CN101642470A - Deer product effervescent tablets prepared by microshearing-additive interaction technology and preparation method thereof - Google Patents
Deer product effervescent tablets prepared by microshearing-additive interaction technology and preparation method thereof Download PDFInfo
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- CN101642470A CN101642470A CN200910304694A CN200910304694A CN101642470A CN 101642470 A CN101642470 A CN 101642470A CN 200910304694 A CN200910304694 A CN 200910304694A CN 200910304694 A CN200910304694 A CN 200910304694A CN 101642470 A CN101642470 A CN 101642470A
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Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses deer product effervescent tablets prepared by microshearing-additive interaction technology and a preparation method thereof, belonging to the technical field of the preparation process of effervescent tablets. The deer product effervescent tablets prepared by microshearing-additive interaction technology is characterized in that in the pretreatment process, the deer product used as main material is cleaned, dried and crushed coarsely to be processed to deer product microshearing additive powder by using microshearing-additive interaction technology. The components areas follows by weight percent: 1-20% of deer product microshearing additive powder, disintegrant containing 10-35% of acidic agent, 10-35% of basic agent and 0-30% of auxiliary disintegrant, auxiliarymaterial containing 0-15% of adhesive, 0-15% of lubricant, 0-10% of sweetener and 0-10% of aromatizer. The effect and advantage of the invention are that the deer product effervescent tablets of the invention have the functions of regulating balance of organisms, relaxing muscle and tendons, resisting aging and the like; the deer product effervescent tablets obtained of the invention have simple use, high effective utilization and wide market prospect.
Description
Technical field
The invention belongs to the fabricating technology field of effervescent tablet, be specifically related to micro-shear transformation accessory ingredient interaction and make deer product effervescent tablets of technology preparation and preparation method thereof.
Background technology
Deer is the traditional precious medicinal animal of China, and deer a lot of positions and products thereof on one's body all has long medicinal history in China.Existing so far 28 positions and processed goods thereof are applied to nourishing and fit keeping function and the multiple disease of treatment.
Cornu Cervi Pantotrichum is a kind of traditional famous and precious health care medical material in China, puts down in writing in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica: " Cornu Cervi Pantotrichum can promote the production of body fluid benefit marrow, the Yiyang of nourishing blood; strengthening the tendons and bones ", Shennong's Herbal meaning Cornu Cervi Pantotrichum " the sweet in the mouth temperature, the main stagnant blood that leaks down; cold and heat are shied carbuncle, the strong will of QI invigorating, the population is not old ".Cornu Cervi Pantotrichum not only is used for clinical being used as medicine and prescription among the people historical of long standing and well established in China, is also extensively quoted in Japan, Korea, the Soviet Union, Mongolia and south east asia folk medicine.The scientific research in modern age proves that further its pharmacological action mainly is to regulate the body metabolism, promotes effects such as various physiological function activities.
Embryo cervi is Embryo cervi beast and Placenta Hominis.First year of the pharmacological action of Embryo cervi " book on Chinese herbal medicine is newly organized " has the effect of " kidney tonifying sun, replenishing vital essence and blood ", is mainly used in deficiency of kidney essence, and is weak unable, asthenia of essence and blood, and menoxenia, bleeding not during menses, disease such as fail to be impregnated for a long time is in the custom that also has as tonic among the people.
LUJIAOMAO is after Cornu Cervi Pantotrichum amputates, and stays the ossified thing of residue Cornu Cervi Pantotrichum on the bone knob, and take off every year, and shape is as dish.Cornu Cervi, LUJIAOMAO are different is that the ossification intensity of Cornu Cervi is lower than LUJIAOMAO.LUJIAOMAO is the raw material of Cornu Cervi Degelatinatum, Colla cornus cervi, its chemical constituent mainly comprises water, inorganic matter and Organic substance three major types, be rich in that a large amount of human bodies need and can not synthetic aminoacid, also contain elements such as calcium, phosphorus, magnesium, sodium, potassium, ferrum, manganese, zinc, strontium, barium.
Sanguis cervi, Compendium of Material Medica record road " big tonifying deficiency, benefiting essence-blood ".Modern study thinks that Sanguis cervi enhances metabolism, and constitutional effect has better curative effect to neurasthenia, insomnia and various deficient disease.
In addition, deer products such as Carnis Cervi, deer milk, deer perfume, Cauda cervi, Penis et testis cervi, deer testicular fluid, Ligamentum cervi, Corium Cervi, Adeps Cervi, Cor Cervi, deer liver, deer lung, Os Cervi, brain of Cervus nippon Temminck (C. elaphus L.), Medulla cervi also have good tonic effect.
But, the method of the simple pulverizing that traditional deer product processing is adopted can not make the various active component of deer product effectively discharge, though and the superfine communication technique that grows up is subsequently compared with conventional art and is had marked improvement, but its essence all is the different physical means of utilization, make plant granule group or micel generation physical change, do not change the dissolubility of effective ingredient, so some effective ingredient poorly water-soluble, problem that bioavailability is low are not solved at all.And the organic solvent extraction method has not only been wasted a large amount of organic solvents, and is difficult to avoid the negative issue that residual organic solvent brought in the deer product.
Micro-shear transformation accessory ingredient interaction is made technology as the new method of extracting the animals and plants active component in recent years, its ultimate principle is: the animal-plant material cluster of grains is through the micro-cutting born of the same parents' fragmentation that attenuates, cell surface produces fresh tangent plane, group or intermolecular mutual absorption or effect take place between auxiliary agent and the effective ingredient, change the micro-property of effective ingredient, surface energy increases, specific surface area increases, adsorptivity and polarity increase, and the micro-cutting of doing to obtain after the technical finesse by micro-shear transformation accessory ingredient interaction helps the dissolubility of powder in water to improve greatly.
Patent of invention: a kind of effective plant component extracting process that is used for, granted patent number: ZL200510130852, its main technical scheme is that the plant material that will be extracted is pulverized, in the plant coarse powder, add the chemical assistant of 0.5%-20% solid base, solid acid, sucrose or salt compounds powder, mechanical activation comminution together again, select water or dissolve with ethanol ground product for use, separated and collected solubility component obtains effective ingredient.
The former dosage form of deer product has oral liquid, unguentum, granule and capsule.Wherein the less stable of oral liquid formulations is transported and carries also very inconvenient; Though unguentum and granule stability and portable aspect certain advantage is arranged, have drawbacks such as mouthfeel is poor, the effective ingredient dissolution rate is low; Inconvenient crowd takes capsule because it is not suitable for swallowing again, has therefore limited the application of deer product to a certain extent.Effervescent tablet is to make disintegration of tablet form foamy dosage form according to suitable bronsted lowry acids and bases bronsted lowry chemically reactive release of carbon dioxide.This dosage form drug release rate is fast, bioavailability is high, take with easy to carry, the consumer that is particularly useful for child, old man and can not swallows solid preparation, advantages such as having the dosage form novelty, conveniently use, efficiently utilize, market prospect is wide.
Therefore, this novel dosage form of effervescent tablet and micro-shear transformation accessory ingredient interaction are made this technology of technology deer product effervescent tablets of producing that combines and had vast market.
Summary of the invention
The technical problem to be solved in the present invention provides micro-shear transformation accessory ingredient interaction and makes deer product effervescent tablets of technology preparation and preparation method thereof.
Technical scheme following steps of the present invention:
This product effervescent tablets, in the pre-treatment process, as the deer product of major ingredient through cleaning, after dry, the coarse pulverization, adopting micro-shear transformation accessory ingredient interaction to be processed as deer product micro-cutting and help powder as technology.Each set of dispense than (percentage by weight) is: deer product micro-cutting helps powder 1-20%, and disintegrating agent comprises sour agent 10-35%, alkaline agent 10-35% and auxiliary disintegrating agent 0-30%; Other adjuvants comprise binding agent 0-15%, lubricant 0-15%, sweeting agent 0-10%, aromatic 0-10%.
The acid agent can be selected one or more in citric acid, tartaric acid, malic acid, fumaric acid, citric acid, the sodium dihydrogen citrate salt for use.
Alkaline agent can be selected one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium bicarbonate, the calcium carbonate for use.
Auxiliary disintegrating agent can select and draw in low-substituted hydroxypropyl cellulose (L-HPC), microcrystalline Cellulose (MCC), the crospolyvinylpyrrolidone (PVPP) one or more.
Binding agent can be selected one or more in polyvinylpyrrolidone (PVP), ethanol, the isopropyl alcohol for use.
Lubricant can be selected one or more in Polyethylene Glycol (PEG) 6000, ethylene glycol (PEG) 4000, sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide for use.
Sweeting agent can be selected one or more in xylitol, sucrose, lactose, protein sugar, cyclamate, steviosin, acesulfame potassium, aspartame, saccharin sodium, Calcium o-benzolsulfimide, glycyrrhizin, the sucralose for use.
Aromatic can be selected one or more in Fructus Citri Limoniae essence, hami melon essence, blue berry essence, orange essence, flavoring orange essence, honey peach essence, flavoring banana essence, Herba Menthae essence, the tea flavour additive for use.
The preparation method of this deer product effervescent tablets has following three kinds:
Method one: the deer product obtains the above deer product micro-cutting of 200 orders and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, and airtight preservation is standby; With top sieve, airtight preservation is standby with sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, lubricant, sweeting agent and aromatic pulverize separately, mistake 60 orders; The temperature that controls environment in the preparation process is at 15-30 ℃, and humidity is below 50%; By aforesaid deer product effervescent tablets proportion of composing micro-cutting is helped powder and sour agent, alkaline agent, assists disintegrating agent, binding agent, lubricant, sweeting agent, the abundant mixing of aromatic fine powder, tabletting, obtain required deer product effervescent tablets.
Method two: the deer product obtains the above deer product micro-cutting of 200 orders and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, and airtight preservation is standby; With top sieve, airtight preservation is standby with sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, lubricant, sweeting agent and aromatic pulverize separately, mistake 60 orders; The temperature that controls environment in the preparation process is at 15-30 ℃, and humidity is below 50%; After by aforesaid deer product effervescent tablets proportion of composing micro-cutting being helped powder and sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, sweeting agent, aromatic, the abundant mixing of part lubricant fine powder, 12-18 order granule is made in mixed powder compression, fragmentation; Tabletting behind granule and the abundant mixing of part lubricant fine powder obtains required deer product effervescent tablets.
Method three: the deer product obtains the above deer product micro-cutting of 200 orders and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, and airtight preservation is standby; With top sieve, airtight preservation is standby with sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, lubricant, sweeting agent and aromatic pulverize separately, mistake 60 orders; The temperature that controls environment in the preparation process is at 15-30 ℃, and humidity is below 50%; Press aforesaid deer product effervescent tablets proportion of composing with sour agent fine powder and after partly assisting disintegrating agent, binding agent fine powder mix homogeneously, 12-18 order granule is made in mixed powder compression, fragmentation, the dry A granule that gets, standby; Behind the auxiliary disintegrating agent of alkaline agent fine powder and part, binding agent fine powder mix homogeneously, 12-18 order granule is made in mixed powder compression, fragmentation, the dry B granule that gets, standby; Help powder to mix the gained micro-cutting, add lubricant, sweeting agent and aromatic fine powder, fully mix and tabletting, obtain required deer product effervescent tablets with A, B granule.
The prepared effervescent tablet profile of the present invention can be annular, spheroid, spheroid, cylinder, Rotary-table, square, cuboid, special-shaped assembly or the like.
Effect of the present invention and benefit are:
(1) micro-cutting that obtains of the present invention helps the powder effervescent tablet to have effects such as the organism balance of adjusting, channels sootheing and network vessel quickening, kidney tonifying sun, replenishing vital essence and blood, resisting fatigue, defying age, calmness;
(2) micro-cutting that obtains of the present invention helps powder effervescent tablet raw material consumption rationally, accurately;
(3) micro-cutting that obtains of the present invention helps that the powder effervescent tablet safe and reliablely, convenient uses, efficiently utilizes, market prospect is wide.
The specific embodiment
Be described in detail embodiments of the invention below in conjunction with technical scheme.
Embodiment 1
Micro-cutting change-auxiliary agent is made the Cornu Cervi Pantotrichum effervescent tablet of technology preparation mutually
Cornu Cervi Pantotrichum obtains 220 purpose micro-cutting and helps powder after cleaning, making beating, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, gets 16 weight portion Cornu Cervi Pantotrichum micro-cutting and helps powder, and airtight preservation is standby; After citric acid, sodium bicarbonate crossed 100 mesh sieves and handle, get 25 weight portions, 30 weight portions respectively, airtight preservation is standby; Lactose, steviosin, polyethylene glycol 6000, low-substituted hydroxypropyl cellulose, silicon dioxide, magnesium stearate, blue berry essence are crossed 80 mesh sieves, get 5 weight portions, 5 weight portions, 6 weight portions, 10 weight portions, 0.7 weight portion, 1.3 weight portions, 1 weight portion respectively, airtight preservation is standby; The temperature that controls environment in the preparation process is at 25 ℃, and humidity is below 40%; The Cornu Cervi Pantotrichum micro-cutting is helped powder and citric acid, sodium bicarbonate, lactose, steviosin, polyethylene glycol 6000, low-substituted hydroxypropyl cellulose, silicon dioxide, magnesium stearate, the abundant mixing of blue berry essence fine powder, tabletting, obtain the Cornu Cervi Pantotrichum effervescent tablet of every heavy 4 grams.
Embodiment 2
Micro-shear transformation accessory ingredient interaction is made the Embryo cervi effervescent tablet of technology preparation
Embryo cervi obtains 220 purpose micro-cutting and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, gets 20 weight portion Embryo cervi micro-cutting and helps powder, and airtight preservation is standby; After citric acid, sodium bicarbonate, sodium carbonate crossed 100 mesh sieves and handle, get 22.5 weight portions, 35.5 weight portions, 7 weight portions respectively, airtight preservation is standby; Protein sugar, lactose, polyethylene glycol 6000, crospolyvinylpyrrolidone, hami melon essence are crossed 80 mesh sieves, get 3 weight portions, 2.5 weight portions, 5 weight portions, 2 weight portions, 2.5 weight portions respectively, and airtight preservation is standby; The temperature that controls environment in the preparation process is at 25 ℃, and humidity is below 40%; After above-mentioned Embryo cervi micro-cutting helped powder and citric acid, sodium bicarbonate, sodium carbonate, protein sugar, lactose, crospolyvinylpyrrolidone, hami melon essence, the abundant mixing of 2.5 weight portion polyethylene glycol 6000 fine powders, 12 order granules are made in mixed powder compression, fragmentation; Tabletting behind granule and the abundant mixing of 2.5 weight portion polyethylene glycol 6000 fine powders obtains every heavy 4 Embryo cervi effervescent tablet that restrains.
Embodiment 3
Micro-shear transformation accessory ingredient interaction is made the LUJIAOMAO effervescent tablet of technology preparation
LUJIAOMAO obtains 220 purpose micro-cutting and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, gets 10 parts of LUJIAOMAO micro-cutting and helps powder, and airtight preservation is standby; After citric acid, sodium bicarbonate crossed 100 mesh sieves and handle, get 25.5 weight portions, 30.5 weight portions respectively, airtight preservation is standby; Microcrystalline Cellulose, polyvinylpyrrolidone, magnesium stearate, xylitol, Fructus Citri Limoniae essence are crossed 80 mesh sieves, get 10 weight portions, 4 weight portions, 3 weight portions, 15 weight portions, 2 weight portions respectively, and airtight preservation is standby; The temperature that controls environment in the preparation process is at 25 ℃, and humidity is below 40%; Behind citric acid fine powder and part microcrystalline Cellulose, polyvinylpyrrolidone fine powder mix homogeneously, 12 order granules are made in mixed powder compression, fragmentation, dry A granule, standby; Behind sodium bicarbonate and part microcrystalline Cellulose, polyvinylpyrrolidone fine powder mix homogeneously, 12 order granules are made in mixed powder compression, fragmentation, dry B granule, standby; Help powder to mix gained LUJIAOMAO micro-cutting, add magnesium stearate, xylitol and Fructus Citri Limoniae essence fine powder, fully mix and tabletting, obtain the LUJIAOMAO effervescent tablet of every heavy 4 grams with A, B granule.
Claims (7)
1. micro-cutting change-auxiliary agent is made the deer product effervescent tablets of technology preparation mutually, it is characterized in that:
In the pre-treatment process, as the deer product of major ingredient through cleaning, after dry, the coarse pulverization, adopting micro-shear transformation accessory ingredient interaction to be processed as deer product micro-cutting and help powder as technology; The percentage by weight of each component is as follows: deer product micro-cutting helps powder 1-20%, and disintegrating agent comprises sour agent 10-35%, alkaline agent 10-35% and auxiliary disintegrating agent 0-30%; Other adjuvants comprise binding agent 0-15%, lubricant 0-15%, sweeting agent 0-10%, aromatic 0-10%;
One or more in citric acid, tartaric acid, malic acid, fumaric acid, citric acid, the sodium dihydrogen citrate salt are selected in the acid agent for use;
Alkaline agent is selected one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, calcium bicarbonate, the calcium carbonate for use;
Auxiliary disintegrating agent is selected from one or more in low-substituted hydroxypropyl cellulose, microcrystalline Cellulose, the crospolyvinylpyrrolidone;
Binding agent is selected one or more in polyvinylpyrrolidone, ethanol, the isopropyl alcohol for use;
Lubricant is selected one or more in polyethylene glycol 6000, ethylene glycol 4000, sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide for use;
Sweeting agent is selected one or more in xylitol, sucrose, lactose, protein sugar, cyclamate, steviosin, acesulfame potassium, aspartame, saccharin sodium, Calcium o-benzolsulfimide, glycyrrhizin, the sucralose for use;
Aromatic is selected one or more in Fructus Citri Limoniae essence, hami melon essence, blue berry essence, orange essence, flavoring orange essence, honey peach essence, flavoring banana essence, Herba Menthae essence, the tea flavour additive for use.
2. the preparation method of the described deer product effervescent tablets of claim 1 is characterized in that following steps:
The deer product obtains the above deer product micro-cutting of 200 orders and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, and airtight preservation is standby; With top sieve, airtight preservation is standby with sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, lubricant, sweeting agent and aromatic pulverize separately, mistake 60 orders; The temperature that controls environment in the preparation process is at 15-30 ℃, and humidity is below 50%; By the described deer product effervescent tablets proportion of composing of claim 1 micro-cutting is helped powder and sour agent, alkaline agent, assists disintegrating agent, binding agent, lubricant, sweeting agent, the abundant mixing of aromatic fine powder, tabletting, obtain required deer product effervescent tablets.
3. the preparation method of the described deer product effervescent tablets of claim 1 is characterized in that following steps:
The deer product obtains the above deer product micro-cutting of 200 orders and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, and airtight preservation is standby; With top sieve, airtight preservation is standby with sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, lubricant, sweeting agent and aromatic pulverize separately, mistake 60 orders; The temperature that controls environment in the preparation process is at 15-30 ℃, and humidity is below 50%; After by the described deer product effervescent tablets proportion of composing of claim 1 micro-cutting being helped powder and sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, sweeting agent, aromatic, the abundant mixing of part lubricant fine powder, 12-18 order granule is made in mixed powder compression, fragmentation; Tabletting behind granule and the abundant mixing of part lubricant fine powder obtains required deer product effervescent tablets.
4. the preparation method of the described deer product effervescent tablets of claim 1 is characterized in that following steps:
The deer product obtains the above deer product micro-cutting of 200 orders and helps powder after cleaning, drying, coarse pulverization, micro-shear transformation accessory ingredient interaction are done technical finesse, and airtight preservation is standby; With top sieve, airtight preservation is standby with sour agent, alkaline agent, auxiliary disintegrating agent, binding agent, lubricant, sweeting agent and aromatic pulverize separately, mistake 60 orders; The temperature that controls environment in the preparation process is at 15-30 ℃, and humidity is below 50%; Press the described deer product effervescent tablets proportion of composing of claim 1 with sour agent fine powder and after partly assisting disintegrating agent, binding agent fine powder mix homogeneously, 12-18 order granule is made in mixed powder compression, fragmentation, the dry A granule that gets, standby; Behind the auxiliary disintegrating agent of alkaline agent fine powder and part, binding agent fine powder mix homogeneously, 12-18 order granule is made in mixed powder compression, fragmentation, the dry B granule that gets, standby; Help powder to mix the gained micro-cutting, add lubricant, sweeting agent and aromatic fine powder, fully mix and tabletting, obtain required deer product effervescent tablets with A, B granule.
5. according to the preparation method of the described deer product effervescent tablets of claim 2, its feature also is to utilize the Cornu Cervi Pantotrichum effervescent tablet step of this method preparation as follows:
Cornu Cervi Pantotrichum obtains 220 purpose micro-cutting and helps powder after cleaning, drying, coarse pulverization, micro-cutting change-auxiliary agent are done technical finesse mutually, gets 16 weight portion Cornu Cervi Pantotrichum micro-cutting and helps powder, and airtight preservation is standby; After citric acid, sodium bicarbonate crossed 100 mesh sieves and handle, get 25 weight portions, 30 weight portions respectively, airtight preservation is standby; Lactose, steviosin, polyethylene glycol 6000, low-substituted hydroxypropyl cellulose, silicon dioxide, magnesium stearate, blue berry essence are crossed 80 mesh sieves, get 5 weight portions, 5 weight portions, 6 weight portions, 10 weight portions, 0.7 weight portion, 1.3 weight portions, 1 weight portion respectively, airtight preservation is standby; The temperature that controls environment in the preparation process is at 25 ℃, and humidity is below 40%; The Cornu Cervi Pantotrichum micro-cutting is helped powder and citric acid, sodium bicarbonate, lactose, steviosin, polyethylene glycol 6000, low-substituted hydroxypropyl cellulose, silicon dioxide, magnesium stearate, the abundant mixing of blue berry essence fine powder, tabletting, obtain the Cornu Cervi Pantotrichum effervescent tablet of every heavy 4 grams.
6. according to the preparation method of the described deer product effervescent tablets of claim 3, its feature also is to utilize the Embryo cervi effervescent tablet step of this method preparation as follows:
Embryo cervi obtains 220 purpose micro-cutting and helps powder after cleaning, drying, coarse pulverization, micro-cutting change-auxiliary agent are done technical finesse mutually, gets 20 weight portion Embryo cervi micro-cutting and helps powder, and airtight preservation is standby; After citric acid, sodium bicarbonate, sodium carbonate crossed 100 mesh sieves and handle, get 22.5 weight portions, 35.5 weight portions, 7 weight portions respectively, airtight preservation is standby; Protein sugar, lactose, polyethylene glycol 6000, crospolyvinylpyrrolidone, hami melon essence are crossed 80 mesh sieves, get 3 weight portions, 2.5 weight portions, 5 weight portions, 2 weight portions, 2.5 weight portions respectively, and airtight preservation is standby; The temperature that controls environment in the preparation process is at 25 ℃, and humidity is below 40%; After the Embryo cervi micro-cutting helped powder and citric acid, sodium bicarbonate, sodium carbonate, protein sugar, lactose, crospolyvinylpyrrolidone, hami melon essence, the abundant mixing of 2.5 weight portion polyethylene glycol 6000 fine powders, 12 order granules are made in mixed powder compression, fragmentation; Tabletting behind granule and the abundant mixing of 2.5 weight portion polyethylene glycol 6000 fine powders obtains every heavy 4 Embryo cervi effervescent tablet that restrains.
7. according to the preparation method of the described deer product effervescent tablets of claim 4, its feature also is to utilize the LUJIAOMAO effervescent tablet step of this method preparation as follows:
LUJIAOMAO obtains 220 purpose micro-cutting and helps powder after cleaning, drying, coarse pulverization, micro-cutting change-auxiliary agent are done technical finesse mutually, gets 10 parts of LUJIAOMAO micro-cutting and helps powder, and airtight preservation is standby; After citric acid, sodium bicarbonate crossed 100 mesh sieves and handle, get 25.5 weight portions, 30.5 weight portions respectively, airtight preservation is standby; Microcrystalline Cellulose, polyvinylpyrrolidone, magnesium stearate, xylitol, Fructus Citri Limoniae essence are crossed 80 mesh sieves, get 10 weight portions, 4 weight portions, 3 weight portions, 15 weight portions, 2 weight portions respectively, and airtight preservation is standby; The temperature that controls environment in the preparation process is at 25 ℃, and humidity is below 40%; Behind citric acid fine powder and part microcrystalline Cellulose, polyvinylpyrrolidone fine powder mix homogeneously, 12 order granules are made in mixed powder compression, fragmentation, dry A granule, standby; Behind sodium bicarbonate and part microcrystalline Cellulose, polyvinylpyrrolidone fine powder mix homogeneously, 12 order granules are made in mixed powder compression, fragmentation, dry B granule, standby; Help powder to mix gained LUJIAOMAO micro-cutting, add magnesium stearate, xylitol and Fructus Citri Limoniae essence fine powder, fully mix and tabletting, obtain the LUJIAOMAO effervescent tablet of every heavy 4 grams with A, B granule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621551A (en) * | 2013-11-07 | 2015-05-20 | 中国科学院兰州化学物理研究所 | Deer blood polypeptide effervescent tablet and preparation method thereof |
| CN105795462A (en) * | 2016-03-29 | 2016-07-27 | 吉林省国鹿生物科技有限公司 | Preparation method of deer blood tablet polypeptide dry powder |
| CN108783175A (en) * | 2018-05-02 | 2018-11-13 | 西华大学 | A kind of beef effervescent tablet and preparation method thereof |
| CN109156693A (en) * | 2018-08-06 | 2019-01-08 | 吉林大学 | A kind of preparation method of pilose antler effervescent tablet |
-
2009
- 2009-07-23 CN CN200910304694A patent/CN101642470A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104621551A (en) * | 2013-11-07 | 2015-05-20 | 中国科学院兰州化学物理研究所 | Deer blood polypeptide effervescent tablet and preparation method thereof |
| CN105795462A (en) * | 2016-03-29 | 2016-07-27 | 吉林省国鹿生物科技有限公司 | Preparation method of deer blood tablet polypeptide dry powder |
| CN108783175A (en) * | 2018-05-02 | 2018-11-13 | 西华大学 | A kind of beef effervescent tablet and preparation method thereof |
| CN109156693A (en) * | 2018-08-06 | 2019-01-08 | 吉林大学 | A kind of preparation method of pilose antler effervescent tablet |
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