CN104474259A - Saffron-containing traditional Chinese medicinal composition for enhancing immunity - Google Patents
Saffron-containing traditional Chinese medicinal composition for enhancing immunity Download PDFInfo
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Abstract
The invention discloses a saffron-containing medicinal composition for enhancing immunity. The medicinal composition comprises Rhodiola rosea, coneflower, Salvia miltiorrhiza, saffron, Polygonatum sibiricum, Rhizoma Atractylodis Macrocephalae and flower of Chloranthus spicatus (Thunb.) Makino. The traditional Chinese medicinal composition can be taken for a long term to obviously enhance the body immunity, protect the health of the body, prevent the invasion of exogenous evil, reduce the disease infection probability of users, improve the life quality and increase the work efficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition containing croceous raising immunity.
Background technology
Modern metropolitan cities population density is large, traffic congestion, agglomeration of industries, and air pollution is serious, and the monitoring result of pm2.5 sends warning red repeatedly, the serious old people that have impact on and the immunity of youngsters and children.When season alternation, old people and child are more easily subject to pathogenic wind-cold invasion, infect respiratory tract disease.Meanwhile, city white collar is because rhythm of life is fast, and operating pressure is large, the work of long-time over loading, and lack motion, immunity also reduces greatly, make city white collar also very easily infect wind and cold, or QI and blood is not smooth.
The traditional Chinese medical science thinks that the generation of disease is mainly because exopathogen invasion, and healthy energy is weak, points out in "Nei Jing": " healthy energy deposit in, heresy can not be done " really shows the relation resulting from the advance and retreat of the gas of good and evil of disease.Record in " The Yellow Emperor's Canon of Internal Medicine ": " be therefore sage is therefore sage does not know preventive treatment of disease ", show the attention that the traditional Chinese medical science is nursed one's health for health preserving.Healthy energy in conditioned body, then immunity is powerful, is not easy to catch, and more can improve duty, improves individual mind state, promotes that in body, healthy energy is assembled, and realizes good circulation.
The medicine of the raising immunity that Western medicine provides mostly is single target spot and strengthens promotive factor, and there is many side effect, and Chinese medicine is with the feature of its Mutiple Targets, be particularly good at physiological regulation, can well realize improving health, reduces the infection of urbanite's disease.
Summary of the invention
The object of the invention is to overcome the defect that prior art Chinese medicine and western medicine exists side effect, provide a kind of improve body immunity Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
Improve a pharmaceutical composition for immunity, comprise following composition: Radix Rhodiolae, Echinacea, Radix Salviae Miltiorrhizae, Stigma Croci, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and chu lan flower.Preferred above-mentioned compositions, weight is: Radix Rhodiolae 1-20 part, Echinacea 1-20 part, Radix Salviae Miltiorrhizae 1-12 part, Stigma Croci 1-6 part, Rhizoma Polygonati 1-12 part, Rhizoma Atractylodis Macrocephalae 1-6 part, chu lan flower 1-6 part.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, the Chinese medicine composition of the raising immunity of preparation.Although prescription is simple, but the collaborative facilitation comprehensively achieved between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieve the effect that single medicinal herbs do not have, improve the ability of body immunity significantly, and there is no toxic and side effects, be applicable to environmental pollution, season alternation, the hypoimmunity crowd that long-time overwork etc. causes.
Further, preferably improve the pharmaceutical composition of immunity, comprise the composition of following weight portion: Radix Rhodiolae 6-14 part, Echinacea 6-14 part, Radix Salviae Miltiorrhizae 3-9 part, Stigma Croci 2-5 part, Rhizoma Polygonati 3-9 part, Rhizoma Atractylodis Macrocephalae 2-5 part, chu lan flower 2-5 part.
Further, preferably improve the pharmaceutical composition of immunity, comprise the composition of following weight portion: Radix Rhodiolae 9 parts, Echinacea 9 parts, Radix Salviae Miltiorrhizae 6 parts, Stigma Croci 3 parts, Rhizoma Polygonati 6 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, chu lan flower 3 parts.
Compared with prior art, beneficial effect of the present invention: Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, the Chinese medicine composition of the raising immunity of preparation.Although prescription is simple, but the collaborative facilitation comprehensively achieved between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieve the effect that single medicinal herbs do not have, improve the ability of body immunity significantly, and there is no toxic and side effects, be applicable to environmental pollution, season alternation, the hypoimmunity crowd that long-time overwork etc. causes.Long-term taking Chinese medicine composition of the present invention, can significantly improve the immunity of body, protects healthy, prevents exopathogen from invading, and reduce the probability that user catches, quality of making the life better, increases work efficiency.
Detailed description of the invention
In the present invention, Radix Rhodiolae, sweet-bitter flavor, property is put down, GUIXIN, lung meridian.QI invigorating lung heat clearing, promotes blood circulation and relievings asthma.Main deficiency of vital energy and physically weak, shortness of breath and fatigue.Echinacea is a kind of Echinacea plant originating in North America and southern Canada, containing chicoric acid, polysaccharide, polyphenol, polyacetylene and alkaloid, has and improves immunity and antibacterial and anti-inflammation functions.Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature, GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain ， lumps in the chest and abdomen, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.Stigma Croci, sweet in the mouth, property is put down, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, traumatic injury etc.Rhizoma Polygonati, has another name called polygonatum sibiricum Redoute, yellow chicken dish, sweet in the mouth, and property is put down, and returns spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat is quenched one's thirst.The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature, return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Chu lan flower is the flower of evergreen climing property fruticuli spice berry chu lan tree Chloranthus spicatus (Thunb.) Makinocha of Chloranthaceae Chloranthaceae Chloranthus Chloranthus integration of edible and medicinal herbs; The fragrance of chu lan flower is elegant, alcohol and, durable, quite like Cymbidium ensifolium (L.) Sw..According to traditional Chinese medical science pharmacology, ingredients is grouped together, achieve the collaborative facilitation between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieves the effect that single medicinal herbs do not have, improves the ability of body immunity significantly, and there is no toxic and side effects, effectively can improve body immunity, reduce disease and infect, improve the quality of living and work efficiency.
Pharmaceutical composition of the present invention can adopt but be not limited to following methods:
Preparation method one: get Radix Rhodiolae, Echinacea, Radix Salviae Miltiorrhizae, Stigma Croci, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and chu lan flower in proportion, pulverized 40-80 mesh sieve respectively, mix homogeneously, after adding the acceptable auxiliary element of pharmacy as required, makes the oral type pharmaceutical preparatioies such as tablet, capsule, granule or micropill.
Preparation method two: by Radix Rhodiolae, Echinacea, Radix Salviae Miltiorrhizae, Stigma Croci, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and chu lan flower ethanol, water or its mixture reflux, extract, 1-4 time, extracting solution is concentrated into dry, obtains extract.In above-mentioned extract, add the acceptable auxiliary element of pharmacy as required, make the oral type pharmaceutical preparatioies such as tablet, capsule, drop pill or micropill.
Preparation method three:
Prepare the method for Chinese medicine composition of the present invention, comprise the following steps:
(1) get Radix Rhodiolae, add the high concentration ethanol solution of 4 ~ 6 times of volumes, 80 ~ 90 DEG C are extracted 1 ~ 3 hour, filter, and collect filtrate.Filtering residue adds the high concentration ethanol of 2 ~ 4 times of volumes, 90 ~ 95 DEG C are extracted 1 ~ 2 hour, filter, merging filtrate, be concentrated into without ethanol abnormal smells from the patient (ethanol content is lower than 5%), adsorb with D101 macroporous resin, first use clear water drip washing colourless to effluent, then use the ethanol elution of more than 90%, obtain Radix Rhodiolae extract.
(2) get Echinacea, add 6-10 times of soak by water 1-4 time, each 1-3 hour, collecting decoction, evaporation and concentration, to dry, obtains Echinacea extract.
(3) get red rooted salvia, add 8-10 times of volume high concentration ethanol reflux, extract, 1-2 hour, filter, collect extracting solution, the filtering residue high concentration ethanol of 2-3 times continues reflux, extract, 1-2 hour, filters, merging filtrate, concentrated, dry, both obtains Radix Salviae Miltiorrhizae extract.
(4) get Stigma Croci, add the dense ethanol of 1-2 times of volume, 60-70 DEG C of heating extraction 0.5-2 hour, repeat to extract 4-6 time, merge extractive liquid, reclaim ethanol, centrifugal, discard precipitation, supernatant is evaporated to dry, obtain Stigma Croci extract.Or Stigma Croci pulverize at low temperature is obtained Stigma Croci powder.
(5) get Rhizoma Polygonati, preferably through the Rhizoma Polygonati of dried, add 60%-80% alcohol reflux 2-5 time, each 1-3 hour, merge extractive liquid, reclaim ethanol, with petroleum ether extraction, petroleum ether layer extract evaporated under reduced pressure, obtains Rhizoma Polygonati extract.
(6) get the Rhizoma Atractylodis Macrocephalae, section/pulverize (crossing 20-40 mesh sieve), add 4-8 times of water, boil 2-6 hour, condensing steam obtains steaming thing, and this is steamed thing decompression and dewater, obtaining yellowish-brown material, is Rhizoma Atractylodis Macrocephalae extract.
(7) get chu lan flower, add 4-8 times of 20%-50% alcohol reflux 2-4 time, each 1-2 hour, merge extractive liquid, reclaim ethanol, be concentrated into dry, obtain chu lan flower extract.
(8) by above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into the dosage form such as tablet, capsule.
Wherein most preferably preparation method three, preparation method three is according to different medicines characteristic separately, select suitable extracting method farthest to be extracted by the effective ingredient in medicinal raw material, avoid the impact of the impurity of toxic side effect, so most preferably preparation method three.
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.In the embodiment of the present invention, mixed solution reagent used does not do and illustrates, is percent by volume mixing.Such as 20% ethanol refers to the ethanol water of 20:80 volume ratio.The amount ratio of Raw of the present invention and extracting solution is w/v (kg/L), and such as 8kg medical material 30% alcohol reflux of 4 times of volumes, by the 30:70 ethanol water adding 32L in 8kg medical material.
Embodiment 1
Get Radix Rhodiolae 1kg, Echinacea 1kg, Radix Salviae Miltiorrhizae 1kg, Stigma Croci 1kg, Rhizoma Polygonati 1kg, Rhizoma Atractylodis Macrocephalae 1kg, chu lan flower 1kg pulverized 40 mesh sieves, mix homogeneously respectively, add appropriate filler, adhesive and disintegrating agent, make tablet.
Comparative example 1
Get Radix Salviae Miltiorrhizae 6kg, Stigma Croci 3kg, Rhizoma Polygonati 6kg, Rhizoma Atractylodis Macrocephalae 3kg, chu lan flower 3kg pulverized 40 mesh sieves, mix homogeneously respectively, dry, add appropriate filler, adhesive and disintegrating agent, make tablet.
Comparative example 2
Get Radix Rhodiolae 9kg, Echinacea 9kg, Radix Salviae Miltiorrhizae 6kg, Rhizoma Polygonati 6kg, Rhizoma Atractylodis Macrocephalae 3kg 45% alcohol reflux 3 times, each 2 hours, merge extractive liquid, was concentrated into dry, obtains extract, adds appropriate auxiliary agent, tabletted.
Embodiment 2
Get raw material dosage: Radix Rhodiolae 14kg, Echinacea 14kg, Radix Salviae Miltiorrhizae 3kg, Stigma Croci 2kg, Rhizoma Polygonati 9kg, Rhizoma Atractylodis Macrocephalae 5kg, chu lan flower 2kg.Obtain mixed powder by the method for embodiment 1, make capsule casing material with gelatin, make capsule.
Embodiment 3
By Radix Rhodiolae 6kg, Echinacea 6kg, Radix Salviae Miltiorrhizae 9kg, Stigma Croci 5kg, Rhizoma Polygonati 3kg, Rhizoma Atractylodis Macrocephalae 2kg, chu lan flower 5kg 30% alcohol reflux 4 times of 4 times of volumes, each 1 hour, merge extractive liquid, was concentrated into dry, obtains extract.By said extracted thing, add appropriate auxiliary agent, tabletted.
Embodiment 4
By Echinacea 20kg, Radix Salviae Miltiorrhizae 12kg, Rhizoma Polygonati 12kg, Rhizoma Atractylodis Macrocephalae 6kg, chu lan flower 6kg water boiling and extraction 4 times, each 1.5 hours, collecting decoction, was concentrated into dry, obtains extract.Get Radix Rhodiolae 20kg and Stigma Croci 6kg, after pulverizing 40 mesh sieves, and aforementioned extract mix homogeneously, dry, add appropriate auxiliary agent, tabletted.
Embodiment 5
Get Radix Rhodiolae 9kg, add the high concentration ethanol solution of 4 times of volumes, 90 DEG C are extracted 3 hours, filter, and collect filtrate.Filtering residue adds the high concentration ethanol of 4 times of volumes, 90 DEG C are extracted 1 hour, filter, merging filtrate, be concentrated into without ethanol abnormal smells from the patient (ethanol content is lower than 5%), adsorb with D101 macroporous resin, first use clear water drip washing colourless to effluent, then use the ethanol elution of more than 90%, obtain Radix Rhodiolae extract.Get Echinacea 9kg, add 6 times of soak by water 4 times, each 3 hours, collecting decoction, evaporation and concentration, to dry, obtains Echinacea extract.Get Radix Salviae Miltiorrhizae 6kg, add 10 times of volume high concentration ethanol reflux, extract, 2 hours, filter, collection extracting solution, the filtering residue high concentration ethanol of 3 times continues reflux, extract, 1 hour, filters, merging filtrate, concentrated, dry, both obtains Radix Salviae Miltiorrhizae extract.Get Stigma Croci 3kg, add the dense ethanol of 1 times of volume, 60 DEG C of heating extraction 2 hours, repeat extraction 4 times, merge extractive liquid, reclaim ethanol, centrifugal, discard precipitation, are evaporated to by supernatant dry, obtain Stigma Croci extract.Or Stigma Croci pulverize at low temperature is obtained Stigma Croci powder.Get Rhizoma Polygonati 6kg, preferably through the Rhizoma Polygonati of dried, add 60% alcohol reflux 2 times, each 3 hours, merge extractive liquid, reclaim ethanol, with petroleum ether extraction, petroleum ether layer extract evaporated under reduced pressure, obtains Rhizoma Polygonati extract.Get Rhizoma Atractylodis Macrocephalae 3kg, pulverized 20 mesh sieves, add 4 times of water, boil 2 hours, condensing steam obtains steaming thing, and this is steamed thing decompression and dewater, obtaining yellowish-brown material, is Rhizoma Atractylodis Macrocephalae extract.Get chu lan flower 3kg, add 8 times of 20% alcohol reflux 2 times, each 2 hours, merge extractive liquid, reclaim ethanol, be concentrated into dry, obtain chu lan flower extract.By above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into capsule.
Embodiment 6
Get Radix Rhodiolae 9kg, add the high concentration ethanol solution of 6 times of volumes, 80 DEG C are extracted 3 hours, filter, and collect filtrate.Filtering residue adds the high concentration ethanol of 2 times of volumes, 95 DEG C are extracted 1 hour, filter, merging filtrate, be concentrated into without ethanol abnormal smells from the patient (ethanol content is lower than 5%), adsorb with D101 macroporous resin, first use clear water drip washing colourless to effluent, then use the ethanol elution of more than 90%, obtain Radix Rhodiolae extract.Get Echinacea 9kg, add 6 times of soak by water 4 times, each 1 hour, collecting decoction, evaporation and concentration, to dry, obtains Echinacea extract.Get Radix Salviae Miltiorrhizae 6kg, add 8 times of volume high concentration ethanol reflux, extract, 1-2 hour, filter, collection extracting solution, the filtering residue high concentration ethanol of 2 times continues reflux, extract, 2 hours, filters, merging filtrate, concentrated, dry, both obtains Radix Salviae Miltiorrhizae extract.Get Stigma Croci 3kg, add the dense ethanol of 1 times of volume, 70 DEG C of heating extraction 0.5 hour, repeat extraction 4 times, merge extractive liquid, reclaim ethanol, centrifugal, discard precipitation, are evaporated to by supernatant dry, obtain Stigma Croci extract.Or Stigma Croci pulverize at low temperature is obtained Stigma Croci powder.Get Rhizoma Polygonati 6kg, preferably through the Rhizoma Polygonati of dried, add 60% alcohol reflux 2 times, each 1 hour, merge extractive liquid, reclaim ethanol, with petroleum ether extraction, petroleum ether layer extract evaporated under reduced pressure, obtains Rhizoma Polygonati extract.Get Rhizoma Atractylodis Macrocephalae 3kg, section, add 4 times of water, boil 6 hours, condensing steam obtains steaming thing, and this is steamed thing decompression and dewater, obtaining yellowish-brown material, is Rhizoma Atractylodis Macrocephalae extract.Get chu lan flower 3kg, add 8 times of 20% alcohol reflux 2 times, each 2 hours, merge extractive liquid, reclaim ethanol, be concentrated into dry, obtain chu lan flower extract.By above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, tabletted.
The influence research of Phagocytosis By The Peritoneal Macrophages In Mice
One, test material and reagent:
Product: with embodiment 1,5,6, medicine prepared by comparative example 1-2.
Test animal: experimental animal is kunming mice, male and female half and half, body weight 18 ~ 22 grams.
Two, on the impact of functions of murine peritoneal macrophages/activity
Treating excess syndrome is tested and is divided into 6 groups at random with kunming mice, blank group diet every day, experimental group 5 groups, give test medicine, daily 2 times, after 10 days, after last administration 30 minutes (blank group after feeding 30 minutes), each group of mouse peritoneal only injects 6% chicken erythrocyte suspension 1.5ml/, extract mouse peritoneal liquid, in basis of microscopic observation, to record in 5 minutes macrophage phagocytic chicken red blood cell number in the visual field, and with the formula: phagocytic percentage=by Erythrocytes × 100% in the RBC number/visual field of engulfing; Phagocytic index=by the macrophage number in the Erythrocytes/visual field of engulfing.Calculate phagocytic percentage, experimental result sees the following form.
The impact of functions of murine peritoneal macrophages
Note: compare with comparative example
▲p < 0.05,
★p < 0.05.
Can find out that the mice of experimental group is after using medicine of the present invention continuously from upper table data, the sum of macrophage is strengthened by a small margin, the activity of macrophage is significantly promoted simultaneously, and visible pharmaceutical composition of the present invention has the good effect of building up resistance.
Model case
1. Wang, female, 22 years old, lethargy, fatigue and weak, appetite reduced, sleep disorder.Take Chinese medicine preparation prepared by embodiment 1, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of of taking medicine, symptom alleviates, and continues to take condition after 1 course for the treatment of, notes regulating not recurrence after health.
2. Lee, female, 34 years old, emotion was irritated, anxiety.Take Chinese medicine preparation prepared by embodiment 5, every day 3 times, continuous 5 days is a course for the treatment of, symptom recovery from illness after 1 course for the treatment of of taking medicine, and does not have recurrence after noting regulating health.
3. Wang, man, 66 years old, flu recurrent exerbation, dreaminess, night sweat.Take Chinese medicine preparation prepared by embodiment 2, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of, symptom alleviates, and continues to take condition after 4 courses for the treatment of, notes regulating not recurrence after health.
Claims (4)
1. improve a pharmaceutical composition for immunity, comprise following composition: Radix Rhodiolae, Echinacea, Radix Salviae Miltiorrhizae, Stigma Croci, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and chu lan flower.
2. the pharmaceutical composition of raising immunity according to claim 1, it is characterized in that, comprise the composition of following weight portion: Radix Rhodiolae 1-20 part, Echinacea 1-20 part, Radix Salviae Miltiorrhizae 1-12 part, Stigma Croci 1-6 part, Rhizoma Polygonati 1-12 part, Rhizoma Atractylodis Macrocephalae 1-6 part, chu lan flower 1-6 part.
3. the pharmaceutical composition of raising immunity according to claim 2, it is characterized in that, comprise the composition of following weight portion: Radix Rhodiolae 6-14 part, Echinacea 6-14 part, Radix Salviae Miltiorrhizae 3-9 part, Stigma Croci 2-5 part, Rhizoma Polygonati 3-9 part, Rhizoma Atractylodis Macrocephalae 2-5 part, chu lan flower 2-5 part.
4. the pharmaceutical composition of raising immunity according to claim 3, is characterized in that, comprises the composition of following weight portion: Radix Rhodiolae 9 parts, Echinacea 9 parts, Radix Salviae Miltiorrhizae 6 parts, Stigma Croci 3 parts, Rhizoma Polygonati 6 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, chu lan flower 3 parts.
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| CN107174630A (en) * | 2017-05-08 | 2017-09-19 | 张友明 | A kind of carbuncle gram ball |
| CN110205223A (en) * | 2019-07-23 | 2019-09-06 | 江西五谷村酒业有限公司 | Using the method for jungle fermentation technique production sealwort wine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110205223A (en) * | 2019-07-23 | 2019-09-06 | 江西五谷村酒业有限公司 | Using the method for jungle fermentation technique production sealwort wine |
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