3-9 part, Folium Ginkgo 3-9 part.
4. the pharmaceutical composition of raising immunity according to claim 3, is characterized in that, comprises the composition of following weight portion: Bulbus Lilii 25 parts, Radix Polygoni Multiflori 8 parts, spirulina 5 parts, Thallus Porphyrae 6 parts, Stichopus japonicus 6 parts, Fructus Hippophae 6 parts, Herb Gynostemmae Pentaphylli 6 parts, Folium Ginkgo 6 parts.
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| CN104799286A (en) * | 2015-04-30 | 2015-07-29 | 南京中生生物科技有限公司 | Composition for improving immunity and preparation method of composition |
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