CN109674042A - A kind of nutriment and preparation method thereof improving immunity - Google Patents
A kind of nutriment and preparation method thereof improving immunity Download PDFInfo
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- CN109674042A CN109674042A CN201910108146.0A CN201910108146A CN109674042A CN 109674042 A CN109674042 A CN 109674042A CN 201910108146 A CN201910108146 A CN 201910108146A CN 109674042 A CN109674042 A CN 109674042A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/05—Mashed or comminuted pulses or legumes; Products made therefrom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of nutriment and preparation method thereof for improving immunity.A kind of nutriment improving immunity, mainly it is made of following component: by weight, 14~30 parts of red bean, 2~10 parts of jujube, 1~7 part of fructus lycii, 2~10 parts of red peanut, 0.1~5 part of russule, 0.1~2 part of ginseng, 0.002~0.0106 part of selenoprotein, 0.01~0.3 part of 0.5~3 part of raw-food material and Epigallo-catechin gallate (EGCG) (EGCG) rich in chlorogenic acid.Nutriment of the present invention can significantly improve body immunity, improve the malnutritive situation of tumor patient, tolerance of the enhancing body to treatment means such as chemicotherapies, quality of life after raising Chemotherapy in Patients, it is very useful to tumor patient, and the ingredient without the taboo of the tumor patients such as sugar, it is safer efficient；Nutriment is processed into solid articles by the present invention, no longer Confined Liquids long processing time, be not easy to transport, the problems such as shelf-life is short.
Description
Technical field
The present invention relates to field of food, more particularly, to a kind of nutriment and preparation method thereof for improving immunity, especially
Suitable for the immune improvement of tumor patient.
Background technique
Immunity is the defense mechanism of human body itself, is that human bioequivalence and any foreign matter of the external intrusion of elimination are (viral, thin
Bacterium etc.), processing aging, damage, death, even cancerous tumor cell ability, be army and the police of human body.Tumor patient is due to cancer
Cell shifts everywhere, the reasons hypoimmunity such as low that destroys function of human body, chronic high deficiency, nutritional deficiency, positive energy, such as
The immunity what improves tumor patient is very crucial to patient's service life is extended.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of nutriment for improving immunity, which can significantly improve people
Body immunity, it is very useful to tumor patient, and the ingredient without the taboo of the tumor patients such as sugar, it is safer efficient.
The second object of the present invention is to provide the preparation method of the nutriment of above-mentioned raising immunity, preparation method general
Nutriment is processed into solid articles, no longer Confined Liquids long processing time, be not easy to transport, the problems such as shelf-life is short.
In order to solve the above technical problems, the present invention provides following technical schemes:
A kind of nutriment improving immunity, is mainly made of following component:
By weight, 14~30 parts of red bean, 2~10 parts of jujube, 1~7 part of fructus lycii, 2~10 parts of red peanut, russule
0.1~5 part, 0.1~2 part of ginseng, 0.002~0.0106 part of selenoprotein, 0.5~3 part of raw-food material and table rich in chlorogenic acid
0.01~0.3 part of nutgall catechin gallic acid ester (EGCG).
Nutriment of the invention is in addition to containing with increasing leukocytes and blood platelets such as red bean, jujube, fructus lycii and red peanuts
Ordinary nutritional ingredient outside, also added can specific aim improve tumor patient rehabilitation the effect of ingredient --- russule, ginseng, selenium egg
Raw-food material and Epigallo-catechin gallate (EGCG) (EGCG) white, rich in chlorogenic acid.Therefore, nutritional ingredient of the present invention
More comprehensively, the effect for improving immunity is more significant for function, and product are reinforced in the nutrition that can be used not only for tumor patient, can be also used for just
The daily health caring of ordinary person group.
Wherein, the raw-food material rich in chlorogenic acid refers to its chlorogenic acid content >=1%, preferably one of the following raw material or
It is a variety of: honeysuckle, hawthorn, sweet potato leaves, Saussurea involucrata culture, folium cortex eucommiae.These raw material Content of Chlorogenic Acid are usual are as follows: and honeysuckle >=
1.5%, hawthorn 3%~7%, sweet potato leaves 6.25%, Saussurea involucrata culture >=1.0%, folium cortex eucommiae >=5%.
Form, such as the natural or artificial growth without artificial can be arbitrary rich in chlorogenic acid raw-food material
Food materials, or by processing, such as extracting solution, extract or concentration powder etc..
In addition, the ingredient of nutriment of the invention without the taboo of the tumor patients such as sugar, safer efficient, may be not present existing
The shifting problem of product.
To sum up, the beneficial effects of the present invention are:
1, it is adjusted by immunity nourishment, can not only improve the malnutritive situation of tumor patient, and promotion can be played
Blood-supplementing blood-nourishing improves hemoglobin and red blood cell content, promotes the effect of lymphopoiesis ability；
2, inhibit or induce tumor cell invasion and apoptosis by immunological regulation, play enhancing immunity of organisms, it is antitumor
Effect；
3, nutraceutical of the invention, rich in protein, fat, vitamin, organic selenium and other lot of trace nutrition members
Element can be effectively improved the nutrition condition of tumor patient, tolerance of the enhancing body to treatment means such as chemicotherapies.
4, the support by immunity nourishment food in the treatment, in tired, nauseous and vomiting, insomnia, loss of appetite, just
During multiple indexs such as secret, diarrhea are evaluated, it was demonstrated that immunity nourishment food of the present invention supports that the battalion for improving patient can be passed through
The situation of supporting and improve quality of life after the chemotherapy of patient, extend the life cycle of patient.
In the present invention, each ingredient is very crucial with mutual cooperation is compared.Using the number of other compositions as base
Plinth, every kind of ingredient can be selected arbitrarily within its scope.
Such as any number within the scope of desirable 14~30 parts of red bean, 14 parts, 16 parts, 22 parts, 23 parts, 30 parts etc..
Any number within the scope of jujube is 2~10 parts desirable, 2 parts, 3 parts, 5 parts, 6 parts, 10 parts etc..
Any number within the scope of fructus lycii is 1~7 part desirable, 1 part, 3 parts, 4 parts, 5 parts, 7 parts etc..
Any number within the scope of red peanut is 2~10 parts desirable, 2 parts, 3 parts, 4 parts, 6 parts, 10 parts etc..
Any number within the scope of russule is 0.1~5 part desirable, 0.1 part, 0.5 part, 2 parts, 5 parts etc..
Any number within the scope of ginseng is 0.1~2 part desirable, 0.1 part, 0.3 part, 1 part, 2 parts etc..
Any number within the scope of selenoprotein is 0.002~0.0106 part desirable, 0.002 part, 0.004 part, 0.0106 part etc..
Any number within the scope of desirable 0.5~3 part of raw-food material rich in chlorogenic acid, 0.5 part, 1 part, 1.3 parts, 2 parts,
3 parts etc..
Any number within the scope of Epigallo-catechin gallate (EGCG) (EGCG) is 0.01~0.3 part desirable, 0.01 part,
0.06 part, 0.1 part, 0.3 part etc..
Preferred scheme is as follows in the above optional scheme.
Preferably, by weight, 14~23 parts of red bean, 3~10 parts of jujube, 1~5 part of fructus lycii, red peanut 3~10
Part, 0.1~5 part of russule, 0.1~2 part of ginseng, 0.002~0.0106 part of selenoprotein, the raw-food material 0.5~3 rich in chlorogenic acid
Part and 0.01~0.3 part of Epigallo-catechin gallate (EGCG) (EGCG).
Preferably, by weight, 16~23 parts of red bean, 5~10 parts of jujube, 1~4 part of fructus lycii, red peanut 4~10
Part, 0.1~5 part of russule, 0.1~2 part of ginseng, 0.002~0.0106 part of selenoprotein, the raw-food material 0.5~3 rich in chlorogenic acid
Part and 0.01~0.3 part of Epigallo-catechin gallate (EGCG) (EGCG).
Preferably, by weight, 22 parts of red bean, 6 parts of jujube, 3 parts of fructus lycii, 6 parts of red peanut, 0.5 part of russule, people
Join 0.3 part, 0.004 part of selenoprotein, 1.3 parts of raw-food material, Epigallo-catechin gallate (EGCG) 0.06 rich in chlorogenic acid
Part.
The solids systems such as any form, such as nutrient solution, nutrient tablet, particle or bulk can be made in nutriment of the invention
Agent or even paste.However nutrient solution and process paste are time-consuming and laborious, and product is not easy to maintain, is not easy to transport, for this purpose,
It is as follows the present invention provides the preparation method of solid articles.
Mode one,
All raw materials are mixed with beating, are dried to preset shape later；
Mode two,
It is mixed with beating after russule is cooked with other raw materials, is dried to preset shape later.
The shape of above two mode can utilize specific mold or mechanical realization in the drying process.
In both the above production method, specific operating condition can be optimized, to improve production efficiency or improve effect
The activity of the factor, it is specific as follows.
Preferably, solid-liquid mass ratio is 2:5~8, such as 2:5,2:6,2:7,2:8 when the mashing in two ways
Deng.
Preferably, the preset shape is thin slice, bulk or particle.
Preferably, the drying carries out in roller drier, and the temperature of the drying is 125 ± 5 DEG C.
Preferably, the time that the russule cooks is 30min or more.
Preferably, the raw material carries out stripping and slicing or crushing before mashing, and the crushing was preferably crushed to 80 meshes.
Stripping and slicing or crushing for the different ingredient property of can choose, such as the raw-food material rich in chlorogenic acid and cook
Russule stripping and slicing, other crushing.
To sum up, compared with prior art, invention achieves following technical effects:
(1) it improves immunity by the formula composition and proportion that improve nutriment and enhances effect, also have raising white thin
The basic effect of born of the same parents and blood platelet, function is richer, provides stronger guarantee to extend the service life of tumor patient；
(2) ingredient without tumor patient taboo in nutriment；
(3) preparation method of nutriment is improved, it is not only time saving and energy saving, but also the shelf-life of nutriment is extended, and be easier to transport
It is defeated.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with specific embodiment, but ability
Field technique personnel will be understood that following described embodiments are some of the embodiments of the present invention, instead of all the embodiments,
It is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument
Production firm person is not specified, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
Take red bean 22g, jujube 6g, fructus lycii 3g, red peanut 6g, russule 0.5g, ginseng 0.3g, selenoprotein 4mg, gold and silver
Flower concentration powder 1.3g, Epigallo-catechin gallate (EGCG) (EGCG) 0.06g.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, gold and silver
Flower concentration powder is uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food, thickness about 4mm.
Embodiment 2
Take red bean 14g, jujube 10g, fructus lycii 4g, red peanut 10g, russule 0.5g, ginseng 0.1g, selenoprotein 4mg, mountain
Powder 0.5g, Epigallo-catechin gallate (EGCG) (EGCG) 0.01g is concentrated in short, bristly hair or beard.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, hawthorn
Powder is concentrated to be uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
Food is supported in bulk.
Embodiment 3
Take red bean 30g, jujube 2g, fructus lycii 1g, red peanut 2g, russule 2g, ginseng 1g, selenoprotein 2mg, saussurea involucrata culture
Object 1g, Epigallo-catechin gallate (EGCG) (EGCG) 0.1g.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, saussurea involucrata
Culture is uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
Feeding food is in granular form.
Embodiment 4
Take red bean 23g, jujube 3g, fructus lycii 5g, red peanut 3g, russule 0.1g, ginseng 2g, selenoprotein 10.6mg, red
Powder 3g, Epigallo-catechin gallate (EGCG) (EGCG) 0.3g is concentrated in potato leaf.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, sweet potato
Leaf is concentrated powder and is uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food.
Embodiment 5
Take red bean 16g, jujube 5g, fructus lycii 7g, red peanut 4g, russule 5g, ginseng 0.3g, selenoprotein 4mg, folium cortex eucommiae
Powder 2g, Epigallo-catechin gallate (EGCG) (EGCG) 0.06g is concentrated.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Raw-food material or concentration powder rich in chlorogenic acid are broken into fritter or cross 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, Cortex Eucommiae
Leaf is concentrated powder and is uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food.
Embodiment 6
Take red bean 22g, jujube 6g, fructus lycii 3g, red peanut 6g, russule 0.5g, ginseng 0.3g, selenoprotein 4mg, Cortex Eucommiae
Powder 1.3g, Epigallo-catechin gallate (EGCG) (EGCG) 0.06g is concentrated in leaf.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, Cortex Eucommiae
Leaf is concentrated powder and is uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food, thickness about 4mm.
Embodiment 7
Take red bean 22g, jujube 6g, fructus lycii 3g, red peanut 6g, russule 0.5g, ginseng 0.3g, selenoprotein 4mg, saussurea involucrata
Culture 1.3g, Epigallo-catechin gallate (EGCG) (EGCG) 0.06g.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Ginseng crushes, and crosses 80 meshes；
Russule steams 30min, takes out, is broken into fritter；
2) by the ginseng pulverate in step 1), selenoprotein powder and Epigallo-catechin gallate (EGCG) (EGCG) powder, saussurea involucrata
Culture is uniformly mixed；
3) by all raw materials handled well of step 1-2), purified water (solid-liquid mass ratio 2:8) is added and stirs evenly.
4) raw slurry of step 3) is added in colloid mill, 3 times repeatedly, obtains emulsion；
5) by the emulsion of step 4), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food, thickness about 4mm.
Comparative example 1
Red bean, jujube, fructus lycii, red peanut, brown sugar are taken by the weight ratio of 8:12:10:6:1.5.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Brown sugar, which is added, to be mixed；
2) by all raw materials handled well of step 1), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
3) raw slurry of step 2) is added in colloid mill, 3 times repeatedly, obtains emulsion；
4) by the emulsion of step 3), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food, thickness about 4mm.
Comparative example 2
Red bean, jujube, fructus lycii, red peanut, russule are taken by the weight ratio of 22:6:3:6:0.5.
1) red bean crushes, and crosses 80 meshes；
Jujube, fructus lycii and red peanut, which are mixed together, is ground into little particle；
Russule steams 30min, takes out, is broken into fritter；
2) by all raw materials handled well of step 1), purified water (solid-liquid mass ratio 2:5) is added and stirs evenly.
3) raw slurry of step 2) is added in colloid mill, 3 times repeatedly, obtains emulsion；
4) by the emulsion of step 3), drying in roller drier is added, sieving is packaged into bag, obtains nutraceutical；The battalion
It is flaky to support food, thickness about 4mm.
The immunity for comparing nutriment obtained by product of the present invention obtained by above embodiments and comparative example enhances effect, and discovery exists
After chemotherapy damage in terms of increasing leukocyte, product of the present invention can significantly increase subject after chemotherapy damage white blood cell count(WBC) (P <
0.01) as follows in detail, and better than the liter white effect of traditional five red soup.
One, animal efficacy test:
Kunming mouse is divided into 5 groups at random: blank group, chemotherapy group, chemotherapy+comparative example 1 (traditional five red soup groups), chemotherapy
+ comparative example 2, chemotherapy+embodiment 1, every group 16.Wherein chemotherapy group, chemotherapy+comparative example 1 (traditional five red soup groups), chemotherapy+right
CTX 100mgkg is continuously injected intraperitoneally in ratio 2, chemotherapy+embodiment 1-1·d-1, total 3d establishes chemotherapy damage model.Blank
Group continuous intraperitoneal injection of saline 0.3ml/d, totally 3 days.Start to tested material, wherein chemotherapy+comparison within the 1st day after the completion of modeling
Example 1 (traditional five red soup groups), chemotherapy+comparative example 2,1 mouse continuous gavage of chemotherapy+embodiment give tested material 10gkg-1·d-1, total 8d；Chemotherapy group and naive mice continuous gavage Isodose physiological saline (0.3ml/d), total 8d.Record mouse daily
Changes of weight, to adjust tested material dosage.
(8d) carries out inner canthus venous blood collection method to every mouse respectively after (0d), intervention after (- 3d), modeling before modeling
Take a blood sample 50 μ L.After the completion for the treatment of, mouse is put to death with cervical dislocation, on medical type clean bench, is swum using reverse post-mortem method
Bone cells suspension is prepared from femur.Under sterile working environment, the bone cells suspension being collected into is blown repeatedly with 1ml syringe
Individual cells are broken into, abandon supernatant after 1200r/min centrifugation 5min, the bone cells of precipitating are respectively used to mononuclearcell meter
Number, hematopoietic progenitor cells and CD34+The measurement of cell expression.
1 each group mouse different time points peripheral blood WBC of table compare (n=16, x ± s, × 109/L)
Note: using the rank sum test of multiple independent samples.0d, compared with blank group, #P < 0.05, ##P < 0.01；8d, with
Blank group compares, P < 0.01 * P < 0.05, * *；Compared with chemotherapy+comparative example 1,△P < 0.05,△△P<0.01；With chemotherapy+comparative example
2 groups are compared, P < 0.01 ※ P < 0.05, ※ ※.Similarly hereinafter.
Table 1 shows chemotherapy group, chemotherapy+comparative example 1 (traditional five red soup groups), chemotherapy+comparative example 2, chemotherapy+embodiment 1
WBC decline, is significantly lower than blank group, shows the success of chemotherapy Establishing an injured model；After intervening 8d with tested material, chemotherapy+comparison
The WBC of example 2 is higher than blank group and 1 group of chemotherapy+comparative example (P < 0.05)；The WBC of chemotherapy+embodiment 1 be higher than blank group (P <
And chemotherapy+comparative example 1 (traditional five red soup groups) (P < 0.05) and 2 groups of chemotherapy+comparative example (P < 0.05) 0.01).
2 each group different time points peripheral blood RBC of table (n=16, x ± s, × 1012/L)
Table 2 shows the RBC decline of chemotherapy group, 1 group of chemotherapy+comparative example, 2 groups of chemotherapy+comparative example, chemotherapy+embodiment 1,
Significantly lower than blank group, show the success of chemotherapy Establishing an injured model；After intervening 8d with tested material, the RBC high of chemotherapy+comparative example 2
In blank group and 1 group of chemotherapy+comparative example (P < 0.05)；The RBC of chemotherapy+embodiment 1 is higher than blank group (P < 0.01) and chemotherapy+right
Ratio 1 (traditional five red soup groups) (P < 0.05) and 2 groups of chemotherapy+comparative example (P < 0.05).
3 each group mouse different time points peripheral blood PLT of table compare (n=16, x ± s, × 109/L)
Table 3 shows the PLT decline of chemotherapy group, chemotherapy+comparative example 1, chemotherapy+comparative example 2, chemotherapy+embodiment 1, obviously
Lower than blank group, show the success of chemotherapy Establishing an injured model；After intervening 8d with tested material, the PLT of chemotherapy+comparative example 2 is higher than sky
White group and 1 group of chemotherapy+comparative example (P < 0.05)；The PLT of chemotherapy+embodiment 1 is higher than blank group (P < 0.05) and chemotherapy+comparative example
1 (traditional five red soup groups) (P < 0.05) and 2 groups of chemotherapy+comparative example (P < 0.05).
Table 4 is to mouse each group Bone Morrow Hematopoietic Progenitor Cells colony number, CD34+The influence (x ± s) of expression
Note: BFU-E: hemopoietic progenitor cell of red blood cell line；CFU-GM: grain system hematopoietic progenitor cells；
Table 4 show chemotherapy+embodiment 1 and chemotherapy group compare and 1 group of chemotherapy+comparative example, chemotherapy+comparative example 2 compared with: it is small
Mouse marrow BFU-E, CFU-GM and CD34+ expression rate has improvement result, but not statistically significant.
These results suggest that product of the present invention has certain change to blood index, bone marrow suppression and the immunosupress of tumor patient
Kind effect, and it is better than five traditional 1 group of red soup comparative examples and 2 groups of chemotherapy+comparative example.
Two, to the improvement result of tumor patient complication
Choose 168 tumor patients, random digits table be divided into normal diet group, take 1 group of comparative example, 2 groups of comparative example,
Take product of the present invention group each 42, the period 1 month.Be included in standard: 1, the age is greater than 20 years old；2, it is diagnosed as tumor patient；3,
Plan to implement chemotherapy；4, Nutritional risk screening scores >=3 points；5, the subjective measuring scale comprehensively of self-appraisal scores >=4 points；6, this hospital stay
Between without operation；
Exclusion criteria: 1, the serious insufficiency of the vitals such as liver kidney；2, clouded in mind, it can not normal communication；3, it tests
The person of dropping by the wayside；4, because non-chemotherapy reason causes extended hospital stay；5, high cause spits drug in chemotherapy regimen；Two groups of patient's statistics
Index is shown in Table 5, and each index no difference of science of statistics is comparable.
Each group patient's statistical indicator before table 5 is tested
Using the subjective measuring scale (PG-SGA) comprehensively of Nutritional Risk review tool (NRS2002) and self-appraisal, in every disease
Progress Nutritional Risk assessment in 1st day after people is admitted to hospital.Nutritional risk screening tool, which scores >=3 points, is considered that there are Nutritional Risks；From
Subjective measuring scale comprehensively is commented to score >=4 points as there are Nutritional Risk, tumour patient needs nutritional intervention when treating.In this research
The patient for choosing NRS >=3 point and PG-SGA >=4 point is included in research, and carries out the acquisition and statistics of subsequent related data data.
Appraisal of life quality using European disease research and treats prepared quality of life core scale (EORTC
QLQ-C30): including 5 functional areas (body function, role function, cognitive function, emotional function, social function), 9 diseases
Shape field (tired, pain, nausea and vomiting, expiratory dyspnea, insomnia, loss of appetite, constipation, diarrhea) and 1 holistic health/life
Quality.Holistic health/quality of life is divided into 7 grades, and scoring is 1-7 points；Other component scores are 4 grades: being not 1
Dividing, have any to be 2 points, having some is 3 points, very mostly 4 points.Syndrome Scale score is higher, and symptom is heavier, functional scale and total
The higher function status of scale of construction table score is better.
Observe the blood parameters of 4 groups of patients: total protein, albumin, hemoglobin；And 4 groups of patients ' lives of assessment
Quality score and Nutritional risk screening scoring etc..
Each group patient's index of correlation compares after table 6 is tested
Note: compared with normal diet group, P < 0.01 * P < 0.05, * *；Compared with 1 group of comparative example, #P < 0.05, ##P <
0.01, compared with 2 groups of comparative example, P < 0.01 ※ P < 0.05, ※ ※, similarly hereinafter.
Table 6 is as it can be seen that after the test period, embodiment 1 and traditional five 1 group of red soup comparative examples, 2 groups of comparative example and normal drink
Food group is compared: Nutritional Risk scoring, BMI, total protein, albumin index has improvement, but there was no significant difference；Hemoglobin refers to
Mark: 2 groups of comparative example compared with normal diet group and 1 group of comparative example, there is significant improvement (P < 0.05).Example 1 group and normal
Diet group compares, and has significant difference (P < 0.01), compared with traditional five 1 group of red soup comparative examples and 2 groups of comparative example, there is conspicuousness
Difference (P < 0.05).
Life quality scores compare after 7 two groups of chemotherapy of patients of table
Table 7 is as it can be seen that after the test period, and embodiment 1 is compared with normal diet group: somatic function, emotional function, tired
Tired, shortness of breath, insomnia, loss of appetite have improvement result, have significant difference (P < 0.05), and the above index is better than 1 group of comparative example
With 2 groups of comparative example, but there was no significant difference.Holistic health/Quality Of Well Being Index: 2 groups of comparative example and normal diet group and comparison
1 group of example is compared, the effect of being significantly improved (P < 0.05)；Embodiment 1 and 2 groups of normal diet group, 1 group of comparative example and comparative example phases
Than the effect of being significantly improved (P < 0.05).Illustrate that embodiment 1 has some improvement to the complication of tumor patient, and
Better than five traditional red soup and 2 groups of comparative example.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of nutriment for improving immunity, which is characterized in that be mainly made of following component:
By weight, 14~30 parts of red bean, 2~10 parts of jujube, 1~7 part of fructus lycii, 2~10 parts of red peanut, russule 0.1
~5 parts, 0.1~2 part of ginseng, 0.002~0.0106 part of selenoprotein, 0.5~3 part of the raw-food material rich in chlorogenic acid and table are not eaten
0.01~0.3 part of sub- catechin and gallate；By weight percentage, the chlorogenic acid of the raw-food material rich in chlorogenic acid
Content >=1%.
2. the nutriment according to claim 1 for improving immunity, which is characterized in that by weight, red bean 14~23
Part, 3~10 parts of jujube, 1~5 part of fructus lycii, 3~10 parts of red peanut, 0.1~5 part of russule, 0.1~2 part of ginseng, selenoprotein
0.002~0.0106 part, 0.5~3 part of the raw-food material rich in chlorogenic acid and Epigallo-catechin gallate (EGCG) 0.01~
0.3 part.
3. the nutriment according to claim 1 for improving immunity, which is characterized in that by weight, red bean 16~23
Part, 5~10 parts of jujube, 1~4 part of fructus lycii, 4~10 parts of red peanut, 0.1~5 part of russule, 0.1~2 part of ginseng, selenoprotein
0.002~0.0106 part, 0.5~3 part of the raw-food material rich in chlorogenic acid and Epigallo-catechin gallate (EGCG) 0.01~
0.3 part.
4. the nutriment according to claim 1 for improving immunity, which is characterized in that by weight, 22 parts of red bean, red
6 parts of jujube, 3 parts of fructus lycii, 6 parts of red peanut, 0.5 part of russule, 0.3 part of ginseng, 0.004 part of selenoprotein, the food rich in chlorogenic acid
1.3 parts of product raw material, 0.06 part of Epigallo-catechin gallate (EGCG).
5. the nutriment according to claim 1-4 for improving immunity, which is characterized in that described to be rich in chlorogenic acid
Raw-food material be one of following: one of honeysuckle, hawthorn, sweet potato leaves, Saussurea involucrata culture and folium cortex eucommiae are a variety of；
Powder is preferably concentrated in the raw-food material rich in chlorogenic acid.
6. the nutriment according to claim 1-4 for improving immunity, which is characterized in that the nutriment is solid
System product.
7. the preparation method of the nutriment described in any one of claims 1-6 for improving immunity, which is characterized in that using following
One of mode:
Mode one,
All raw materials are mixed with beating, are dried to preset shape later；
Mode two,
It is mixed with beating after russule is cooked with other raw materials, is dried to preset shape later.
8. the preparation method of the nutriment according to claim 7 for improving immunity, which is characterized in that in two ways
Solid-liquid mass ratio is 2:5~8 when the mashing；
Preferably, the preset shape is thin slice, bulk or particle.
9. the preparation method of the nutriment according to claim 7 for improving immunity, which is characterized in that the drying is being rolled
It is carried out in drum drier, the temperature of the drying is 125 ± 5 DEG C.
10. the preparation method of the nutriment according to claim 7 for improving immunity, which is characterized in that the russule is steamed
The ripe time is 30min or more；
Preferably, the raw material carries out stripping and slicing or crushing before mashing, and the crushing was preferably crushed to 80 meshes.
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