CN104306541A - Traditional Chinese medicine dispersible tablet capable of nourishing blood and tranquilization and preparation method thereof - Google Patents
Traditional Chinese medicine dispersible tablet capable of nourishing blood and tranquilization and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention relates to a traditional Chinese medicine dispersible tablet capable of nourishing blood and tranquilization and a preparation method of the traditional Chinese medicine dispersible tablet. The traditional Chinese medicine dispersible tablet comprises 10 percent-60 percent of traditional Chinese medicine extracts, 15 percent-70 percent of filling agents, 5 percent-45 percent of internally added disintegrating agents, 5 percent-15 percent of externally added disintegrating agents, 0.1 percent-12 percent of flavoring agents, 0.1 percent-12 percent of wetting agents, 0.05 percent-5 percent of emollients and 0.1 percent -20 percent of glidants. The traditional Chinese medicine extracts comprise hairyvein agrimony, prepared rehmannia roots, vines of multiflower knotweed, eclipta, radix rehmanniae, caulis spatho lobi and cortex albiziae. The traditional Chinese medicine dispersible tablet is scientific in raw material selection, advanced in production technology and has the effects of nourishing blood and tranquilization and tonifying middle-Jiao and Qi; the solubleness and disperstiveness of the traditional Chinese medicine dispersible tablet are good, the dissolution rate is high, bioavailability is high, the tablet can be distributed in a human body quickly, and the tablet is stable in quality, good in taste, convenient to take and capable of being swallowed or chewed.
Description
Technical field
the invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to dispersible tablets of Chinese medicine of a kind of nourishing blood to tranquillize the mind and preparation method thereof.
Background technology
the energy produced by " original matter of life " is exactly " gas ".In Chinese medicine, this is a very important concept, because it is regarded as the growth promoter of human body, internal organs running, substance in vivo transport, transmits and the fundamental impulses energy of excretion." dying " that proverb is said shows the death of a body, has not had gas just not have life.Human body oxygen content is not enough, just there will be hypoxic conditions, comprises headache, tired, dyspnea, dizzy etc., serious or paroxysmal, can cause that stupor is even dead.
blood nourishes exactly to the most important effect of human body, and the nutritional labeling that it carries and oxygen are the material bases that each histoorgan of human body carries out vital movement.If anemia is damaged or run not normally will cause various discomfort, such as have a sleepless night, forgetful, irritated, palpitation with fear, to go into a coma etc.If things go on like this will cause more serious disease.
there is the medicine of multiple nourishing blood to tranquillize the mind in the market, but its price is not but common people can bear, and ordinary people cannot make the QI and blood of oneself well be nourished, and its its dissolubility, dispersibility are bad, bioavailability is low, and therapeutic effect is unstable.Therefore, be badly in need of in the market a kind of can nourishing blood to tranquillize the mind, invigorating the spleen and replenishing QI dispersible tablets of Chinese medicine.
Summary of the invention
the object of this invention is to provide a kind of can the dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind.
object of the present invention is achieved through the following technical solutions: a kind of dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind, by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, fluidizer, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 60%, filler 15 ~ 70%, in disintegrating agent 5 ~ 45%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 12%, wetting agent 0.1 ~ 12%, lubricant 0.05 ~ 5%, fluidizer 0.1 ~ 20%; The preferred weight number proportioning of described Chinese medicine extract Raw is: Herba Agrimoniae 160-170 part, Radix Rehmanniae Preparata 100-110 part, Caulis Polygoni Multiflori 100-110 part, Herba Ecliptae 100-110 part, Radix Rehmanniae 100-110 part, Caulis Spatholobi 100-110 part, Cortex Albiziae 100-110 part.
the dispersible tablets of Chinese medicine of described a kind of nourishing blood to tranquillize the mind, the optimum weight number proportioning of described Chinese medicine extract Raw is: Herba Agrimoniae 167 parts, Radix Rehmanniae Preparata 100 parts, Caulis Polygoni Multiflori 100 parts, Herba Ecliptae 100 parts, Radix Rehmanniae 100 parts, Caulis Spatholobi 100 parts, Cortex Albiziae 100 parts.
the dispersible tablets of Chinese medicine of described a kind of nourishing blood to tranquillize the mind, proportioning by weight, Chinese medicine extract 10 ~ 60 parts, filler 15 ~ 70 parts, in disintegrating agent 5 ~ 45 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 12 part, wetting agent 0.1 ~ 12 part, lubricant 0.05 ~ 5 part, fluidizer 0.1 ~ 20 part.
the dispersible tablets of Chinese medicine of described a kind of nourishing blood to tranquillize the mind, by optimum weight number proportioning, Chinese medicine extract 55 parts, filler 32 parts, in disintegrating agent 25 parts, additional disintegrating agent 7 parts, correctives 6 parts, wetting agent 6 parts, lubricant 5 parts, fluidizer 4 parts.
the dispersible tablets of Chinese medicine of described a kind of nourishing blood to tranquillize the mind, described filler is the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; Be the mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, flavoring orange essence, orange flavor, flavoring pineapple essence; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
the dispersible tablets of Chinese medicine of described a kind of nourishing blood to tranquillize the mind, the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by mass fraction proportioning, choose the Herba Agrimoniae of high-quality, Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Herba Ecliptae, Radix Rehmanniae, Caulis Spatholobi, Cortex Albiziae, clean and remove impurity, for subsequent use;
step 2: extract: after Caulis Polygoni Multiflori, Caulis Spatholobi, Cortex Albiziae are soaked 2 hours, decoct 1.5 hours, add Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Ecliptae, Radix Rehmanniae, decoct secondary, first time decocts 1 hour, and second time decocts 1.5 hours, filter, merging filtrate, leaves standstill, gets supernatant concentrating under reduced pressure, make it under the temperature conditions of 50 DEG C, for the thick paste of relative density about 1.35, vacuum drying, obtains extract;
step 3, preparation:
(1) extract is ground into fine powder, cross 100 mesh sieves, 80 mesh sieves crossed by other adjuvants, for subsequent use;
(2) by extract fine powder, filler, not containing essence correctives, in disintegrating agent be placed in three-dimensional motion mixer mixing 60 minutes;
(3) mixed material is placed in fluidised bed granulator, sprays into wetting agent, adopt fluidized bed granulation technology to granulate, dry, setup parameter: air inducing frequency 30-50Hz, feed flow frequency 25-80Hz, atomizing pressure 0.18-0.2Hz, inlet temperature 45-75 DEG C;
(4) adopt oscillating granulator granulate, sieve number is 12-20 order;
(5) granulate, additional disintegrating agent, lubricant, fluidizer and essence are put three-dimensional motion mixer and mix 30 minutes;
(6) adopt rotary tablet press, Hardness Control is at 4.0-7.0 k part/cm
2
between, dispersing uniformity disperseed in 1.5-2.5 minute, and tabletting speed controlling 15-20 r/min, obtains a kind of dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind.
in medicine: Herba Agrimoniae, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, for hemoptysis, spit blood, epistaxis, malaria, de-power impairment caused by overstrain, carbuncle, Radix Rehmanniae Preparata, enriches blood moist, and beneficial essence fills out marrow, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, collapses more than, hepatic and renal YIN deficiency, hectic fever night sweat, seminal emission sexual impotence, infertility, menoxenia, metrostaxis, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted, early whitening of beard and hair, quenches one's thirst, constipation, to suffer from a deficiency of the kidney dyspnea with rapid and short breath, Caulis Polygoni Multiflori, nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral, for insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia, Herba Ecliptae, nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the diseases such as enterorrhagia, Radix Rehmanniae, have enriching yin and nourishing kidney, nourish blood and enrich blood, effect of removing heat from blood, Caulis Spatholobi, has relaxing muscles and tendons to promote blood circulation, and effect of nourishing blood for regulating menstruation, cures mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia, and Cortex Albiziae has resolving depression, and blood, mind calming, the merit of subduing inflammation, controls irritability, melancholy is strongly fragrant, insomnia, lung abscess, carbuncle, scrofula, the effect of injured bone.
beneficial effect of the present invention: the dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind of the present invention, has effect of nourishing blood to tranquillize the mind, invigorating the spleen and replenishing QI, its dissolubility, favorable dispersibility, and dissolution is high, bioavailability is good, and distribution in vivo is rapid, steady quality, mouthfeel is good, taking convenience, can swallow, chew, containing sucking or taking with after aqueous dispersion, be more suitable for old man and the patient of difficulty of swallowing, there is medicine stability good, packaging, transport, the advantages such as storage is convenient, its preparation method is simple, is applicable to commercial production.
the present invention is through two groups of clinical verifications, wherein one group is that treatment group eats the present invention, eat the present invention every day once, it within 7 days, is a course for the treatment of, another group matched group takes nourishing blood to tranquillize the mind capsule, every day uses once, within 7 days, be every group selection outpatient 110 example course for the treatment of, wherein man 40 example, female 70 example, max age 75 years old, minimal ages 35 years old, clinical manifestation is haematemesis, hematuria, menoxenia, blood deficiency and yellow complexion, dizzy cardiopalmus, fatigue and weakness, trusted subordinate's cold type of pain, and table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
process characteristic of the present invention: 1, select raw material science, production technology is advanced, and its product is conveniently deposited and used; 2, product Chinese medicine composition is easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
a kind of dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind, by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, fluidizer, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 60%, filler 15 ~ 70%, in disintegrating agent 5 ~ 45%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 12%, wetting agent 0.1 ~ 12%, lubricant 0.05 ~ 5%, fluidizer 0.1 ~ 20%; The preferred weight number proportioning of described Chinese medicine extract Raw is: Herba Agrimoniae 160-170 part, Radix Rehmanniae Preparata 100-110 part, Caulis Polygoni Multiflori 100-110 part, Herba Ecliptae 100-110 part, Radix Rehmanniae 100-110 part, Caulis Spatholobi 100-110 part, Cortex Albiziae 100-110 part.
embodiment 2
a dispersible tablets of Chinese medicine for nourishing blood to tranquillize the mind, the optimum weight number proportioning of described Chinese medicine extract Raw is: Herba Agrimoniae 167 parts, Radix Rehmanniae Preparata 100 parts, Caulis Polygoni Multiflori 100 parts, Herba Ecliptae 100 parts, Radix Rehmanniae 100 parts, Caulis Spatholobi 100 parts, Cortex Albiziae 100 parts.
embodiment 3
a kind of dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind, proportioning by weight, Chinese medicine extract 10 ~ 60 parts, filler 15 ~ 70 parts, in disintegrating agent 5 ~ 45 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 12 part, wetting agent 0.1 ~ 12 part, lubricant 0.05 ~ 5 part, fluidizer 0.1 ~ 20 part.
embodiment 4
a dispersible tablets of Chinese medicine for nourishing blood to tranquillize the mind, by optimum weight number proportioning, Chinese medicine extract 55 parts, filler 32 parts, in disintegrating agent 25 parts, additional disintegrating agent 7 parts, correctives 6 parts, wetting agent 6 parts, lubricant 5 parts, fluidizer 4 parts.
embodiment 5
a dispersible tablets of Chinese medicine for nourishing blood to tranquillize the mind, described filler is the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; Be the mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, flavoring orange essence, orange flavor, flavoring pineapple essence; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
embodiment 6
a dispersible tablets of Chinese medicine for nourishing blood to tranquillize the mind, the concrete steps of its preparation method are:
step 1, to get the raw materials ready: proportioning by weight, choose the Herba Agrimoniae of high-quality, Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Herba Ecliptae, Radix Rehmanniae, Caulis Spatholobi, Cortex Albiziae, clean and remove impurity, for subsequent use;
step 2: extract: after Caulis Polygoni Multiflori, Caulis Spatholobi, Cortex Albiziae are soaked 2 hours, decoct 1.5 hours, add Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Ecliptae, Radix Rehmanniae, decoct secondary, first time decocts 1 hour, and second time decocts 1.5 hours, filter, merging filtrate, leaves standstill, gets supernatant concentrating under reduced pressure, make it under the temperature conditions of 50 DEG C, for the thick paste of relative density about 1.35, vacuum drying, obtains extract;
step 3, preparation:
(1) extract is ground into fine powder, cross 100 mesh sieves, 80 mesh sieves crossed by other adjuvants, for subsequent use;
(2) by extract fine powder, filler, not containing essence correctives, in disintegrating agent be placed in three-dimensional motion mixer mixing 60 minutes;
(3) mixed material is placed in fluidised bed granulator, sprays into wetting agent, adopt fluidized bed granulation technology to granulate, dry, setup parameter: air inducing frequency 30-50Hz, feed flow frequency 25-80Hz, atomizing pressure 0.18-0.2Hz, inlet temperature 45-75 DEG C;
(4) adopt oscillating granulator granulate, sieve number is 12-20 order;
(5) granulate, additional disintegrating agent, lubricant, fluidizer and essence are put three-dimensional motion mixer and mix 30 minutes;
(6) adopt rotary tablet press, Hardness Control is at 4.0-7.0 k part/cm
2
between, dispersing uniformity disperseed in 1.5-2.5 minute, and tabletting speed controlling 15-20 r/min, obtains a kind of dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind.
Claims (6)
1. the dispersible tablets of Chinese medicine of a nourishing blood to tranquillize the mind, it is characterized in that: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, fluidizer, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 60%, filler 15 ~ 70%, in disintegrating agent 5 ~ 45%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 12%, wetting agent 0.1 ~ 12%, lubricant 0.05 ~ 5%, fluidizer 0.1 ~ 20%; The preferred weight number proportioning of described Chinese medicine extract Raw is: Herba Agrimoniae 160-170 part, Radix Rehmanniae Preparata 100-110 part, Caulis Polygoni Multiflori 100-110 part, Herba Ecliptae 100-110 part, Radix Rehmanniae 100-110 part, Caulis Spatholobi 100-110 part, Cortex Albiziae 100-110 part.
2. the dispersible tablets of Chinese medicine of a kind of nourishing blood to tranquillize the mind according to claim 1, is characterized in that: the optimum weight number proportioning of described Chinese medicine extract Raw is: Herba Agrimoniae 167 parts, Radix Rehmanniae Preparata 100 parts, Caulis Polygoni Multiflori 100 parts, Herba Ecliptae 100 parts, Radix Rehmanniae 100 parts, Caulis Spatholobi 100 parts, Cortex Albiziae 100 parts.
3. the dispersible tablets of Chinese medicine of a kind of nourishing blood to tranquillize the mind according to claim 1, it is characterized in that: number proportioning by weight, Chinese medicine extract 10 ~ 60 parts, filler 15 ~ 70 parts, in disintegrating agent 5 ~ 45 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 12 part, wetting agent 0.1 ~ 12 part, lubricant 0.05 ~ 5 part, fluidizer 0.1 ~ 20 part.
4. the dispersible tablets of Chinese medicine of a kind of nourishing blood to tranquillize the mind according to claim 1, it is characterized in that: by optimum weight number proportioning, Chinese medicine extract 55 parts, filler 32 parts, in disintegrating agent 25 parts, additional disintegrating agent 7 parts, correctives 6 parts, wetting agent 6 parts, lubricant 5 parts, fluidizer 4 parts.
5. the dispersible tablets of Chinese medicine of a kind of nourishing blood to tranquillize the mind according to claim 1, is characterized in that: described filler is the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; Be the mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, flavoring orange essence, orange flavor, flavoring pineapple essence; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate; Described fluidizer is one or both the mixing in silicon dioxide, Pulvis Talci.
6. the dispersible tablets of Chinese medicine of a kind of nourishing blood to tranquillize the mind according to claim 1-5, is characterized in that: the concrete steps of its preparation method are:
Step 1, to get the raw materials ready: proportioning by weight, choose the Herba Agrimoniae of high-quality, Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Herba Ecliptae, Radix Rehmanniae, Caulis Spatholobi, Cortex Albiziae, clean and remove impurity, for subsequent use;
Step 2: extract: after Caulis Polygoni Multiflori, Caulis Spatholobi, Cortex Albiziae are soaked 2 hours, decoct 1.5 hours, add Herba Agrimoniae, Radix Rehmanniae Preparata, Herba Ecliptae, Radix Rehmanniae, decoct secondary, first time decocts 1 hour, and second time decocts 1.5 hours, filter, merging filtrate, leaves standstill, gets supernatant concentrating under reduced pressure, make it under the temperature conditions of 50 DEG C, for the thick paste of relative density about 1.35, vacuum drying, obtains extract;
Step 3, preparation:
(1) extract is ground into fine powder, cross 100 mesh sieves, 80 mesh sieves crossed by other adjuvants, for subsequent use;
(2) by extract fine powder, filler, not containing essence correctives, in disintegrating agent be placed in three-dimensional motion mixer mixing 60 minutes;
(3) mixed material is placed in fluidised bed granulator, sprays into wetting agent, adopt fluidized bed granulation technology to granulate, dry, setup parameter: air inducing frequency 30-50Hz, feed flow frequency 25-80Hz, atomizing pressure 0.18-0.2Hz, inlet temperature 45-75 DEG C;
(4) adopt oscillating granulator granulate, sieve number is 12-20 order;
(5) granulate, additional disintegrating agent, lubricant, fluidizer and essence are put three-dimensional motion mixer and mix 30 minutes;
(6) adopt rotary tablet press, Hardness Control is at 4.0-7.0 k part/cm
2between, dispersing uniformity disperseed in 1.5-2.5 minute, and tabletting speed controlling 15-20 r/min, obtains a kind of dispersible tablets of Chinese medicine of nourishing blood to tranquillize the mind.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410688637.4A CN104306541A (en) | 2014-11-26 | 2014-11-26 | Traditional Chinese medicine dispersible tablet capable of nourishing blood and tranquilization and preparation method thereof |
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| CN201410688637.4A CN104306541A (en) | 2014-11-26 | 2014-11-26 | Traditional Chinese medicine dispersible tablet capable of nourishing blood and tranquilization and preparation method thereof |
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| CN104306541A true CN104306541A (en) | 2015-01-28 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN105232652A (en) * | 2015-11-19 | 2016-01-13 | 哈尔滨圣吉药业股份有限公司 | Huangxiang dispersible tablet and preparation method thereof |
| CN105232778A (en) * | 2015-11-19 | 2016-01-13 | 哈尔滨圣吉药业股份有限公司 | Dispersible tablet used for treating neurasthenia and preparing method thereof |
| CN105232671A (en) * | 2015-11-19 | 2016-01-13 | 哈尔滨圣吉药业股份有限公司 | Four-flavor snow lotus herb traditional Chinese medicine dispersible tablets and preparation method thereof |
| CN105878551A (en) * | 2016-06-02 | 2016-08-24 | 林正秋 | Medicine microfilaments with tranquilizing effect and preparation method thereof |
| CN107320564A (en) * | 2017-07-03 | 2017-11-07 | 广西大海阳光药业有限公司 | A kind of Chinese medicine preparation for treating vertigo and palpitation, insomnia forgetfulness and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213466A (en) * | 2015-11-19 | 2016-01-06 | 哈尔滨圣吉药业股份有限公司 | A kind of XIAOKECHUAN dispersible tablet and preparation method thereof |
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| CN105232671A (en) * | 2015-11-19 | 2016-01-13 | 哈尔滨圣吉药业股份有限公司 | Four-flavor snow lotus herb traditional Chinese medicine dispersible tablets and preparation method thereof |
| CN105878551A (en) * | 2016-06-02 | 2016-08-24 | 林正秋 | Medicine microfilaments with tranquilizing effect and preparation method thereof |
| CN107320564A (en) * | 2017-07-03 | 2017-11-07 | 广西大海阳光药业有限公司 | A kind of Chinese medicine preparation for treating vertigo and palpitation, insomnia forgetfulness and preparation method thereof |
| CN107362272A (en) * | 2017-08-31 | 2017-11-21 | 江西金顶药业有限公司 | A kind of Yangxue Anshen Syrup |
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