CN106265992A - Xiaojin Capsules and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Xiaojin Capsules and preparation method thereof, described Xiaojin Capsules includes that the raw material of following weight parts is prepared from: Moschus, Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, Resina Liquidambaris, Olibanum (is made), Myrrha (processed), Oletum Trogopterori (vinegar-fried), Radix Angelicae Sinensis (wine stir-fry), Pheretima, XIANGMO(sic).Xiaojin Capsules of the present invention, is natural Chinese medicines product, has mass dissipating and swelling eliminating, effect of blood-activating analgetic, adds antistaling agent and sugar alcohol, it is ensured that the steady quality of medicine, promote drug quality in preparation process.

Description

Xiaojin Capsules and preparation method thereof

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Xiaojin Capsules and preparation method thereof.

Background technology

Xiaojin Capsules is that the agent of " Chinese Pharmacopoeia " 2005 editions XIAOJIN WAN changes kind, and prescription is by Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, breast Perfume, Myrrha, Radix Angelicae Sinensis, Moschus, Resina Liquidambaris, Pheretima, Oletum Trogopterori, XIANGMO(sic) totally 10 taste medical material composition；There is mass dissipating and swelling eliminating, silt releasing and analgesia Effect；For the sluggish caused scrofula of mental disorder, goiter, breast carcinoma, nodules of the breast, disease sees lump one or several places under skin or skin, Push away is active, or bone and osteoarthritis, color of the leather is constant, swollen firmly has a pain.

Radix Aconiti Kusnezoffii belongs to ranunculaceae plant, has another name called Aconitum kusnezoffii Reichb, and containing aconitine, isoaconitine etc., toxic, big gun is processed rear toxicity and subtracted Little.Pharmacological research, its alkaloid has enhancing sinus-node self-activity, improves atrioventricular node conduction, makes heart rate, improves heart output Amount, expands peripheral blood vessel, makes limbs warm.Additionally, also antiinflammatory, analgesia, sedation.Radix Angelicae Sinensis, Oletum Trogopterori, Olibanum, Myrrha Etc. platelet aggregation can be suppressed, increase plasmin activity, improve microcirculation, eliminate the spasm pain of ischemia organ.Can also suppress Fibrocyte produces collagen effect, eliminates adhesion, wart, benign tissue hypertrophy.Moschus contains muscone, muscopyridine, fat Acid, nitride and potassium, sodium, calcium, magnesium.Low dose of Moschus can stimulating central nervous system system, heavy dose can suppress central nervous system. Meanwhile, also can resist isoproterenol, make decreased heart rate, increase myocardial flow, its aqueous solution can make blood capillary penetrating Property increase and leukoplania, alleviate and ooze out and edema.Moschus also can increase IgM antibody, increases mononuclear phagocyte system and swashs Live and act on.Therefore this product has bactericidal antiphlogistic, tuberculosis, antitumor, sedation-analgesia and improves immunity of organisms and resistance against diseases Effect, promote that lump and cicatrix alleviate or dissipate.It is clinically used for treating lump in breast disease and has significant curative effect.

After making capsule, overcome former paste pill agent disintegrate difficulty, need before taking to smash, therefore disintegrate is rapid, the release of medicine Speed is fast.Capsule sealingly secure, has good stability, and capsule formulation carries with easy to use simultaneously, meets the modernization of Chinese medicine and wants Ask.

Summary of the invention

For above-mentioned deficiency present in prior art, one of the technical problem to be solved is to provide a kind of little Gold size capsule.

Solve the technical problem that the two of the present invention are to provide the preparation method of a kind of Xiaojin Capsules.

The present invention seeks to be achieved through the following technical solutions:

A kind of Xiaojin Capsules, the raw material including following weight parts is prepared from: Moschus, Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, Resina Liquidambaris, Olibanum (is made), Myrrha (processed), Oletum Trogopterori (vinegar-fried), Radix Angelicae Sinensis (wine stir-fry), Pheretima, XIANGMO(sic).

A kind of Xiaojin Capsules, is prepared from by the raw material of following weight parts: Moschus 40-50 part, and Semen Momordicae (shells and deoils) 120-180 part, Radix Aconiti Kusnezoffii Preparata 120-180 part, Resina Liquidambaris 120-180 part, Olibanum (system) 50-100 part, Myrrha (processed) 50-100 part, Oletum Trogopterori (vinegar-fried) 120-180 part, Radix Angelicae Sinensis (wine stir-fry) 50-100 part, Pheretima 120-180 part, XIANGMO(sic) 8-18 part, antistaling agent 0.1-1 Part, sugar alcohol 1-5 part.

Preferably, described antistaling agent is that one or more in ellagic acid, glycyrrhizic acid, chrysophanic acid mix.

It is highly preferred that described antistaling agent is mixed by ellagic acid, glycyrrhizic acid, chrysophanic acid, described ellagic acid, Radix Glycyrrhizae Acid, the mass ratio of chrysophanic acid are (1-3): (1-3): (1-3).

Preferably, one or more during described sugar alcohol is mannitol, maltose alcohol, lactose mix.

It is highly preferred that described sugar alcohol is mixed by mannitol, maltose alcohol, lactose, described mannitol, Fructus Hordei Germinatus Mass ratio in sugar alcohol, lactose is (1-3): (1-3): (1-3).

The preparation method of a kind of Xiaojin Capsules, comprises the following steps:

(1) Olibanum, Myrrha, Resina Liquidambaris are pulverized as 20-50 mesh coarse powder, obtain ground product (I)；

(2) Pheretima is pulverized is 10-30 mesh coarse powder, sieves, obtains ground product (II)；

(3) Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, Oletum Trogopterori, Radix Angelicae Sinensis, XIANGMO(sic) are pulverized as the thick mesh of 60-100, sieve, obtain ground product (Ⅲ)；

(4) by ground product I, II, III mix homogeneously, pulverize as 100-150 mesh fine powder, obtain ground product (IV)；

(5) Moschus is ground 100-150 mesh, then mix homogeneously with ground product IV, antistaling agent, sugar alcohol, encapsulated, to obtain final product.

Concrete, in the present invention:

Moschus, Classification system: Angelica sinensis, nature and flavor: pungent, temperature.Gui Jing: GUIXIN, spleen channel.Effect: have one's ideas straightened out awake God, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Curing mainly: for calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea, abdominal mass, Difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, laryngopharynx swelling and pain, fall and flutter the pain of injury, arthralgia pain is numb.

Semen Momordicae, Classification system: Momordica cochinchinensis (Lour.) Spreng., bitter micro-sweet, temperature, have Poison.Enter liver, spleen, stomach warp.Dispersing swelling and dissipating binds, toxic removing.Control carbuncle, furuncle, scrofula, hemorrhoid, innominate toxic swelling, tinea skin ulcer, rheumatic arthralgia, muscle Arteries and veins contracture.Concocting method: take Semen Momordicae and shell and take core, smash to pieces, make popular, grinds, and paper using is wrapped up, and pressurization is deoiled.

Radix Aconiti Kusnezoffii Preparata, for the Preparation process product of Radix Aconiti Kusnezoffii.Acrid in the mouth, hardship, property heat.The heart, liver,kidney,spleen warp.Expelling wind and removing dampness, warming the meridian is only Bitterly.For anemofrigid-damp arthralgia, arthralgia, the cool pain of trusted subordinate, colic of cold type pain relieving.

Resina Liquidambaris, being dried for Hamamelidaceae Plants Chinese sweet gum, nature and flavor: hardship pungent, micro-are flat.Gui Jing: return lung, spleen channel.Merit Effect: promoting blood circulation and stopping pain, removing toxic substances, granulation promoting, removing heat from blood.Cure mainly: for injury from falling down, ulcer sore pain, spit blood, epistaxis, traumatic hemorrhage.

Olibanum, Classification system: Boswelliacarteri, property is pungent, warm, bitter in the mouth.Enter the heart, liver, spleen channel.Invigorate blood circulation, circulation of qi promoting, only Bitterly.Control the epigastric pain of the stasis blocking stagnation of QI, rheumatic arthralgia, traumatic injury, dysmenorrhea, puerperal abdonimal pain.Concocting method: take the breast picking clean Perfume (or spice), is slightly shown in melting point with slow fire stir-fry to surface in putting pot, and slightly in yellow, taking-up cools.

Myrrha, for olive subject plant myrrh CommiphoramyrrhaEngl. or the gum resin of Alan fort myrrh.Adopt The white oleo-gum-resin oozed out by bark crack of collection, becomes rufous and hard nahlock in air.After smashing, fry to burnt Black is applied.Cure mainly chest and abdomen stasis of blood pain, dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.Only invigorate blood circulation Bitterly, effect such as detumescence and promoting granulation.Drug for invigorating blood circulation and eliminating stasis.Concocting method: take to pick in pot put by clean Myrrha and slightly see to surface molten with slow fire stir-fry Changing point, taking-up cools.

Oletum Trogopterori, for the dry feces of trogopterus xanthipes Milne-Edwards, promoting blood circulation to remove blood stasis, parch to black stops blooding.Sweet in the mouth warm in nature, makees for trusted subordinate's congestion Bitterly, dysmenorrhea, blood stasis amenorrhea, curing postpartum bleeding is suffered from abdominal pain；Parch to black controls metrostaxis；Traumatic injury, Serpentis, insect bite wound are controlled in external.Process of preparing Chinese medicine side Method: take clean Oletum Trogopterori, make popular, sprays vinegar and mixes thoroughly, every clean Oletum Trogopterori 100g, uses vinegar 10g, vexed, then fried dry, standby.

Radix Angelicae Sinensis, Classification system: Angelica sinensis, sweet in the mouth, pungent, bitter, warm in nature.Return liver, the heart, spleen channel.Can enrich blood, Invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.Can treat all cards of blood deficiency, menoxenia, lump in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, flesh Skin is numb, dryness of the intestine dyschezia, weight, ulcer sores, injury from falling down after bloody dysentery.With control apoplexy syncope, spit out white foams, puerperal exposure to wind Paralysis.Concocting method: take clean Radix Angelicae Sinensis Tabellae, processs method fried dry according to " Chinese Pharmacopoeia 2005 " appendix II D wine.

Pheretima, the popular Pheretimatschiliensis of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation, comb blind Pheretimatschiliensis Dry body.Nature and flavor: salty, cold.Gui Jing: return liver, spleen, bladder warp.Effect: heat clearing away is calmed the frightened, dredging collateral is relievingd asthma, diuresis.Cure mainly: be used for Unconsciousness due to high fever, frightened disease tic, arthralgia, numb limbs and tense tendons, hemiplegia.Dyspnea and cough due to lung-heat, oliguria edema；Hypertension.

XIANGMO(sic), for processed ink made such as pine soot, glue juice, Borneolum Syntheticum and spice.There is hemostasis, the confession effect of detumescence, in order to The diseases such as treatment is spitted blood, epistaxis, metrorrhagia and metrostaxis, dysentery, carbuncle carbuncle on the back.

Ellagic acid, No. CAS: 476-66-4.

Glycyrrhizic acid, No. CAS: 1405-86-3.

Chrysophanic acid, No. CAS: 478-43-3.

Mannitol, No. CAS: 69-65-8.

Maltose alcohol, No. CAS: 585-88-6.

Lactose, No. CAS: 585-86-4.

Xiaojin Capsules of the present invention, is natural Chinese medicines product, has mass dissipating and swelling eliminating, effect of blood-activating analgetic, preparation process Middle interpolation antistaling agent and sugar alcohol, it is ensured that the steady quality of medicine, promote drug quality.

Detailed description of the invention

Embodiment 1

Xiaojin Capsules raw material (weight portion): 45 parts of Moschus, Semen Momordicae (shell and deoil) 150 parts, Radix Aconiti Kusnezoffii Preparata 150 parts, sweetgum 150 parts of fat, Olibanum (system) 80 parts, Myrrha (processed) 80 parts, Oletum Trogopterori (vinegar-fried) 150 parts, Radix Angelicae Sinensis (wine stir-fry) 80 parts, Pheretima 150 parts, XIANGMO(sic) 14 parts, antistaling agent 0.3 part, sugar alcohol 3 parts.

The preparation method of Xiaojin Capsules, comprises the following steps:

(1) by Olibanum, Myrrha, Resina Liquidambaris pulverize be 30 mesh coarse powder, obtain ground product (I)；

(2) Pheretima is pulverized is 20 mesh coarse powder, sieves, obtains ground product (II)；

(3) by Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, Oletum Trogopterori, Radix Angelicae Sinensis, XIANGMO(sic) pulverize be 80 thick mesh, sieve, obtain ground product (III)；

(4) by ground product I, ground product II, ground product III mix homogeneously, pulverizing is 120 mesh fine powders, obtains ground product (IV)；

(5) Moschus is ground 120 mesh, then mix homogeneously with ground product IV, antistaling agent, sugar alcohol, encapsulated, to obtain final product.

Described antistaling agent is mixed by ellagic acid, glycyrrhizic acid, chrysophanic acid, described ellagic acid, glycyrrhizic acid, chrysophanic acid Mass ratio is 1:1:1.

Described sugar alcohol is mixed by mannitol, maltose alcohol, lactose, described mannitol, maltose alcohol, lactose Mass ratio in alcohol is 1:1:1.

Embodiment 2

Substantially the same manner as Example 1, differ only in: described antistaling agent is 1:1 in mass ratio by ellagic acid, glycyrrhizic acid Mix homogeneously obtains.Obtain the Xiaojin Capsules of embodiment 2.

Embodiment 3

Substantially the same manner as Example 1, differ only in: described antistaling agent is 1:1 in mass ratio by ellagic acid, chrysophanic acid Mix homogeneously obtains.Obtain the Xiaojin Capsules of embodiment 3.

Embodiment 4

Substantially the same manner as Example 1, differ only in: described antistaling agent is 1:1 in mass ratio by glycyrrhizic acid, chrysophanic acid Mix homogeneously obtains.Obtain the Xiaojin Capsules of embodiment 4.

Embodiment 5

Substantially the same manner as Example 1, differ only in: described sugar alcohol by mannitol, maltose alcohol is in mass ratio 1:1 mix homogeneously obtains.Obtain the Xiaojin Capsules of embodiment 5.

Embodiment 6

Substantially the same manner as Example 1, differ only in: described sugar alcohol is 1:1 in mass ratio by mannitol, lactose Mix homogeneously obtains.Obtain the Xiaojin Capsules of embodiment 6.

Embodiment 7

Substantially the same manner as Example 1, differ only in: described sugar alcohol is 1:1 in mass ratio by maltose alcohol, lactose Mix homogeneously obtains.Obtain the Xiaojin Capsules of embodiment 7.

Test case 1

Xiaojin Capsules embodiment 1-7 prepared, is placed in 25 DEG C, and under relative humidity 85% environment, preservation half a year, then enters Row escherichia coli (ATYCC 25922) total plate count is tested, with reference to " GBT 4789.2-2008 microbiological test of food hygiene Total plate count measures ".Concrete test result is shown in Table 1.

Table 1: total plate count test table cfu/g

	E. coli clones sum
		Embodiment 1	205
Embodiment 2	525
		Embodiment 3	498
Embodiment 4	537
		Embodiment 5	459
Embodiment 6	464
		Embodiment 7	452

Comparing embodiment 1 and embodiment 2-4, embodiment 1 (ellagic acid, glycyrrhizic acid, chrysophanic acid are compounding) antiseptic property is obvious It is better than embodiment 2-4 (arbitrarily the two compounds for ellagic acid, glycyrrhizic acid, chrysophanic acid).Comparing embodiment 1 and embodiment 5-7, embodiment 1 (mannitol, maltose alcohol, lactose are compounding) antiseptic property is substantially better than embodiment 5-7 (mannitol, maltose alcohol, breast Arbitrarily the two compounds sugar alcohol).

Claims (7)

1. an Xiaojin Capsules, it is characterised in that include that the raw material of following weight parts is prepared from: Moschus, Semen Momordicae, system grass Crow, Resina Liquidambaris, Olibanum (makes), Myrrha (processed), Oletum Trogopterori (vinegar-fried), Radix Angelicae Sinensis (wine stir-fry), Pheretima, XIANGMO(sic).

2. an Xiaojin Capsules, it is characterised in that be prepared from by the raw material of following weight parts: Moschus 40-50 part, Semen Momordicae (shell and deoil) 120-180 part, Radix Aconiti Kusnezoffii Preparata 120-180 part, Resina Liquidambaris 120-180 part, Olibanum (system) 50-100 part, Myrrha (processed) 50-100 part, Oletum Trogopterori (vinegar-fried) 120-180 part, Radix Angelicae Sinensis (wine stir-fry) 50-100 part, Pheretima 120-180 part, XIANGMO(sic) 8-18 part, protect Fresh dose of 0.1-1 part, sugar alcohol 1-5 part.

3. the preparation method of Xiaojin Capsules as claimed in claim 2, it is characterised in that: described antistaling agent is ellagic acid, sweet One or more in oxalic acid, chrysophanic acid mix.

4. the preparation method of Xiaojin Capsules as claimed in claim 3, it is characterised in that: described antistaling agent is by ellagic acid, sweet Oxalic acid, chrysophanic acid mix, and described ellagic acid, glycyrrhizic acid, the mass ratio of chrysophanic acid are (1-3): (1-3): (1-3).

5. the preparation method of the Xiaojin Capsules as described in claim 2 or 4, it is characterised in that: described sugar alcohol is mannitol, wheat One or more in bud sugar alcohol, lactose mix.

6. the preparation method of Xiaojin Capsules as claimed in claim 5, it is characterised in that: described sugar alcohol is by mannitol, Fructus Hordei Germinatus Sugar alcohol, lactose mix, and the mass ratio in described mannitol, maltose alcohol, lactose is (1-3): (1-3): (1- 3)。

7. the preparation method of the Xiaojin Capsules as according to any one of claim 1-6, it is characterised in that comprise the following steps:

(1) Olibanum, Myrrha, Resina Liquidambaris are pulverized as 20-50 mesh coarse powder, obtain ground product (I)；

(2) Pheretima is pulverized is 10-30 mesh coarse powder, sieves, obtains ground product (II)；

(3) Semen Momordicae, Radix Aconiti Kusnezoffii Preparata, Oletum Trogopterori, Radix Angelicae Sinensis, XIANGMO(sic) are pulverized as the thick mesh of 60-100, sieve, obtain ground product (III)；

(4) by ground product I, II, III mix homogeneously, pulverize as 100-150 mesh fine powder, obtain ground product (IV)；

(5) Moschus is ground 100-150 mesh, then mix homogeneously with ground product IV, antistaling agent, sugar alcohol, encapsulated, to obtain final product.