CN103623120B - A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof - Google Patents
A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to Chinese medicine or field of health care food, in particular to a kind of buccal tablet and preparation method thereof of pharynx-clearing throat-benefiting, this buccal tablet is prepared from by the Chinese medicine composition of pharynx-clearing throat-benefiting effective dose and excipient base, described Traditional Chinese medicine composition formula science, rationally, each raw material is cleaning throat and moistening larynx good medicine, largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae heat-clearing and toxic substances removing; Radix Glycyrrhizae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Mentha leave cool pain-alleviating; Five tastes pharmaceutical worker gathers effect of cleaning throat and moistening larynx, can play splendid pharynx-clearing throat-benefiting health care and therapeutic effect.Buccal tablet buccal of the present invention is convenient, and mouthfeel is good, can be formulated into different taste, has effect of pharynx-clearing throat-benefiting; Effective percentage of the present invention is high, rapid-action.
Description
Technical field
The invention belongs to tcm field, particularly a kind of Chinese medicine of pharynx-clearing throat-benefiting and preparation thereof.
Background technology
Pharyngolaryngitis is the modal a kind of disease of department of otorhinolaryngology, is under pharyngeal mucosa, mucosa and adenoid diffuse inflammation.Modern medicine confirms: antibacterial, virus and some materialization factors (as smoking, drinking) stimulation can make pharyngeal being inflamed, cause pharyngeal mucous membrane layer congested, mucosa bottom connective tissue and lymphadenosis, mucous gland is loose, hypersecretion, thus cause pharyngeal sense of discomfort, as dry, itch, scorching hot, hypodynia, foreign body sensation and hoarseness etc.The pharyngolaryngitis cause of disease is clinical inside and outside dividing, and exopathogenic factor mostly is the heresy be affected by the cold, the heresy of strongly fragrant heat-transformation of a specified duration or wind heat; Endogenous cause of ill mostly is the ferritic deficiency of YIN, pungently decocts stir-fry, stagnation of phlegm-heat again addicted to food, upper bright throat or with the passing of time consume the moon of impairing the lung kidney, and cause hyperactivity of deficient fire, consumption of body fluid by heat becomes expectorant, expectorant heat follow through on disturb throat, clean the street caused by failure.In modern medicine, generally pharyngolaryngitis is divided acute pharyngitis and chronic pharyngitis two kinds.Acute pharyngitis is often a part for upper respiratory tract infection, how to be caused by antibacterial, viral infection, its symptom can show as acute simple pharyngitis and acute festering type pharyngitis, generally uses the non-drug therapy methods such as laser, microwave or Neulized inhalation or uses chemical medicine treatment to cure.Chronic pharyngitis then causes by acute pharyngitis recurrent exerbation or by harmful micro-tapping, generally can be divided into chronic simple pharyngitis, chronic hypertrophic pharyngitis and chronic atrophic pharyngitis three kinds, for patients with chronic pharyngitis, though non-drug therapy or chemical medicine treatment can contribute to improving symptom, but be difficult to remove the focus causing disease, easily recur after remission.
In theory of Chinese medical science, swallow the pass into stomach, larynx is the door of lung, and the heresy of diseases caused by exogenous pathogenic factor enters lung and easily hinders larynx, and improper diet enters stomach and is vulnerable to pharynx, and throat is the ground that evil malicious good leaching is stayed for a long time.The traditional Chinese medical science thinks that throat illness is relevant with visceral dysfunction, wind-heat invading the lung, dysfunction of the spleen in transportation, gastric qi weakness etc. all can cause, and prevent available heat-clearing and toxic substances removing, activating QI to eliminate phlegm from being method, in treatment, Chinese medicine demonstrates quite large advantage, perhaps also has very large potentiality to dig.Spring Medicine (Xiamen) Co., Ltd. reports oral formulations of a kind of pharynx-clearing throat-benefiting and preparation method thereof (Authorization Notice No. CN101822786B), the active component of its pharynx-clearing throat-benefiting is prepared by the raw material of following weight proportion: Flos Lonicerae 5-10 part, Rhizoma Imperatae 3-10 part, Fructus Momordicae 5-8 part and Herba Menthae 5-8 part, take Flos Lonicerae as monarch drug, Rhizoma Imperatae, Fructus Momordicae are ministerial drug, Herba Menthae is adjuvant drug, can play splendid pharynx-clearing throat-benefiting health care and therapeutic effect.Application number be 201010195847.1 patent of invention disclose a kind of Chinese medicine preparation for the treatment of chronic pharyngitis, be made up of the raw material of following part by weight: Flos Lonicerae 34-36 gram, Radix Scrophulariae 14-16 gram, Rhizoma Anemarrhenae 9-11 gram, Radix Scutellariae 9-11 gram, Radix Platycodonis 9-11 gram, Radix Glycyrrhizae 9-11 gram, Mel 30-35 gram, the Chinese medicine preparation of preparation can treat throat discomfort, dry symptom of to itch etc.Shanghai Yusen New Medicine Development Co., Ltd reports a kind of buccal tablet and the preparation technology (Authorization Notice No. CN1321657C) that treat acute/chronic pharyngitis and oral inflammation, it is made up of Fructus Canarii 6-15 part of weight, Herba Houttuyniae 6-12 part, Flos Lonicerae 3-9 part, Flos Chrysanthemi 3-9 part, Radix Glycyrrhizae 1-3 part and adjuvant, and this buccal tablet has the effect of good antiinflammatory, analgesia, antiviral and pharynx-clearing throat-benefiting.Patent of invention (Authorization Notice No. CN102177998B) reports a kind of throat-clearing health-care tea, be made up of the component of following weight: Folium Camelliae sinensis 10 parts, Semen Sterculiae Lychnophorae 9-10 part, Radix Glycyrrhizae 9-12 part, Radix Scrophulariae 10-11 part, Radix Ophiopogonis 9-10 part, Flos Lonicerae 8-11 part, Radix Isatidis 10-12 part and Flos Chrysanthemi 10 parts, this health tea of long-term drink, effectively can moisten throat, moistening and cleaning throat pain relieving, cough-relieving is subsided a swelling, especially patients with chronic pharyngitis long-term taking curative effect is better, this health tea is by prevention and health care simultaneously, during treatment is resided in and is drunk tea, be applicable to the living habit of people, be easy to accept, expense is low.At present, on market, the Chinese patent medicine of existing treatment pharyngitis disease is more, as LIUSHEN WAN, powdered medicine for treatment of laryngopathy, watermelon crystal and siren buccal tablet etc.
Because the consumer objects of general cleaning throat and moistening larynx product is patients with chronic pharyngitis, these patients have the symptoms such as throat is itched, twinge, dry cough more, with capsule, peroral tablets treatment not too suitable, therapeutic effect is bad; Edible tea or other beverages regulate inside of human body, prevention throat discomfort effect is also good, but action time is short; And confection, buccal tablet can the long time, directly act on affected part, effectiveness comparison is good, and confection, buccal tablet also help carry, the advantage of instant edible, therefore, current existing cleaning throat and moistening larynx product is in the majority with confection, buccal tablet, many experts think that confection, buccal tablet will be the main flow dosage forms of cleaning throat and moistening larynx product, can also develop more new varieties and meet market demand.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has the effect of pharynx-clearing throat-benefiting.Two of object of the present invention is the preparation providing described Chinese medicine composition, and said preparation is easy to use, successful.Three of object of the present invention is to provide a kind of pharynx-clearing throat-benefiting buccal tablet taking Chinese medicine composition as main active and prepare, and this buccal tablet is easy to use, and taste is suitable for, and has significant pharynx-clearing throat-benefiting curative effect.Four of object of the present invention is the preparation method providing pharynx-clearing throat-benefiting buccal tablet, and the method program is simple, is applicable to large-scale production.
For achieving the above object, technical scheme of the present invention is:
The Chinese medicine composition of pharynx-clearing throat-benefiting, specifically composed of the following components according to listed as parts by weight:
The plant that largeflower-like honeysuckle flower (formal name used at school: Loniceramacranthoides) is Caprifoliaceae Lonicera is the endemic plant of China.Another name: large Jiedu tea, large mountain flower, large Flos Lonicerae, Herba lonicerae delavayi (Xinning, Hunan), intends Flos Lonicerae macranthae (Chinese Higher plant illustrated handbook), Japanese Climbing Fern Spore (Suichuan, Jiangxi).Largeflower-like honeysuckle flower Herb all can be used as medicine, and wherein alabastrum is conventional medicinal part.Find in the chemical constitution study of Buds of Lonicera macranthoides, the chemical composition contained by it is mainly this four large class of flavonoid, volatile oil, saponins and chlorogenic acid, is secondly the compositions such as sterols, saccharide, inorganic elements class.Largeflower-like honeysuckle flower, tcm clinical practice and the epidemic febrile disease that is widely used among the people are generated heat, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the diseases such as redness and swelling of joints burning pain, and have heat-clearing and toxic substances removing, effect of dispelling wind dredging collateral, are southwest conventional Chinese medicine.Radix Scrophulariae is the root of Scrophulariaceae herbaceos perennial Radix Scrophulariae and Radix Scrophulariae.This product bitter in the mouth cold in nature, sweet, salty, return lung, stomach, kidney channel.Function clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.Be used for warm febrile disease to join the army blood, disease is seen fever of the body, excessive thirst, is sent out speckle etc.; The caused disease such as cough parched throat, osteopyrexia and fever, spitting of blood, spontaneous sweating of burning is handed over again for hyperactivity of fire caused by deficiency of YIN, lung yin; Also for laryngopharynx swelling and pain, carbuncle sore tumefacting virus, scrofula sucutaneous nodule.Radix Scutellariae is the root of labiate Radix Scutellariae.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, jaundice due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.Radix Glycyrrhizae taste is put down, and enters spleen, stomach, lung meridian, has invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, heat-clearing and toxic substances removing, qualcomm meridian, sharp vim and vigour, the function of coordinating the actions of various ingredients in a prescription, have the title of " gentle man ".With the extractum of Radix Glycyrrhizae processing, treatment tracheitis, pharyngitis, urethritis, diarrhoea, rheumatoid arthritis etc.Radix Glycyrrhizae is pulse family herbaceos perennial, tcm clinical practice and be among the peoplely widely used in relieving spasm to stop pain, heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, effect of coordinating the actions of various ingredients in a prescription.Mentha leave is the leaf of plant Herba Menthae, and taste is refrigerant, and the traditional Chinese medical science thinks that Herba Menthae has effect of acrid in the mouth cool in nature, the dispelling wind-heat, Cheongju head, rash.
The Chinese medicine composition of preferred described pharynx-clearing throat-benefiting, specifically composed of the following components according to listed as parts by weight:
The Chinese medical concrete prepared by described Chinese medicine composition.
The preparation method of described Chinese medical concrete, get largeflower-like honeysuckle flower 5-15 weight portion, Radix Scrophulariae 5-15 weight portion, Radix Scutellariae 3-5 weight portion, mentha leave 1-2 weight portion and Radix Glycyrrhizae 1-2 weight portion are raw material, largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae are mixed, picks remove impurity, cleaning, spreading for cooling, pulverize, cross 40-50 mesh sieve and obtain crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, the water adding raw material 8-15 times volume carries out heating extraction, filter, concentrate filtration gained filtrate, gained concentrate is Chinese medical concrete.In order to make the effective ingredient of Chinese crude drug be extracted fully, the heating extraction can carrying out repeatedly to raw material, concentrates extracting to filter after the filtrate obtained merges at every turn again.The concentrated method for concentration that any routine can be taked feasible, as adopted rotary evaporation ware evaporation and concentration, reduction vaporization concentrated.
Preferably, described preparation method, described heating extraction also adopts ultrasonic assistant to extract simultaneously.When extracting, hyperacoustic frequency and extraction time can illustrate according to instrument used and operate, and the ultrasonic power being generally mainly used in Chinese crude drug extraction is 20KW to 75KW.Ultrasound wave is extracting the cavitation effect and mechanism that produce in solvent, on the one hand can the cell wall of crushing material effectively, make effective ingredient be free state fast and dissolve in extract in solvent, the molecular motion of extracting solvent can be accelerated on the other hand, make to extract the effective ingredient Rapid contact in solvent and material, mutually fused, mixing.Ultrasonic extraction (also referred to as extraction) has the unique advantage that Extracting temperature is low, extraction ratio is high, extraction time is short.
Preferably, described preparation method, described concentrated be through concentrated by the advanced technology of preparing of Chinese medicine preparation; First gained filtrate is sieved with double-deck screen shale shaker and carry out coarse filtration, remove oarse-grained impurity and indissoluble thing, then carry out ultrafiltration with hollow-fibre membrane, then adopt polyamide composite film to carry out membrance concentration and obtain concentrate.
The buccal tablet of pharynx-clearing throat-benefiting, described buccal tablet is prepared from by as the Chinese medical concrete of active component and excipient base, and described Chinese medical concrete is prepared by the Chinese medicine composition of following weight proportion: largeflower-like honeysuckle flower 5-15 part, Radix Scrophulariae 5-15 part, Radix Scutellariae 3-5 part, mentha leave 1-2 part, Radix Glycyrrhizae 1-2 part; Described excipient base is made up of one or more of following component according to parts by weight: white sugar 5-30 part, glucose syrup 5-30 part, hydroxyl isomaltulose 5-20 part.Described excipient base includes but not limited to white sugar, glucose syrup and hydroxyl isomaltulose, also can be starch, dextrin, lactose, Icing Sugar etc.
Preferably, described buccal tablet also comprises taste regulator, and described taste regulator can be made up of one or more of following component according to parts by weight: edible salt 0.004-0.5 part, citric acid 0.02-0.2 part.Also the buccal tablet that different taste made by appropriate table sugar, lactic acid or other flavoring agents can be added.
The preparation method of described buccal tablet, comprises the step of carrying out as follows:
1) Chinese medical concrete is prepared
Largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae, Radix Glycyrrhizae is got by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverizes, cross 40-50 mesh sieve and obtain crushed mixture, added by the mentha leave of formula ratio in described crushed mixture after mix homogeneously, the water adding raw material 8-15 times volume carries out ultrasound wave heating extraction, filters, concentrate filtration gained filtrate, being concentrated into relative density under 60 DEG C of conditions is 1.2-1.5g/cm
3thick paste, obtain Chinese medical concrete;
2) excipient of above-mentioned formula ratio is added to the water heating, dissolves, filter gained Chinese medical concrete in rear and step 1) and mix, be brewed into paste, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products.
Preferably, the preparation method of described buccal tablet, described step 2) in, be brewed into paste, stir with taste regulator below 95 DEG C, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products, described taste regulator is made up of one or more of following component according to parts by weight: edible salt 0.004-0.5 part, citric acid 0.02-0.2 part.
In buccal tablet of the present invention manufactures, do not add and manufacture normal lubricant, binding agent and the disintegrating agent added in general tablet process, but excipient base is boiled into paste, utilize the viscosity of himself to carry out obtained buccal tablet, thus simplify the production process of buccal tablet greatly.
The pharynx-clearing throat-benefiting buccal tablet obtained by described preparation method.
Beneficial effect of the present invention is: 1) buccal tablet scientific formulation of the present invention, rationally, each raw material is cleaning throat and moistening larynx good medicine.Largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae heat-clearing and toxic substances removing; Radix Glycyrrhizae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Mentha leave cool pain-alleviating; Five tastes pharmaceutical worker gathers effect of cleaning throat and moistening larynx.2) buccal tablet buccal of the present invention is convenient, and mouthfeel is good, can be formulated into different taste, has effect of enhancing human body immunity power, heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, pharynx-clearing throat-benefiting; Be prepared into buccal tablet, throat is directly acted on by oral mucosal absorption, to realize the function of quick cleaning throat and moistening larynx, having positive effect to pharyngitis, oral inflammation and the disease such as halitosis, throat discomfort, is the medicine-food two-purpose health food of laryngopharynx swelling and pain, hoarseness, throat discomfort crowd.
Detailed description of the invention
Illustrated embodiment is to be described content of the present invention better, but is not that content of the present invention is only limitted to illustrated embodiment.So those of ordinary skill in the art carry out nonessential improvement and adjustment according to foregoing invention content to embodiment, still belong to protection scope of the present invention.
The preparation of embodiment 1 Chinese medical concrete
Get largeflower-like honeysuckle flower 1300g, Radix Scrophulariae 1200g, Radix Scutellariae 500g, mentha leave 130g and Radix Glycyrrhizae 150g is raw material, by largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae mixing, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 40 mesh sieves and obtain crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, the heat ultrasonic that adds water extracts twice, add water 10 times amount for the first time, under 80 DEG C of conditions, 30kHz supersound extraction 1 hour, add water 8 times amount for the second time, the same terms supersound extraction 30 minutes, merge extracted twice liquid, filter, filtrate first to be sieved coarse filtration with double-deck screen shale shaker, ultrafiltration is carried out again with hollow-fibre membrane, then adopting polyamide composite film to carry out relative density under membrance concentration to 60 DEG C condition is that the thick paste of 1.35-1.40 obtains Chinese medical concrete.Chinese medical concrete can use mixing in water for oral taking.
The preparation of embodiment 2 pharynx-clearing throat-benefiting buccal tablet
One formula
Largeflower-like honeysuckle flower 1500g, Radix Scrophulariae 500g, Radix Scutellariae 300g, mentha leave 180g, Radix Glycyrrhizae 120g, white sugar 1300g, glucose syrup 600g, edible salt 0.4g
Two preparation methoies
Largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae are mixed, picks remove impurity, cleaning, spreading for cooling, pulverizes, and crosses 40 mesh sieves and obtains crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, add water heating extraction twice, and 10 times amount that add water for the first time decoct 1.5 hours, and 8 times amount that add water for the second time decoct 1 hour, merge extracted twice liquid, filter, gained filtrate reduced in volume is to relative density 1.35-1.40(60 DEG C) thick paste, for subsequent use.In jacketed pan, add white sugar, glucose syrup and water 800ml, heating makes it dissolve, and is filtered in vacuum sugar cooker, add above-mentioned thick paste, mixing, boil to moisture about 4% time, stop heating, treat that temperature is down to about 90 DEG C, add edible salt while stirring, stir, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products, the heavy 2.0g of every sheet.
The preparation of embodiment 3 pharynx-clearing throat-benefiting buccal tablet
One formula
Largeflower-like honeysuckle flower 1000g, Radix Scrophulariae 1000g, Radix Scutellariae 500g, mentha leave 130g, Radix Glycyrrhizae 170g, white sugar 500g, glucose syrup 1300g, edible salt 4g
Two preparation methoies
By largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae mixing, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 50 mesh sieves and obtain crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, the heat ultrasonic that adds water extracts twice, add water 12 times amount for the first time, under 80 DEG C of conditions, 30kHz supersound extraction 1 hour, add water 10 times amount for the second time, the same terms supersound extraction 45 minutes, merge extracted twice liquid, filter, filtrate first to be sieved coarse filtration with double-deck screen shale shaker, ultrafiltration is carried out again with hollow-fibre membrane, then adopting polyamide composite film to carry out relative density under membrance concentration to 60 DEG C condition is that the thick paste of 1.35-1.35 obtains Chinese medical concrete, for subsequent use.In jacketed pan, add white sugar, glucose syrup and water 850mL, heating makes it dissolve, and is filtered in vacuum sugar cooker, add above-mentioned thick paste, mixing, boil to moisture about 3% time, stop heating, treat that temperature is down to about 80 DEG C, add edible salt while stirring, stir, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products, the heavy 2.2g of every sheet.
The preparation of embodiment 4 pharynx-clearing throat-benefiting buccal tablet
One formula
Largeflower-like honeysuckle flower 700g, Radix Scrophulariae 1300g, Radix Scutellariae 400g, mentha leave 100g, Radix Glycyrrhizae 200g, white sugar 800g, glucose syrup 1000g, edible salt 3g
Two preparation methoies
By largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae mixing, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 50 mesh sieves and obtain crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, the heat ultrasonic that adds water extracts twice, add water 11 times amount for the first time, under 80 DEG C of conditions, 40kHz supersound extraction 1 hour, add water 9 times amount for the second time, the same terms supersound extraction 45 minutes, merge extracted twice liquid, filter, filtrate first to be sieved coarse filtration with double-deck screen shale shaker, ultrafiltration is carried out again with hollow-fibre membrane, then adopting polyamide composite film to carry out relative density under membrance concentration to 60 DEG C condition is that the thick paste of 1.35-1.35 obtains Chinese medical concrete, for subsequent use.In jacketed pan, add white sugar, glucose syrup and water 750mL, heating makes it dissolve, and is filtered in vacuum sugar cooker, add above-mentioned thick paste, mixing, boil to moisture about 4.5% time, stop heating, treat that temperature is down to about 70 DEG C, add edible salt while stirring, stir, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products, the heavy 1.8g of every sheet.
The preparation of embodiment 5 pharynx-clearing throat-benefiting buccal tablet
One formula
Largeflower-like honeysuckle flower 500g, Radix Scrophulariae 1500g, Radix Scutellariae 500g, mentha leave 150g, Radix Glycyrrhizae 150g, hydroxyl isomaltulose 300g, edible salt 1g, citric acid 2g
Two preparation methoies
By largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae mixing, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 40 mesh sieves and obtain crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, the heat ultrasonic that adds water extracts twice, add water 10 times amount for the first time, under 80 DEG C of conditions, 40kHz supersound extraction 1 hour, add water 8 times amount for the second time, the same terms supersound extraction 40 minutes, merge extracted twice liquid, filter, filtrate first to be sieved coarse filtration with double-deck screen shale shaker, ultrafiltration is carried out again with hollow-fibre membrane, then adopting polyamide composite film to carry out relative density under membrance concentration to 60 DEG C condition is that the thick paste of 1.25-1.30 obtains Chinese medical concrete, for subsequent use.In jacketed pan, add hydroxyl isomaltulose and water 700mL, heating makes it dissolve, and is filtered in vacuum sugar cooker, add above-mentioned thick paste, mixing, boil to moisture about 3.5% time, stop heating, treat that temperature is down to about 75 DEG C, add edible salt, citric acid while stirring, stir, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products, the heavy 1.5g of every sheet.
The mouthfeel evaluation of test example one buccal tablet
Select buccal tablet product prepared by embodiment 2-5,40 DEG C, exposed placement 3 days under the condition of RH75%, the situation of change of product sensory index is examined; In addition, random invitation 10 has the personages of buccal tablet sense organ experience, evaluates the mouthfeel index of buccal tablet, mark separately by ten point system, with very for full marks, more than 6 points is better, less than 5 points is poor, makes comprehensive statistics analysis to appraisal result, the mouthfeel of each buccal tablet of last overall merit.
Buccal tablet product prepared by embodiment 2-5,40 DEG C, under the condition of RH75% exposed placement after 3 days outward appearance have no significant change.The result of subjective appreciation index shows, the sensory evaluation scores of the buccal tablet product prepared by embodiment 2-5 is respectively 9.3,9.5,9.6 and 9.5, all meet the broken brittleness requirement of buccal tablet tablet, without tooth gluing sense, in oral cavity, the buccal tablet prepared by embodiment 2-5 all can dissolve release completely in 10 minutes.
Test example two buccal tablet result of use
1 sample
The Chinese medical concrete of embodiment 1, is prepared into Chinese medical concrete aqueous solution, containing Chinese medical concrete described in 0.1g in every ml water solution.Each oral 10ml, 3 times/day.
The pharynx-clearing throat-benefiting buccal tablet of embodiment 2,2g/ sheet, human body recommendation amount is 2 pieces/times, 3 times/day.
Reference substance is all happy board siren buccal tablet, the accurate word B20020993 of traditional Chinese medicines, batch number 20050107, and produced by Guangxi Gold throat pharmaceutcal corporation, Ltd, 2g/ sheet, instructions of taking is 1 piece/times, 6 times/day.
2 study subjects
Select the age 18-65 year patients with chronic pharyngitis 150 (without organic diseases such as severe cardiac, liver, kidneys), cardinal symptom has pharyngalgia, itching throat, dry pharynx, dry cough, foreign body sensation etc., is divided into 3 groups at random, often group 50.150 patients check that discovery all has pharyngeal mucosa edema in various degree, mucous hyperemia, retropharyneal folliculosis, and secretions adheres to.Gestation or women breast-feeding their children and this product allergy sufferers is got rid of.Avoid pungent food at period in a medicine, greasy and heavy food.Detailed medical history-taking before taking medicine, observes or inquiry cardinal symptom: the puckery and foreign body sensation of pharyngalgia, itching throat, dry cough, dry pharynx.Severe, moderate and slight is divided into by symptom weight.
3 instructions of taking
Illustrate according to sample in 1 and take, take 15 days all continuously.Check after 15 days and add up symptom and improve situation.
Effect criterion:
Effective: symptom alleviates 1 degree.
Invalid: symptom is without significant change.
4 results
| Group | Number of cases | Effectively | Invalid | Total effective rate (%) |
| Embodiment 1 | 50 | 34 | 16 | 68 |
| Embodiment 2 | 50 | 43 | 7 | 86 |
| Reference substance | 50 | 36 | 14 | 72 |
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1., for the Chinese medicine composition of the pharynx-clearing throat-benefiting of pharyngitis, it is characterized in that, composed of the following components according to listed as parts by weight:
2. the Chinese medicine composition of the pharynx-clearing throat-benefiting for pharyngitis according to claim 1, is characterized in that, composed of the following components according to listed as parts by weight:
3. the Chinese medical concrete prepared by the Chinese medicine composition described in claim 1 or 2.
4. the preparation method of Chinese medical concrete according to claim 3, it is characterized in that, get largeflower-like honeysuckle flower 5-15 weight portion, Radix Scrophulariae 5-15 weight portion, Radix Scutellariae 3-5 weight portion, mentha leave 1-2 weight portion and Radix Glycyrrhizae 1-2 weight portion are raw material, by largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae and Radix Glycyrrhizae mixing, pick remove impurity, cleaning, spreading for cooling, pulverize, cross 40-50 mesh sieve and obtain crushed mixture, mentha leave to be added in described crushed mixture after mix homogeneously, the water adding raw material 8-15 times volume carries out heating extraction, filter, filtration gained filtrate is concentrated, gained concentrate is Chinese medical concrete.
5. preparation method according to claim 4, is characterized in that, described heating extraction also adopts ultrasonic assistant to extract simultaneously.
6. preparation method according to claim 4, is characterized in that, described concentrating first gained filtrate is sieved with double-deck screen shale shaker, then carry out ultrafiltration with hollow-fibre membrane, then adopts polyamide composite film to carry out membrance concentration and obtains concentrate.
7. for the buccal tablet of the pharynx-clearing throat-benefiting of pharyngitis, it is characterized in that, active component in described buccal tablet is Chinese medical concrete, described buccal tablet also comprises excipient base, and described Chinese medical concrete is prepared by the Chinese medicine composition of following weight proportion: largeflower-like honeysuckle flower 5-15 part, Radix Scrophulariae 5-15 part, Radix Scutellariae 3-5 part, mentha leave 1-2 part, Radix Glycyrrhizae 1-2 part; Described excipient base is made up of one or more of following component according to parts by weight: white sugar 5-30 part, glucose syrup 5-30 part, hydroxyl isomaltulose 5-20 part.
8. buccal tablet according to claim 7, is characterized in that, described buccal tablet also comprises taste regulator, and described taste regulator is made up of one or more of following component according to parts by weight: edible salt 0.004-0.5 part, citric acid 0.02-0.2 part.
9. the preparation method of buccal tablet according to claim 7, is characterized in that, comprises the step of carrying out as follows:
1) Chinese medical concrete is prepared: get largeflower-like honeysuckle flower, Radix Scrophulariae, Radix Scutellariae, Radix Glycyrrhizae by formulation ratio, pick remove impurity, cleaning, spreading for cooling, pulverizes, cross 40-50 mesh sieve and obtain crushed mixture, added by the mentha leave of formula ratio in described crushed mixture after mix homogeneously, the water adding raw material 8-15 times volume carries out ultrasound wave heating extraction, filters, concentrate filtration gained filtrate, being concentrated into relative density under 60 DEG C of conditions is 1.2-1.5g/cm
3thick paste, obtain Chinese medical concrete;
2) excipient of formula ratio is added to the water heating, dissolve, filter after with step 1) in gained Chinese medical concrete mix, be brewed into paste, granulation, drying, tabletting, metal inspection, plastic-aluminum, packaging into products.
10. the preparation method of buccal tablet according to claim 9, it is characterized in that, described step 2) in, be brewed into paste, stir with taste regulator below 95 DEG C, granulate, dry, tabletting, metal inspection, plastic-aluminum, packaging into products, described taste regulator is made up of one or more of following component according to parts by weight: edible salt 0.004-0.5 part, citric acid 0.02-0.2 part.
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| CN105832900A (en) * | 2016-03-30 | 2016-08-10 | 南宁市百济生物工程有限公司 | Traditional Chinese medicine preparation for improving sow milk production and preparation method thereof |
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| CN1985923A (en) * | 2005-12-21 | 2007-06-27 | 骆春秀 | Medicine composition for preventing and treating throat diseases and its preparing method |
| CN102727556A (en) * | 2012-07-16 | 2012-10-17 | 西南大学 | Throat-clearing traditional Chinese medicine buccal tablet and preparation method thereof |
| CN103156950A (en) * | 2011-12-08 | 2013-06-19 | 尹光军 | Medicament for treating pharyngolaryngitis |
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| CN1985923A (en) * | 2005-12-21 | 2007-06-27 | 骆春秀 | Medicine composition for preventing and treating throat diseases and its preparing method |
| CN103156950A (en) * | 2011-12-08 | 2013-06-19 | 尹光军 | Medicament for treating pharyngolaryngitis |
| CN102727556A (en) * | 2012-07-16 | 2012-10-17 | 西南大学 | Throat-clearing traditional Chinese medicine buccal tablet and preparation method thereof |
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Effective date of registration: 20181220 Address after: 409800 Building A, Phase 2, Banxi Light Industrial Park, Youyang County, Chongqing Patentee after: Chongqing Wanyuan Pharmaceutical Co., Ltd. Address before: No. 34 Nanshan Road, Nanshan Street, Nanan District, Chongqing 400065 Patentee before: Chongqing Academy of Chinese Materia Medica |
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