CN104940710A - Traditional Chinese medicine Kangning composition comprising soncretio silicea bambusae for treating epilepsy, and preparation method thereof - Google Patents
Traditional Chinese medicine Kangning composition comprising soncretio silicea bambusae for treating epilepsy, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine Kangning composition comprising soncretio silicea bambusae for treating epilepsy, and a preparation method thereof. The traditional Chinese medicine Kangning composition is prepared from the raw materials of radix bupleuri, valeriana officinalis Linn, rhizoma arisaematis cum bile, soncretio silicea bambusae, radix polygalae, acorus tatarinowii Schott, uncaria rhynchophylla, rhizom gastrodiae, salvia miltiorrhiza Bunge, white paeony roots, calculus bovis factitious, pernulo, scorpio, arthropleura armata, periostracum cicadae, geosaurus, bombyx batryticatus, ambrum, borneol, panax ginseng and glycyrrhizae, has the efficiencies of clearing and dissipating heat-phlegm, calming endogenous wind and arresting convulsion, and inducing resuscitation and arresting epilepsy, and is applied to patients suffering from epilepsy caused by excessive inside phlegm-fire. According to the traditional Chinese medicine Kangning composition, the synergy of the efficacy is enhanced, the curative effect is improved, the therapeutic effect is definite, the recovery is quick, side effects and long-term relapse are avoided, the treatment cost is low, the treatment effect is high, the efficiency is 91.2% and the cure rate is 37.2%. The traditional Chinese medicine Kangning composition is wide in raw material resource, inexpensive, safe and non-toxic, free of drug resistance, convenient to use, and simple in preparation method process, and has higher market competitiveness and better economic and social benefits.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to healthy and free from worry Chinese medicine composition of a kind of Concretio Silicea Bambusae epilepsy and preparation method thereof.
Background technology
Epilepsy is commonly called as epilepsy again, and modern medicine thinks the unexpected and of short duration brain function imbalance of the recurrent exerbation caused by brain cell over-discharge, shows as the different obstructs such as motion, sensation, consciousness, vegetative nerve, spirit, maybe can have both at the same time.Cause the reason of epilepsy various, essential epilepsy agnogenio, secondary epilepsy, also known as symptomatic epilepsy, refers to the epilepsy that can find the cause of disease.Common reason has suffers from brain diseases, congenital diseases, anoxia, metabolic disease, endocrinopathy, cardiovascular disease, poisoning disease etc.During morbidity, the lighter is inattentive to stare blankly, nod, severe one is fallen suddenly, and loss of consciousness, tic of the limbs, spits out white foams, gnathospasma, two is turned over, gatism, even death by suffocation, as ordinary person after reviving.This type of disease is in rising trend at China's sickness rate, sickness rate about 3%, the childhood period that this disease being mainly in and adolescence.
Epileptics is a kind of difficult pertinacious disease, and complicated symptoms, the course for the treatment of is long, recurrent exerbation is comparatively strong, and as irregular treatment, often cause obstinate, many patient's long-term taking epilepsy Western medicine control symptom, not only thoroughly can not effect a radical cure epilepsy, not reach the object for the treatment of.At present, the principle of western medical treatment epilepsy is first sleeping, the namely tranquillizing and allaying excitement said of the traditional Chinese medical science, so multiplex phenytoin sodium and phenobarbital, stable etc. suppress medicine, then add piracetam, vitamin medicaments treats that this type of is sick, after clothes, toxic and side effects is large, as erythra, nauseating, hyponoia, easily recur, and cure rate is low, can only take stopgap measures and can not effect a permanent cure, bring very large misery and financial burden to a lot of patient.At present, modern medicine has invented again operation and laser therapy method, still thoroughly can not cure epilepsy, avoids recurrence.The traditional Chinese medical science is then multiplex determines epilepsy nine " medical science innermost thoughts and feelings ", mixed gallbladder soup " dry Jin Yaofang " treatment, treatment time is long, cures slow, cure rate is low, treatment is neither desirable, and drug dependence is strong, produces spirit depressing, emotional responses is lacked of proper care, IQ, dysnoesia, these side effect that cannot avoid such as child's gingival hyperplasia, are therefore not easily accepted by patient.
Chinese patent CN 03146130.1, a kind of Chinese medicine composition for the treatment of epileptics and preparation method thereof.Chinese medicine composition of the present invention comprises the raw material of following weight parts: Rhizoma Gastrodiae 30-90 part, Arisaema Cum Bile 60-100 part, Radix Polygalae 60-110 part, Herba Lophatheri 30-90 part, Radix Ginseng 10-40 part, Rhizoma Acori Graminei 130-170 part, Bulbus Fritillariae Cirrhosae 20-50 part, Scorpio 30-90 part, Rhizoma Zingiberis Recens 50-70 part, Borneolum Syntheticum 5-20 part, Bombyx Batryticatus 70-100 part, Radix Salviae Miltiorrhizae 90-120 part, Radix Ophiopogonis 80-100 part, succinum 20-50 part, artificial Calculus Bovis 8-20 part.
Chinese patent CN 97115261.6, a kind of Chinese medicine for the treatment of insane disease.It is made up of the Chinese medicine of following parts by weight proportioning: Calculus Bovis 2-4 part, Moschus 0.3-0.5 part, Margarita 6-8 part, Cornu Saigae Tataricae 2-4 part, succinum 2-4 part, Korean Ginseng 8-12 part, dried Alumen 2-4 part, Rhizoma Acori Graminei 7-9 part, Ramulus Uncariae Cum Uncis 7-9 part, Rhizoma Gastrodiae 8-12 part, Radix Polygoni Multiflori 6-8 part, Pheretima 7-9 part, Periostracum Cicadae 6-8 part, Arisaema Cum Bile 8-11 part, Bombyx Batryticatus 8-10 part, joy clam 7-9 part, Scorpio 7-9 part, Radix Salviae Miltiorrhizae 8-11 part, obtain luxuriant growth 8-11 part, the yellow 8-11 part of sky silk.This Chinese medicine is theoretical according to Chinese traditional treatment epilepsy, employing restores menstrual flow and invigorates blood circulation, subduing wind syndrom by clearing away phlegm, waking up the patient from unconsciousness by dissipating phlegm, mind tranquilizing and the heart calming principle are made, have whole body and the many-sided opsonic action of central nervous system, by applying the Clinical Observation of Short-term of said preparation, result shows: this Chinese medicine disease-resistant spasmolytic spectrum width for the treatment of insane disease is wide, all types ofly insanely closely relatedly all have significant control effects to clinical, total effective rate can reach 92.76%, and obvious effective rate is 70.06%.There is the features such as safe, effective, reliable, convenient.
Chinese patent CN 200710115283.4, a kind of medicine for the treatment of epilepsy.The crude drug of effective ingredient by following weight is: Cornu Saigae Tataricae 5-15 gram, Ramulus Uncariae Cum Uncis 5-15 gram, Folium Mori 5-15 gram, Radix Paeoniae Alba 5-15 gram, Radix Rehmanniae 5-15 gram, the fragrant 5-15 gram of coat, coat god 5-10 gram, Radix Salviae Miltiorrhizae 5-10 gram, Radix Glycyrrhizae 3-6 gram, Bulbus Fritillariae Cirrhosae 5-15 gram, Caulis Bambusae In Taenia 5-15 gram.
Chinese patent CN 201110316459.9, a kind of Chinese medicine composition for the treatment of epilepsy and preparation method thereof.It is formulated by the raw material of Chinese medicine of following weight portion: 6 parts, Moschus, Alumen 50 parts, Radix Curcumae 60 parts, Bombyx Batryticatus 45 parts, Arisaema Cum Bile 45 parts, Rhizoma Pinelliae 30 parts, Rhizoma Acori Calami 45 parts, be on the point of grass 60 parts, Ramulus Uncariae Cum Uncis 50 parts, Benzoinum 60 parts, Os Draconis 45 parts, Concha Ostreae 45 parts, Magnetitum 50 parts, Periostracum Serpentis 30 parts, Pheretima 30 parts, Placenta Hominis 60 parts, Colla cornus cervi 60 parts, the Radix Astragali 60 parts, 45 parts, Poria, Fructus Crataegi 100 parts, Massa Medicata Fermentata 60 parts, the Radix Aucklandiae 30 parts, Semen Strychni (processed) 30 parts.
Above Chinese medicine composition to eliminate phlegm for resuscitation to epileptics treatment, relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and surely forgives, stupid spleen appetizing, and benefiting essence and marrow, reduce as far as possible and take in medicine to the harm of human body, treatment cost is low, but the treatment phase is long.So find a kind of therapeutic effect better, curative effect is certain, soon effective, has no side effect, without bounce-back at a specified future date, the Chinese medicine composition that medical expense is low remains an important topic.
Summary of the invention
Object of the present invention provides a kind of therapeutic effect better, and curative effect is certain, soon effective, has no side effect, without bounce-back at a specified future date, and healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy of medical expense low treatment epileptics and preparation method thereof.
The present invention is achieved in that
The healthy and free from worry Chinese medicine composition of a kind of Concretio Silicea Bambusae epilepsy, comprise the former medicine component of following medicine and proportioning parts by weight are made: Radix Bupleuri 40-46 part, Rhizoma et radix valerianae 140-150 part, Arisaema Cum Bile 75-85 part, Concretio Silicea Bambusae 30-35 part, Radix Polygalae 56-64 part, Rhizoma Acori Graminei 56-64 part, Ramulus Uncariae Cum Uncis 80-88 part, Rhizoma Gastrodiae 46-50 part, Radix Salviae Miltiorrhizae 92-100 part, Radix Paeoniae Alba 57-63 part, artificial Calculus Bovis 5-7 part, Margarita 37-45 part, Scorpio 6-10 part, Scolopendra 6-10 part, Periostracum Cicadae 68-75 part, Pheretima 34-38 part, Bombyx Batryticatus 34-38 part, succinum 14-18 part, Borneolum Syntheticum 12-16 part, Radix Ginseng 45-52 part, Radix Glycyrrhizae 34-38 part.
The healthy and free from worry Chinese medicine composition of a kind of Concretio Silicea Bambusae epilepsy, is made up of following former medicine component and proportioning parts by weight: Radix Bupleuri 42 grams, Rhizoma et radix valerianae 146 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 60 grams, Rhizoma Acori Graminei 60 grams, Ramulus Uncariae Cum Uncis 84 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 60 grams, artificial Calculus Bovis 6 grams, Margarita 40 grams, Scorpio 8 grams, Scolopendra 8 grams, Periostracum Cicadae 72 grams, Pheretima 36 grams, Bombyx Batryticatus 36 grams, succinum 16 grams, Borneolum Syntheticum 14 grams, Radix Ginseng 48 grams, 36 grams, Radix Glycyrrhizae.
The healthy and free from worry Chinese medicine composition of above-described Concretio Silicea Bambusae epilepsy, directly can to pulverize or through the water extraction of this area routine or the Hydrolysis kinetics of the alcohol extracting method active component as treatment volume epilepsy medicine, then active component and pharmaceutically acceptable carrier or excipient composition are made various pharmaceutical formulation: oral liquid, granule, pill, tablet, capsule.
Above-described carrier or excipient are selected according to different dosage forms, these carriers or excipient for the those of ordinary skill of pharmaceutical field be can determine as starch, modified starch, dextrin, sodium carboxymethylcellulose pyce, ethyl cellulose, the third methylcellulose, Pulvis Talci, magnesium stearate, calcium phosphate and micropowder silica gel.
The active component of pharmaceutical composition of the present invention can be prepared according to following three kinds of methods:
First method, comprises the steps: to take raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; First Chinese crude drug artificial Calculus Bovis, Margarita, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, succinum, Borneolum Syntheticum, Radix Ginseng, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Chinese crude drug Radix Bupleuri, Rhizoma et radix valerianae, Arisaema Cum Bile, Concretio Silicea Bambusae, Radix Polygalae, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba are ground into coarse powder respectively, then are ground into fine powder, cross 120 mesh sieves; The all fine powders of mix homogeneously formula as active component, and together with pharmaceutically acceptable excipient, make various dosage form according to a conventional method.
Second method, comprises the steps: to take raw materials of traditional Chinese medicinal materials according to above-mentioned consumption, first Chinese crude drug artificial Calculus Bovis, Margarita, succinum, Borneolum Syntheticum, Radix Ginseng are ground into fine powder respectively, cross 120 mesh sieves for subsequent use, again by Radix Bupleuri, Rhizoma et radix valerianae, Arisaema Cum Bile, Concretio Silicea Bambusae, Radix Polygalae, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Radix Glycyrrhizae adds 5-8 times of soak by water secondary, each 2 hours, merge and decoct, obtain extracting solution and filter, gained extracting solution is condensed into thick paste, add above-mentioned succinum, Radix Ginseng, Margarita fine powder, mixing, drying and crushing to 120 object fine powder, again by artificial Calculus Bovis, whole fine powders that Borneolum Syntheticum does not add add mix homogeneously as active component, and together with pharmaceutically acceptable excipient, make various dosage form according to a conventional method.
The third method, comprises the steps: to take raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; First Chinese crude drug artificial Calculus Bovis, Margarita, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, succinum, Borneolum Syntheticum, Radix Ginseng, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Again the medical material of Radix Bupleuri, Rhizoma et radix valerianae, Arisaema Cum Bile, Concretio Silicea Bambusae, Radix Polygalae, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba is added again the alcohol solvent of 5-8 times of 50-60%, within 1-2 hour, extract 55-65 DEG C of backflow, overanxiously obtain extracting solution, consider slag and repeat backflow extraction in 1-2 hour once, overanxious, merge extractive liquid, cryoconcentration becomes thick extractum, dry, pulverize into fine powder; Using above-mentioned whole fine powders in described ratio mix homogeneously as active component, and make various dosage form together with pharmaceutically acceptable excipient.Recovery alcohol solvent is reused.
Dose and instructions of taking: morning every day, late taking medicine after meal 2 times, each serving 1.8 grams, under mixed boiled water clothes; After transference cure, drop to and often fasten late taking medicine after meal with a bolt or latch 1 time, each serving 1.8 grams, under mixed boiled water clothes.
Effect of prescription Chinese medicine of the present invention and pharmacology thereof illustrate:
Radix Bupleuri (Radix Bupleuri), another name: ground is smoked, Asia puecon Hu, mountain dish, eat grass, faggot, rue Artemisia.Meridian distribution of property and flavor: cold nature, bitter in the mouth, pungent, returns Liver Channel, gallbladder meridian.There is depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, elevate a turnable ladder yang-energy, loose effect of fire.Cure mainly: cure cold heating, cold and heat deficient fever, children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, and uterus comes off, menoxenia.
Rhizoma et radix valerianae (ValerianaofficinalisLinn), another name: punching Herba lysimachiae capillipedis, deer grass, Radix Et Rhizoma Nardostachyos, cat are eaten dish, pool Caulis et Folium Hyptidis suaveolentis, Rhizoma et radix valerianae, Rhizoma et radix valerianae, Radix Buddlejae Butterflybush, rescue greatly, littlely to be rescued, Rhizoma et radix valerianae, Rhizoma valerianae latifoliae, pool slope perfume.Meridian distribution of property and flavor: acrid in the mouth, sweet, warm in nature, GUIXIN, Liver Channel.There is nourishing blood to tranquillize the mind, calmness, dispel the wind, spasmolytic effect.Cure mainly irritability, insomnia is slept less, cardiopalmus severe palpitation, abnormal mind, the diseases such as tic of the limbs.
Arisaema Cum Bile (Rhizoma Arisaematis Cum Bile), for the fine powder of Rhizoma Arisaematis (processed) and cattle, sheep or Fel Sus domestica process from strand, or forms through fermentation processing for Arisaema Cum Bile fine powder and cattle and sheep, pig.Meridian distribution of property and flavor: bitter cold, micro-pungent, cool in nature, returns lung, liver, spleen channel.Have removing heat-phlegm, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. the effect of surely forgiving, and without dry strong fraud.Cure mainly phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, dementedly forgive the diseases such as epilepsy.
Radix Ginseng (Panax ginseng C.A.Mey.), another name: Radix Ginseng Sativus, Sphallerocarpus gracilis, wooden club, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), SHENCAO, Rhizoma Panacis Japonici, Herba Stellariae Saxatilis, sea fat, people Participation.Meridian distribution of property and flavor: sweet, micro-hardship, tepor, returns spleen, lung meridian.There is strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, calm the nerves and increase effect of intelligence.Cure mainly: impairment caused by overstrain is deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
Concretio Silicea Bambusae (Concretio Silicea Bambusae), another name: Concretio silicea Bambusae seu schizostachyi, Concretio silicea Bambusae seu schizostachyi, bamboo cream, bamboo sugar, bamboo, bamboo cocoon, red dumpling.Meridian distribution of property and flavor: sweet, cold, GUIXIN, liver, lung meridian.Have clear heat and eliminate phlegm, the cool heart is calmed the frightened effect.Cure mainly phlegm-heat cough, calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.
Radix Polygalae (Radix Polygalae), another name: Lush is around, sour jujube Tu, sour jujube aster, Herba Ceratophylli Demeersi, Chicken Drumsticks, little clavus, sour jujube Herba Alii fistulosi, Polygala amara.Meridian distribution of property and flavor: warm, bitter, pungent, GUIXIN, kidney, lung meridian.There is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence function.Cure mainly: the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, epilepsy mania and irritation, spasm is twitched, and expectoration is not well, sore swollen toxin, breast swell and pain.
Rhizoma Acori Graminei (Acorus tatarinowii Schott), another name: mountain Rhizoma Acori Graminei, medicine Rhizoma Acori Graminei, money Pu, Folium Acori graminei, water Rhizoma Acori Graminei, white flag.Meridian distribution of property and flavor: acrid, bitter, warm.GUIXIN, stomach warp.There is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, refreshment effect of benefiting intelligence.Cure mainly: gastral cavity painful abdominal mass is not hungry, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness, syncope due to accumulation of phlegm, calentura coma, ambition is unhappy, stomachache stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Ramulus Uncariae Cum Uncis (Uncaria rhynchophylla (Miq.) Miq.ex Havil.), another name: Ramulus Uncariae Cum Uncis, Wang Gambirplant Branchlet.Meridian distribution of property and flavor: sweet, cool, enters liver, heart channel.There is heat clearing away suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion effect.Cure mainly: liver-wind stirring up internally, infantile convulsion is twitched, and adult's slight Hypertension is dizzy, dizzy, married woman's eclamposia.
Rhizoma Gastrodiae (Rhizom Gastrodiae), another name: rhizoma gastrodiae sesame, solely shake sesame, from female, close from grass, SHENCAO, yellow moccasin flower, Mokpo, RHIZONA GASTRODIAE, DINGFENGCAO, Bai Longpi, rhizoma gastrodiae.Meridian distribution of property and flavor: sweet, flat, returns Liver Channel.There is endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral effect.Cure mainly: dizziness and headache, infantile convulsion is twitched.
Radix Salviae Miltiorrhizae (Salvia miltiorrhiza Bunge), another name: Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, also ginseng, wooden Lac caprae seu ovis, by horse, SHANSHEN, Arisaema balansae Engl., purple Radix Codonopsis, red root ginseng, mountain Radix Dauci Sativae, Herba Rabdosiae glaucocalycis root.Meridian distribution of property and flavor: bitter, is slightly cold, GUIXIN, pericardium, Liver Channel.There is qualcomm meridian, change stasiss, clearing away heart-fire, removing heat from blood be warm, will of calming the nerves, except tired effect of throbbing with fear.Cure mainly: obstruction of qi in the chest and cardialgia, menoxenia, skin infection are swollen and ache, and insomnia and congestion such as to swell and ache the disease.
The Radix Paeoniae Alba (White Paeony Root), another name: beggar, Radix Paeoniae Alba, golden Radix Paeoniae, Radix Paeoniae Alba, the large Radix Paeoniae Alba, Radix Paeoniae Alba, Radix Paeoniae Alba (parched), stir-fry Radix Paeoniae Alba, Radix Paeoniae Alba, Radix Paeoniae Alba (processed with vinegar), the burnt Radix Paeoniae Alba, Radix Paeoniae Alba charcoal.Meridian distribution of property and flavor: cool, bitter in the mouth acid, be slightly cold, enter liver, spleen channel.There is the effects such as easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receipts antiperspirant.Cure mainly: fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction urgency, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.
Artificial Calculus Bovis is be made up of the cholic acid, cholesterol, bilirubin, inorganic salt etc. of cattle and Fel Sus domestica.Meridian distribution of property and flavor: sweet in the mouth, cool in nature; GUIXIN, Liver Channel.Have and clear away heart-fire, eliminating phlegm, have one's ideas straightened out, cool liver, suffer from wind, effect of removing toxic substances.Cure mainly: the hot delirium of expectorant, coma in silence, acute infantile convulsion wind, laryngopharynx swelling and pain, aphtha of the mouth and tongue, the treatment of the diseases such as carbuncle furuncle.
Margarita (Pernulo), another name: true Zhu, natural pearls, pearl inside the body of a freshwater mussel, pearl, Lian pearl.Meridian distribution of property and flavor: salty in the mouth, sweet, cold, GUIXIN, Liver Channel.The Main Ingredients and Appearance of Margarita is calcium carbonate, prove through modern medicine study, Margarita is rich in needed by human body several amino acids if leucine, glycine methionine, alanine, glutamic acid, aspartic acid and 20 various trace elements are as ferrum, copper, magnesium, zinc, manganese, sodium, selenium etc., can effectively participate in and promote human life activity, endocrine regulation, conditioning homoiostasis, takes good care of QI and blood, skin care.
The dry body of Scorpio (Scorpio) Buthidae animal Scorpio, another name: Scorpio, Scorpio, Scorpio, Fu carries on the back worm.Meridian distribution of property and flavor: pungent, flat, poisonous, returns Liver Channel.There is effect of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Cure mainly: infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Scolopendra (Arthropleura armata), another name: Gekko Swinhonis, centipede, Wu Gong.Meridian distribution of property and flavor: warm in nature, acrid in the mouth, returns Liver Channel, poisonous.There is the function of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Cure mainly: infantile convulsion, tic spasm, apoplexy facial hemiparalysis, hemiplegia, tetanus disease, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Periostracum Cicadae (Periostracum Cicadae), another name: Cicadae moves back, Periostracum Cicadae, larval moult, Cicadae shell, Zha Liao skin, cicada skin, Taurus, Periostracum Cicadae.Meridian distribution of property and flavor: sweet, cold, return lung, Liver Channel.There is loose wind heat extraction, sore-throat relieving, rash, nebula removing, effect of spasmolytic.Cure mainly: anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Pheretima (Geosaurus), another name: Lumbricus, razor clam, leech, mound leech, wriggle transmute, draw nothing, attached earthworm, cold earthworm, song transmute, earthworm, Lumbricus, Pheretima is sub, soil transmutes, worm earthworm.Meridian distribution of property and flavor: salty in the mouth, cold in nature, returns liver, spleen, urinary bladder channel.There is gesture relieving convulsion clearly, suppressing the hyperactive liver to relieve the wind syndrome, dredge the meridian passage, diuresis effect of relievining asthma.Cure mainly: unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Bombyx Batryticatus (Bombyx Batryticatus) is that the larva in Bombycis mori material insecticide silkworm 4-5 age infects, muscardine and lethal dry polypide, another name: Bombyx Batryticatus, Bombyx Batryticatus, flying worm.Meridian distribution of property and flavor: salty in the mouth, pungent, property are put down, and return liver, spleen channel.There is effect of relieving spasm by subduing liver-wind, wind-expelling pain-stopping, dissipating phlegm and resolving masses.Cure mainly: forgive epilepsy and twitch, forgive wind, epilepsy and hold the hot person of expectorant under the arm.
Succinum (Ambrum), is the resin of taxodiaceae plant in ancient times, is transformed for a long time year in year out under burial ground.Meridian distribution of property and flavor: sweet, flat, GUIXIN, liver, urinary bladder channel, energy blood circulation promoting and blood stasis dispelling, also has effect that arresting convulsion is calmed the nerves.Cure mainly: malaise, palpitation and insomnia, infantile convulsion, epilepsy.
Borneolum Syntheticum (Borneol) is the tree tire processed goods of Dipterocarpaceae plant borneo camphor tree, another name: Borneolum Syntheticum, Borneolum Syntheticum, brain, Borneolum Syntheticum, sheet brain, Borneolum Syntheticum brain, Flos Mume brain, natural Broneolum Syntheticum, old borneol, borneol.Meridian distribution of property and flavor: pungent, bitter, is slightly cold.GUIXIN, spleen, lung meridian.There is logical all keys, loose stagnated fire, removing nebula improving eyesight, effect of clearing away heat to alleviate pain.Cure mainly: apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
Radix Glycyrrhizae (Glycyrrhizae), another name: Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae.Meridian distribution of property and flavor: sweet in the mouth, property are flat, nontoxic, GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, grow and cough lung moistening, emergency removing toxic substances, hundred medicines that are in harmonious proportion, have the function of antiinflammatory and the reflection of resistance state.Cure mainly: laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.
Advantage of the present invention and good effect:
1, we of the present invention are for containing caused epilepsy syndrome and establishing in phlegm-fire.In side, Arisaema Cum Bile, Concretio Silicea Bambusae, artificial Calculus Bovis, Ramulus Uncariae Cum Uncis are monarch drug; ministerial drug has Rhizoma Gastrodiae, Radix Polygalae, Margarita, Rhizoma Acori Graminei, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, Borneolum Syntheticum 10 herbal medicine; adjuvant drug has Radix Bupleuri, Radix Salviae Miltiorrhizae, succinum, the Radix Paeoniae Alba, makes medicine have Radix Ginseng, Rhizoma et radix valerianae, Radix Glycyrrhizae.All medicines share, and become Qinghua heat-phlegm altogether, dispelling wind and relieving convulsion, have one's ideas straightened out and determine the agent of epilepsy, pair time giddiness and downfall with salivation and convulsion, or cry and shout, emotion is irritable on ordinary days, and vexed insomnia, coughs up phlegm not well, bitter taste and dryness in the mouth, constipation, red tongue with yellowish and greasy fur, stringy and rolling pulse number, contains caused epilepsy syndrome patient and is suitable in phlegm-fire.
2, the present invention strengthens the synergism of curative effect, improves therapeutic effect, and curative effect is certain, soon effective, have no side effect, without bounce-back at a specified future date, medical expense is low, and 2008 ~ 2013 treat total case load 113 people altogether in Nanning Green Lake hospital, 45 days each courses for the treatment of, the lighter, 2-4 the course for the treatment of can cure; Severe one 5-7 the course for the treatment of can cure.Therapeutic effect: effective percentage 91.2%, cure rate 37.2%, firmly gets accreditation and the commendation of patient household.
3, raw material sources of the present invention are extensive, and cheap, safety non-toxic, does not develop immunity to drugs, easy to use, and preparation method technique is simple, have the stronger market competitiveness and good economic benefit and social benefit.
Detailed description of the invention
Be described in further detail the present invention below in conjunction with embodiment, listed embodiment is only the present invention is described and is never limited to the present invention.
One, raw material components and proportioning weight number:
Prescription 1:
Radix Bupleuri 42 grams, Rhizoma et radix valerianae 146 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 60 grams, Rhizoma Acori Graminei 60 grams, Ramulus Uncariae Cum Uncis 84 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 60 grams, artificial Calculus Bovis 6 grams, Margarita 40 grams, Scorpio 8 grams, Scolopendra 8 grams, Periostracum Cicadae 72 grams, Pheretima 36 grams, Bombyx Batryticatus 36 grams, succinum 16 grams, Borneolum Syntheticum 14 grams, Radix Ginseng 48 grams, 36 grams, Radix Glycyrrhizae.
Prescription 2:
Radix Bupleuri 40 grams, Rhizoma et radix valerianae 110 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 30 grams, Radix Polygalae 56 grams, Rhizoma Acori Graminei 56 grams, Ramulus Uncariae Cum Uncis 80 grams, 46 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 92 grams, the Radix Paeoniae Alba 57 grams, artificial Calculus Bovis 5 grams, Margarita 37 grams, Scorpio 6 grams, Scolopendra 6 grams, Periostracum Cicadae 68 grams, Pheretima 34 grams, Bombyx Batryticatus 34 grams, succinum 14 grams, Borneolum Syntheticum 12 grams, Radix Ginseng 45 grams, 34 grams, Radix Glycyrrhizae.
Prescription 3:
Radix Bupleuri 46 grams, Rhizoma et radix valerianae 130 grams, Arisaema Cum Bile 85 grams, Concretio Silicea Bambusae 35 grams, Radix Polygalae 64 grams, Rhizoma Acori Graminei 64 grams, Ramulus Uncariae Cum Uncis 88 grams, 50 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 100 grams, the Radix Paeoniae Alba 63 grams, artificial Calculus Bovis 7 grams, Margarita 45 grams, Scorpio 10 grams, Scolopendra 10 grams, Periostracum Cicadae 75 grams, Pheretima 38 grams, Bombyx Batryticatus 38 grams, succinum 18 grams, Borneolum Syntheticum 16 grams, Radix Ginseng 52 grams, 38 grams, Radix Glycyrrhizae.
Prescription 4:
Radix Bupleuri 44 grams, Rhizoma et radix valerianae 125 grams, Arisaema Cum Bile 78 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 58 grams, Rhizoma Acori Graminei 58 grams, Ramulus Uncariae Cum Uncis 83 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 61 grams, artificial Calculus Bovis 5 grams, Margarita 42 grams, Scorpio 7 grams, Scolopendra 9 grams, Periostracum Cicadae 72 grams, Pheretima 38 grams, Bombyx Batryticatus 34 grams, succinum 18 grams, Borneolum Syntheticum 15 grams, Radix Ginseng 48 grams, 38 grams, Radix Glycyrrhizae.
Prescription 5:
Radix Bupleuri 35 grams, Rhizoma et radix valerianae 123 grams, Arisaema Cum Bile 63 grams, Concretio Silicea Bambusae 27 grams, Radix Polygalae 50 grams, Rhizoma Acori Graminei 50 grams, Ramulus Uncariae Cum Uncis 70 grams, 40 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 81 grams, the Radix Paeoniae Alba 50 grams, artificial Calculus Bovis 0.5 gram, Margarita 34 grams, Scorpio 7 grams, Scolopendra 7 grams, Periostracum Cicadae 60 grams, Pheretima 30 grams, Bombyx Batryticatus 30 grams, succinum 13 grams, Borneolum Syntheticum 12 grams, Radix Ginseng 40 grams, 30 grams, Radix Glycyrrhizae.
Two, preparation method
Embodiment 1 (capsule preparation):
Raw materials of traditional Chinese medicinal materials is taken according to above-mentioned prescription 1 consumption, first Chinese crude drug artificial Calculus Bovis 6 grams, Margarita 40 grams, succinum 16 grams, Borneolum Syntheticum 14 grams, Radix Ginseng 48 grams are ground into fine powder respectively, cross 120 mesh sieves for subsequent use, by Chinese crude drug Radix Bupleuri 42 grams, Rhizoma et radix valerianae 146 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 60 grams, Rhizoma Acori Graminei 60 grams, Ramulus Uncariae Cum Uncis 84 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 60 grams, Scorpio 8 grams, Scolopendra 8 grams, Periostracum Cicadae 72 grams, Pheretima 36 grams, Bombyx Batryticatus 36 grams, 36 grams, Radix Glycyrrhizae adds 5-8 times of soak by water secondary, each 2 hours, merge and decoct, obtain extracting solution and filter, gained extracting solution is condensed into thick paste, dry, be ground into coarse powder, add above artificial Calculus Bovis again, Margarita, succinum, Borneolum Syntheticum, Radix Ginseng fine powder mix homogeneously is ground into fine powder as active component, cross 120 mesh sieves, and add suitable supplementary product starch mix homogeneously, make capsule product according to a conventional method.
Embodiment 2 (pill preparation):
Raw materials of traditional Chinese medicinal materials is taken according to above-mentioned prescription 2 consumption; First Chinese crude drug artificial Calculus Bovis 5 grams, Margarita 37 grams, Scorpio 6 grams, Scolopendra 6 grams, Periostracum Cicadae 68 grams, Pheretima 34 grams, Bombyx Batryticatus 34 grams, succinum 14 grams, Borneolum Syntheticum 12 grams, Radix Ginseng 45 grams, 34 grams, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Chinese crude drug Radix Bupleuri 40 grams, Rhizoma et radix valerianae 110 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 30 grams, Radix Polygalae 56 grams, Rhizoma Acori Graminei 56 grams, Ramulus Uncariae Cum Uncis 80 grams, 46 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 92 grams, the Radix Paeoniae Alba 57 grams are ground into coarse powder respectively, then are ground into fine powder, crosses 120 mesh sieves; The all fine powders of mix homogeneously formula as active component, and add pharmaceutically acceptable excipient sodium carboxymethylcellulose pyce, calcium phosphate mix homogeneously, make pellet product according to a conventional method.
Embodiment 3 (packed oral liquid preparation):
Raw materials of traditional Chinese medicinal materials is taken according to above-mentioned prescription 1 consumption; First Chinese crude drug artificial Calculus Bovis 7 grams, Margarita 45 grams, succinum 18 grams, Borneolum Syntheticum 16 grams, Radix Ginseng 52 grams are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Chinese crude drug Radix Bupleuri 46 grams, Rhizoma et radix valerianae 130 grams, Arisaema Cum Bile 85 grams, Concretio Silicea Bambusae 35 grams, Radix Polygalae 64 grams, Rhizoma Acori Graminei 64 grams, Ramulus Uncariae Cum Uncis 88 grams, 50 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 100 grams, the Radix Paeoniae Alba 63 grams, Scorpio 10 grams, Scolopendra 10 grams, Periostracum Cicadae 75 grams, Pheretima 38 grams, Bombyx Batryticatus 38 grams, succinum 18 grams, Borneolum Syntheticum 16 grams, Radix Ginseng 52 grams, 38 grams, Radix Glycyrrhizae are added 5-8 times of soak by water secondary; each 2 hours; merge and decoct; obtain extracting solution and filter, then throw in above artificial Calculus Bovis, Margarita, succinum, Borneolum Syntheticum, Radix Ginseng fine powder stir evenly in medicinal liquid.Make packed oral liquid product according to a conventional method.
Embodiment 4 (tablet preparation):
Raw materials of traditional Chinese medicinal materials is taken according to above-mentioned prescription 4 consumption; First Chinese crude drug artificial Calculus Bovis 5 grams, Margarita 42 grams, Scorpio 7 grams, Scolopendra 9 grams, Periostracum Cicadae 72 grams, Pheretima 38 grams, Bombyx Batryticatus 34 grams, succinum 18 grams, Borneolum Syntheticum 15 grams, Radix Ginseng 48 grams, 38 grams, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Again Radix Bupleuri 44 grams, Rhizoma et radix valerianae 125 grams, Arisaema Cum Bile 78 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 58 grams, Rhizoma Acori Graminei 58 grams, Ramulus Uncariae Cum Uncis 83 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 61 grams of medical materials are added again the alcohol solvent of 8 times 55%, within 1.5 hours, extract 65 DEG C of backflows, overanxiously obtain extracting solution, consider slag and repeat backflow extraction in 1.5 hours once, overanxious, merge extractive liquid, cryoconcentration becomes thick extractum, dry, pulverize into fine powder; Using above-mentioned whole fine powders in described ratio mix homogeneously as active component, add excipient modified starch, magnesium stearate and micropowder silica gel according to a conventional method and be mixed together, make tablet.Recovery alcohol solvent is reused.
Embodiment 5 (granule preparation):
Raw materials of traditional Chinese medicinal materials is taken according to above-mentioned prescription 4 consumption; First Chinese crude drug artificial Calculus Bovis 0.5 gram, Margarita 34 grams, Scorpio 7 grams, Scolopendra 7 grams, Periostracum Cicadae 60 grams, Pheretima 30 grams, Bombyx Batryticatus 30 grams, succinum 13 grams, Borneolum Syntheticum 12 grams, Radix Ginseng 40 grams, 30 grams, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Again Radix Bupleuri 35 grams, Rhizoma et radix valerianae 123 grams, Arisaema Cum Bile 63 grams, Concretio Silicea Bambusae 27 grams, Radix Polygalae 50 grams, Rhizoma Acori Graminei 50 grams, Ramulus Uncariae Cum Uncis 70 grams, 40 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 81 grams, the Radix Paeoniae Alba 50 grams of medical materials are added again the alcohol solvent of 6 times 60%, within 2 hours, extract 55 DEG C of backflows, overanxiously obtain extracting solution, consider slag and repeat backflow extraction in 2 hours once, overanxious, merge extractive liquid, cryoconcentration becomes thick extractum, dry, pulverize into fine powder; Using above-mentioned whole fine powders in described ratio mix homogeneously as active component, add excipient starch, dextrin, magnesium stearate and calcium phosphate according to a conventional method and be mixed together, make granule product.Recovery alcohol solvent is reused.
Three, product beta test and effect
(1) case selection:
Mainly meet in " the Chinese medical disease Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine's issue in 1994 and suffer from epileptics.Get rid of merge intentionally, liver, serious disease and the allergic constitution person such as kidney and hemopoietic system.
(2) Therapeutic Method:
This epileptics Chinese medicine composition for oral administration, 2 times on the one.45 days each courses for the treatment of, the lighter, 2-4 the course for the treatment of; Severe one 5-7 the course for the treatment of.Viewing duration requires the medicine without other treatment primary disease.
(3) criterion is imitated:
(1) clinical cure: withdraw this medicine after a year, then without recurrence.
(2) take a turn for the better: during outbreak, symptom is than front alleviating, and the intermission obviously extends.
(3) do not heal: outbreak is frequent, and symptom is without improvement.
(4) result:
2008 ~ 2013 treat total case load 113 people altogether in Nanning Green Lake hospital, wherein: effective 103 people, clinical cure 42 people, invalid 10 people; Wherein the lighter, 2-4 the course for the treatment of can cure 13 people; Severe one 5-7 the course for the treatment of can cure 29 people.Total therapeutic effect: effective percentage 91.2%, cure rate 37.2%.There is good clinical efficacy.
(5) model case:
Case 1
Deep certain, man, 26 years old, Zhuang.People from Liunan District, Liuzhou city, Guangxi province.Patient has cerebral trauma history, starts to occur outbreak after 3 years, has tendency during outbreak, show as feel uncomfortable in chest, nervous.The disease persistent period 2--3 minute such as outbreak symptom main manifestations is loss of consciousness, tic of the limbs, spit out white foams, face is livid purple, eye turns over, duration of seizure is many before and after supper, and what interval time was long has more than 20 day, and short has one day several times.After spontaneous remission, sensation headache, malaise, drowsy.Electroencephalogram is checked: slight abnormality of electroencephalogram, is diagnosed as epilepsy according to clinical manifestation in the People's Hospital of city.Once took phenytoin sodium tablet, the Carbamazepine Tablets state of an illness did not control completely.Come after being introduced to withdraw Western medicine when I institute application the party treats.Take medicine first the course for the treatment of symptom obviously have minimizing; Only have for second course for the treatment of face livid purple, extremity one more is twitched; Just also have a small amount of face livid purple without having twitched after 3rd course for the treatment of.After taking for 6 courses for the treatment of continuously, the livid purple symptom of face also disappears completely, and after 1 year, call-on back by phone is without outbreak symptom.
Case 2
Wei, female, 21 years old, the Yao nationality, people from Qingxiu District, Nanning.Mother patient Dai Shu: patient hour because of hyperpyrexia once occurred twitching several times after transference cure, patient 13 occurs screaming time of tide the beginning of the year, falls, and tic of the limbs, spits out white foams, and stares, the diseases such as urinary incontinence, susceptible disease before and after official holiday, persistent period 3-5 minute.After send doctor to be diagnosed as epilepsy, check CT and electroencephalogram all normal.Once took valpromide sheet, sodium valproate sheet, the medicines such as phenobarbital, the state of an illness does not control completely.Still taking phenobarbitone tablet when coming my institute, 2 times on the one, one time 2, application is after the party treats a course for the treatment of, and patients symptomatic obviously reduces, and Western medicine subtracts simultaneously at every turn and takes a slice, and after second course for the treatment of, Western medicine reduces to once a day, and an a slice, the state of an illness is controlled substantially.When entering for the 3rd course for the treatment of, withdraw Western medicine, have no outbreak.Drug withdrawal after the after treatment of lasting 6 courses for the treatment of, pays a return visit and has no recurrence for 1 year afterwards.
Case 3
Thank certain, man, 20 years old, Han nationality, people from Liucheng County, Liuzhou, patient started before 12 years to break out on eyes and turns over, and orthocolosis, tics of fainting, continues to alleviate for 3 minutes, can not recall afterwards, feel drowsy, headache, dizziness.Zeng city the People's Hospital's hospitalization, be diagnosed as epilepsy (concrete medication is not quite clear), the state of an illness is controlled very well, and symptom is recurrent exerbation still, general interval first quarter moon, once shows effect 2 to 3 minutes, carrys out my institute's treatment upon somebody's introduction.The no abnormality seens such as my institute is diagnosed as epilepsy, gives patient and takes this prescription, and after the course for the treatment of, patient episode's number of times reduces, and does not take other drug therebetween, check routine blood test hepatic and renal function, after three courses for the treatment of, patients symptomatic disappears, and still continues to strengthen treatment seven course for the treatment of.Patient's drug withdrawal is call-on back by phone after 1 year three months, and the reflection state of an illness is steady, outbreak that so far there are no.
Case 4
Patient Huang, female, 45 years old, Zhuang, people from Fusui.Patient's readme starts to occur dizziness, dim eyesight, the symptoms such as paraesthesia is loss of consciousness then, falls, whole body tic without obvious inducement the year before.After outbreak, sense is weak, drowsy, headache.Fall ill irregular, sometimes outbreak in a day for several times, sometimes first quarter moon outbreak once, comes institute front ten days because of overfatigue, number of incidences comparatively before frequent, symptom is the same, once be interrupted and control undesirable from taking phenytoin Sodium, it is to our hospital that the present seeks traditional Chinese medical herbal treatment, and my institute is according to patients symptomatic, to have a medical check-up red tongue, yellowish fur, pulse condition is sliding, is to sum up diagnosed as epilepsy, taken the treatment of this prescription, after taking three courses for the treatment of, patient episode's number of times obviously reduces, and attack degree obviously alleviates, after four courses for the treatment of, patient reflects transference cure.Check routine blood test, the no abnormality seens such as hepatic and renal function, look into body of the tongue light red, white and thin fur, thready and rolling pulse.Then medicine after treatment is subtracted.Call-on back by phone after 1 year, patient now drug withdrawal half a year, the state of an illness has no outbreak.
Claims (8)
1. the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy, it is characterized in that: comprise the former medicine component of following medicine and proportioning parts by weight are made: Radix Bupleuri 40-46 part, Rhizoma et radix valerianae 140-150 part, Arisaema Cum Bile 75-85 part, Concretio Silicea Bambusae 30-35 part, Radix Polygalae 56-64 part, Rhizoma Acori Graminei 56-64 part, Ramulus Uncariae Cum Uncis 80-88 part, Rhizoma Gastrodiae 46-50 part, Radix Salviae Miltiorrhizae 92-100 part, Radix Paeoniae Alba 57-63 part, artificial Calculus Bovis 5-7 part, Margarita 37-45 part, Scorpio 6-10 part, Scolopendra 6-10 part, Periostracum Cicadae 68-75 part, Pheretima 34-38 part, Bombyx Batryticatus 34-38 part, succinum 14-18 part, Borneolum Syntheticum 12-16 part, Radix Ginseng 45-52 part, Radix Glycyrrhizae 34-38 part.
2. the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy, is characterized in that: be made up of following former medicine component and proportioning parts by weight: Radix Bupleuri 42 grams, Rhizoma et radix valerianae 146 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 60 grams, Rhizoma Acori Graminei 60 grams, Ramulus Uncariae Cum Uncis 84 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 60 grams, artificial Calculus Bovis 6 grams, Margarita 40 grams, Scorpio 8 grams, Scolopendra 8 grams, Periostracum Cicadae 72 grams, Pheretima 36 grams, Bombyx Batryticatus 36 grams, succinum 16 grams, Borneolum Syntheticum 14 grams, Radix Ginseng 48 grams, 36 grams, Radix Glycyrrhizae.
3. the preparation method of the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy according to claim 1, it is characterized in that: can directly to pulverize or through the water extraction of this area routine or the Hydrolysis kinetics of the alcohol extracting method active component as treatment volume epilepsy medicine, then active component and pharmaceutically acceptable carrier or excipient composition are made various pharmaceutical formulation: oral liquid, granule, pill, tablet, capsule.
4. the preparation method of the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy according to claim 3, it is characterized in that: described carrier or excipient are selected according to different dosage forms, these carriers or excipient for the those of ordinary skill of pharmaceutical field be can determine as starch, modified starch, dextrin, sodium carboxymethylcellulose pyce, ethyl cellulose, the third methylcellulose, Pulvis Talci, magnesium stearate, calcium phosphate and micropowder silica gel.
5. the preparation method of the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy according to claim 3, is characterized in that: take raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; First Chinese crude drug artificial Calculus Bovis, Margarita, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, succinum, Borneolum Syntheticum, Radix Ginseng, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Chinese crude drug Radix Bupleuri, Rhizoma et radix valerianae, Arisaema Cum Bile, Concretio silicea Bambusae seu schizostachyi, Radix Polygalae, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba are ground into coarse powder respectively, then are ground into fine powder, cross 120 mesh sieves; The all fine powders of mix homogeneously formula as active component, and together with pharmaceutically acceptable excipient, make various dosage form according to a conventional method.
6. the preparation method of the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy according to claim 3, is characterized in that: take raw materials of traditional Chinese medicinal materials according to above-mentioned consumption, first Chinese crude drug artificial Calculus Bovis, Margarita, succinum, Borneolum Syntheticum, Radix Ginseng are ground into fine powder respectively, cross 120 mesh sieves for subsequent use, again by Radix Bupleuri, Rhizoma et radix valerianae, Arisaema Cum Bile, Concretio silicea Bambusae seu schizostachyi, Radix Polygalae, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Radix Glycyrrhizae adds 5-8 times of soak by water secondary, each 2 hours, merge and decoct, obtain extracting solution and filter, gained extracting solution is condensed into thick paste, add above-mentioned succinum, Radix Ginseng, Margarita fine powder, mixing, drying and crushing to 120 object fine powder, again by artificial Calculus Bovis, whole fine powders that Borneolum Syntheticum does not add add mix homogeneously as active component, and together with pharmaceutically acceptable excipient, make various dosage form according to a conventional method.
7. the preparation method of the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy according to claim 3, is characterized in that: take raw materials of traditional Chinese medicinal materials according to above-mentioned consumption; First Chinese crude drug artificial Calculus Bovis, Margarita, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, succinum, Borneolum Syntheticum, Radix Ginseng, Radix Glycyrrhizae are ground into fine powder respectively, cross 120 mesh sieves for subsequent use; Again the medical material of Radix Bupleuri, Rhizoma et radix valerianae, Arisaema Cum Bile, Concretio silicea Bambusae seu schizostachyi, Radix Polygalae, Rhizoma Acori Graminei, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba is added again the alcohol solvent of 5-8 times of 50-60%, within 1-2 hour, extract 55-65 DEG C of backflow, overanxiously obtain extracting solution, consider slag and repeat backflow extraction in 1-2 hour once, overanxious, merge extractive liquid, cryoconcentration becomes thick extractum, dry, pulverize into fine powder; Using above-mentioned whole fine powders in described ratio mix homogeneously as active component, and make various dosage form together with pharmaceutically acceptable excipient, reclaim alcohol solvent and reuse.
8. the preparation method of the healthy and free from worry Chinese medicine composition of Concretio Silicea Bambusae epilepsy according to claim 5, is characterized in that: first Chinese crude drug artificial Calculus Bovis 6 grams, Margarita 40 grams, succinum 16 grams, Borneolum Syntheticum 14 grams, Radix Ginseng 48 grams are ground into fine powder respectively, crosses 120 mesh sieves for subsequent use, by Chinese crude drug Radix Bupleuri 42 grams, Rhizoma et radix valerianae 146 grams, Arisaema Cum Bile 75 grams, Concretio Silicea Bambusae 32 grams, Radix Polygalae 60 grams, Rhizoma Acori Graminei 60 grams, Ramulus Uncariae Cum Uncis 84 grams, 48 grams, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 96 grams, the Radix Paeoniae Alba 60 grams, Scorpio 8 grams, Scolopendra 8 grams, Periostracum Cicadae 72 grams, Pheretima 36 grams, Bombyx Batryticatus 36 grams, 36 grams, Radix Glycyrrhizae adds 5-8 times of soak by water secondary, each 2 hours, merge and decoct, obtain extracting solution and filter, gained extracting solution is condensed into thick paste, dry, be ground into coarse powder, add above artificial Calculus Bovis again, Margarita, succinum, Borneolum Syntheticum, Radix Ginseng fine powder mix homogeneously is ground into fine powder as active component, cross 120 mesh sieves, and add suitable supplementary product starch mix homogeneously, make capsule product according to a conventional method.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998164A (en) * | 2016-06-20 | 2016-10-12 | 中国人民解放军空军总医院 | Traditional Chinese medicine composition and granules for treating atopic dermatitis and preparation method |
| CN105998164B (en) * | 2016-06-20 | 2020-03-17 | 中国人民解放军空军总医院 | Traditional Chinese medicine composition for treating atopic dermatitis and granules and preparation method thereof |
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| CN104940710B (en) | 2019-03-05 |
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