CN108095082A - A kind of health food containing curcumin and preparation method thereof - Google Patents
A kind of health food containing curcumin and preparation method thereof Download PDFInfo
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- CN108095082A CN108095082A CN201711384759.4A CN201711384759A CN108095082A CN 108095082 A CN108095082 A CN 108095082A CN 201711384759 A CN201711384759 A CN 201711384759A CN 108095082 A CN108095082 A CN 108095082A
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- 235000015816 nutrient absorption Nutrition 0.000 description 1
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- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
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- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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- 230000008719 thickening Effects 0.000 description 1
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- 239000010936 titanium Substances 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of health foods containing curcumin and preparation method thereof.The health food includes the raw material of following parts by weight：0~50 part of bisdemethoxycurcumin, 20~40 parts of agate card extract, 5~15 parts of wolfberry fruit extract, 10~30 parts of xylo-oligosaccharide.Health food according to the present invention containing curcumin has strengthen immunity, the effect of slowing down aging, adjust intestinal flora, human nutrition is promoted to absorb, alleviates subhealth symptom；Health food of the present invention also has many advantages, such as to be convenient for carrying, and is easy to take.
Description
Technical field
The present invention relates to technical field of health care food, are more particularly to a kind of health food containing curcumin and its preparation
Method.
Background technology
It is with the improvement of people ' s living standards and the accelerating rhythm of life, increasingly prominent the problem of unreasonable diet structure,
Generally existing life stress increases therewith, a kind of non-sick unhealthy status occurs and is known as sub-health state.Inferior health refers to people
Body is in a kind of state between health and disease.In sub-health state person, it is impossible to reach the standard of health, show as certain
Vigor in time reduces, the symptom of function and adaptability decline, but does not meet modern medicine and have the clinical or sub- of related disorders
Clinical criteria.Generally existing confirmed fatigue and vigor decline phenomenon in the crowd of inferior health, confirmed fatigue is inferior health
One of state most typically, most important performance.The situation of confirmed fatigue is relatively more prominent in China, the white collar of 40 years old or more
Go out, wherein 75% belongs to sub-health population, 40% is mainly confirmed fatigue, and is chronically at the people of sub-health state, although
There is no specific disease, but the decline of mental energy and adaptability occur, if this state cannot timely be entangled
Just, it is very easy to cause psychosomatic disease.In order to correct this state, people are typically to be improved by taking health products.Cause
This current urgent need is developed and develops the better health food that a kind of suitable sub-health population is taken, to alleviate them well
Subhealth symptom, improve their quality of life.
The content of the invention
The technical problem to be solved in the present invention is to how alleviate people's subhealth symptom, people's quality of life is improved, and
A kind of health food containing curcumin and preparation method thereof is provided.
In order to solve the above-mentioned technical problem, according to an aspect of the present invention, the present invention provides one kind to contain curcumin
Health food, which includes the raw material (raw materials used commercially available acquisition) of following parts by weight：Bisdemethoxycurcumin 0~50
Part, 20~40 parts of agate card extract, 5~15 parts of wolfberry fruit extract, 10~30 parts of xylo-oligosaccharide.
Preferably, the health food includes the raw material of following parts by weight：5~45 parts of bisdemethoxycurcumin, agate card extract 25~
35 parts, 6~10 parts of wolfberry fruit extract, 15~25 parts of xylo-oligosaccharide.
Preferably, the health food includes the raw material of following parts by weight：40 parts of curcumin, 30 parts of agate card extract, Chinese holly
7 parts of Qi extract, 20 parts of xylo-oligosaccharide.
Preferably, the granularity of the curcumin is 120~200 mesh.The curcumin can be made through superfine grinding method.
Preferably, the curcumin is to be extracted in autumn Rhizoma Curcumae Longae.
Not necessarily, the health food further includes the raw material of following parts by weight：Hydroxypropyl methylcellulose aqueous solution 1.5~2
Part, 0.5~1 part of magnesium stearate.
Preferably, the health food includes the raw material of following parts by weight：2 parts of hydroxypropyl methylcellulose aqueous solution, stearic acid
1 part of magnesium.
Preferably, the mass concentration of the hydroxypropyl methylcellulose aqueous solution is 1.5%~2%.
According to another aspect of the present invention, the present invention also provides a kind of preparation sides of the health food containing curcumin
Method, this method comprises the following steps：
1) stock up：Raw material is weighed by weight；
2) mix：Curcumin, agate card extract, wolfberry fruit extract and xylo-oligosaccharide are uniformly mixed 35~45 minutes, it is standby
With；
3) it is granulated：Hydroxypropyl methylcellulose aqueous solution is added in into said mixture, uniformly mixes, is made on granulator
Grain, obtains wet granular, and granularity is 14~16 mesh；
4) it is dry：It is the 3%~4% of gross weight by the wet granular drying to moisture；
5) whole grain：Dried particle is subjected to whole grain, granularity is 14~16 mesh；
6) tabletting：Magnesium stearate is added in particle after whole grain uniformly to mix, and is pressed into sheet, is sterilized, is packed, i.e.,
Obtain finished product.
Preferably, in drying steps, drying temperature is 50~60 DEG C, and drying time is 4~5 hours.
Ultramicro grinding, mixing, granulation, drying, whole grain, tabletting, sterilization, packaging are common process used in the present invention.
Advantageous effect
Health food of the present invention containing curcumin has strengthen immunity, slows down aging, and adjusts intestinal flora, promotes people
The effect of body nutrient absorption, alleviation subhealth symptom；Health food of the present invention also has many advantages, such as to be convenient for carrying, and is easy to take.
Specific embodiment
Hereinafter, it will be described in detail the present invention.Before doing so, it should be appreciated that in this specification and appended
Claims in the term that uses should not be construed as being limited to general sense and dictionary meanings, and inventor should allowed
On the basis of appropriate definition term is to carry out the principle of best interpretations, according to meaning corresponding with the technical aspect of the present invention and generally
Thought explains.Therefore, description presented herein is not intended to limitation originally merely for the sake of the preferred embodiment for illustrating purpose
The scope of invention, it will thus be appreciated that without departing from the spirit and scope of the present invention, it can be obtained by it
His equivalents or improved procedure.
" turmeric " existing 5000 in human history, except being flavorant, it may have anti-oxidant, anti-inflammatory work(
Effect.Curcumin is a kind of pigment extracted from zingiberaceous plant turmeric, and there is also in other zingiberaceous plants.Modern study finds ginger
Flavine can inhibit inflammatory reaction, anti-oxidant, resisting rheumatoid disease effect.U.S. VITY vitamin magazine rans：" the master of curcumin
Pharmacological action is wanted to have anti-oxidant, anti-inflammatory, anti-freezing, lipid-loweringing, antiatherosclerosis, anti-aging to eliminate free radical and inhibit tumour life
It is long etc..In November, 2006, the U.S.《Arthritis and rheumatism》One article of periodical points out, curcumin can prevent arthrocele,
Arthritis is again effective to angiocardiopathy, cancer etc..
1st, anti-inflammatory effect
Current experiment is it has been found that the anti-inflammatory effectiveness of curcumin even can be compared to some steroid hormones.And so far
Until, people, which are not found curcumin, any toxic side effect.This effect of nothing suspected of curcumin in anti-inflammatory field from now on,
Depict the very attracting prospect of a width.
2nd, antitumaous effect
Scientific research personnel has found that curcumin is to much very pernicious cancer cell, such as breast cancer, cancer of pancreas, oophoroma, white blood
Sick cell and the very high rectum cancer cell of incidence, all very effectively.National Health Service (NIH) the approved curcumin in the U.S.
Clinical trial is come into effect, treats breast cancer, the carcinoma of the rectum and cancer of pancreas.At present, has the data confirm that of some clinical tests
Curcumin authoritative conclusion effective to rectum cancer treatment but last, may also need more clinical datas that can just draw.
3rd, antioxidation
The aging of organism and the generation of many diseases are since organism generates excess in the reaction of aerobic respiration
Free radical, and if the lipid film, DNA and albumen qualitative response of these excessive free radicals and cell can cause oxidative damage.
This oxidative damage the result is that the eubolism functional imbalance of organism, the integration ability of cell itself is lost, many enzymes
Vigor change etc., finally results in disease.Experiment shows that curcumin has very strong antioxidation.
4th, nervous system protective effect anti-senile dementia disease
The activity for suffering from this enzyme in senile dementia patient's brain, which reduces, even to be lost, and does not remove this amylaceous egg
White matter.It has been demonstrated that, curcumin can be by the adjusting of enzymatic activity and other effects, preventing amyloid protein in brain
Aggregation, is effectively prevented this albumen and is deposited on neuromere.
5th, protect liver effect
Liver is the most multi-functional organ of human body, except that can exclude various interior exotic toxins and important metabolism
Center has the function of to generate energy, synthesis nutrient etc..Can say be in addition to giving birth to a child, what all can liver because with excellent
Regeneration function, even if be damaged can self-healing regeneration, it is not excessive it is impaired reache a certain level, just easily trigger various
Liver diseases (such as hepatitis, fatty liver, liver cancer, hepatic sclerosis) oxidative pressure is played an important role in liver diseases.And curcumin
Because having mechanism that is special anti-oxidant and inhibiting NF-kB transcription factors, therefore protect liver effect has been taken off at most studying at present
Dew has effects that prevent a variety of toxin damage liver (such as Aflatoxin, Fe supply, antibiotic, alcohol, carcinogenic substance ＂ sulphur acetyl
Amine ＂ carbon tetrachloride etc.), but belong to animal and cell experiment mostly.In addition, other researchs also find curcumin with anti-grease in succession
Fat liver is reversed because of the effect for the liver fibrosis that carbon tetrachloride is triggered.
Agate card (scientific name：Lepidium meyenii Walp.), it is (Spanish：Maca).It is the one kind for originating in South America
Crucifer.Leaf is oval, and rhizome likeness in form turnip radish, edible is a kind of natural food, and nutrition is enriched, and is had
The reputation of " South America ginseng ".The hypocotyl of agate card may be in golden either faint yellow, red, purple, blueness, black or green.
Flaxen most common, and shape, taste are preferably also.
Agate card is rich in high unit nutrient, there is the function of nourishing and fit keeping function to human body.Italian scientist DiniA was in 1994
The chemical composition composition in the dry root of agate card has systematically been drawn for the first time：Protein content is more than 10% (the agate card of Hu Ning lakesides
The protein content of kind is more than 14%) 59% carbohydrate；8.5% fiber, include abundant zinc, calcium, iron, titanium,
The minerals such as rubidium, potassium, sodium, copper, manganese, magnesium, strontium, phosphorus, iodine, and contain vitamin C, B1, B2, B6, A, E, B12, B5, fat content
Not high but be wherein mostly unrighted acid, up to more than 53%, natural activity composition includes life for the content of linoleic acid plus linolenic acid
Alkaloids, glucosinolate and its decomposition product benzyl isothiocyanate, sterol, polyphenols etc..1999, American scientist was found
Containing the new vegetable active composition of two classes in agate card, macamides (macamides) He Maka is dilute (macaenes), and determines
Both substances have remarkable effect to balanced human's hormone secretion, the natural hormone engine so agate card is otherwise known as.
Wolfberry fruit extract extracts for natural Chinese wolfberry fruit, has nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint,
Dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.There is facilitation to immunity, while there is immunoregulation effect；
Plasma testosterone level can be improved, is served strong；There is facilitation to hematopoiesis function；Also there is notable increasing leucocyte to normal healthy people
Effect；Also anti-aging, anti-mutation, antitumor, reducing blood lipid, liver protection and anti-fatty liver, hypoglycemic, hypotensive activity.
Xylo-oligosaccharide is a kind of natural active matter.Sugariness is 0.3-0.6 times of sucrose.Both the pure sweet tea of sucrose had been maintained
Taste property, but it is salubriouser than sucrose sweet taste, have and adjust intestinal flora, be proliferated Bifidobacterium, promote the absorption of calcium, adjust blood fat,
Immune, anti-caries tooth is adjusted, prevents the novel sweetener of the healthcare functions such as diarrhea and constipation.Xylo-oligosaccharide is in enteron aisle to bifid bar
Bacterium also has highly selective cultivation effect；Enhance body immunity by being proliferated intestinal bifidobacteria.
Hydroxypropyl methylcellulose has a thickening capabilities, salt tolerance, low ashes, pH stability, water-retaining property, dimensional stability, excellent
The features such as good film forming and extensive resistance to enzymatic, dispersiveness and caking property.
Magnesium stearate is the light fine powder without grittiness of white, micro- to have special smell, has a soapy feeling with skin contact, not soluble in water,
Ethyl alcohol and ether, are dissolved in hot water, hot ethanol, and acid decomposition is stearic acid and corresponding magnesium salts.
Following embodiment is enumerated only as the example of embodiment of the present invention, does not form any limit to the present invention
System, it will be appreciated by those skilled in the art that each falling within the present invention without departing from the modification in the range of the essence of the present invention and design
Protection domain.Unless stated otherwise, the reagent and instrument used in following embodiment is commercially available product.
Embodiment 1
The health food includes the raw material of following parts by weight：40 parts of curcumin, 30 parts of agate card extract, wolfberry fruit extract 7
Part, 20 parts of xylo-oligosaccharide, mass concentration be 2% 2 parts of hydroxypropyl methylcellulose aqueous solution, 1 part of magnesium stearate.
The preparation method of above-mentioned health food, comprises the following steps：Raw material is weighed by weight.By curcumin, agate card carries
Object is taken, is uniformly mixed in wolfberry fruit extract and xylo-oligosaccharide input mixer, incorporation time is 40 minutes, obtains mixture；
It will add in the hydroxypropyl methylcellulose aqueous solution input oscillating granulator that 2 parts of mass concentrations are 2% and carry out in the mixture
It is granulated, obtains wet granular, 14 mesh of granularity；Then the wet granular is placed in drying in 55 DEG C of drying box, drying time is 4 small
When, drying to pellet moisture is down to the 3% of gross weight；Dried particle is subjected to whole grain again, the granularity of whole grain is 14 mesh；Exist again
1 part of magnesium stearate is added in dried particle, is uniformly mixed, is sent into tabletting in tablet press machine；Finally by the tablet after tabletting
It is sterilized, packs, finished product is made.
Embodiment 2
The health food includes the raw material of following parts by weight：5 parts of bisdemethoxycurcumin, 25 parts of agate card extract, wolfberry fruit extract 6
Part, 15 parts of xylo-oligosaccharide, mass concentration be 1.5% 2 parts of hydroxypropyl methylcellulose aqueous solution, 1 part of magnesium stearate.
The preparation method of above-mentioned health food, comprises the following steps：Raw material is weighed by weight.By curcumin, agate card carries
Object is taken, is uniformly mixed in wolfberry fruit extract and xylo-oligosaccharide input mixer, incorporation time is 35 minutes, obtains mixture；
To be added in the mixture hydroxypropyl methylcellulose aqueous solution that 2 parts of mass concentrations are 1.5% put into oscillating granulator into
Row is granulated, and obtains wet granular, 15 mesh of granularity；Then the wet granular is placed in drying in 50 DEG C of drying box, drying time is 5
Hour, drying to pellet moisture is down to the 4% of gross weight；Dried particle is subjected to whole grain again, the granularity of whole grain is 15 mesh；Again
1 part of magnesium stearate is added in particle after the drying, is uniformly mixed, is sent into tabletting in tablet press machine；Finally by the piece after tabletting
Agent is sterilized, and finished product is made in packaging.
Embodiment 3
The health food includes the raw material of following parts by weight：45 parts of curcumin, 35 parts of agate card extract, wolfberry fruit extract 10
Part, 25 parts of xylo-oligosaccharide, mass concentration be 1.5% 1.5 parts of hydroxypropyl methylcellulose aqueous solution, 0.5 part of magnesium stearate.
The preparation method of above-mentioned health food, comprises the following steps：Raw material is weighed by weight.By curcumin, agate card carries
Object is taken, is uniformly mixed in wolfberry fruit extract and xylo-oligosaccharide input mixer, incorporation time is 45 minutes, obtains mixture；
The hydroxypropyl methylcellulose aqueous solution that 1.5 parts of mass concentrations are 1.5% will be added in the mixture to put into oscillating granulator
It is granulated, obtains wet granular, 16 mesh of granularity；Then the wet granular is placed in drying in 60 DEG C of drying box, drying time is 4
A hour, drying to pellet moisture are down to the 3% of gross weight；Dried particle is subjected to whole grain again, the granularity of whole grain is 16 mesh；
1 part of magnesium stearate is added in particle after the drying again, is uniformly mixed, is sent into tabletting in tablet press machine；It finally will be after tabletting
Tablet is sterilized, and finished product is made in packaging.
Embodiment 4
Compared with Example 1, distinctive points are only that, specific formula is as follows in the present embodiment：
The health food includes the raw material of following parts by weight：0 part of bisdemethoxycurcumin, 20 parts of agate card extract, wolfberry fruit extract 5
Part, 10 parts of xylo-oligosaccharide, mass concentration be 2% 2 parts of hydroxypropyl methylcellulose aqueous solution, 1 part of magnesium stearate.
Finished tablet is prepared according to the same procedure described in embodiment 1.
Embodiment 5
Compared with Example 1, distinctive points are only that, specific formula is as follows in the present embodiment：
The health food includes the raw material of following parts by weight：50 parts of curcumin, 40 parts of agate card extract, wolfberry fruit extract 15
Part, 30 parts of xylo-oligosaccharide, mass concentration be 1.5% 1.5 parts of hydroxypropyl methylcellulose aqueous solution, 0.5 part of magnesium stearate.
Finished tablet is prepared according to the same procedure described in embodiment 1.
Test example 1
Health food made from embodiment 1 is subjected to edible safety test and Ergonomy test, foundation《Health food is examined
It tests and assessment technique specification (2003 editions)》Content is tested.As a result it is as follows：
First, acute toxicity test
1. sample：Sample prepared by formula and technique as described in embodiment 1.
2. experimental animal：SPF grades of Kunming mouses.
3. its mouse oral acute toxicity test (MTD)：Selection SPF grades of 18~22g Kunming mouses 20, half male and half female,
With the oral secondary gavage of the dosage of 20g/kgBW, it is observed continuously after administration 14 days.Record poisoning manifestations and death condition.
4. result：With the mouse of two kinds of genders of dosage gavage of 20g/kgBW, observe 14 days.During the experiment has no apparent
Poisoning manifestations, without death in the observation period.Tested material is all higher than 20g/ to the acute oral toxicity (MTD) of the mouse of two kinds of genders
KgBW, according to《Toxicological evaluation of food safety procedure and method》(version in 2003) acute toxicity is classified, and belongs to nontoxic grade.
Table 1：The acute toxicity tests of sample mouse
2nd, 30 days feeding trials
1. sample：Sample prepared by formula and technique as described in embodiment 1.It is 2.0g/50kgBW that people, which intends with dosage,
Day.
2. experimental animal：Select weight 50~60g, SD rat 60, half male and half female.
3. test method：Rat is randomly divided into three tested material groups and a control group, every group 20, half male and half female.
Control group is fed with arm's length basis block, and tested material group is then fed with incorporation various dose sample, and dose design is：Low,
Middle and high dosage group is respectively 1,2,4g/kgBW (be respectively equivalent to people and intend 25 times, 50 times, 100 times with dosage).It is continuous to see
It examines 30 days.
4. observation index and result
4.1 ordinary circumstances are observed：
Performance, behavior, toxicity performance and the death condition of observation animal daily.It weighs weekly 1 time and food intake dose
Twice, food utilization and total food utilization weekly are calculated.As a result each group animal growth, activity are normal, without in
Poison performance and dead, each group animal weight, weekly body weight evolution, weekly food-intake and food utilization and total weekly weekly
Body weight evolution, total food-intake and the equal no difference of science of statistics (P of total food utilization rate>0.05).
4.2 hematological examination：
It measures content of hemoglobin (Hgb), red blood cell (RBC) and leucocyte (WBC) to count, leukocyte differential count (lymph, list
Core, neutral grain, acidophilus, basophilic).Latter stage hematological indices are tested in range of normal value, each group animal blood red eggs
In vain, red blood cell and white blood cell count(WBC), leukocyte differential count equal no difference of science of statistics (P compared with the control group>0.05).
4.3 Biochemical Indexes：
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN),
Cholesterol (CHO), triglycerides (TG), blood glucose (GLU), total protein (TP), albumin (ALB), creatinine (CRE).Test latter stage
Experimental animal items biochemical indicator is in range of normal value, and each group animal blood biochemistry index is compared with the control group without statistics
Difference (P>0.05).
4.4 gross examination of skeletal muscle and pathologic diagnosis：
It tests latter stage cervical dislocation and puts to death animal, observe each main organs and chest, abdominal cavity general pathology change.It takes out all
Liver, kidney, spleen, the testis of animal weigh and calculate organ coefficient.Take out control group and high dose group animal liver,
Kidney, spleen, testis (or ovary), stomach and duodenum, are fixed with 12% formalin, paraffin embedding, section, HE dyeing,
Histological examination is carried out under light microscopic.The pathology that each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) are showed no meaning changes
Become.
Above-mentioned acute toxicity test and 30 days feeding trials, can be long-term use of the result shows that this product belongs to nontoxic grade.
3rd, Ergonomy is tested
1st, sample：Sample prepared by formula and technique as described in embodiment 1.Negative controls are turmeric plain piece, are formulated
For 77 parts of curcumin, mass concentration is 2% 2 parts of hydroxypropyl methylcellulose aqueous solution, 1 part of magnesium stearate.
2nd, experimental animal：SPF grades of health NIH kinds male mices 240, weight are 18~22 grams.
3rd, experimental method
It is taken according to population and recommends dosage, if the basic, normal, high dosage group difference 200 of sample, 400,800mg/kgBW are (respectively
It is equivalent to 5,10,20 times that human body recommends dosage), if a negative control group, every group of 10 animals.Embodiment 1 is weighed respectively
Sample 2,4,8 grams respectively plus pure water is to 200ml, mixing, be made into 10,20,40mg/mL strength solutions, by the body of 0.2mL/10g BW
Product gives corresponding dosage group animal gavage, and negative control group (full turmeric plain piece) gives isometric pure water, daily gavage once,
Continuous gavage measures every strengthen immunity functional parameter after 30 days.
4th, observation index
The influence of 4.1 pairs of mouse weights
Different immune groups experiment initial stage, experiment mid-term, experiment latter stage embodiment 1 each dosage group of sample mouse weight and
Comparison between the body weight increase and negative control group (full turmeric plain piece) of during the experiment mouse, there are no significant for difference (P ＞
0.05), show that the sample has no significant effect the body weight increase of mouse.
The influence of 4.2 pairs of mouse thymus, spleen organ
Table 2：Influence to mouse thymus, spleen organ
By table 2 as it can be seen that 1 sample of embodiment of orally administration mouse various dose 30 days, the thymus gland/weight and spleen of mouse
For dirty/weight ratio compared with negative control group (full turmeric plain piece), difference that there are no significant (P ＞ 0.05) shows the sample pair
The immune organ weight of mouse has no significant effect.
The influence of the cellular immunity of 4.3 pairs of mouse：Influence to the mouse spleen lymphocyte conversion capability of ConA inductions
Table 3：The influence converted to the mouse spleen lymphocyte of ConA inductions
As seen from Table 3,1 sample of embodiment of orally administration mouse various dose 30 days, the lymph of each dosage group mouse is thin
Born of the same parents' conversion capability is above negative control group (full turmeric plain piece), and the difference of high, middle dose group and negative control group is with aobvious
Work property (P ＞ 0.05) shows that the sample plays an important role of the lymphocyte proliferation, the conversion capability that promote mouse.
The influence of the humoral immunity of 4.4 pairs of mouse：Influence to the antibody-producting cell number of mouse
Table 4：Influence to mouse hemolysis plaque number
As seen from Table 4,1 sample of embodiment of orally administration mouse various dose 30 days, the antibody life of each dosage group mouse
Negative control group (full turmeric plain piece) is above into cell number, the difference of high dose group and negative control group therein has significantly
Property (P ＜ 0.05), show the sample play an important role of promote mouse antibody-producting cell multiplication.
The influence of the NK cytoactives of 4.5 pairs of mouse
Table 5：Influence to NK cytoactives
As seen from Table 5,1 sample of embodiment of orally administration mouse various dose 30 days, the NK of each dosage group mouse of sample
Cytoactive is above negative control group (full turmeric plain piece), and the wherein difference of high dose group and negative control group has conspicuousness
(P ＜ 0.05) shows that the sample plays an important role of the NK cytoactives for promoting mouse.
5th, functional evaluation result
Experimental result shows that 1 sample of embodiment can promote the lymphopoiesis of mouse, transformation, promote mouse
Antibody-producting cell is proliferated, and promotes the NK cytoactives of mouse, body weight increase, thymus gland/weight ratio, spleen/body to mouse
Weight ratio has no significant effect.According to《Health food is examined and assessment technique specification》, can determine that 1 sample of embodiment is small with enhancing
The effect of mouse immunity is better than negative controls (full turmeric plain piece) effect.
Embodiment of above is merely to illustrate the present invention rather than limitation of the present invention.Although with reference to embodiment to this hair
It is bright to be described in detail, it will be understood by those of ordinary skill in the art that, to technical scheme carry out it is various combination,
Modification or equivalent substitution, without departure from the spirit and scope of technical solution of the present invention, the right that should all cover in the present invention is wanted
It asks among scope.
Claims (9)
1. a kind of health food containing curcumin, the health food include the raw material of following parts by weight：0~50 part of bisdemethoxycurcumin,
20~40 parts of agate card extract, 5~15 parts of wolfberry fruit extract, 10~30 parts of xylo-oligosaccharide.
2. the health food according to claim 1 containing curcumin, which is characterized in that the health food includes as follows
The raw material of parts by weight：5~45 parts of bisdemethoxycurcumin, 25~35 parts of agate card extract, 6~10 parts of wolfberry fruit extract, xylo-oligosaccharide 15~
25 parts.
3. the health food according to claim 1 containing curcumin, which is characterized in that the health food includes as follows
The raw material of parts by weight：40 parts of curcumin, 30 parts of agate card extract, 7 parts of wolfberry fruit extract, 20 parts of xylo-oligosaccharide.
4. the health food as claimed in any of claims 1 to 3 containing curcumin, which is characterized in that the ginger
Flavine is to be extracted in autumn Rhizoma Curcumae Longae.
5. the health food as claimed in any of claims 1 to 3 containing curcumin, which is characterized in that nonessential
Ground, the health food further include the raw material of following parts by weight：1.5~2 parts of hydroxypropyl methylcellulose aqueous solution, magnesium stearate 0.5
~1 part.
6. the health food according to claim 5 containing curcumin, which is characterized in that the hydroxypropyl methylcellulose is water-soluble
Liquid is 2 parts, and magnesium stearate is 1 part.
7. the health food according to claim 5 containing curcumin, which is characterized in that the hydroxypropyl methylcellulose is water-soluble
The mass concentration of liquid is 1.5%~2%.
8. a kind of preparation method of the health food containing curcumin, this method comprises the following steps：
1) stock up：Raw material is weighed by weight；
2) mix：Curcumin, agate card extract, wolfberry fruit extract and xylo-oligosaccharide are uniformly mixed 35~45 minutes, it is spare；
3) it is granulated：Hydroxypropyl methylcellulose aqueous solution is added in into said mixture, uniformly mixes, pelletizes on granulator,
Wet granular is obtained, granularity is 14~16 mesh；
4) it is dry：It is the 3%~4% of gross weight by the wet granular drying to moisture；
5) whole grain：Dried particle is subjected to whole grain, granularity is 14~16 mesh；
6) tabletting：In particle after whole grain add magnesium stearate uniformly mix, be pressed into sheet, sterilized, pack to get into
Product.
9. preparation method according to claim 8, which is characterized in that in drying steps, drying temperature is 50~60 DEG C,
Drying time is 4~5 hours.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114698720A (en) * | 2022-05-13 | 2022-07-05 | 河南羚锐制药股份有限公司 | Chewing or buccal candy for enhancing immunity |
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