CN104474239A - Mythic Fungus-containing traditional Chinese medicinal composition for enhancing immunity - Google Patents
Mythic Fungus-containing traditional Chinese medicinal composition for enhancing immunity Download PDFInfo
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- CN104474239A CN104474239A CN201410640366.5A CN201410640366A CN104474239A CN 104474239 A CN104474239 A CN 104474239A CN 201410640366 A CN201410640366 A CN 201410640366A CN 104474239 A CN104474239 A CN 104474239A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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Abstract
The invention discloses a Mythic Fungus-containing medicinal composition for enhancing immunity. The medicinal composition comprises Hippophae rhamnoides, coneflower, lily, Mythic Fungus, Gynostemma pentaphylla and jujube. The traditional Chinese medicinal composition can be taken for a long term to obviously enhance the body immunity, protect the health of the body, prevent the invasion of exogenous evil, reduce the disease infection probability of users, improve the life quality and increase the work efficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition of the raising immunity containing Ganoderma.
Background technology
Modern metropolitan cities population density is large, traffic congestion, agglomeration of industries, and air pollution is serious, and the monitoring result of pm2.5 sends warning red repeatedly, the serious old people that have impact on and the immunity of youngsters and children.When season alternation, old people and child are more easily subject to pathogenic wind-cold invasion, infect respiratory tract disease.Meanwhile, city white collar is because rhythm of life is fast, and operating pressure is large, the work of long-time over loading, and lack motion, immunity also reduces greatly, make city white collar also very easily infect wind and cold, or QI and blood is not smooth.
The traditional Chinese medical science thinks that the generation of disease is mainly because exopathogen invasion, and healthy energy is weak, points out in "Nei Jing": " healthy energy deposit in, heresy can not be done " really shows the relation resulting from the advance and retreat of the gas of good and evil of disease.Record in " The Yellow Emperor's Canon of Internal Medicine ": " be therefore sage is therefore sage does not know preventive treatment of disease ", show the attention that the traditional Chinese medical science is nursed one's health for health preserving.Healthy energy in conditioned body, then immunity is powerful, is not easy to catch, and more can improve duty, improves individual mind state, promotes that in body, healthy energy is assembled, and realizes good circulation.
The medicine of the raising immunity that Western medicine provides mostly is single target spot and strengthens promotive factor, and there is many side effect, and Chinese medicine is with the feature of its Mutiple Targets, be particularly good at physiological regulation, can well realize improving health, reduces the infection of urbanite's disease.
Summary of the invention
The object of the invention is to overcome the defect that prior art Chinese medicine and western medicine exists side effect, provide a kind of improve body immunity Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
Improve a pharmaceutical composition for immunity, comprise following composition: Fructus Hippophae, Echinacea, Bulbus Lilii, Ganoderma, Herb Gynostemmae Pentaphylli and Fructus Jujubae.Preferred above-mentioned compositions, weight is: Fructus Hippophae 1-30 part, Echinacea 1-25 part, Bulbus Lilii 1-10 part, Ganoderma 1-20 part, Herb Gynostemmae Pentaphylli 1-12 part, Fructus Jujubae 1-6 part.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, the Chinese medicine composition of the raising immunity of preparation.Although prescription is simple, but the collaborative facilitation comprehensively achieved between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieve the effect that single medicinal herbs do not have, improve the ability of body immunity significantly, and there is no toxic and side effects, be applicable to environmental pollution, season alternation, the hypoimmunity crowd that long-time overwork etc. causes.
Further, preferably improve the pharmaceutical composition of immunity, comprise the composition of following weight portion: Fructus Hippophae 10-20 part, Echinacea 8-16 part, Bulbus Lilii 2-8 part, Ganoderma 3-14 part, Herb Gynostemmae Pentaphylli 2-9 part, Fructus Jujubae 2-5 part.
Further, preferably improve the pharmaceutical composition of immunity, comprise the composition of following weight portion: Fructus Hippophae 15 parts, Echinacea 12 parts, Bulbus Lilii 5 parts, Ganoderma 9 parts, Herb Gynostemmae Pentaphylli 6 parts, 3 parts, Fructus Jujubae.
Compared with prior art, beneficial effect of the present invention: Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience instruct, the Chinese medicine composition of the raising immunity of preparation.Although prescription is simple, but the collaborative facilitation comprehensively achieved between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieve the effect that single medicinal herbs do not have, improve the ability of body immunity significantly, and there is no toxic and side effects, be applicable to environmental pollution, season alternation, the hypoimmunity crowd that long-time overwork etc. causes.Long-term taking Chinese medicine composition of the present invention, can significantly improve the immunity of body, protects healthy, prevents exopathogen from invading, and reduce the probability that user catches, quality of making the life better, increases work efficiency.
Detailed description of the invention
In the present invention, Fructus Hippophae, sour-puckery flavor, warm in nature.Return spleen, stomach, lung, heart channel.Strengthening the spleen to promote digestion, eliminating phlegm and stopping cough, promoting blood circulation to remove blood stasis.For insufficiency of the spleen lack of appetite, abdominal pain due to retention of food, cough with copious phlegm, obstruction of qi in the chest and cardialgia, blood stasis amenorrhea, falls and flutters congestive edema.Bulbus Lilii, sweet in the mouth, cold in nature, GUIXIN lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN cough caused by dryness, chronic cough hemoptysis, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Ganoderma, sweet in the mouth, property is put down.GUIXIN, lung, liver, kidney channel.Invigorating QI and tranquilization, relieving cough and asthma.For malaise, insomnia cardiopalmus, cough and asthma due to lung deficiency, asthenia is losed heart, anorexia.Herb Gynostemmae Pentaphylli, sweet-bitter flavor, cold nature, returns spleen lung meridian.Replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, changes turbid blood fat reducing.For deficiency of spleen-QI and stomach-QI, asthenia lack of appetite, deficiency of the lung cough caused by dryness, has sore throat, hyperlipemia.Fructus Jujubae, sweet in the mouth, warm in nature.Return spleen, stomach, heart channel.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.According to traditional Chinese medical science pharmacology, ingredients is grouped together, achieve the collaborative facilitation between every medicine, the effect of prescription is far superior to the effect superposition of single medical material, achieves the effect that single medicinal herbs do not have, improves the ability of body immunity significantly, and there is no toxic and side effects, effectively can improve body immunity, reduce disease and infect, improve the quality of living and work efficiency.
Pharmaceutical composition of the present invention can adopt but be not limited to following methods:
Preparation method one: get Fructus Hippophae, Echinacea, Bulbus Lilii, Ganoderma, Herb Gynostemmae Pentaphylli and Fructus Jujubae in proportion, pulverized 40-80 mesh sieve respectively, mix homogeneously, after adding the acceptable auxiliary element of pharmacy as required, makes the oral type pharmaceutical preparatioies such as tablet, capsule, granule or micropill.
Preparation method two: by Fructus Hippophae, Echinacea, Bulbus Lilii, Ganoderma, Herb Gynostemmae Pentaphylli and Fructus Jujubae ethanol, water or its mixture reflux, extract, 1-4 time, extracting solution is concentrated into dry, obtains extract.In above-mentioned extract, add the acceptable auxiliary element of pharmacy as required, make the oral type pharmaceutical preparatioies such as tablet, capsule, drop pill or micropill.
Preparation method three:
Prepare the method for Chinese medicine composition of the present invention, comprise the following steps:
(1) Fructus Hippophae, through pulverizing obtained powder, extracting this powder and obtaining oily liquids and be Oleum Hippophae in CO2 supercritical extracting equipment.
(2) get Echinacea, add 6-10 times of soak by water 1-4 time, each 1-3 hour, collecting decoction, evaporation and concentration, to dry, obtains Echinacea extract.
(3) get Bulbus Lilii, add 6-10 times of 10%-30% alcohol reflux 1-4 time, each 1-3 hour, merge extractive liquid, evaporation and concentration, to dry, obtains Bulbus Lilii extract.
(4) get Ganoderma, first cryogenic mechanical is pulverized, and rear comminution by gas stream, obtains wall-breaking lucidum powder.Preferred comminution by gas stream is that low-temperature airflow is pulverized.The temperature of whole crushing process Ganoderma medical material is no more than 10 DEG C.
(5) Herb Gynostemmae Pentaphylli is added 6-10 times of water reflux, extract, 3-4 time, each 2-3 hour, merge extractive liquid, filter, be concentrated into dry, obtain Herb Gynostemmae Pentaphylli extract.
(6) get Fructus Jujubae, it is for subsequent use that pulverize at low temperature obtains Fructus Jujubae powder.
(7) by above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into the dosage form such as tablet, capsule.
Wherein most preferably preparation method three, preparation method three is according to different medicines characteristic separately, select suitable extracting method farthest to be extracted by the effective ingredient in medicinal raw material, avoid the impact of the impurity of toxic side effect, so most preferably preparation method three.
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.In the embodiment of the present invention, mixed solution reagent used does not do and illustrates, is percent by volume mixing.Such as 20% ethanol refers to the ethanol water of 20:80 volume ratio.The amount ratio of Raw of the present invention and extracting solution is w/v (kg/L), and such as 8kg medical material 30% alcohol reflux of 4 times of volumes, by the 30:70 ethanol water adding 32L in 8kg medical material.
Embodiment 1
Get Fructus Hippophae 15kg, Echinacea 12kg, Bulbus Lilii 5kg, Ganoderma 9kg, Herb Gynostemmae Pentaphylli 6kg, Fructus Jujubae 3kg pulverized 40 mesh sieves, mix homogeneously respectively, add appropriate filler, adhesive and disintegrating agent, make tablet.
Comparative example 1
Get Fructus Hippophae 15kg, Echinacea 12kg, Ganoderma 9kg, Fructus Jujubae 3kg pulverized 40 mesh sieves, mix homogeneously respectively, dry, add appropriate filler, adhesive and disintegrating agent, make tablet.
Comparative example 2
Get Echinacea 12kg, Bulbus Lilii 5kg, Ganoderma 9kg, Herb Gynostemmae Pentaphylli 6kg 30% alcohol reflux 4 times, each 1 hour, merge extractive liquid, was concentrated into dry, obtains extract, adds appropriate auxiliary agent, tabletted.
Embodiment 2
Get raw material dosage: Fructus Hippophae 20kg, Echinacea 16kg, Bulbus Lilii 8kg, Ganoderma 3kg, Herb Gynostemmae Pentaphylli 9kg, Fructus Jujubae 5kg.Obtain mixed powder by the method for embodiment 1, make capsule casing material with gelatin, make capsule.
Embodiment 3
By Fructus Hippophae 10kg, Echinacea 8kg, Bulbus Lilii 2kg, Ganoderma 14kg, Herb Gynostemmae Pentaphylli 2kg, Fructus Jujubae 2kg, 30% alcohol reflux 4 times with 4 times of volumes, each 1 hour, merge extractive liquid, was concentrated into dry, obtains extract.By said extracted thing, add appropriate auxiliary agent, tabletted.
Fructus Hippophae 10kg, Echinacea 10kg, Bulbus Lilii 10kg, Ganoderma 10kg, Herb Gynostemmae Pentaphylli 10kg, Fructus Jujubae 12kg
Fructus Hippophae 30kg, Echinacea 25kg, Bulbus Lilii 10kg, Ganoderma 20kg, Herb Gynostemmae Pentaphylli 12kg, Fructus Jujubae 6kg
Embodiment 4
By Fructus Hippophae 30kg, Echinacea 25kg, Bulbus Lilii 10kg, Herb Gynostemmae Pentaphylli 12kg water boiling and extraction 4 times, each 1.5 hours, collecting decoction, was concentrated into dry, obtains extract.Get Ganoderma 20kg and Fructus Jujubae 6kg pulverized 40 mesh sieves, and aforementioned extract mix homogeneously, dry, add appropriate auxiliary agent, tabletted.
Embodiment 5
Fructus Hippophae 15kg, through pulverizing obtained powder, extracting this powder and obtaining oily liquids and be Oleum Hippophae in CO2 supercritical extracting equipment.Get Echinacea 12kg, add 8 times of soak by water 4 times, each 2 hours, collecting decoction, evaporation and concentration, to dry, obtains Echinacea extract.Get Bulbus Lilii 5kg, add 6 times of 30% alcohol reflux 3 times, each 1 hour, merge extractive liquid, evaporation and concentration, to dry, obtains Bulbus Lilii extract.Get Ganoderma 9kg, first cryogenic mechanical is pulverized, and rear comminution by gas stream, obtains wall-breaking lucidum powder.Preferred comminution by gas stream is that low-temperature airflow is pulverized.The temperature of whole crushing process Ganoderma medical material is no more than 10 DEG C.Get Herb Gynostemmae Pentaphylli 6kg, add 10 times of water reflux, extract, 4 times, each 3 hours, merge extractive liquid, filter, be concentrated into dry, obtain Herb Gynostemmae Pentaphylli extract.Get Fructus Jujubae 3kg, it is for subsequent use that pulverize at low temperature obtains Fructus Jujubae powder.By above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into capsule.
Embodiment 6
Fructus Hippophae 14kg, through pulverizing obtained powder, extracting this powder and obtaining oily liquids and be Oleum Hippophae in CO2 supercritical extracting equipment.Get Echinacea 11kg, add 10 times of soak by water 2 times, each 1 hour, collecting decoction, evaporation and concentration, to dry, obtains Echinacea extract.Get Bulbus Lilii 3kg, add 7 times of 10% alcohol reflux 2 times, each 1 hour, merge extractive liquid, evaporation and concentration, to dry, obtains Bulbus Lilii extract.Get Ganoderma 9kg, first cryogenic mechanical is pulverized, and rear comminution by gas stream, obtains wall-breaking lucidum powder.Preferred comminution by gas stream is that low-temperature airflow is pulverized.The temperature of whole crushing process Ganoderma medical material is no more than 10 DEG C.Get Herb Gynostemmae Pentaphylli 6kg, add 6 times of water reflux, extract, 3 times, each 3 hours, merge extractive liquid, filter, be concentrated into dry, obtain Herb Gynostemmae Pentaphylli extract.Get Fructus Jujubae 3kg, it is for subsequent use that pulverize at low temperature obtains Fructus Jujubae powder.By above-mentioned through the pretreated composition mix homogeneously obtained, dry, add the acceptable additive of appropriate pharmacy, be prepared into capsule.
The influence research of Phagocytosis By The Peritoneal Macrophages In Mice
One, test material and reagent:
Product: with embodiment 1,5,6, medicine prepared by comparative example 1-2.
Test animal: experimental animal is kunming mice, male and female half and half, body weight 18 ~ 22 grams.
Two, on the impact of functions of murine peritoneal macrophages/activity
Treating excess syndrome is tested and is divided into 6 groups at random with kunming mice, blank group diet every day, experimental group 5 groups, give test medicine, daily 2 times, after 10 days, after last administration 30 minutes (blank group after feeding 30 minutes), each group of mouse peritoneal only injects 6% chicken erythrocyte suspension 1.5ml/, extract mouse peritoneal liquid, in basis of microscopic observation, to record in 5 minutes macrophage phagocytic chicken red blood cell number in the visual field, and with the formula: phagocytic percentage=by Erythrocytes × 100% in the RBC number/visual field of engulfing; Phagocytic index=by the macrophage number in the Erythrocytes/visual field of engulfing.Calculate phagocytic percentage, experimental result sees the following form.
The impact of functions of murine peritoneal macrophages
Note: compare with comparative example
▲p < 0.05,
★p < 0.05.
Can find out that the mice of experimental group is after using medicine of the present invention continuously from upper table data, the sum of macrophage is strengthened by a small margin, the activity of macrophage is significantly promoted simultaneously, and visible pharmaceutical composition of the present invention has the good effect of building up resistance.
Model case
1. Zheng, female, 32 years old, lethargy, fatigue and weak, appetite reduced, sleep disorder.Take Chinese medicine preparation prepared by embodiment 1, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of of taking medicine, symptom alleviates, and continues to take condition after 1 course for the treatment of, notes regulating not recurrence after health.
2. Lee, man, 34 years old, emotion was irritated, anxiety.Take Chinese medicine preparation prepared by embodiment 5, every day 3 times, continuous 5 days is a course for the treatment of, symptom recovery from illness after 1 course for the treatment of of taking medicine, and does not have recurrence after noting regulating health.
3. single certain, female, 46 years old, flu recurrent exerbation, dreaminess, night sweat.Take Chinese medicine preparation prepared by embodiment 2, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of, symptom alleviates, and continues to take condition after 6 courses for the treatment of, notes regulating not recurrence after health.
4. Deng, female, 24 years old, work was often felt tired spiritless, and slightly does something and has just felt tired.Take Chinese medicine preparation prepared by embodiment 6, every day 3 times, continuous 5 days is a course for the treatment of, and after 1 course for the treatment of, symptom alleviates, and continues to take condition after 1 course for the treatment of, notes regulating not recurrence after health.
Claims (4)
1. improve a pharmaceutical composition for immunity, comprise following composition: Fructus Hippophae, Echinacea, Bulbus Lilii, Ganoderma, Herb Gynostemmae Pentaphylli and Fructus Jujubae.
2. the pharmaceutical composition of raising immunity according to claim 1, is characterized in that, comprises the composition of following weight portion: Fructus Hippophae 1-30 part, Echinacea 1-25 part, Bulbus Lilii 1-10 part, Ganoderma 1-20 part, Herb Gynostemmae Pentaphylli 1-12 part, Fructus Jujubae 1-6 part.
3. the pharmaceutical composition of raising immunity according to claim 2, is characterized in that, comprises the composition of following weight portion: Fructus Hippophae 10-20 part, Echinacea 8-16 part, Bulbus Lilii 2-8 part, Ganoderma 3-14 part, Herb Gynostemmae Pentaphylli 2-9 part, Fructus Jujubae 2-5 part.
4. the pharmaceutical composition of raising immunity according to claim 3, is characterized in that, comprises the composition of following weight portion: Fructus Hippophae 15 parts, Echinacea 12 parts, Bulbus Lilii 5 parts, Ganoderma 9 parts, Herb Gynostemmae Pentaphylli 6 parts, 3 parts, Fructus Jujubae.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562129A (en) * | 2004-04-16 | 2005-01-12 | 任志田 | Seabuckthora fruit and lucid ganoderma nutrition mixture with auxiliary anti-cancer function |
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| KR101339706B1 (en) * | 2013-06-20 | 2013-12-10 | 재단법인 금산국제인삼약초연구소 | A compound for immune strengthen inclusion reducing the bitterness of red ginseng, the extract of immune, and the probiotics |
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2014
- 2014-11-13 CN CN201410640366.5A patent/CN104474239A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562129A (en) * | 2004-04-16 | 2005-01-12 | 任志田 | Seabuckthora fruit and lucid ganoderma nutrition mixture with auxiliary anti-cancer function |
| CN101850052A (en) * | 2009-03-31 | 2010-10-06 | 北京因科瑞斯医药科技有限公司 | Immunity-enhancing pharmaceutical composition and preparation method thereof |
| KR101339706B1 (en) * | 2013-06-20 | 2013-12-10 | 재단법인 금산국제인삼약초연구소 | A compound for immune strengthen inclusion reducing the bitterness of red ginseng, the extract of immune, and the probiotics |
Non-Patent Citations (3)
| Title |
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| 刘建春: "《抗衰老秘籍——认识衰老规律 延长人类生命》", 30 June 2013, 湖南科学技术出版社 * |
| 白鸿: "《保健食品功效成分检测方法》", 31 May 2011, 中国中医药出版社 * |
| 阮克锋: "中药抗衰老免疫研究", 《中成药》 * |
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