CN1957968A - Composition of medication for treating disease of altitude striss, preparation method and usage - Google Patents
Composition of medication for treating disease of altitude striss, preparation method and usage Download PDFInfo
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- CN1957968A CN1957968A CN 200510022014 CN200510022014A CN1957968A CN 1957968 A CN1957968 A CN 1957968A CN 200510022014 CN200510022014 CN 200510022014 CN 200510022014 A CN200510022014 A CN 200510022014A CN 1957968 A CN1957968 A CN 1957968A
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Abstract
A Chinese medicine for treating the altitude stress and the anoxia, fatigue and hypoimmunity caused by altitude stress is prepared from rhodiola root, girald acanthopanax bark and saffron. Its preparing process is also disclosed.
Description
Technical field
The invention provides the pharmaceutical composition of a kind of prevention, treatment altitude sickness disease, specifically, it is to be the pharmaceutical composition that feedstock production forms with the crude drug, belongs to drug world.
Background technology
Area more than 3000 meters above sea level is called the highlands.The highlands rarefaction of air, oxygen content on average lacks 25%～30% than interior ground, thereby formed with low pressure, anoxia, low temperature, solar radiation is strong, the temperature difference is big, strong wind, drying etc. are the plateau climate of distinguishing feature.Come the crowd on plateau from the low altitude area, because the rapid variation of aspects such as weather, surpassed the self-regulating limit of normal person's body, in height above sea level location more than 4000 meters, have the people of 60%-100% that acute anoxia reaction or disease can take place approximately, its symptom is common headache, giddy, have palpitation, breathe hard, inappetence, nausea and vomiting, abdominal distention, uncomfortable in chest, chest pain, fatigue and weak, facial slight edema, cheilosis, epistaxis etc.; When critical blood pressure increase, palpitating speed, even comatose state appears.The somebody can occur then that exaltation, polylogia are multi-lingual, instability of gait, hallucination, insomnia etc.High altitude anoxia and all symptoms of showing, medically being called altitude acclimatization can disease.
After entering the highlands, people's cognition is made corresponding adjustment according to environmental change, change in various degree all can appear in its blood system, respiratory system, blood circulation, immune system each several part function, to adapt to the plateau special natural environment, more or less all dizziness can appear, symptoms such as insomnia, the tired power of whole body.Because the factor of aspects such as self body constitution of individual and metabolic function, groups of people even altitude sickness can occur are as acute mountain sickness, plateau pneumochysis, HACE etc.The medicine instant effect that is used for the treatment of altitude sickness at present, but side reaction is comparatively serious.Be usually used in preventing and treating the edema disease that causes because of the plateau discomfort as acetazolamide, furosemide.And use the acetazolamide common adverse reactions that sleepy, face and numb limbs and tense tendons sense are arranged, can cause renal complication etc.Too much use untoward reaction such as slightly feeling sick may appear in furosemide, diarrhoea, drug eruption, pruritus, blurred vision, the vertigo that can stand up sometimes, weak, tired, muscle spasm, thirsty.And inhibitor commonly used, flesh liver sheet, glucose etc. often are subjected to individual technical ability condition influence, and dose is bigger, and effect is not too obvious.
Radix Rhodiolae is Crassulaceae (Crassulaceae) Sedum (Rhodiola Champ.ex Hook) plant, and Tibetan language name " sulu Calculus Equi " belongs to the rare wild plant of a national class, kind surplus the whole world has 90, kind surplus China has 80.Mainly be distributed in stone crack, hillside, many stone shrubbery, meadow and the periphery clitter area, farmland of Qinghai-Tibet weather cold, soil property drying, height above sea level 2500-5200M.Main areal area, Sichuan is western part and plateau, the northwestward.Radix Rhodiolae contains unique tyrosol butyl alcohol and 18 seed amino acids (wherein 8 kinds is that human body is necessary), 34 kinds of trace element and 7 kinds of vitamin, has nourishing and medicinal efficacy.Wherein peculiar rhodioloside of Radix Rhodiolae (Salidroside) and Jujubogenin tyrosol have anti-high altitude anoxia, resisting fatigue, radioprotective, defying age, enhancing human body immunity power, effects such as two-ways regulation body function.The medical expert proves that through zoopery Radix Rhodiolae can effectively improve the life span of animal under hypoxia condition, alleviates the altitude sickness that causes because of anoxia, intensive ultraviolet radiation etc., buccal or be taken after being infused in hot water or decoction and can play ideal effect.The report that the natural drug compatibility is used treatment or prevention altitude sickness is also arranged at present, but because the selection difference of medicine, the usage of raw material, consumption difference, the indication that stresses is also inequality.But the report that also Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Stigma Croci compatibility is not used for the prophylactic treatment altitude sickness at present.
Summary of the invention
Technical scheme of the present invention has provided the pharmaceutical composition of a kind of prevention, treatment altitude sickness disease, and this preparation of drug combination method also is provided.
The invention provides the pharmaceutical composition of a kind of prevention, treatment altitude sickness disease, it is characterized in that: it is to contain the medicament that is prepared from by the following weight proportion raw material:
90～75 parts of Radix Rhodiolaes, 30～25 parts of Cortex Acanthopanacis Giraldii, 30～25 parts of Stigma Crocis.
Further, it is the medicament that is prepared from by the following weight proportion raw material:
90～75 parts of Radix Rhodiolaes, 30～25 parts of Cortex Acanthopanacis Giraldii, 30～25 parts of Stigma Crocis.
Further, it is the medicament that is prepared from by the following weight proportion raw material:
80 parts of Radix Rhodiolaes, 25 parts of Cortex Acanthopanacis Giraldii, 25 parts of Stigma Crocis.
Wherein, described Radix Rhodiolae is a Crassulaceae Crassulaceae rhodiola Rhodiola Champ.ex Hook plant root and rhizome; Described Cortex Acanthopanacis Giraldii is the skin of Araliaceae Acanthopanax giraldii (Regel) Regel plant; Described Stigma Croci is the dry stigma of Iridaceae Crocus sativus L plant.
Pharmaceutical composition of the present invention is to be active component with Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Stigma Croci crude drug or extract, adds the medicament that acceptable accessories or complementary composition are prepared from.
Wherein, described medicament is capsule, tablet, granule, pill or oral liquid.
Further, every of described capsule contains rhodioside C
14H
2OO
7Must not be less than 2.4mg; Every in described tablet contains rhodioside C
14H
2OO
7Must not be less than 1.6mg; The every 10g of described granule contains rhodioside C
14H
2OO
7Must not be less than 4mg; The every ball of described pill contains rhodioside C
14H
2OO
7Must not be less than 0.6mg; The every 10ml of described oral liquid contains rhodioside C
14H
2OO
7Must not be less than 3.2mg.
The present invention also provides this preparation of drug combination method, and it comprises the steps:
A, take by weighing 90～75 parts of Radix Rhodiolaes, 30～25 parts of Cortex Acanthopanacis Giraldii, 30～25 parts of Stigma Crocis.
B, get Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Stigma Croci and soak with the alcohols of concentration 70～75% and extract, soak filters, and is condensed into extractum, adds the medicament that acceptable accessories or complementary composition are prepared from; Or
C, get Radix Rhodiolae and soak with the alcohols of concentration 70～75% and extract, soak filters, and is condensed into extractum;
D, get Cortex Acanthopanacis Giraldii, Stigma Croci and soak with the alcohols of concentration 70～75% and extract, soak filters, and is condensed into extractum, mixes the medicament that adding acceptable accessories or complementary composition are prepared from the extractum of step c gained.Described alcohols is an ethanol.
Medicine material Radix Rhodiolae of the present invention to mainly contain effective constituent be rhodosin, rhodioloside with and glycoside unit (butyl alcohol), etc., have health-care effects such as resisting fatigue, anti-hypoxia, radioprotective and inhibition tumor, and itself and have no side effect.Radix Rhodiolae has benefiting QI for activating blood circulation, the effect of promoting blood circulation and relievining asthma; Be used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.Cortex Acanthopanacis Giraldii has wind-damp dispelling, invigorating the liver and kidney, the effect of bone and muscle strengthening; Be used for rheumatic arthralgia, the muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi.Stigma Croci has blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, the effect of resolving stagnation for tranquilization; Be used for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.Cortex Acanthopanacis Giraldii has well is healthy and strong, prevents empty effect, and Stigma Croci has effects such as resolving stagnation for tranquilization, and altitude sickness usually can cause accessory symptomses such as body void is weak, palpitate with fear, have palpitation.The present invention selects this stimulating food material combination, except fundamentally preventing and treating altitude sickness, the related symptoms that alleviates and eliminate altitude sickness is had better auxiliary function.
Medicine of the present invention is at the regional hypoxia in Qinghai-Tibet Platean, send Tibetan medicine's theory according to tradition south, the good Radix Rhodiolae in selected area, Qinghai-Tibet Platean " plateau ecology medicine-valley ", and be equipped with Cortex Acanthopanacis Giraldii and Stigma Croci and make with extra care and form.Raw material Cortex Acanthopanacis Giraldii and Stigma Croci in the raw material prescription of the present invention, symptoms such as the deficiency of vital energy that altitude sickness is produced, palpitation with fear have good auxiliary curative effect.Can obviously prolong the time of mice normal pressure anoxia enduring through pharmacodynamic experiment proof medicine height of the present invention, middle dosage, and can increase the ability of mice decompression anoxia enduring, improve the mice survival rate; Can obviously increase the tolerance of mice to cerebral hypoxia ischemia (ligation common carotid artery); Can obviously prolong the time of mice swimming.Medicine of the present invention can improve the phagocytic function of the netted chrotoplast of normal mouse immunocompromised model mice monokaryon; Also can significantly improve normal mouse immunocompromised model mice serum hemolysin antibody horizontal, three crude drug compatibilities have been brought into play the effect of Synergistic.
Medicine anti-hypoxia of the present invention, resisting fatigue, anti-immunologic hypofunction effect are remarkable, and safety is stable, controlled, are clinical treatment prevention altitude sickness disease, and alleviating the various symptoms that altitude sickness causes provides a kind of new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 medicine capsule of the present invention
A, get Radix Rhodiolae 180kg, Cortex Acanthopanacis Giraldii 60kg, Stigma Croci 60kg directly soaks extraction with the ethanol of concentration about 70%, is condensed into extractum;
B, get Radix Rhodiolae extract, the Cortex Acanthopanacis Giraldii extract, each 93kg of Stigma Croci extract, 3kg, 3kg mixes, and adds adjuvant, stirs, and through granulation, granulate, oven drying at low temperature, encapsulated, polishing, packing, sterilization, quality inspection, packing form.
The preparation of embodiment 2 medicinal tablets of the present invention
A, get Radix Rhodiolae 180kg, Cortex Acanthopanacis Giraldii 60kg, Stigma Croci 60kg, with the alcohol reflux of concentration 70～75% 12～14 hours, filter, filtrate is condensed into extractum;
B, get b step extractum and add magnesium oxide 0.02kg, Pulvis Talci 0.03kg, medical starch 0.3kg mixing, drying is pulverized, mixing, and the granulate that sieves, tabletting are promptly.
The preparation of embodiment 3 medicinal granules of the present invention
A, get Radix Rhodiolae 150kg, Cortex Acanthopanacis Giraldii 50kg, Stigma Croci 50kg, with the alcohol reflux of concentration 70～75% 12～14 hours, filter, filtrate is condensed into extractum;
B, get b step extractum and add the adjuvant mix homogeneously, make soft material, with the machine-processed granule of granulating, dry, granulate are sub-packed in the non-toxic polyvinyl chloride plastic packaging bag, and the dress box promptly.
The preparation of embodiment 4 bolus of drug of the present invention
A, get Radix Rhodiolae 180kg, Cortex Acanthopanacis Giraldii 60kg, Stigma Croci 60kg, with the alcohol reflux of concentration 70～75% 12～14 hours, filter, filtrate is condensed into extractum;
B, get b step extractum and add the adjuvant mix homogeneously, make soft material, use the coating pan pill, dry granulate is packed promptly.
The preparation of embodiment 5 medicine oral liquids of the present invention
A, get Radix Rhodiolae 150kg, Cortex Acanthopanacis Giraldii 60kg, Stigma Croci 60kg, be ground into fine powder.With the alcohol reflux of concentration 70～75% 12～14 hours, filter.
B, filtrate decompression distillation ethanol, centrifugal, sucking filtration obtains Radix Rhodiolae extracting solution, and remaining ethanol distilling under reduced pressure is removed.
C, adding distilled water, regulating extracting solution is 1: 1 concentration, adds stabilizing agent, places 12h, filters.The filtrate standardize solution, embedding is gone out mattress promptly.
The preparation of embodiment 6 medicine capsules of the present invention
A, get Radix Rhodiolae 190kg, Cortex Acanthopanacis Giraldii 55kg, Stigma Croci 55kg directly soaks extraction with the ethanol of concentration about 70%, is condensed into extractum;
B, get Radix Rhodiolae extract, the Cortex Acanthopanacis Giraldii extract, the Stigma Croci extract mixes, and adds adjuvant, stirs, and through granulation, granulate, oven drying at low temperature, encapsulated, polishing, packing, sterilization, quality inspection, packing form.
The preparation of embodiment 7 medicinal granules of the present invention
Get Radix Rhodiolae 180kg, Cortex Acanthopanacis Giraldii 60kg, Stigma Croci 60kg, Rhizoma Polygonati 60kg:
Press embodiment 3 preparation methoies preparations and get.
Below beneficial effect by pharmacodynamics test proof medicine of the present invention
1 experiment material
1.1 medicine
Get embodiment 1 and be prepared into capsule of the present invention, every 1g capsule powders contains crude drug 4.17g, clinical capsule adult (60kg) consumption of the present invention is 6g, crude drug (being the 1.44g capsule powders) lot number 040611, it is standby during experiment powder to be made into 2.25%, 1.125%, 0.375% concentration with distilled water, and the mice dosage is the 0.2ml/10g body weight.Dosage is pressed the calculating of crude drug amount in the table.
The Nuodikang capsule, West China Pharmaceutical Group Co.,Ltd product, lot number 030155, dosage calculates by capsule powders weight in the table.
The Radix Acanthopanacis Senticosi sheet, Guangdong Longchuan pharmaceutical factory product, lot number 020901.
Cyclophosphamide for injection, the permanent auspicious medical company limited product in Jiangsu, lot number 030616.
1.2 reagent
2,4 one dinitrochlorobenzene, Chengdu chemical reagent factory product; The red rock ink, Chongqing red rock ink company limited product product.
1.3 instrument
Beckman700 type biochemistry analyzer (U.S.).
1.4 animal
Kunming kind white mice, the male and female dual-purpose, body weight 18 ~ 22g, Chengdu University of Traditional Chinese Medicine's Experimental Animal Center and Sichuan antibiotic industrial research institute of State Pharmaceutical Administration Animal Lab. provide.
2 methods and result
2.1 medicine capsule of the present invention is to the influence of normal mouse normobaric hypoxia
Choose 60 of healthy Kunming mouses, body weight 18～22g, male and female half and half, be divided into 5 groups at random by body weight, sex, every group 12, each treated animal gastric infusion every day 1 time, the blank group gives normal saline, continuous 6d, and 30min experimentizes after the last administration, with the single 250ml wide mouthed bottle that the 5g sodica calx is housed of putting into of mice, cover bottle cap, be coated with vaseline to guarantee sealing, observation and record anoxia in mice death time, relatively the hypoxia endurance time of administration group and control group mice the results are shown in Table 1.
Table 1 medicine capsule of the present invention to the influence of normal mouse normobaric hypoxia (x ± s, n=12)
| Group | Dosage (g/kg) | Hypoxia endurance time (min) |
| Blank group Radix Et Caulis Acanthopanacis Senticosi group medicine capsule group of the present invention | Isometric(al) NS 0.150 1.875 0.938 0.313 | 13.5±1.9 17.0±3.3 ** 17.0±3.6 ** 17.5±2.3 ** 15.2±2.8 |
Annotate: compare with the blank group.*P＜0.05。* P＜0.01 (down together)
2.2 medicine capsule of the present invention is to the normal mouse anoxybiotic influence of reducing pressure
Choose 100 of healthy Kunming mouses, body weight 18～22g, male and female half and half, be divided into 5 groups at random by body weight, sex, 20 every group, each treated animal gastric infusion every day 1 time, the blank group gives normal saline, continuous 6d, and 30min experimentizes after the last administration, get at every turn and respectively organize the airtight glass container that 4 mices place the decompression hypoxia device, vacuum pump is decompressed to 350mmHg, recovers normal pressure, writing time when treating experimental animal death half, add up the survival rate of each treated animal, press x
2Statistical analysis is carried out in check, the results are shown in Table 2.
Table 2 medicine capsule of the present invention to normal mouse reduce pressure anoxybiotic influence (x ± s, n=20)
| Group | Dosage (g/kg) | Surviving animals number (only) | The white branch rate (%) of surviving |
| Blank group Nuodikang Capsules group medicine capsule group of the present invention | Isometric(al) NS 0.225 0.875 0.938 0.313 | 3 14 14 11 8 | 15.0 70.0 ** 70.0 ** 55.0 ** 40.0 |
2.3 medicine capsule of the present invention is to the influence of mouse brain stagnant anoxia
Choose 70 of healthy Kunming mouses, body weight 25～30g, the male and female dual-purpose is divided into 5 groups at random by body weight, sex, every group 14, each treated animal gastric infusion every day 1 time, the blank group gives normal saline, and continuously 30min carries out operation on neck after with the mice etherization after the administration of 6d last, separate bilateral carotid, observe the influence of medicine to life span after the ligation, relatively the life span of administration group and control group mice the results are shown in Table 3.
Table 3 medicine capsule of the present invention is to the influence of mouse brain stagnant anoxia (x ± s)
| Group | Dosage (g/kg) | Life span (min) |
| Blank group Nuodikang Capsules group medicine capsule group of the present invention | Isometric(al) NS 0.225 1.875 0.938 0.313 | 1.83±0.66 4.61±2.81 ** 5.44±4.20 ** 3.06±1.89 ** 4.70±3.10 ** |
2.4 anti-fatigue test
Choose 55 of healthy Kunming mouses, body weight 18～22g, male and female half and half are divided into 5 groups at random by body weight, sex, 11 every group, each treated animal gastric infusion every day 1 time, the blank group gives the isometric(al) normal saline, continuous 6d, and 30min puts into tank with mice and carries out swimming test after the last administration, depth of water 30cm, 16 ℃ of every mouse tails of water temperature bear a heavy burden and are 10% of body weight.Write down every mice swimming continuance time (putting into water to head certainly can not emerge time of 10s), the results are shown in Table 4.
Table 4 medicine capsule of the present invention to the influence of mice swimming time (x ± s, n=11)
| Group | Dosage (g/kg) | Swimming time (min) |
| Blank group Nuodikang Capsules group medicine capsule group of the present invention | Isometric(al) NS 0.150 1.875 0.938 0.313 | 2.04±0.68 2.69±0.53 * 2.68±0.55 * 2.68±0.58 * 2.70±0.52 ** |
2.5 medicine capsule of the present invention is to the influence (carbon clearance method) of normal mouse reticuloendothelial cell phagocytic function
Choose 72 of healthy Kunming mouses, male and female half and half, body weight 18～22g, by body weight, sex is divided into 6 groups at random, every group 12, positive drug cyclophosphamide treated animal intraperitoneal injection every day, all the other each treated animal gastric infusions every day 1 time (the blank group gives normal saline), successive administration 8d, 30min experimentizes after the last administration, every mouse tail vein injection China prepared Chinese ink (pressing 1: 5 dilution proportion) 0.1ml/10g body weight with normal saline, the injection back is got blood 20ul respectively at 1min (t) and 2min (t2) from mice vena orbitalis posterior clump, adds 2ml 0.I%Na ~ CO, shake up in the solution, 580nm place colorimetric on BeckMan700 type biochemistry analyzer is measured optical density value (OD, and OD2) and after getting blood the 2nd time mice is put to death, cut open and get liver and spleen, weigh, by formula calculate and clean up index (K) and correction index (A), the results are shown in Table 5.K=(10gOD ,-logOD2)/(t2-t) A=body weight/liver weight+spleen weight * √ x
Table 5 medicine capsule of the present invention to the influence of normal mouse reticuloendothelial cell phagocytic function (x ± s, n=12)
| Group | Dosage (g/kg) | Clean up index (K) | Correction index (a) |
| Blank group cyclophosphamide group Nuodikang Capsules group medicine capsule group of the present invention | Isometric(al) NS 0.020 0.225 1.875 0.938 0.313 | 0.0158±0.0056 0.0122±0.0057 0.0168±0.0085 0.0307±0.0140 ** 0.0214±0.0126 0.0408±0.0227 ** | 5.02±1.17 3.84±1.18 * 4.97±1.27 5.84±0.99 * 4.74±1.17 6.14±1.14 * |
2.6 medicine capsule of the present invention is to the influence of normal mice serum hemolytic antibody level
Choose 72 of healthy Kunming mouses, male and female half and half, body weight 18～22g, be divided into 6 groups at random by body weight, sex, every group 12, each treated animal gastric infusion every day 1 time, the blank group gives normal saline, continuous 10d, every mouse peritoneal injection 5%CEBC suspension 0.2ml carries out immunity before the administration in the 2nd day.0.5h experimentizes after each treated animal last administration.Mice is plucked eyeball and gets blood, centrifugal, separation of serum, with 100 times of serum dilutions, getting dilute serum 1ml adds in the reaction tube, add 0.5%CEBC suspension 0.5ml again, in frozen water, add 0.5ml complement solution (10%3 Cavia porcellus pooled serums) then, solution in the reaction tube is shaken up, place 37 ℃ water bath with thermostatic control to react 30min, jolting is 2 times in the course of reaction, and reaction is taken out cessation reaction in frozen water with reaction tube after finishing, centrifugal, get supernatant in Becldtan700 type biochemistry analyzer 540nm place colorimetric.Represent the height of mice serum hemolytic antibody level with the absorbance (OD) of supernatant, the results are shown in Table 7.
Table 6 medicine capsule of the present invention to the influence of normal mice serum hemolytic antibody level (x ± s, n=12)
| Group | Dosage (g/kg) | Supernatant absorbance (OD) |
| Blank group cyclophosphamide group Nuodikang Capsules group medicine capsule group of the present invention | (NS) 0.020 0.225 1.875 0.938 0.313 | 0.405±0.302 0.102±0.009 ** 0.632±0.278 1.067±0.446 ** 0.690±0.283 * 0.650±0.391 |
3 conclusions
Medicine height of the present invention, middle dosage can obviously prolong the time (P＜0.01) of mice normal pressure anoxia enduring, and can increase the ability of mice decompression anoxia enduring, improve mice survival rate (P＜0.05, P＜0.01); Can obviously increase the tolerance (P＜0.05, P＜0.01) of mice to cerebral hypoxia ischemia (ligation common carotid artery); Can obviously prolong the time (P＜0.05) of mice swimming.Medicine of the present invention can improve the phagocytic function (P＜0.05, P＜0.01) of the netted chrotoplast of normal mouse immunocompromised model mice monokaryon; Also can significantly improve normal mouse immunocompromised model mice serum hemolysin antibody horizontal (P＜0.05, P＞0.01).
Above-mentioned pharmacodynamics test explanation, the anti-hypoxia of medicine of the present invention, resisting fatigue, anti-immunologic hypofunction effect are clear and definite, and safety range is big, steady quality, controlled is for the clinical prevention altitude sickness provides new selection.
Claims (8)
- The pharmaceutical composition of 1, a kind of prevention, treatment altitude sickness disease, it is characterized in that: it is to contain the medicament that is prepared from by the following weight proportion raw material:90～75 parts of Radix Rhodiolaes, 30～25 parts of Cortex Acanthopanacis Giraldii, 30～25 parts of Stigma Crocis.
- The pharmaceutical composition of 2, prevention according to claim 1, treatment altitude sickness disease, it is characterized in that: it is the medicament that is prepared from by the following weight proportion raw material:90～75 parts of Radix Rhodiolaes, 30～25 parts of Cortex Acanthopanacis Giraldii, 30～25 parts of Stigma Crocis.
- The pharmaceutical composition of 3, prevention according to claim 2, treatment altitude sickness disease, it is characterized in that: it is the medicament that is prepared from by the following weight proportion raw material:80 parts of Radix Rhodiolaes, 25 parts of Cortex Acanthopanacis Giraldii, 25 parts of Stigma Crocis.
- 4, according to the pharmaceutical composition of each described prevention of claim 1-3, treatment altitude sickness disease, it is characterized in that: it is to be active component with Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Stigma Croci, adds the medicament that acceptable accessories or complementary composition are prepared from.
- The pharmaceutical composition of 5, prevention according to claim 4, treatment altitude sickness disease, it is characterized in that: described medicament is capsule, tablet, granule, pill or oral liquid.
- The pharmaceutical composition of 6, prevention according to claim 5, treatment altitude sickness disease, it is characterized in that: every of described capsule contains rhodioside C 14H 2OO 7Must not be less than 2.4mg; Every in described tablet contains rhodioside C 14H 2OO 7Must not be less than 1.6mg; The every 10g of described granule contains rhodioside C 14H 2OO 7Must not be less than 4mg; The every ball of described pill contains rhodioside C 14H 2OO 7Must not be less than 0.6mg; The every 10ml of described oral liquid contains rhodioside C 14H 2OO 7Must not be less than 3.2mg.
- 7, a kind of method for preparing the pharmaceutical composition of each described prevention of claim 1～6, treatment altitude sickness disease, it comprises the steps:A, take by weighing 90～75 parts of Radix Rhodiolaes, 30～25 parts of Cortex Acanthopanacis Giraldii, 30～25 parts of Stigma Crocis.B, get Radix Rhodiolae, Cortex Acanthopanacis Giraldii, Stigma Croci and soak with the alcohols of concentration 70～75% and extract, soak filters, and is condensed into extractum, adds the medicament that acceptable accessories or complementary composition are prepared from; OrC, get Radix Rhodiolae and soak with the alcohols of concentration 70～75% and extract, soak filters, and is condensed into extractum;D, get Cortex Acanthopanacis Giraldii, Stigma Croci and soak with the alcohols of concentration 70～75% and extract, soak filters, and is condensed into extractum, mixes the medicament that adding acceptable accessories or complementary composition are prepared from the extractum of step c gained.
- 8, the purposes of the described pharmaceutical composition of claim 1～6 in the medicine of preparation prevention, treatment altitude sickness disease.
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| CN 200510022014 CN1957968A (en) | 2005-11-04 | 2005-11-04 | Composition of medication for treating disease of altitude striss, preparation method and usage |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288476A (en) * | 2014-10-29 | 2015-01-21 | 苗娥 | Buccal tablets for preventing altitude stress and preparation method thereof |
| CN104474259A (en) * | 2014-11-13 | 2015-04-01 | 成都华熹科技有限公司 | Saffron-containing traditional Chinese medicinal composition for enhancing immunity |
-
2005
- 2005-11-04 CN CN 200510022014 patent/CN1957968A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288476A (en) * | 2014-10-29 | 2015-01-21 | 苗娥 | Buccal tablets for preventing altitude stress and preparation method thereof |
| CN104474259A (en) * | 2014-11-13 | 2015-04-01 | 成都华熹科技有限公司 | Saffron-containing traditional Chinese medicinal composition for enhancing immunity |
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